James Higham


University position

PhD student
Supervised by Dr David Bulmer

Departments

Department of Pharmacology

Email

jph87@cam.ac.uk

Home page

https://www.neuroscience.cam.ac.uk/directo...

Research Theme

Cellular and Molecular Neuroscience

Interests

Current project: Interactions between novel inflammatory mediators and nociceptive neurons.

Previous work: 1) Neuronal basis of behavioural defects in Alzheimer's Disease. 2) Assembly of calcium-activated potassium channel sub-units.

Research Focus

Keywords

Nociceptor

Inflammation

Ion channels

Neurophysiology

Clinical conditions

Inflammatory bowel disease

No direct clinical relevance

Equipment

Calcium imaging

Cell culture

Electrophysiological recording techniques

Immunohistochemistry

Whole cell patch clamp

Collaborators

United Kingdom

Neil Marrion Web: http://www.bristol.ac.uk/phys-ph...

Associated News Items


    Publications

    2019

    Edgar Buhl*, James P Higham*, James J L Hodge (2019), “Alzheimer's Disease-Associated Tau Alters Drosophila Circadian Activity, Sleep and Clock Neuron Electrophysiology” Neurobiol of Dis Vol 130

    James Higham, Giriraj Sahu, Rima-Marie Wazen, Pina Colarusso, Alice Gregorie, Bartholomew S. J. Harvey, Lucy Goudswaard, Gemma Varley, David N Sheppard, Ray W Turner and Neil V Marrion (2019), “Preferred formation of heteromeric channels between co-expressed SK1 and IKCa channel subunits provides a unique pharmacological profile of Ca2+-activated K+ channels” Mol Pharm 97(5): 115-126

    James P. Higham*, Bilal R. Malik*, Edgar Buhl, Jennifer M. Dawson, Anna S. Ogier, Katie Lunnon and James J. L. Hodge (2019), “Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila” Front Cell Neuro Vol 13; pp260

    James P. Higham†, Sergio Hidalgo†, Edgar Buhl and James J. L. Hodge* (2019), “Restoration of Olfactory Memory in Drosophila Overexpressing Human Alzheimer’s Disease Associated Tau by Manipulation of L-Type Ca2+ Channels” Front Cell Neuro Vol 13; pp409

    2017

    James P Higham (2017), “Letter: Tangled tau: Active pathology or footprint of disease?” Alzheimer's and Demantia 3(4): 658-659