Dr James Higham

University position

PhD student
Supervised by Dr David Bulmer


Department of Pharmacology



Home page


Research Theme

Cellular and Molecular Neuroscience


I am a Research Associate in Pharmacology interested in the interaction between novel inflammatory mediators and sensory neurons, with the aim of better understanding nociceptive signalling during inflammatory disease. My PhD with Dr David Bulmer was primarily focussed on investigating the interaction between Angiotensin II and sensory neurons in vitro, using genetically engineered neurons (in collaboration with Prof John Wood and Prof James Cox, UCL) and pharmacological tools in tandem with calcium imaging, patch-clamp electrophysiology and immunofluorescence.

Research Focus




Ion channels


Clinical conditions

Inflammatory bowel disease

No direct clinical relevance


Calcium imaging

Cell culture

Electrophysiological recording techniques


Whole cell patch clamp


United Kingdom

Neil Marrion Web: http://www.bristol.ac.uk/phys-ph...

Associated News Items



    Edgar Buhl*, James P Higham*, James J L Hodge (2019), “Alzheimer's Disease-Associated Tau Alters Drosophila Circadian Activity, Sleep and Clock Neuron Electrophysiology” Neurobiol of Dis Vol 130

    James Higham, Giriraj Sahu, Rima-Marie Wazen, Pina Colarusso, Alice Gregorie, Bartholomew S. J. Harvey, Lucy Goudswaard, Gemma Varley, David N Sheppard, Ray W Turner and Neil V Marrion (2019), “Preferred formation of heteromeric channels between co-expressed SK1 and IKCa channel subunits provides a unique pharmacological profile of Ca2+-activated K+ channels” Mol Pharm 97(5): 115-126

    James P. Higham*, Bilal R. Malik*, Edgar Buhl, Jennifer M. Dawson, Anna S. Ogier, Katie Lunnon and James J. L. Hodge (2019), “Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila” Front Cell Neuro Vol 13; pp260

    James P. Higham†, Sergio Hidalgo†, Edgar Buhl and James J. L. Hodge* (2019), “Restoration of Olfactory Memory in Drosophila Overexpressing Human Alzheimer’s Disease Associated Tau by Manipulation of L-Type Ca2+ Channels” Front Cell Neuro Vol 13; pp409


    James P Higham (2017), “Letter: Tangled tau: Active pathology or footprint of disease?” Alzheimer's and Demantia 3(4): 658-659