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Department
  • Pharmacology
    • Research Theme Neurons, Circuits and Networks
    Research Focus

    Keywords

  • Visceral Nociception
  • Neurobiology
  • Sensory Transduction

    • Clinical Conditions

  • Visceral pain

    • Equipment & Techniques

  • Calcium imaging
  • Electrophysiological recording techniques
  • Immunohistochemistry

    • Science Culture

  • Teaching

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    Dr James Higham

    University Position
    Research Associate

    Interests

    I am a Research Associate in Pharmacology interested in the interaction between novel inflammatory mediators and sensory neurons, with the aim of better understanding nociceptive signalling during inflammatory disease. My PhD with Dr David Bulmer was primarily focussed on investigating the interaction between Angiotensin II and sensory neurons in vitro, using genetically engineered neurons (in collaboration with Prof John Wood and Prof James Cox, UCL) and pharmacological tools in tandem with calcium imaging, patch-clamp electrophysiology and immunofluorescence.

    Key Publications

    Publications

    Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity.

    DOI: http://doi.org/10.1152/ajpgi.00280.2022
    Journal: Am J Physiol Gastrointest Liver Physiol
    E-pub date: 1 Apr 2023
    Authors: KH Barker, JP Higham, LA Pattison, IP Chessell, F Welsh, ESJ Smith, DC Bulmer

    Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity.

    DOI: http://doi.org/10.1113/JP283170
    Journal: J Physiol
    E-pub date: 31 Aug 2022
    Authors: KH Barker, JP Higham, LA Pattison, TS Taylor, IP Chessell, F Welsh, ESJ Smith, DC Bulmer