Dr Jing Ren


University position

Group Leader

Dr Jing Ren is pleased to consider applications from prospective PhD students.

Departments

MRC Laboratory of Molecular Biology

Institutes

Medical Research Council Laboratory of Molecular Biology

Home page

https://www2.mrc-lmb.cam.ac.uk/groups/...

Research Themes

Developmental Neuroscience

Cellular and Molecular Neuroscience

Interests

The serotonin system is the most frequently targeted neural system for treating mental illnesses, including depression and anxiety. Our team focuses on bridging the huge gap on the link between the abnormalities of serotonergic wiring and transmission, and the vulnerability to mental illnesses. The serotonin system innervates nearly every area of the brain and has been implicated in the modulation of seemingly every human behavior. We recently revealed that there are anatomically defined parallel serotonin sub-systems that exert different influences on distinct behavioral functions of mice. Furthermore, we elucidated the molecular architecture of these sub-systems. The next key questions that intrigue us are: How is the organization of the serotonin system determined during development, and how do disruptions in these developmental programs alter this organization? How multiple transmitters’ co-release is modulated in serotonin system? How do these abnormalities influences behaviors?

Research Focus

Keywords

serotonin

dorsal raphe

mental disorder

wiring specificity

co-transmission

Clinical conditions

No direct clinical relevance

Equipment

Behavioural analysis

Calcium imaging

Cell culture

Confocal microscopy

Electrophysiological recording techniques

Fluorescence microscopy

Immunohistochemistry

Microscopy

single cell RNA sequencing; Light-sheet microscopy; Flow cytometry; Fiber photometry;

Whole cell patch clamp

Collaborators

Cambridge

Micheal Hastings

Madeline Lancaster

Trevor Robbins

Marco Tripodi

International

Bryan Roth

Associated News Items