Dr Hugh Matthews

Hugh Matthews

University position

Reader

Dr Hugh Matthews is pleased to consider applications from prospective PhD students.

Departments

Department of Physiology, Development and Neuroscience

Email

hrm1@cam.ac.uk

Home page

http://www.pdn.cam.ac.uk/staff/m... (personal home page)

Research Theme

Cellular and Molecular Neuroscience

The Cambridge Neuroscience Community

Interests

Phototransduction and olfactory transduction. Calcium homeostasis in vertebrate photoreceptors and olfactory receptors, and its role in modulating their electrical responses to stimulation. Light-induced calcium release within the photoreceptor outer segment. Mechanisms of response termination in cone photoreceptors. Mechanisms for calcium extrusion in vertebrate olfactory receptors.

Pseudo-colour image of salamander rod photoreceptor during simultaneous recording of electrical response and calcium dye fluorescence during stimulation by a bar of light
Pseudo-colour image of salamander rod photoreceptor during simultaneous recording of electrical response and calcium dye fluorescence during stimulation by a bar of light
Click image to view full-size

Research Focus

Keywords

phototransduction

olfactory transduction

calcium

sensory adaptation

light adaptation

Clinical conditions

No direct clinical relevance

Equipment

Calcium imaging

Electrophysiological recording techniques

Whole cell patch clamp

Collaborators

International

Carter Cornwall Web: http://biophysics.bumc.bu.edu/faculty...

Rosalie Crouch Web: http://www.musc.edu/neurosc...

Gordon Fain Web: http://www.physci.ucla.edu/researc...

Johannes Reisert Web: http://www.monell.org/faculty...

Alapakkam Sampath Web: http://www.usc.edu/program...

Associated News Items


    Key publications

    Antolin S, Reisert J, Matthews HR (2010), “Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia.” J Gen Physiol 135(4):367-78 Details

    Matthews HR, Sampath AP (2010), “Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors.” J Gen Physiol 135(4):355-66 Details

    Antolin S, Matthews HR (2007), “The effect of external sodium concentration on sodium-calcium exchange in frog olfactory receptor cells.” J Physiol 581(Pt 2):495-503 Details

    Leung YT, Fain GL, Matthews HR (2007), “Simultaneous measurement of current and calcium in the ultraviolet-sensitive cones of zebrafish” Journal of Physiology 579:15-27 Details

    Matthews HR, Fain GL (2003), “The effect of light on outer segment calcium in salamander rods” Journal of Physiology 552:763-776

    Publications

    2013

    King JH, Wickramarachchi C, Kua K, Du Y, Jeevaratnam K, Matthews HR, Grace AA, Huang CL, Fraser JA (2013), “Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.” Cardiovasc Res 99(4):751-9 Details

    2012

    Ponissery Saidu S, Dibattista M, Matthews HR, Reisert J (2012), “Odorant-induced responses recorded from olfactory receptor neurons using the suction pipette technique.” J Vis Exp (62):e3862 Details

    Zang J, Matthews HR (2012), “Origin and control of the dominant time constant of salamander cone photoreceptors.” J Gen Physiol 140(2):219-33 Details