Dr Hugh Matthews
Dr Hugh Matthews is pleased to consider applications from prospective PhD students.
Department of Physiology, Development and Neuroscience
http://www.pdn.cam.ac.uk/staff/m... (personal home page)
Phototransduction and olfactory transduction. Calcium homeostasis in vertebrate photoreceptors and olfactory receptors, and its role in modulating their electrical responses to stimulation. Light-induced calcium release within the photoreceptor outer segment. Mechanisms of response termination in cone photoreceptors. Mechanisms for calcium extrusion in vertebrate olfactory receptors.
Electrophysiological recording techniques
Whole cell patch clamp
Associated News Items
Antolin S, Reisert J, Matthews HR (2010), “Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia.” J Gen Physiol 135(4):367-78 Details
Matthews HR, Sampath AP (2010), “Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors.” J Gen Physiol 135(4):355-66 Details
Antolin S, Matthews HR (2007), “The effect of external sodium concentration on sodium-calcium exchange in frog olfactory receptor cells.” J Physiol 581(Pt 2):495-503 Details
Leung YT, Fain GL, Matthews HR (2007), “Simultaneous measurement of current and calcium in the ultraviolet-sensitive cones of zebrafish” Journal of Physiology 579:15-27 Details
Matthews HR, Fain GL (2003), “The effect of light on outer segment calcium in salamander rods” Journal of Physiology 552:763-776
King JH, Wickramarachchi C, Kua K, Du Y, Jeevaratnam K, Matthews HR, Grace AA, Huang CL, Fraser JA (2013), “Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation.” Cardiovasc Res 99(4):751-9 Details
Ponissery Saidu S, Dibattista M, Matthews HR, Reisert J (2012), “Odorant-induced responses recorded from olfactory receptor neurons using the suction pipette technique.” J Vis Exp (62):e3862 Details
Zang J, Matthews HR (2012), “Origin and control of the dominant time constant of salamander cone photoreceptors.” J Gen Physiol 140(2):219-33 Details