Dr Florian Merkle
Senior Research Associate
Dr Florian Merkle is pleased to consider applications from prospective PhD students.
My laboratory uses pluripotent stem cells to model human diseases that arise from the loss of aberrant function of neurons in the hypothalamus that regulate essential physiological and behavioural processes. In particular, obesity is thought to result from abnormal function of hypothalamic neurons that regulate food intake, and the sleep disorder obesity results from the specific loss of sleep-regulatory hypothalamic neurones. I recently developed methods to generate these hypothalamic neurone populations from human pluripotent stem cells, and edit their genomes to generate reporter cell lines and to introduce disease-causing mutations. Our laboratory combines these tools and interrogates the resulting cellular and molecular phenotypes using imaging, sequencing, and biochemical tools.
Outstanding graduate students or postdoctoral candidates interested in contributing to this work should contact me at email@example.com.
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