Dr Fabricio Moreira

Fabricio Moreira

University position

Visiting Scholar (2014)


Department of Psychology

Home page


Research Theme

Cognitive and Behavioural Neuroscience


-Pharmacology of the Endocannabinoid System

-Pharmacology of Antipsychotics

Research Focus







Clinical conditions


Anxiety disorders

Bipolar disorder

Depressive disorders


Panic disorder

Post-traumatic stress disorder



Behavioural analysis



Jeffrey Dalley


Carsten Wotjak

Associated News Items



    Aguiar DC, Moreira FA, Terzian AL, Fogaça MV, Lisboa SF, Wotjak CT, Guimaraes FS (2014), “Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channels.” Neurosci Biobehav Rev Details

    Almeida-Santos AF, Gobira PH, Souza DP, Ferreira RC, Romero TR, Duarte ID, Aguiar DC, Moreira FA (2014), “The antipsychotic aripiprazole selectively prevents the stimulant and rewarding effects of morphine in mice.” Eur J Pharmacol Details

    Batista LA, Gobira PH, Viana TG, Aguiar DC, Moreira FA (2014), “Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs.” Behav Pharmacol 25(5-6):425-33 Details

    Bergamaschi MM, Queiroz RH, Chagas MH, Linares IM, Arrais KC, de Oliveira DC, Queiroz ME, Nardi AE, Huestis MA, Hallak JE, Zuardi AW, Moreira FA, Crippa JA (2014), “Rimonabant effects on anxiety induced by simulated public speaking in healthy humans: a preliminary report.” Hum Psychopharmacol 29(1):94-9 Details

    Ferreira-Vieira TH, Bastos CP, Pereira GS, Moreira FA, Massensini AR (2014), “A role for the endocannabinoid system in exercise-induced spatial memory enhancement in mice.” Hippocampus 24(1):79-88 Details

    Monteiro BM, Moreira FA, Massensini AR, Moraes MF, Pereira GS (2014), “Enriched environment increases neurogenesis and improves social memory persistence in socially isolated adult mice.” Hippocampus 24(2):239-48 Details

    Vilela LR, Medeiros DC, de Oliveira AC, Moraes MF, Moreira FA (2014), “Anticonvulsant Effects of N-Arachidonoyl-Serotonin, a Dual Fatty Acid Amide Hydrolase Enzyme and Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Blocker, on Experimental Seizures: The Roles of Cannabinoid CB1 Receptors and TRPV1 Channels.” Basic Clin Pharmacol Toxicol 115(4):330-4 Details


    Almeida-Santos AF, Gobira PH, Rosa LC, Guimaraes FS, Moreira FA, Aguiar DC (2013), “Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray.” Behav Brain Res 252:10-7 Details

    Almeida-Santos AF, Moreira FA, Guimarães FS, Aguiar DC (2013), “Role of TRPV1 receptors on panic-like behaviors mediated by the dorsolateral periaqueductal gray in rats.” Pharmacol Biochem Behav 105:166-72 Details

    Campos AC, Ortega Z, Palazuelos J, Fogaça MV, Aguiar DC, Díaz-Alonso J, Ortega-Gutiérrez S, Vázquez-Villa H, Moreira FA, Guzmán M, Galve-Roperh I, Guimarães FS (2013), “The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.” Int J Neuropsychopharmacol 16(6):1407-19 Details

    Fogaça MV, Gomes FV, Moreira FA, Guimarães FS, Aguiar DC (2013), “Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats.” Psychopharmacology (Berl) 226(3):579-87 Details

    Gobira PH, Aguiar DC, Moreira FA (2013), “Effects of compounds that interfere with the endocannabinoid system on behaviors predictive of anxiolytic and panicolytic activities in the elevated T-maze.” Pharmacol Biochem Behav 110:33-9 Details

    Gobira PH, Ropke J, Aguiar DC, Crippa JA, Moreira FA (2013), “Animal models for predicting the efficacy and side effects of antipsychotic drugs.” Rev Bras Psiquiatr 35 Suppl 2:S132-9 Details

    Häring M, Grieb M, Monory K, Lutz B, Moreira FA (2013), “Cannabinoid CB₁ receptor in the modulation of stress coping behavior in mice: the role of serotonin and different forebrain neuronal subpopulations.” Neuropharmacology 65:83-9 Details

    Moreira FA, Gobira PH, Viana TG, Vicente MA, Zangrossi H, Graeff FG (2013), “Modeling panic disorder in rodents.” Cell Tissue Res 354(1):119-25 Details

    Viana TG, Almeida-Santos AF, Aguiar DC, Moreira FA (2013), “Effects of aripiprazole, an atypical antipsychotic, on the motor alterations induced by acute ethanol administration in mice.” Basic Clin Pharmacol Toxicol 112(5):319-24 Details

    Vilela LR, Medeiros DC, Rezende GH, de Oliveira AC, Moraes MF, Moreira FA (2013), “Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats.” Epilepsy Res 104(3):195-202 Details


    Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (2012), “Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.” Philos Trans R Soc Lond B Biol Sci 367(1607):3364-78 Details

    Casarotto PC, Terzian AL, Aguiar DC, Zangrossi H, Guimarães FS, Wotjak CT, Moreira FA (2012), “Opposing roles for cannabinoid receptor type-1 (CB₁) and transient receptor potential vanilloid type-1 channel (TRPV1) on the modulation of panic-like responses in rats.” Neuropsychopharmacology 37(2):478-86 Details

    Ferretjans R, Moreira FA, Teixeira AL, Salgado JV (2012), “The endocannabinoid system and its role in schizophrenia: a systematic review of the literature.” Rev Bras Psiquiatr 34 Suppl 2:S163-77 Details

    Fogaça MV, Aguiar DC, Moreira FA, Guimarães FS (2012), “The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior.” Neuropharmacology 63(2):202-10 Details

    Fogaça MV, Lisboa SF, Aguiar DC, Moreira FA, Gomes FV, Casarotto PC, Guimarães FS (2012), “Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters.” Braz J Med Biol Res 45(4):357-65 Details

    Moreira FA, Aguiar DC, Resstel LB, Lisboa SF, Campos AC, Gomes FV, Guimarães FS (2012), “Neuroanatomical substrates involved in cannabinoid modulation of defensive responses.” J Psychopharmacol 26(1):40-55 Details

    Moreira FA, Aguiar DC, Terzian AL, Guimarães FS, Wotjak CT (2012), “Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels in fear and anxiety-two sides of one coin?” Neuroscience 204:186-92 Details


    Biojone C, Casarotto PC, Resstel LB, Zangrossi H Jr, Guimarães FS, Moreira FA (2011), “Anti-aversive effects of the atypical antipsychotic, aripiprazole, in animal models of anxiety.” J Psychopharmacol 25(6):801-7 Details

    Marco EM, García-Gutiérrez MS, Bermúdez-Silva FJ, Moreira FA, Guimarães F, Manzanares J, Viveros MP (2011), “Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects.” Front Behav Neurosci 5:63 Details


    Moreira FA, Wotjak CT (2010), “Cannabinoids and anxiety.” Curr Top Behav Neurosci 2:429-50 Details

    Saito VM, Wotjak CT, Moreira FA (2010), “[Pharmacological exploitation of the endocannabinoid system: new perspectives for the treatment of depression and anxiety disorders?].” Rev Bras Psiquiatr 32 Suppl 1:S7-14 Details

    Zanelati TV, Biojone C, Moreira FA, Guimarães FS, Joca SR (2010), “Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors.” Br J Pharmacol 159(1):122-8 Details


    Aguiar DC, Terzian AL, Guimarães FS, Moreira FA (2009), “Anxiolytic-like effects induced by blockade of transient receptor potential vanilloid type 1 (TRPV1) channels in the medial prefrontal cortex of rats.” Psychopharmacology (Berl) 205(2):217-25 Details

    Moreira FA, Aguiar DC, Campos AC, Lisboa SF, Terzian AL, Resstel LB, Guimarães FS (2009), “Antiaversive effects of cannabinoids: is the periaqueductal gray involved?” Neural Plast 2009:625469 Details

    Moreira FA, Crippa JA (2009), “The psychiatric side-effects of rimonabant.” Rev Bras Psiquiatr 31(2):145-53 Details

    Moreira FA, Grieb M, Lutz B (2009), “Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression.” Best Pract Res Clin Endocrinol Metab 23(1):133-44 Details

    Resstel LB, Moreira FA, Guimarães FS (2009), “Endocannabinoid system and fear conditioning.” Vitam Horm 81:421-40 Details

    Terzian AL, Aguiar DC, Guimarães FS, Moreira FA (2009), “Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray.” Eur Neuropsychopharmacol 19(3):188-95 Details


    Leite JV, Guimarães FS, Moreira FA (2008), “Aripiprazole, an atypical antipsychotic, prevents the motor hyperactivity induced by psychotomimetics and psychostimulants in mice.” Eur J Pharmacol 578(2-3):222-7 Details

    Moreira FA, Guimarães FS (2008), “Lack of effects of clomipramine on Fos and NADPH-diaphorase double-staining in the periaqueductal gray after exposure to an innate fear stimulus.” Physiol Behav 94(3):316-21 Details

    Moreira FA, Kaiser N, Monory K, Lutz B (2008), “Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors.” Neuropharmacology 54(1):141-50 Details

    Moreira FA, Lutz B (2008), “The endocannabinoid system: emotion, learning and addiction.” Addict Biol 13(2):196-212 Details


    Moreira FA (2007), “Serotonin, the prefrontal cortex, and the antidepressant-like effect of cannabinoids.” J Neurosci 27(49):13369-70 Details

    Moreira FA, Aguiar DC, Guimarães FS (2007), “Anxiolytic-like effect of cannabinoids injected into the rat dorsolateral periaqueductal gray.” Neuropharmacology 52(3):958-65 Details

    Moreira FA, Baptista Lde P, Soares AH, Lederman HM, Ajzen SA, Szejnfeld J (2007), “National examination of Brazilian residents and specialization trainees in radiology and diagnostic imaging: a tool for evaluating the qualifications of future radiologists.” Clinics (Sao Paulo) 62(6):691-8 Details


    Aguiar DC, Moreira FA, Guimarães FS (2006), “Flight reactions induced by injection of glutamate N-methyl-d-aspartate receptor agonist into the rat dorsolateral periaqueductal gray are not dependent on endogenous nitric oxide.” Pharmacol Biochem Behav 83(2):296-301 Details

    Moreira FA, Aguiar DC, Guimarães FS (2006), “Anxiolytic-like effect of cannabidiol in the rat Vogel conflict test.” Prog Neuropsychopharmacol Biol Psychiatry 30(8):1466-71 Details

    Resstel LB, Joca SR, Moreira FA, Corrêa FM, Guimarães FS (2006), “Effects of cannabidiol and diazepam on behavioral and cardiovascular responses induced by contextual conditioned fear in rats.” Behav Brain Res 172(2):294-8 Details

    Zuardi AW, Crippa JA, Hallak JE, Moreira FA, Guimarães FS (2006), “Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.” Braz J Med Biol Res 39(4):421-9 Details


    Guimarães FS, Beijamini V, Moreira FA, Aguiar DC, de Lucca AC (2005), “Role of nitric oxide in brain regions related to defensive reactions.” Neurosci Biobehav Rev 29(8):1313-22 Details

    Jardim MC, Aguiar DC, Moreira FA, Guimarães FS (2005), “Role of glutamate ionotropic and benzodiazepine receptors in the ventromedial hypothalamic nucleus on anxiety.” Pharmacol Biochem Behav 82(1):182-9 Details

    Moreira FA, Guimarães FS (2005), “Role of serotonin receptors in panic-like behavior induced by nitric oxide in the rat dorsolateral periaqueductal gray: effects of chronic clomipramine treatment.” Life Sci 77(16):1972-82 Details

    Moreira FA, Guimarães FS (2005), “Cannabidiol inhibits the hyperlocomotion induced by psychotomimetic drugs in mice.” Eur J Pharmacol 512(2-3):199-205 Details


    Moreira FA, Guimarães FS (2004), “Benzodiazepine receptor and serotonin 2A receptor modulate the aversive-like effects of nitric oxide in the dorsolateral periaqueductal gray of rats.” Psychopharmacology (Berl) 176(3-4):362-8 Details

    Moreira FA, Molchanov ML, Guimarães FS (2004), “Ionotropic glutamate-receptor antagonists inhibit the aversive effects of nitric oxide donor injected into the dorsolateral periaqueductal gray of rats.” Psychopharmacology (Berl) 171(2):199-203 Details


    de Araújo Moreira F, Molchanov ML, Guimarães FS (2003), “Flight reactions to nitric oxide in the inferior colliculus of rats depend on NMDA receptor activation.” Pharmacol Biochem Behav 76(1):35-41 Details


    Souza AL, Moreira FA, Almeida KR, Bertollo CM, Costa KA, Coelho MM (2002), “In vivo evidence for a role of protein kinase C in peripheral nociceptive processing.” Br J Pharmacol 135(1):239-47 Details