Kristian Franze is pleased to consider applications from prospective PhD students.
Department of Physiology, Development and Neuroscience
http://www.pdn.cam.ac.uk/staff/f... (personal home page)
We are taking an interdisciplinary approach to investigate how cellular forces, local cell and tissue stiffness and cellular mechanosensitivity contribute to CNS development and disease. Methods we are exploiting include atomic force microscopy, traction force microscopy, custom-built simple and complex compliant cell culture substrates, optogenetics and cell biological techniques.
Atomic force microscopy
Open laser systems
Soft cell culture substrates
Traction force microscopy
Associated News Items
Koser DE, Moeendarbary E, Hanne J, Kuerten S, Franze K (2015), “CNS cell distribution and axon orientation determine local spinal cord mechanical properties.” Biophys J 108(9):2137-47 Details
Moshayedi P, Ng G, Kwok JC, Yeo GS, Bryant CE, Fawcett JW, Franze K, Guck J (2014), “The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system.” Biomaterials 35(13):3919-25 Details
Pagliara S, Franze K, McClain CR, Wylde GW, Fisher CL, Franklin RJ, Kabla AJ, Keyser UF, Chalut KJ (2014), “Auxetic nuclei in embryonic stem cells exiting pluripotency.” Nat Mater 13(6):638-44 Details
Franze K (2013), “The mechanical control of nervous system development.” Development 140(15):3069-77 Details
Hardie RC, Franze K (2012), “Photomechanical responses in Drosophila photoreceptors.” Science 338(6104):260-3 Details
Betz T, Koch D, Lu YB, Franze K, Käs JA (2011), “Growth cones as soft and weak force generators.” Proc Natl Acad Sci U S A 108(33):13420-5 Details