Professor Carol Brayne

Collaborators

Associated News Items

• Interdisciplinary team awarded an Allen Distinguished Investigator grant worth $1.32 million
• OLD BRAINS 2016 – pathways to neurodegeneration not forgetting the vessels
• Brains of overweight people ‘ten years older’ than lean counterparts at middle-age
• Video Launch: World Alzhemier's Day - Dementia: Catching the memory thief
• 1st International Forum on Women’s Brain and Mental Health
• Selected Awards and Honours to Cambridge Neuroscience members in 2017
• Sense of control and meaning helps protect women from anxiety, study suggests
• Cambridge Neuroscientists rank in the top 1% Highly Cited Researchers for 2018
• Levels of autism in China similar to the West, joint Chinese-UK study shows
• The use of antidepressants by over 65s has a substantial increase in 20 years
• Cambridge Neuroscience Interdisciplinary Seminar Series
• East of England Global Health Conference
• Autism rates have increased and show differences in ethnic minorities and links to social disadvantage
• CUED Bioengineering conference

Publications

2014

Bennett DA, Arnold SE, Valenzuela MJ, Brayne C, Schneider JA (2014), “Cognitive and social lifestyle: links with neuropathology and cognition in late life.” Acta Neuropathol 127(1):137-50 Details

Brayne C (2014), “A population perspective on the IWG-2 research diagnostic criteria for Alzheimer's disease.” Lancet Neurol 13(6):532-4 Details

Cosco TD, Prina AM, Perales J, Stephan BC, Brayne C (2014), “Operational definitions of successful aging: a systematic review.” Int Psychogeriatr 26(3):373-81 Details

D'Alton S, Hunter S, Whitehouse P, Brayne C, George D (2014), “Adapting to Dementia in Society: A Challenge for Our Lifetimes and a Charge for Public Health.” J Alzheimers Dis Details

Davis DH, Barnes LE, Stephan BM, MacLullich AM, Meagher D, Copeland J, Matthews FE, Brayne C (2014), “The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” BMC Geriatr 14(1):87 Details

Docking RE, Fleming J, Brayne C, Zhao J, Macfarlane GJ, Jones GT, Cambridge City over-75s Cohort (CC75C) study collaboration (2014), “The relationship between back pain and mortality in older adults varies with disability and gender: Results from the Cambridge City over-75s Cohort (CC75C) study.” Eur J Pain Details

Dufouil C, Brayne C (2014), “The continuing challenge of turning promising observational evidence about risk for dementia to evidence supporting prevention.” JAMA Intern Med 174(3):333-5 Details

Duncan GW, Khoo TK, Coleman SY, Brayne C, Yarnall AJ, O'Brien JT, Barker RA, Burn DJ (2014), “The incidence of Parkinson's disease in the North-East of England.” Age Ageing 43(2):257-63 Details

Ekonomou A, Savva GM, Brayne C, Forster G, Francis PT, Johnson M, Perry EK, Attems J, Somani A, Minger SL, Ballard CG, The Medical Research Council Cognitive Function and Ageing Neuropathology Study (2014), “Stage-Specific Changes in Neurogenic and Glial Markers in Alzheimer's Disease.” Biol Psychiatry Details

Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, Jun G, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Denning N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Schmidt H, Kunkle B, Dunstan ML, Vronskaya M, United Kingdom Brain Expression Consortium, Johnson AD, Ruiz A, Bihoreau MT, Reitz C, Pasquier F, Hollingworth P, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Hernández I, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B, Larson EB, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, George-Hyslop PS, Clarimon J, Lleo A, Bayer A, Tsuang (2014), “Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.” PLoS One 9(6):e94661 Details

Garwood CJ, Simpson JE, Al Mashhadi S, Axe C, Wilson S, Heath PR, Shaw PJ, Matthews FE, Brayne C, Ince PG, Wharton SB, MRC Cognitive Function and Ageing Study (2014), “DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population-based study in the MRC-CFAS cohort.” Neuropathol Appl Neurobiol Details

Humphrey A, MacLean C, Ploubidis GB, Granader Y, Clifford M, Haslop M, Neville BG, Yates JR, Bolton PF, Tuberous Sclerosis 2000 Study Group (2014), “Intellectual development before and after the onset of infantile spasms: a controlled prospective longitudinal study in tuberous sclerosis.” Epilepsia 55(1):108-16 Details

Hunter S, Brayne C (2014), “Integrating the molecular and the population approaches to dementia research to help guide the future development of appropriate therapeutics.” Biochem Pharmacol 88(4):652-60 Details

Janaway BM, Simpson JE, Hoggard N, Highley JR, Forster G, Drew D, Gebril OH, Matthews FE, Brayne C, Wharton SB, Ince PG, MRC Cognitive Function and Ageing Neuropathology Study (2014), “Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds.” Neuropathol Appl Neurobiol 40(3):258-69 Details

Keage HA, Hunter S, Matthews FE, Ince PG, Hodges J, Hokkanen S, Highley JR, Dening T, Brayne C (2014), “TDP-43 in the Population: Prevalence and Associations with Dementia and Age.” J Alzheimers Dis Details

Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Hayat S, Luben R, Brayne C, Khaw KT (2014), “Daytime napping and the risk of all-cause and cause-specific mortality: a 13-year follow-up of a British population.” Am J Epidemiol 179(9):1115-24 Details

Leng Y, Wainwright NW, Cappuccio FP, Surtees PG, Luben R, Wareham N, Brayne C, Khaw KT (2014), “Self-reported sleep patterns in a British population cohort.” Sleep Med 15(3):295-302 Details

Lima TA, Adler AL, Minett T, Matthews FE, Brayne C, Marioni RE, Medical Research Council Cognitive Function and Ageing Study (2014), “C-reactive protein, APOE genotype and longitudinal cognitive change in an older population.” Age Ageing 43(2):289-92 Details

Lincoln P, Fenton K, Alessi C, Prince M, Brayne C, Wortmann M, Patel K, Deanfield J, Mwatsama M (2014), “The Blackfriars Consensus on brain health and dementia.” Lancet 383(9931):1805-6 Details

Liu G, Yao L, Liu J, Jiang Y, Ma G, Genetic and Environmental Risk for Alzheimer's disease (GERAD1) Consortium, Chen Z, Zhao B, Li K (2014), “Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies.” Neurobiol Aging 35(4):786-92 Details

Marioni RE, Proust-Lima C, Amieva H, Brayne C, Matthews FE, Dartigues JF, Jacqmin-Gadda H (2014), “Cognitive lifestyle jointly predicts longitudinal cognitive decline and mortality risk.” Eur J Epidemiol 29(3):211-9 Details

Noel-Storr AH, McCleery JM, Richard E, Ritchie CW, Flicker L, Cullum SJ, Davis D, Quinn TJ, Hyde C, Rutjes AW, Smailagic N, Marcus S, Black S, Blennow K, Brayne C, Fiorivanti M, Johnson JK, Köpke S, Schneider LS, Simmons A, Mattsson N, Zetterberg H, Bossuyt PM, Wilcock G, McShane R (2014), “Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative.” Neurology 83(4):364-373 Details

Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C (2014), “Potential for primary prevention of Alzheimer's disease: an analysis of population-based data.” Lancet Neurol 13(8):788-94 Details

Perales J, Cosco TD, Stephan BC, Fleming J, Martin S, Haro JM, Brayne C, CC75C Study (2014), “Health-related quality of life in the Cambridge City over-75s Cohort (CC75C): development of a dementia-specific scale and descriptive analyses.” BMC Geriatr 14:18 Details

Perrels AJ, Fleming J, Zhao J, Barclay S, Farquhar M, Buiting HM, Brayne C, Cambridge City over-75s Cohort (CC75C) study collaboration (2014), “Place of death and end-of-life transitions experienced by very old people with differing cognitive status: retrospective analysis of a prospective population-based cohort aged 85 and over.” Palliat Med 28(3):220-33 Details

Petersen RC, Caracciolo B, Brayne C, Gauthier S, Jelic V, Fratiglioni L (2014), “Mild cognitive impairment: a concept in evolution.” J Intern Med 275(3):214-28 Details

Prina AM, Huisman M, Yeap BB, Hankey GJ, Flicker L, Brayne C, Almeida OP (2014), “Hospital costs associated with depression in a cohort of older men living in Western Australia.” Gen Hosp Psychiatry 36(1):33-7 Details

Prina AM, Marioni RE, Hammond GC, Jones PB, Brayne C, Dening T (2014), “Improving access to psychological therapies and older people: findings from the Eastern Region.” Behav Res Ther 56:75-81 Details

Richard E, Brayne C (2014), “Dementia: Mild cognitive impairment--not always what it seems.” Nat Rev Neurol 10(3):130-1 Details

Stephan BC, Minett T, Muniz Terrera G, Matthews FE, Brayne C (2014), “Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept?” Age Ageing Details

Sun X, Allison C, Auyeung B, Matthews FE, Norton S, Baron-Cohen S, Brayne C (2014), “Psychometric properties of the Mandarin version of the Childhood Autism Spectrum Test (CAST): an exploratory study.” J Autism Dev Disord 44(7):1565-76 Details

Sun X, Allison C, Auyeung B, Matthews FE, Sharp SJ, Baron-Cohen S, Brayne C (2014), “The Mandarin Childhood Autism Spectrum Test (CAST): Sex Differences.” J Autism Dev Disord Details

Sun X, Allison C, Auyeung B, Matthews FE, Zhang Z, Baron-Cohen S, Brayne C (2014), “Comparison between a Mandarin Chinese version of the Childhood Autism Spectrum Test and the Clancy Autism Behaviour Scale in mainland China.” Res Dev Disabil 35(7):1599-608 Details

Terrera GM, Minett T, Brayne C, Matthews FE (2014), “Education associated with a delayed onset of terminal decline.” Age Ageing 43(1):26-31 Details

van der Linde RM, Brayne C, Dening T (2014), “Depression and other behavioral and psychological symptoms of dementia--separate research worlds in need of a common understanding.” Int Psychogeriatr 26(2):177-83 Details

van der Linde RM, Dening T, Matthews FE, Brayne C (2014), “Grouping of behavioural and psychological symptoms of dementia.” Int J Geriatr Psychiatry 29(6):562-8 Details

van der Linde RM, Stephan BC, Dening T, Brayne C (2014), “Instruments to measure behavioural and psychological symptoms of dementia.” Int J Methods Psychiatr Res 23(1):69-98 Details

Wimo A, Ballard C, Brayne C, Gauthier S, Handels R, Jones RW, Jonsson L, Khachaturian AS, Kramberger M (2014), “Health economic evaluation of treatments for Alzheimer's disease: impact of new diagnostic criteria.” J Intern Med 275(3):304-16 Details

Wu YT, Lee HY, Norton S, Prina AM, Fleming J, Matthews FE, Brayne C (2014), “Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: a meta-analysis.” Int J Geriatr Psychiatry Details

Wu YT, Matthews FE, Brayne C (2014), “Dementia: Time trends and policy responses.” Maturitas Details

2013

Brayne C, Barker RA, Harold D, Ince PG, Savva GM, Williams J, Williams-Gray CH, Wharton SB (2013), “From molecule to clinic and community for neurodegeneration: research to bridge translational gaps.” J Alzheimers Dis 33 Suppl 1:S385-96 Details

Breen DP, Evans JR, Farrell K, Brayne C, Barker RA (2013), “Determinants of delayed diagnosis in Parkinson's disease.” J Neurol 260(8):1978-81 Details

Bunn F, Sworn K, Brayne C, Iliffe S, Robinson L, Goodman C (2013), “Contextualizing the findings of a systematic review on patient and carer experiences of dementia diagnosis and treatment: a qualitative study.” Health Expect Details

Chapman J, Rees E, Harold D, Ivanov D, Gerrish A, Sims R, Hollingworth P, Stretton A, GERAD1 Consortium, Holmans P, Owen MJ, O'Donovan MC, Williams J, Kirov G (2013), “A genome-wide study shows a limited contribution of rare copy number variants to Alzheimer's disease risk.” Hum Mol Genet 22(4):816-24 Details

Christa Maree Stephan B, Minett T, Pagett E, Siervo M, Brayne C, McKeith IG (2013), “Diagnosing Mild Cognitive Impairment (MCI) in clinical trials: a systematic review.” BMJ Open 3(2) Details

Cosco TD, Prina AM, Perales J, Stephan BC, Brayne C (2013), “Lay perspectives of successful ageing: a systematic review and meta-ethnography.” BMJ Open 3(6) Details

Cosco TD, Stephan BC, Brayne C (2013), “Deathless models of aging and the importance of acknowledging the dying process.” CMAJ 185(9):751-2 Details

Davis D, Gregson J, Willeit P, Stephan B, Al-Shahi Salman R, Brayne C (2013), “Patent foramen ovale, ischemic stroke and migraine: systematic review and stratified meta-analysis of association studies.” Neuroepidemiology 40(1):56-67 Details

Davis DH, Kreisel SH, Muniz Terrera G, Hall AJ, Morandi A, Boustani M, Neufeld KJ, Lee HB, Maclullich AM, Brayne C (2013), “The epidemiology of delirium: challenges and opportunities for population studies.” Am J Geriatr Psychiatry 21(12):1173-89 Details

Fox C, Lafortune L, Boustani M, Brayne C (2013), “The pros and cons of early diagnosis in dementia.” Br J Gen Pract 63(612):e510-2 Details

Fox C, Lafortune L, Boustani M, Dening T, Rait G, Brayne C (2013), “Screening for dementia--is it a no brainer?” Int J Clin Pract 67(11):1076-80 Details

Gallo V, Leonardi G, Brayne C, Armstrong B, Fletcher T (2013), “Serum perfluoroalkyl acids concentrations and memory impairment in a large cross-sectional study.” BMJ Open 3(6) Details

Gallo V, Wark PA, Jenab M, Pearce N, Brayne C, Vermeulen R, Andersen PM, Hallmans G, Kyrozis A, Vanacore N, Vahdaninia M, Grote V, Kaaks R, Mattiello A, Bueno-de-Mesquita HB, Peeters PH, Travis RC, Petersson J, Hansson O, Arriola L, Jimenez-Martin JM, Tjønneland A, Halkjær J, Agnoli C, Sacerdote C, Bonet C, Trichopoulou A, Gavrila D, Overvad K, Weiderpass E, Palli D, Quirós JR, Tumino R, Khaw KT, Wareham N, Barricante-Gurrea A, Fedirko V, Ferrari P, Clavel-Chapelon F, Boutron-Ruault MC, Boeing H, Vigl M, Middleton L, Riboli E, Vineis P (2013), “Prediagnostic body fat and risk of death from amyotrophic lateral sclerosis: the EPIC cohort.” Neurology 80(9):829-38 Details

Garwood C, Faizullabhoy A, Wharton SB, Ince PG, Heath PR, Shaw PJ, Baxter L, Gelsthorpe C, Forster G, Matthews FE, Brayne C, Simpson JE, MRC Cognitive Function and Ageing Neuropathology Study Group (2013), “Calcium dysregulation in relation to Alzheimer-type pathology in the ageing brain.” Neuropathol Appl Neurobiol 39(7):788-99 Details

Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J, Alzheimer Genetic Analysis Group (2013), “TREM2 variants in Alzheimer's disease.” N Engl J Med 368(2):117-27 Details

Hayat SA, Luben R, Keevil VL, Moore S, Dalzell N, Bhaniani A, Khawaja AP, Foster P, Brayne C, Wareham NJ, Khaw KT (2013), “Cohort Profile: A prospective cohort study of objective physical and cognitive capability and visual health in an ageing population of men and women in Norfolk (EPIC-Norfolk 3).” Int J Epidemiol Details

Hunter S, Arendt T, Brayne C (2013), “The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD.” Mol Neurobiol 48(3):556-70 Details

Köhler S, Allardyce J, Verhey FR, McKeith IG, Matthews F, Brayne C, Savva GM, Medical Research Council Cognitive Function and Ageing Study (2013), “Cognitive decline and dementia risk in older adults with psychotic symptoms: a prospective cohort study.” Am J Geriatr Psychiatry 21(2):119-28 Details

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F, European Alzheimer's Disease Initiative (EADI), Genetic (2013), “Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.” Nat Genet 45(12):1452-8 Details

Le Couteur DG, Doust J, Creasey H, Brayne C (2013), “Political drive to screen for pre-dementia: not evidence based and ignores the harms of diagnosis.” BMJ 347:f5125 Details

Lee SH, Harold D, Nyholt DR, ANZGene Consortium, International Endogene Consortium, Genetic and Environmental Risk for Alzheimer's disease Consortium, Goddard ME, Zondervan KT, Williams J, Montgomery GW, Wray NR, Visscher PM (2013), “Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.” Hum Mol Genet 22(4):832-41 Details

Leng Y, Wainwright NW, Hayat S, Stephan BC, Matthews FE, Luben R, Surtees PG, Khaw KT, Brayne C (2013), “The association between social stress and global cognitive function in a population-based study: the European Prospective Investigation into Cancer (EPIC)-Norfolk study.” Psychol Med 43(3):655-66 Details

Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, Brayne C, Medical Research Council Cognitive Function and Ageing Collaboration (2013), “A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II.” Lancet 382(9902):1405-12 Details

Mavaddat N, Savva GM, Lasserson DS, Giles MF, Brayne C, Mant J (2013), “Transient neurological symptoms in the older population: report of a prospective cohort study--the Medical Research Council Cognitive Function and Ageing Study (CFAS).” BMJ Open 3(7) Details

Mavaddat N, Van der Linde R, Savva GM, Brayne C, Mant J (2013), “What determines the self-rated health of older individuals with stroke compared to other older individuals? A cross-sectional analysis of the Medical Research Council Cognitive Function and Aging Study.” BMC Geriatr 13:85 Details

Murray CJ, Richards MA, Newton JN, Fenton KA, Anderson HR, Atkinson C, Bennett D, Bernabé E, Blencowe H, Bourne R, Braithwaite T, Brayne C, Bruce NG, Brugha TS, Burney P, Dherani M, Dolk H, Edmond K, Ezzati M, Flaxman AD, Fleming TD, Freedman G, Gunnell D, Hay RJ, Hutchings SJ, Ohno SL, Lozano R, Lyons RA, Marcenes W, Naghavi M, Newton CR, Pearce N, Pope D, Rushton L, Salomon JA, Shibuya K, Vos T, Wang H, Williams HC, Woolf AD, Lopez AD, Davis A (2013), “UK health performance: findings of the Global Burden of Disease Study 2010.” Lancet 381(9871):997-1020 Details

Norton S, Matthews FE, Brayne C (2013), “A commentary on studies presenting projections of the future prevalence of dementia.” BMC Public Health 13:1 Details

Perales J, Cosco TD, Stephan BC, Haro JM, Brayne C (2013), “Health-related quality-of-life instruments for Alzheimer's disease and mixed dementia.” Int Psychogeriatr 25(5):691-706 Details

Prina AM, Huisman M, Yeap BB, Hankey GJ, Flicker L, Brayne C, Almeida OP (2013), “Association between depression and hospital outcomes among older men.” CMAJ 185(2):117-23 Details

Restaino M, Matthews FE, Minett T, Albanese E, Brayne C, Stephan BC (2013), “Predicting risk of 2-year incident dementia using the CAMCOG total and subscale scores.” Age Ageing 42(5):649-53 Details

Ruggeri K, Farrington C, Brayne C (2013), “A global model for effective use and evaluation of e-learning in health.” Telemed J E Health 19(4):312-21 Details

Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carrière I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LC, Wong CH, Fung AW, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M, Dodge HH, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabárbara J, COSMIC (2013), “COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.” BMC Neurol 13:165 Details

Savva GM, Pachnio A, Kaul B, Morgan K, Huppert FA, Brayne C, Moss PA, Medical Research Council Cognitive Function and Ageing Study (2013), “Cytomegalovirus infection is associated with increased mortality in the older population.” Aging Cell 12(3):381-7 Details

Sun X, Allison C, Auyeung B, Baron-Cohen S, Brayne C (2013), “A review of healthcare service and education provision of Autism Spectrum Condition in mainland China.” Res Dev Disabil 34(1):469-79 Details

Sun X, Allison C, Auyeung B, Matthews FE, Baron-Cohen S, Brayne C (2013), “Service provision for autism in mainland China: preliminary mapping of service pathways.” Soc Sci Med 98:87-94 Details

Sun X, Allison C, Auyeung B, Matthews FE, Baron-Cohen S, Brayne C (2013), “The Mandarin Chinese version of the childhood autism spectrum test (CAST): test-retest reliability.” Res Dev Disabil 34(10):3267-75 Details

Sun X, Allison C, Auyeung B, Matthews FE, Murray S, Baron-Cohen S, Brayne C (2013), “Service provision for autism in mainland China: a service providers' perspective.” Res Dev Disabil 34(1):440-51 Details

Sun X, Allison C, Matthews FE, Sharp SJ, Auyeung B, Baron-Cohen S, Brayne C (2013), “Prevalence of autism in mainland China, Hong Kong and Taiwan: a systematic review and meta-analysis.” Mol Autism 4(1):7 Details

van der Linde RM, Mavaddat N, Luben R, Brayne C, Simmons RK, Khaw KT, Kinmonth AL (2013), “Self-rated health and cardiovascular disease incidence: results from a longitudinal population-based cohort in Norfolk, UK.” PLoS One 8(6):e65290 Details

van der Linde RM, Stephan BC, Dening T, Brayne C (2013), “Instruments to measure behavioural and psychological symptoms of dementia: changing use over time.” Int J Geriatr Psychiatry 28(4):433-5 Details

van der Linde RM, Stephan BC, Matthews FE, Brayne C, Savva GM, Medical Research Council Cognitive Function and Ageing Study (2013), “The presence of behavioural and psychological symptoms and progression to dementia in the cognitively impaired older population.” Int J Geriatr Psychiatry 28(7):700-9 Details

Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge Rv, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB, Dichgans M, STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1) (2013), “Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration.” Lancet Neurol 12(8):822-38 Details

Williams-Gray CH, Mason SL, Evans JR, Foltynie T, Brayne C, Robbins TW, Barker RA (2013), “The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort.” J Neurol Neurosurg Psychiatry 84(11):1258-64 Details

Wu YT, Lee HY, Norton S, Chen C, Chen H, He C, Fleming J, Matthews FE, Brayne C (2013), “Prevalence studies of dementia in mainland china, Hong Kong and taiwan: a systematic review and meta-analysis.” PLoS One 8(6):e66252 Details

Zou F, Belbin O, Carrasquillo MM, Culley OJ, Hunter TA, Ma L, Bisceglio GD, Allen M, Dickson DW, Graff-Radford NR, Petersen RC, Genetic and Environmental Risk for Alzheimer’s disease (GERAD1) Consortium, Morgan K, Younkin SG (2013), “Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology.” PLoS One 8(5):e64802 Details

2012

Brayne C, Davis D (2012), “Making Alzheimer's and dementia research fit for populations.” Lancet 380(9851):1441-3 Details

Bunn F, Goodman C, Sworn K, Rait G, Brayne C, Robinson L, McNeilly E, Iliffe S (2012), “Psychosocial factors that shape patient and carer experiences of dementia diagnosis and treatment: a systematic review of qualitative studies.” PLoS Med 9(10):e1001331 Details

Davis DH, Muniz Terrera G, Keage H, Rahkonen T, Oinas M, Matthews FE, Cunningham C, Polvikoski T, Sulkava R, MacLullich AM, Brayne C (2012), “Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study.” Brain 135(Pt 9):2809-16 Details

Dent TH, Wright CF, Stephan BC, Brayne C, Janssens AC (2012), “Risk prediction models: a framework for assessment.” Public Health Genomics 15(2):98-105 Details

Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Johnston JA, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Kölsch H, Heun R, Schürmann B, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Davies G, Harris SE, Starr JM, Deary IJ, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Jones L, Holmans PA, O'Donovan MC, Owen MJ, Williams J (2012), “The role of variation at A?PP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease.” J Alzheimers Dis 28(2):377-87 Details

Hamilton G, Harris SE, Davies G, Liewald DC, Tenesa A, Payton A, Horan MA, Ollier WE, Pendleton N, Genetic and Environmental Risk for Alzheimer's Disease (GERAD1) Consortium, Starr JM, Porteous D, Deary IJ (2012), “The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk.” Am J Med Genet B Neuropsychiatr Genet 159B(6):696-709 Details

Hamilton G, Killick R, Genetic and Environmental Risk for Alzheimer's Disease Consortium, Translational Genomics Research Institute Consortium, Lambert JC, Amouyel P, European Alzheimer Disease Initiative, Carrasquillo MM, Pankratz VS, Graff-Radford NR, Dickson DW, Petersen RC, Younkin SG, Powell JF, Wade-Martins R (2012), “Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus.” Neurobiol Aging 33(8):1848.e1-13 Details

Hollingworth P, Sweet R, Sims R, Harold D, Russo G, Abraham R, Stretton A, Jones N, Gerrish A, Chapman J, Ivanov D, Moskvina V, Lovestone S, Priotsi P, Lupton M, Brayne C, Gill M, Lawlor B, Lynch A, Craig D, McGuinness B, Johnston J, Holmes C, Livingston G, Bass NJ, Gurling H, McQuillin A, GERAD Consortium, National Institute on Aging Late-Onset Alzheimer's Disease Family Study Group, Holmans P, Jones L, Devlin B, Klei L, Barmada MM, Demirci FY, DeKosky ST, Lopez OL, Passmore P, Owen MJ, O'Donovan MC, Mayeux R, Kamboh MI, Williams J (2012), “Genome-wide association study of Alzheimer's disease with psychotic symptoms.” Mol Psychiatry 17(12):1316-27 Details

Hudson G, Sims R, Harold D, Chapman J, Hollingworth P, Gerrish A, Russo G, Hamshere M, Moskvina V, Jones N, Thomas C, Stretton A, Holmans PA, O'Donovan MC, Owen MJ, Williams J, Chinnery PF, GERAD1 Consortium (2012), “No consistent evidence for association between mtDNA variants and Alzheimer disease.” Neurology 78(14):1038-42 Details

Hunter S, Brayne C (2012), “Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems.” Alzheimers Res Ther 4(2):10 Details

Keage HA, Banks S, Yang KL, Morgan K, Brayne C, Matthews FE (2012), “What sleep characteristics predict cognitive decline in the elderly?” Sleep Med 13(7):886-92 Details

Keage HA, Ince PG, Matthews FE, Wharton SB, McKeith IG, Brayne C, MRC CFAS and CC75C (2012), “Impact of less common and "disregarded" neurodegenerative pathologies on dementia burden in a population-based cohort.” J Alzheimers Dis 28(2):485-93 Details

Lace G, Ince PG, Brayne C, Savva GM, Matthews FE, de Silva R, Simpson JE, Wharton SB (2012), “Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort.” Dement Geriatr Cogn Disord 34(1):15-24 Details

Marioni RE, Valenzuela MJ, van den Hout A, Brayne C, Matthews FE, MRC Cognitive Function and Ageing Study (2012), “Active cognitive lifestyle is associated with positive cognitive health transitions and compression of morbidity from age sixty-five.” PLoS One 7(12):e50940 Details

Marioni RE, van den Hout A, Valenzuela MJ, Brayne C, Matthews FE, MRC Cognitive Function and Ageing Study (2012), “Active cognitive lifestyle associates with cognitive recovery and a reduced risk of cognitive decline.” J Alzheimers Dis 28(1):223-30 Details

Matthews F, Marioni R, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2012), “Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: a population-based prospective cohort study.” BMC Geriatr 12:45 Details

Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, (2012), “Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.” Lancet 380(9859):2197-223 Details

Prina AM, Deeg D, Brayne C, Beekman A, Huisman M (2012), “The association between depressive symptoms and non-psychiatric hospitalisation in older adults.” PLoS One 7(4):e34821 Details

Proitsi P, Lupton MK, Dudbridge F, Tsolaki M, Hamilton G, Daniilidou M, Pritchard M, Lord K, Martin BM, Johnson J, Craig D, Todd S, McGuinness B, Hollingworth P, Harold D, Kloszewska I, Soininen H, Mecocci P, Velas B, Gill M, Lawlor B, Rubinsztein DC, Brayne C, Passmore PA, Williams J, Lovestone S, Powell JF (2012), “Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation.” Neurobiol Aging 33(8):1843.e9-17 Details

Proitsi P, Lupton MK, Reeves SJ, Hamilton G, Archer N, Martin BM, Iyegbe C, Hollingworth P, Lawlor B, Gill M, Brayne C, Rubinsztein DC, Owen MJ, Williams J, Lovestone S, Powell JF (2012), “Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia.” Neurobiol Aging 33(4):791-803 Details

Richardson K, Hunter S, Dening T, Xuereb JH, Matthews FE, Brayne C, Fleming J, Cambridge City over-75s Cohort (CC75C) Study Neuropathology Collaboration (2012), “Neuropathological correlates of falling in the CC75C population-based sample of the older old.” Curr Alzheimer Res 9(6):697-708 Details

Richardson K, Stephan BC, Ince PG, Brayne C, Matthews FE, Esiri MM (2012), “The neuropathology of vascular disease in the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” Curr Alzheimer Res 9(6):687-96 Details

Roelfsema MT, Hoekstra RA, Allison C, Wheelwright S, Brayne C, Matthews FE, Baron-Cohen S (2012), “Are autism spectrum conditions more prevalent in an information-technology region? A school-based study of three regions in the Netherlands.” J Autism Dev Disord 42(5):734-9 Details

Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J, Lovestone S, Goate A, Younkin S, Passmore P, Genetic and Environmental Risk for Alzheimer's Disease Consortium, Morgan K, Alzheimer's Research UK Consortium (2012), “Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS).” Neurobiol Aging 33(8):1849.e5-18 Details

Stephan BC, Hunter S, Harris D, Llewellyn DJ, Siervo M, Matthews FE, Brayne C (2012), “The neuropathological profile of mild cognitive impairment (MCI): a systematic review.” Mol Psychiatry 17(11):1056-76 Details

Stephan BC, Matthews FE, Hunter S, Savva GM, Bond J, McKeith IG, Ince P, Brayne C, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2012), “Neuropathological profile of mild cognitive impairment from a population perspective.” Alzheimer Dis Assoc Disord 26(3):205-12 Details

Stephan BC, Matthews FE, Ma B, Muniz G, Hunter S, Davis D, McKeith IG, Foster G, Ince PG, Brayne C (2012), “Alzheimer and vascular neuropathological changes associated with different cognitive States in a non-demented sample.” J Alzheimers Dis 29(2):309-18 Details

Valenzuela MJ, Matthews FE, Brayne C, Ince P, Halliday G, Kril JJ, Dalton MA, Richardson K, Forster G, Sachdev PS, Medical Research Council Cognitive Function and Ageing Study (2012), “Multiple biological pathways link cognitive lifestyle to protection from dementia.” Biol Psychiatry 71(9):783-91 Details

van der Linde RM, Stephan BC, Savva GM, Dening T, Brayne C (2012), “Systematic reviews on behavioural and psychological symptoms in the older or demented population.” Alzheimers Res Ther 4(4):28 Details

Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basáñez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabé E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, (2012), “Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010.” Lancet 380(9859):2163-96 Details

2011

Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E (2011), “Alzheimer's disease.” Lancet 377(9770):1019-31 Details

Brayne C, Stephan BC, Matthews FE (2011), “A European perspective on population studies of dementia.” Alzheimers Dement 7(1):3-9 Details

Connelly SJ, Mukaetova-Ladinska EB, Abdul-All Z, Alves da Silva J, Brayne C, Honer WG, Mann DM (2011), “Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype.” Neuropathol Appl Neurobiol 37(4):366-80 Details

Curran S, Dworzynski K, Happé F, Ronald A, Allison C, Baron-Cohen S, Brayne C, Bolton PF (2011), “No major effect of twinning on autistic traits.” Autism Res 4(5):377-82 Details

Docking RE, Fleming J, Brayne C, Zhao J, Macfarlane GJ, Jones GT, Cambridge City over-75s Cohort Study collaboration (2011), “Epidemiology of back pain in older adults: prevalence and risk factors for back pain onset.” Rheumatology (Oxford) 50(9):1645-53 Details

Evans JR, Mason SL, Williams-Gray CH, Foltynie T, Brayne C, Robbins TW, Barker RA (2011), “The natural history of treated Parkinson's disease in an incident, community based cohort.” J Neurol Neurosurg Psychiatry 82(10):1112-8 Details

Fox C, Richardson K, Maidment ID, Savva GM, Matthews FE, Smithard D, Coulton S, Katona C, Boustani MA, Brayne C (2011), “Anticholinergic medication use and cognitive impairment in the older population: the medical research council cognitive function and ageing study.” J Am Geriatr Soc 59(8):1477-83 Details

Gebril OH, Kirby J, Savva G, Brayne C, Ince PG (2011), “HFE H63D, C282Y and AGTR1 A1166C polymorphisms and brain white matter lesions in the aging brain.” J Neurogenet 25(1-2):7-14 Details

Gebril OH, Simpson JE, Kirby J, Brayne C, Ince PG (2011), “Brain iron dysregulation and the risk of ageing white matter lesions.” Neuromolecular Med 13(4):289-99 Details

Hampton JL, Brayne C, Bradley M, Kenny RA (2011), “Mortality in carotid sinus hypersensitivity: a cohort study.” BMJ Open 1(1):e000020 Details

Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichman (2011), “Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.” Nat Genet 43(5):429-35 Details

Keage HA, Gupta S, Brayne C, Alzheimer's Society Systematic Review Group (2011), “Risk for dementia and age at measurement.” Int J Geriatr Psychiatry 26(3):329-30 Details

Marioni RE, Chatfield M, Brayne C, Matthews FE, Medical Research Council Cognitive Function and Ageing Study Group (2011), “The reliability of assigning individuals to cognitive states using the Mini Mental-State Examination: a population-based prospective cohort study.” BMC Med Res Methodol 11:127 Details

Marioni RE, Matthews FE, Brayne C, MRC Cognitive Function and Ageing Study (2011), “The association between late-life cognitive test scores and retrospective informant interview data.” Int Psychogeriatr 23(2):274-9 Details

Matthews FE, Stephan BC, Khaw KT, Hayat S, Luben R, Bhaniani A, Moore S, Brayne C (2011), “Full-scale scores of the Mini Mental State Examination can be generated from an abbreviated version.” J Clin Epidemiol 64(9):1005-13 Details

Muangpaisan W, Assantachai P, Intalapaporn S, Richardson K, Brayne C (2011), “Health expectancies in the older Thai population.” Arch Gerontol Geriatr 53(1):3-7 Details

Muniz-Terrera G, Matthews FE, Stephan B, Brayne C, CC75C Collaboration Group (2011), “Are terminal decline and its potential indicators detectable in population studies of the oldest old?” Int J Geriatr Psychiatry 26(6):584-92 Details

Nicoll JA, Savva GM, Stewart J, Matthews FE, Brayne C, Ince P, Medical Research Council Cognitive Function and Ageing Study (2011), “Association between APOE genotype, neuropathology and dementia in the older population of England and Wales.” Neuropathol Appl Neurobiol 37(3):285-94 Details

Prina AM, Ferri CP, Guerra M, Brayne C, Prince M (2011), “Prevalence of anxiety and its correlates among older adults in Latin America, India and China: cross-cultural study.” Br J Psychiatry 199(6):485-91 Details

Prina AM, Ferri CP, Guerra M, Brayne C, Prince M (2011), “Co-occurrence of anxiety and depression amongst older adults in low- and middle-income countries: findings from the 10/66 study.” Psychol Med 41(10):2047-56 Details

Proitsi P, Hamilton G, Tsolaki M, Lupton M, Daniilidou M, Hollingworth P, Archer N, Foy C, Stylios F, McGuinness B, Todd S, Lawlor B, Gill M, Brayne C, Rubinsztein DC, Owen M, Williams J, Craig D, Passmore P, Lovestone S, Powell JF (2011), “A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD).” Neurobiol Aging 32(3):434-42 Details

Reitz C, Brayne C, Mayeux R (2011), “Epidemiology of Alzheimer disease.” Nat Rev Neurol 7(3):137-52 Details

Richardson K, Ananou A, Lafortune L, Brayne C, Matthews FE (2011), “Variation over time in the association between polypharmacy and mortality in the older population.” Drugs Aging 28(7):547-60 Details

Seidel D, Brayne C, Jagger C (2011), “Limitations in physical functioning among older people as a predictor of subsequent disability in instrumental activities of daily living.” Age Ageing 40(4):463-9 Details

Seidel D, Hjalmarson J, Freitag S, Larsson TJ, Brayne C, Clarkson PJ (2011), “Measurement of stressful postures during daily activities: An observational study with older people.” Gait Posture 34(3):397-401 Details

Sharp SI, Aarsland D, Day S, Sønnesyn H, Alzheimer's Society Vascular Dementia Systematic Review Group, Ballard C (2011), “Hypertension is a potential risk factor for vascular dementia: systematic review.” Int J Geriatr Psychiatry 26(7):661-9 Details

Siervo M, Arnold R, Wells JC, Tagliabue A, Colantuoni A, Albanese E, Brayne C, Stephan BC (2011), “Intentional weight loss in overweight and obese individuals and cognitive function: a systematic review and meta-analysis.” Obes Rev 12(11):968-83 Details

Siervo M, Wells JC, Brayne C, Stephan BC (2011), “Reemphasizing the role of fructose intake as a risk factor for dementia.” J Gerontol A Biol Sci Med Sci 66(5):534-6 Details

Simpson JE, Ince PG, Shaw PJ, Heath PR, Raman R, Garwood CJ, Gelsthorpe C, Baxter L, Forster G, Matthews FE, Brayne C, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2011), “Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype.” Neurobiol Aging 32(10):1795-807 Details

Sims R, Dwyer S, Harold D, Gerrish A, Hollingworth P, Chapman J, Jones N, Abraham R, Ivanov D, Pahwa JS, Moskvina V, Dowzell K, Thomas C, Stretton A, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuiness B, Todd S, Johnston JA, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Livingston G, Bass NJ, Gurling H, McQuillin A, Jones L, Holmans PA, O'Donovan M, Owen MJ, Williams J (2011), “No evidence that extended tracts of homozygosity are associated with Alzheimer's disease.” Am J Med Genet B Neuropsychiatr Genet 156B(7):764-71 Details

Stephan BC, Brayne C, Savva GM, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (2011), “Occurrence of medical co-morbidity in mild cognitive impairment: implications for generalisation of MCI research.” Age Ageing 40(4):501-7 Details

Tsopelas C, Stewart R, Savva GM, Brayne C, Ince P, Thomas A, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (2011), “Neuropathological correlates of late-life depression in older people.” Br J Psychiatry 198(2):109-14 Details

Valenzuela M, Brayne C, Sachdev P, Wilcock G, Matthews F, Medical Research Council Cognitive Function and Ageing Study (2011), “Cognitive lifestyle and long-term risk of dementia and survival after diagnosis in a multicenter population-based cohort.” Am J Epidemiol 173(9):1004-12 Details

Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ, Ince PG (2011), “Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort.” Neurosci Lett 505(1):25-30 Details

Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG (2011), “Epidemiological Neuropathology: The MRC Cognitive Function and Aging Study Experience.” J Alzheimers Dis 25(2):359-72 Details

2010

Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, Frayling TM, Murray A, Melzer D (2010), “Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.” Neurobiol Aging 31(9):1563-8 Details

EClipSE Collaborative Members, Brayne C, Ince PG, Keage HA, McKeith IG, Matthews FE, Polvikoski T, Sulkava R (2010), “Education, the brain and dementia: neuroprotection or compensation?” Brain 133(Pt 8):2210-6 Details

Fleming J, Zhao J, Farquhar M, Brayne C, Barclay S, Cambridge City Over-75s Cohort (CC75C) Study Collaboration (2010), “Place of death for the 'oldest old': > or =85-year-olds in the CC75C population-based cohort.” Br J Gen Pract 60(573):171-9 Details

Hogervorst E, Matthews FE, Brayne C (2010), “Are optimal levels of testosterone associated with better cognitive function in healthy older women and men?” Biochim Biophys Acta 1800(10):1145-52 Details

Hunter S, Friedland RP, Brayne C (2010), “Time for a change in the research paradigm for Alzheimer's disease: the value of a chaotic matrix modeling approach.” CNS Neurosci Ther 16(4):254-62 Details

Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Peters O, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Rüther E, Carrasquillo MM, Pankratz VS, Younkin SG, Hardy J, O'Donovan MC, Owen MJ, Williams J (2010), “Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.” PLoS One 5(11):e13950 Details

Keage HA, Matthews FE, Yip A, Gao L, McCracken C, McKeith IG, Rubinsztein DC, Brayne C, MRC Cognitive Function and Ageing Study (2010), “APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up: 10 years of incidence in the MRC CFA Study.” Age Ageing 39(1):104-11 Details

Lupton MK, Stahl D, Archer N, Foy C, Poppe M, Lovestone S, Hollingworth P, Williams J, Owen MJ, Dowzell K, Abraham R, Sims R, Brayne C, Rubinsztein D, Gill M, Lawlor B, Lynch A, Powell JF (2010), “Education, occupation and retirement age effects on the age of onset of Alzheimer's disease.” Int J Geriatr Psychiatry 25(1):30-6 Details

Matthews FE, Muniz-Terrera G, McKeith I, Brayne C, MRC CFAS (2010), “Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance.” Int J Geriatr Psychiatry 25(7):719-24 Details

Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM, Medical Research Council Cognitive Function and Ageing Study (2010), “The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia.” Brain 133(Pt 5):1328-41 Details

Muangpaisan W, Brayne C, Alzheimer's Society Vascular Dementia Systematic Review Group (2010), “Systematic review of statins for the prevention of vascular dementia or dementia.” Geriatr Gerontol Int 10(2):199-208 Details

Richards M, Brayne C (2010), “What do we mean by Alzheimer's disease?” BMJ 341:c4670 Details

Robinson L, Iliffe S, Brayne C, Goodman C, Rait G, Manthorpe J, Ashley P, Moniz-Cook E, DeNDRoN Primary Care Clinical Studies Group (2010), “Primary care and dementia: 2. Long-term care at home: psychosocial interventions, information provision, carer support and case management.” Int J Geriatr Psychiatry 25(7):657-64 Details

Savva GM, Stephan BC, Alzheimer's Society Vascular Dementia Systematic Review Group (2010), “Epidemiological studies of the effect of stroke on incident dementia: a systematic review.” Stroke 41(1):e41-6 Details

Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE, Savva GM, Brayne C, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2010), “Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.” Neuropathol Appl Neurobiol 36(1):25-40 Details

Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2010), “Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain.” Neurobiol Aging 31(4):578-90 Details

Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C, Ince PG (2010), “Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain.” Neurosci Lett 486(3):246-51 Details

Stephan BC, Kurth T, Matthews FE, Brayne C, Dufouil C (2010), “Dementia risk prediction in the population: are screening models accurate?” Nat Rev Neurol 6(6):318-26 Details

Stephan BC, Savva GM, Brayne C, Bond J, McKeith IG, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) (2010), “Optimizing mild cognitive impairment for discriminating dementia risk in the general older population.” Am J Geriatr Psychiatry 18(8):662-73 Details

Stephan BC, Wells JC, Brayne C, Albanese E, Siervo M (2010), “Increased fructose intake as a risk factor for dementia.” J Gerontol A Biol Sci Med Sci 65(8):809-14 Details

Terrera GM, Brayne C, Matthews F, CC75C Study Collaboration Group (2010), “One size fits all? Why we need more sophisticated analytical methods in the explanation of trajectories of cognition in older age and their potential risk factors.” Int Psychogeriatr 22(2):291-9 Details

van der Linde R, Stephan BC, Matthews FE, Brayne C, Savva GM, Medical Research Council Cognitive Function and Ageing Study (2010), “Behavioural and psychological symptoms in the older population without dementia--relationship with socio-demographics, health and cognition.” BMC Geriatr 10:87 Details

Zhao J, Barclay S, Farquhar M, Kinmonth AL, Brayne C, Fleming J, Cambridge City over-75s Cohort Study Collaboration (2010), “The oldest old in the last year of life: population-based findings from Cambridge city over-75s cohort study participants aged 85 and older at death.” J Am Geriatr Soc 58(1):1-11 Details

2009

Baron-Cohen S, Scott FJ, Allison C, Williams J, Bolton P, Matthews FE, Brayne C (2009), “Prevalence of autism-spectrum conditions: UK school-based population study.” Br J Psychiatry 194(6):500-9 Details

Brayne C, Richardson K, Matthews FE, Fleming J, Hunter S, Xuereb JH, Paykel E, Mukaetova-Ladinska EB, Huppert FA, O'Sullivan A, Dening T, Cambridge City Over-75s Cohort Cc75c Study Neuropathology Collaboration (2009), “Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study.” J Alzheimers Dis 18(3):645-58 Details

Byford M, Brayne C, McKeith I, Chatfield M, Ince P, Matthews F, MRC CFAS Neuropathology group (2009), “Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study.” BMC Geriatr 9:22 Details

EClipSE Collaborative Members (2009), “Cohort profile: Epidemiological Clinicopathological studies in Europe (EClipSE).” J Alzheimers Dis 18(3):659-63 Details

Friedland RP, Brayne C (2009), “What does the pediatrician need to know about Alzheimer disease?” J Dev Behav Pediatr 30(3):239-41 Details

Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Morgan K, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Love S, Kehoe PG, Hardy J, Mead S, Fox N, Rossor M, Collinge J, Maier W, Jessen F, Schürmann B, Heun R, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Hüll M, Rujescu D, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Carrasquillo MM, Pankratz VS, Younkin SG, Holmans PA, O'Donovan M, Owen MJ, Williams J (2009), “Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.” Nat Genet 41(10):1088-93 Details

Iliffe S, Robinson L, Brayne C, Goodman C, Rait G, Manthorpe J, Ashley P, DeNDRoN Primary Care Clinical Studies Group (2009), “Primary care and dementia: 1. diagnosis, screening and disclosure.” Int J Geriatr Psychiatry 24(9):895-901 Details

Jagger C, Matthews R, Lindesay J, Robinson T, Croft P, Brayne C (2009), “The effect of dementia trends and treatments on longevity and disability: a simulation model based on the MRC Cognitive Function and Ageing Study (MRC CFAS).” Age Ageing 38(3):319-25; discussion 251 Details

Keage HA, Carare RO, Friedland RP, Ince PG, Love S, Nicoll JA, Wharton SB, Weller RO, Brayne C (2009), “Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review.” BMC Neurol 9:3 Details

Lace G, Savva GM, Forster G, de Silva R, Brayne C, Matthews FE, Barclay JJ, Dakin L, Ince PG, Wharton SB, MRC-CFAS (2009), “Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study.” Brain 132(Pt 5):1324-34 Details

Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB, Ince P (2009), “Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study.” PLoS Med 6(11):e1000180 Details

Matthews FE, Jagger C, Miller LL, Brayne C, MRC CFAS (2009), “Education differences in life expectancy with cognitive impairment.” J Gerontol A Biol Sci Med Sci 64(1):125-31 Details

Morgan AR, Hollingworth P, Abraham R, Lovestone S, Brayne C, Rubinsztein DC, Lynch A, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J (2009), “Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample.” Am J Med Genet B Neuropsychiatr Genet 150B(1):61-4 Details

Muangpaisan W, Hori H, Brayne C (2009), “Systematic review of the prevalence and incidence of Parkinson's disease in Asia.” J Epidemiol 19(6):281-93 Details

Mukaetova-Ladinska EB, Xuereb JH, Garcia-Sierra F, Hurt J, Gertz HJ, Hills R, Brayne C, Huppert FA, Paykel ES, McGee MA, Jakes R, Honer WG, Harrington CR, Wischik CM (2009), “Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe.” ScientificWorldJournal 9:1463-75 Details

Muniz-Terrera G, Matthews F, Dening T, Huppert FA, Brayne C, CC75C Group (2009), “Education and trajectories of cognitive decline over 9 years in very old people: methods and risk analysis.” Age Ageing 38(3):277-82 Details

Ngondi J, Reacher M, Matthews F, Brayne C, Emerson P (2009), “Trachoma survey methods: a literature review.” Bull World Health Organ 87(2):143-51 Details

Ngondi J, Reacher MH, Matthews FE, Brayne C, Gatpan G, Becknell S, Kur L, King J, Callahan K, Emerson PM (2009), “Risk factors for trachomatous trichiasis in children: cross-sectional household surveys in Southern Sudan.” Trans R Soc Trop Med Hyg 103(3):305-14 Details

Ngondi JM, Matthews FE, Reacher MH, King J, Brayne C, Gouda H, Emerson PM (2009), “What will happen if we do nothing to control trachoma: health expectancies for blinding trachoma in southern Sudan.” PLoS Negl Trop Dis 3(3):e396 Details

Robinson L, Brayne C, Iliffe S, Primary Care Clinical Studies Group, Dementia and Neurodegenerative Diseases Research Network (2009), “TYM and Alzheimer's disease. More testing needed.” BMJ 339:b2825 Details

Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2009), “Age, neuropathology, and dementia.” N Engl J Med 360(22):2302-9 Details

Savva GM, Zaccai J, Matthews FE, Davidson JE, McKeith I, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2009), “Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population.” Br J Psychiatry 194(3):212-9 Details

Seidel D, Crilly N, Matthews FE, Jagger C, Brayne C, Clarkson PJ, Medical Research Council Cognitive Function and Ageing Study (2009), “Patterns of functional loss among older people: a prospective analysis.” Hum Factors 51(5):669-80 Details

Seidel D, Jagger C, Brayne C, Matthews FE, Cfas M (2009), “Recovery in instrumental activities of daily living (IADLs): findings from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” Age Ageing 38(6):663-8 Details

Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Ince PG, Medical Research Council Cognitive Function and Ageing Study Neuropathology Group (2009), “Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways.” Stroke 40(2):369-75 Details

Sims R, Hollingworth P, Moskvina V, Dowzell K, O'Donovan MC, Powell J, Lovestone S, Brayne C, Rubinsztein D, Owen MJ, Williams J, Abraham R (2009), “Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease.” Neurosci Lett 461(1):54-9 Details

Stephan BC, Brayne C (2009), “Dementia: Assessing the risk of dementia in the aging population.” Nat Rev Neurol 5(8):417-8 Details

Stephan BC, Matthews FE, Khaw KT, Dufouil C, Brayne C (2009), “Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND).” Alzheimers Res Ther 1(1):4 Details

Wharton SB, O'Callaghan JP, Savva GM, Nicoll JA, Matthews F, Simpson JE, Forster G, Shaw PJ, Brayne C, Ince PG, MRC Cognitive Function and Ageing Neuropathology Study Group (2009), “Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to Alzheimer-type pathology and dementia.” Dement Geriatr Cogn Disord 27(5):465-73 Details

Williams-Gray CH, Evans JR, Goris A, Foltynie T, Ban M, Robbins TW, Brayne C, Kolachana BS, Weinberger DR, Sawcer SJ, Barker RA (2009), “The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort.” Brain 132(Pt 11):2958-69 Details

Wright CF, Hall A, Matthews FE, Brayne C (2009), “Biomarkers, dementia, and public health.” Ann N Y Acad Sci 1180:11-9 Details

2008

Allison C, Baron-Cohen S, Wheelwright S, Charman T, Richler J, Pasco G, Brayne C (2008), “The Q-CHAT (Quantitative CHecklist for Autism in Toddlers): a normally distributed quantitative measure of autistic traits at 18-24 months of age: preliminary report.” J Autism Dev Disord 38(8):1414-25 Details

Basta NE, Matthews FE, Chatfield MD, Brayne C, MRC-CFAS (2008), “Community-level socio-economic status and cognitive and functional impairment in the older population.” Eur J Public Health 18(1):48-54 Details

Buter TC, van den Hout A, Matthews FE, Larsen JP, Brayne C, Aarsland D (2008), “Dementia and survival in Parkinson disease: a 12-year population study.” Neurology 70(13):1017-22 Details

Cullum S, Metcalfe C, Todd C, Brayne C (2008), “Does depression predict adverse outcomes for older medical inpatients? A prospective cohort study of individuals screened for a trial.” Age Ageing 37(6):690-5 Details

Downes EC, Robson J, Grailly E, Abdel-All Z, Xuereb J, Brayne C, Holland A, Honer WG, Mukaetova-Ladinska EB (2008), “Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals.” Neuropathol Appl Neurobiol 34(1):12-22 Details

Fleming J, Brayne C, Cambridge City over-75s Cohort (CC75C) study collaboration (2008), “Inability to get up after falling, subsequent time on floor, and summoning help: prospective cohort study in people over 90.” BMJ 337:a2227 Details

Fleming J, Matthews FE, Brayne C, Cambridge City over-75s Cohort (CC75C) study collaboration (2008), “Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study.” BMC Geriatr 8:6 Details

Gao L, Matthews FE, Sargeant LA, Brayne C, MRC CFAS (2008), “An investigation of the population impact of variation in HbA1c levels in older people in England and Wales: from a population based multi-centre longitudinal study.” BMC Public Health 8:54 Details

Hogervorst E, Huppert F, Matthews FE, Brayne C (2008), “Thyroid function and cognitive decline in the MRC Cognitive Function and Ageing Study.” Psychoneuroendocrinology 33(7):1013-22 Details

Ishihara-Paul L, Wainwright NW, Khaw KT, Luben RN, Welch AA, Day NE, Brayne C, Surtees PG (2008), “Prospective association between emotional health and clinical evidence of Parkinson's disease.” Eur J Neurol 15(11):1148-54 Details

Kvaal K, McDougall FA, Brayne C, Matthews FE, Dewey ME, MRC CFAS (2008), “Co-occurrence of anxiety and depressive disorders in a community sample of older people: results from the MRC CFAS (Medical Research Council Cognitive Function and Ageing Study).” Int J Geriatr Psychiatry 23(3):229-37 Details

Li Y, Grupe A, Rowland C, Holmans P, Segurado R, Abraham R, Jones L, Catanese J, Ross D, Mayo K, Martinez M, Hollingworth P, Goate A, Cairns NJ, Racette BA, Perlmutter JS, O'Donovan MC, Morris JC, Brayne C, Rubinsztein DC, Lovestone S, Thal LJ, Owen MJ, Williams J (2008), “Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.” Hum Mol Genet 17(5):759-67 Details

Matthews FE, Stephan BC, McKeith IG, Bond J, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2008), “Two-year progression from mild cognitive impairment to dementia: to what extent do different definitions agree?” J Am Geriatr Soc 56(8):1424-33 Details

Mercy L, Hodges JR, Dawson K, Barker RA, Brayne C (2008), “Incidence of early-onset dementias in Cambridgeshire, United Kingdom.” Neurology 71(19):1496-9 Details

Morgan AR, Hamilton G, Turic D, Jehu L, Harold D, Abraham R, Hollingworth P, Moskvina V, Brayne C, Rubinsztein DC, Lynch A, Lawlor B, Gill M, O'Donovan M, Powell J, Lovestone S, Williams J, Owen MJ (2008), “Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease.” Am J Med Genet B Neuropsychiatr Genet 147B(6):727-31 Details

Mukaetova-Ladinska EB, Milne J, Andras A, Abdel-All Z, Cerejeira J, Greally E, Robson J, Jaros E, Perry R, McKeith IG, Brayne C, Xuereb J, Cleghorn A, Doherty J, McIntosh G, Milton I (2008), “Alpha- and gamma-synuclein proteins are present in cerebrospinal fluid and are increased in aged subjects with neurodegenerative and vascular changes.” Dement Geriatr Cogn Disord 26(1):32-42 Details

Ngondi J, Matthews F, Reacher M, Baba S, Brayne C, Emerson P (2008), “Associations between active trachoma and community intervention with Antibiotics, Facial cleanliness, and Environmental improvement (A,F,E).” PLoS Negl Trop Dis 2(4):e229 Details

Stephan BC, Brayne C (2008), “Vascular factors and prevention of dementia.” Int Rev Psychiatry 20(4):344-56 Details

Stephan BC, Brayne C, McKeith IG, Bond J, Matthews FE, Medical Research Council Cognitive Function and Ageing Study (2008), “Mild cognitive impairment in the older population: Who is missed and does it matter?” Int J Geriatr Psychiatry 23(8):863-71 Details

Terrera GM, Matthews F, Brayne C (2008), “A comparison of parametric models for the investigation of the shape of cognitive change in the older population.” BMC Neurol 8:16 Details

Williams JG, Allison C, Scott FJ, Bolton PF, Baron-Cohen S, Matthews FE, Brayne C (2008), “The Childhood Autism Spectrum Test (CAST): sex differences.” J Autism Dev Disord 38(9):1731-9 Details

Xie J, Brayne C, Matthews FE, Medical Research Council Cognitive Function and Ageing Study collaborators (2008), “Survival times in people with dementia: analysis from population based cohort study with 14 year follow-up.” BMJ 336(7638):258-62 Details

Xie J, Matthews FE, Jagger C, Bond J, Brayne C (2008), “The oldest old in England and Wales: a descriptive analysis based on the MRC Cognitive Function and Ageing Study.” Age Ageing 37(4):396-402 Details

Zaccai J, Brayne C, McKeith I, Matthews F, Ince PG, MRC Cognitive Function, Ageing Neuropathology Study (2008), “Patterns and stages of alpha-synucleinopathy: Relevance in a population-based cohort.” Neurology 70(13):1042-8 Details

2007

Allison C, Williams J, Scott F, Stott C, Bolton P, Baron-Cohen S, Brayne C (2007), “The Childhood Asperger Syndrome Test (CAST): test-retest reliability in a high scoring sample.” Autism 11(2):173-85 Details

Brayne C (2007), “The elephant in the room - healthy brains in later life, epidemiology and public health.” Nat Rev Neurosci 8(3):233-9 Details

Brayne C, Fox C, Boustani M (2007), “Dementia screening in primary care: is it time?” JAMA 298(20):2409-11 Details

Chatfield M, Matthews FE, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2007), “Using the Mini-Mental State Examination for tracking cognition in the older population based on longitudinal data.” J Am Geriatr Soc 55(7):1066-71 Details

Cullum S, Tucker S, Todd C, Brayne C (2007), “Effectiveness of liaison psychiatric nursing in older medical inpatients with depression: a randomised controlled trial.” Age Ageing 36(4):436-42 Details

Fleming J, Zhao E, O'Connor DW, Pollitt PA, Brayne C (2007), “Cohort profile: the Cambridge City over-75s Cohort (CC75C).” Int J Epidemiol 36(1):40-6 Details

Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A, Jehu L, Segurado R, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, Brayne C, Rubinsztein D, Gill M, Lawlor B, Lovestone S, Holmans P, O'Donovan M, Morris JC, Thal L, Goate A, Owen MJ, Williams J (2007), “Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants.” Hum Mol Genet 16(8):865-73 Details

Harold D, Jehu L, Turic D, Hollingworth P, Moore P, Summerhayes P, Moskvina V, Foy C, Archer N, Hamilton BA, Lovestone S, Powell J, Brayne C, Rubinsztein DC, Jones L, O'Donovan MC, Owen MJ, Williams J (2007), “Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease.” Am J Med Genet B Neuropsychiatr Genet 144B(4):448-52 Details

Ishihara LS, Cheesbrough A, Brayne C, Schrag A (2007), “Estimated life expectancy of Parkinson's patients compared with the UK population.” J Neurol Neurosurg Psychiatry 78(12):1304-9 Details

Jagger C, Matthews R, Matthews F, Robinson T, Robine JM, Brayne C, Medical Research Council Cognitive Function and Ageing Study Investigators (2007), “The burden of diseases on disability-free life expectancy in later life.” J Gerontol A Biol Sci Med Sci 62(4):408-14 Details

Jagger C, Matthews R, Melzer D, Matthews F, Brayne C, MRC CFAS (2007), “Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS).” Int J Epidemiol 36(2):358-65 Details

Jagger C, Matthews RJ, Matthews FE, Spiers NA, Nickson J, Paykel ES, Huppert FA, Brayne C, Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) (2007), “Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS).” BMC Public Health 7:156 Details

Matthews FE, McKeith I, Bond J, Brayne C, MRC CFAS (2007), “Reaching the population with dementia drugs: what are the challenges?” Int J Geriatr Psychiatry 22(7):627-31 Details

Matthews FE, Stephan BC, Bond J, McKeith I, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2007), “Operationalization of mild cognitive impairment: a graphical approach.” PLoS Med 4(10):1615-9 Details

McDougall F, Brayne C (2007), “Systematic review of the depressive symptoms associated with vascular conditions.” J Affect Disord 104(1-3):25-35 Details

McDougall FA, Kvaal K, Matthews FE, Paykel E, Jones PB, Dewey ME, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2007), “Prevalence of depression in older people in England and Wales: the MRC CFA Study.” Psychol Med 37(12):1787-95 Details

McDougall FA, Matthews FE, Kvaal K, Dewey ME, Brayne C (2007), “Prevalence and symptomatology of depression in older people living in institutions in England and Wales.” Age Ageing 36(5):562-8 Details

Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J (2007), “Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.” Am J Med Genet B Neuropsychiatr Genet 144B(6):762-70 Details

Ngondi J, Matthews F, Reacher M, Onsarigo A, Matende I, Baba S, Brayne C, Zingeser J, Emerson P (2007), “Prevalence of risk factors and severity of active trachoma in southern Sudan: an ordinal analysis.” Am J Trop Med Hyg 77(1):126-32 Details

Ngondi J, Ole-Sempele F, Onsarigo A, Matende I, Baba S, Reacher M, Matthews F, Brayne C, Emerson PM (2007), “Blindness survey methods: response from Sudan study authors.” PLoS Med 4(2):e86 Details

Ngondi J, Reacher M, Matthews F, Ole-Sempele F, Onsarigo A, Matende I, Baba S, Brayne C, Emerson P (2007), “The epidemiology of low vision and blindness associated with trichiasis in southern Sudan.” BMC Ophthalmol 7:12 Details

Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2007), “White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses.” Neuropathol Appl Neurobiol 33(4):410-9 Details

Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Stoeber K, Williams GH, Lewis CE, Wharton SB, MRC Cognitive Function and Ageing Neuropathology Study Group (2007), “Microglial activation in white matter lesions and nonlesional white matter of ageing brains.” Neuropathol Appl Neurobiol 33(6):670-83 Details

Stephan BC, Matthews FE, McKeith IG, Bond J, Brayne C, Medical Research Council Cognitive Function and Aging Study (2007), “Early cognitive change in the general population: how do different definitions work?” J Am Geriatr Soc 55(10):1534-40 Details

Williams-Gray CH, Foltynie T, Brayne CE, Robbins TW, Barker RA (2007), “Evolution of cognitive dysfunction in an incident Parkinson's disease cohort.” Brain 130(Pt 7):1787-98 Details

2006

Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P (2006), “Risk of dementia in diabetes mellitus: a systematic review.” Lancet Neurol 5(1):64-74 Details

Brayne C (2006), “Incidence of dementia in England and Wales: the MRC Cognitive Function and Ageing Study.” Alzheimer Dis Assoc Disord 20(3 Suppl 2):S47-51 Details

Brayne C, Gao L, Dewey M, Matthews FE, Medical Research Council Cognitive Function and Ageing Study Investigators (2006), “Dementia before death in ageing societies--the promise of prevention and the reality.” PLoS Med 3(10):e397 Details

Brayne C, McCracken C, Matthews FE, Medical Research Council Coginitive Function and Ageing Study (CFAS) (2006), “Cohort profile: the Medical Research Council Cognitive Function and Ageing Study (CFAS).” Int J Epidemiol 35(5):1140-5 Details

Chandra V, Pandav R, Laxminarayan R, Tanner C, Manyam B, Rajkumar S, Silberberg D, Brayne C, Chow J, Herman S, Hourihan F, Kasner S, Morillo L, Ogunniyi A, Theodore W, Zhang ZX, Jamison DT, Breman JG, Measham AR, Alleyne G, Claeson M, Evans DB, Jha P, Mills A, Musgrove P (2006), Neurological Disorders,

Cullum S, Tucker S, Todd C, Brayne C (2006), “Screening for depression in older medical inpatients.” Int J Geriatr Psychiatry 21(5):469-76 Details

Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O'Brien JT, Ince PG, MRC Cognitive Function and Ageing Neuropathology Study Group (2006), “White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury.” Stroke 37(6):1391-8 Details

Foltynie T, Matthews FE, Ishihara L, Brayne C, MRC CFAS (2006), “The frequency and validity of self-reported diagnosis of Parkinson's Disease in the UK elderly: MRC CFAS cohort.” BMC Neurol 6:29 Details

Hollingworth P, Hamshere ML, Moskvina V, Dowzell K, Moore PJ, Foy C, Archer N, Lynch A, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, Owen MJ, Williams J (2006), “Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease.” J Am Geriatr Soc 54(9):1348-54 Details

Ishihara L, Brayne C (2006), “What is the evidence for a premorbid parkinsonian personality: a systematic review.” Mov Disord 21(8):1066-72 Details

Ishihara L, Brayne C (2006), “A systematic review of depression and mental illness preceding Parkinson's disease.” Acta Neurol Scand 113(4):211-20 Details

Ishikawa T, Ikeda M, Matsumoto N, Shigenobu K, Brayne C, Tanabe H (2006), “A longitudinal study regarding conversion from mild memory impairment to dementia in a Japanese community.” Int J Geriatr Psychiatry 21(2):134-9 Details

Kerr SR, Pearce MS, Brayne C, Davis RJ, Kenny RA (2006), “Carotid sinus hypersensitivity in asymptomatic older persons: implications for diagnosis of syncope and falls.” Arch Intern Med 166(5):515-20 Details

Li Y, Grupe A, Rowland C, Nowotny P, Kauwe JS, Smemo S, Hinrichs A, Tacey K, Toombs TA, Kwok S, Catanese J, White TJ, Maxwell TJ, Hollingworth P, Abraham R, Rubinsztein DC, Brayne C, Wavrant-De Vrièze F, Hardy J, O'Donovan M, Lovestone S, Morris JC, Thal LJ, Owen M, Williams J, Goate A (2006), “DAPK1 variants are associated with Alzheimer's disease and allele-specific expression.” Hum Mol Genet 15(17):2560-8 Details

Matthews FE, Chatfield M, Brayne C, Medical Research Council Cognitive Function and Ageing Study (2006), “An investigation of whether factors associated with short-term attrition change or persist over ten years: data from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).” BMC Public Health 6:185 Details

Matthews FE, Miller LL, Brayne C, Jagger C, Medical Research Council Cognitive Function and Aging Study (MRC CFAS) (2006), “Regional differences in multidimensional aspects of health: findings from the MRC cognitive function and ageing study.” BMC Public Health 6:90 Details

Ngondi J, Ole-Sempele F, Onsarigo A, Matende I, Baba S, Reacher M, Matthews F, Brayne C, Emerson P (2006), “Blinding trachoma in postconflict southern Sudan.” PLoS Med 3(12):e478 Details

Ngondi J, Ole-Sempele F, Onsarigo A, Matende I, Baba S, Reacher M, Matthews F, Brayne C, Emerson PM (2006), “Prevalence and causes of blindness and low vision in southern Sudan.” PLoS Med 3(12):e477 Details

Ngondi J, Onsarigo A, Matthews F, Reacher M, Brayne C, Baba S, Solomon AW, Zingeser J, Emerson PM (2006), “Effect of 3 years of SAFE (surgery, antibiotics, facial cleanliness, and environmental change) strategy for trachoma control in southern Sudan: a cross-sectional study.” Lancet 368(9535):589-95 Details

Williams J, Allison C, Scott F, Stott C, Bolton P, Baron-Cohen S, Brayne C (2006), “The Childhood Asperger Syndrome Test (CAST): test-retest reliability.” Autism 10(4):415-27 Details

Williams J, Brayne C (2006), “Screening for autism spectrum disorders: what is the evidence?” Autism 10(1):11-35 Details

Williams JG, Higgins JP, Brayne CE (2006), “Systematic review of prevalence studies of autism spectrum disorders.” Arch Dis Child 91(1):8-15 Details

Yip AG, Brayne C, Matthews FE, MRC Cognitive Function and Ageing Study (2006), “Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study.” Age Ageing 35(2):154-60 Details

Zaccai J, Ince P, Brayne C (2006), “Population-based neuropathological studies of dementia: design, methods and areas of investigation--a systematic review.” BMC Neurol 6:2 Details

2005

Aarsland D, Zaccai J, Brayne C (2005), “A systematic review of prevalence studies of dementia in Parkinson's disease.” Mov Disord 20(10):1255-63 Details

Barnes L, Matthews FE, Barber B, Davies L, Lloyd D, Brayne C, Parry B (2005), “Brain donation for research: consent and re-consent post Alder Hey.” Bull Med Ethics (211):17-21 Details

Brayne C, Gao L, Matthews F, MRC Cognitive Function and Ageing Study (2005), “Challenges in the epidemiological investigation of the relationships between physical activity, obesity, diabetes, dementia and depression.” Neurobiol Aging 26 Suppl 1:6-10 Details

Chatfield MD, Brayne CE, Matthews FE (2005), “A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies.” J Clin Epidemiol 58(1):13-9 Details

Cook LJ, Ho LW, Wang L, Terrenoire E, Brayne C, Evans JG, Xuereb J, Cairns NJ, Turic D, Hollingworth P, Moore PJ, Jehu L, Archer N, Walter S, Foy C, Edmondson A, Powell J, Lovestone S, Williams J, Rubinsztein DC (2005), “Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study.” Am J Med Genet B Neuropsychiatr Genet 132B(1):5-8 Details

Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M, Alzheimer's Disease International (2005), “Global prevalence of dementia: a Delphi consensus study.” Lancet 366(9503):2112-7 Details

Foltynie T, Hicks A, Sawcer S, Jonasdottir A, Setakis E, Maranian M, Yeo T, Lewis S, Brayne C, Stefansson K, Compston A, Gulcher J, Barker RA (2005), “A genome wide linkage disequilibrium screen in Parkinson's disease.” J Neurol 252(5):597-602 Details

Ishihara L, Brayne C (2005), “A systematic review of nutritional risk factors of Parkinson's disease.” Nutr Res Rev 18(2):259-82 Details

Ishihara LS, Khaw KT, Luben R, Bingham S, Welch A, Day N, Brayne C (2005), “Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort.” BMC Neurol 5:15 Details

Jamieson SE, White JK, Howson JM, Pask R, Smith AN, Brayne C, Evans JG, Xuereb J, Cairns NJ, Rubinsztein DC, Blackwell JM (2005), “Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease.” Neurosci Lett 374(2):124-8 Details

Matthews F, Brayne C, Medical Research Council Cognitive Function and Ageing Study Investigators (2005), “The incidence of dementia in England and Wales: findings from the five identical sites of the MRC CFA Study.” PLoS Med 2(8):e193 Details

Rait G, Fletcher A, Smeeth L, Brayne C, Stirling S, Nunes M, Breeze E, Ng ES, Bulpitt CJ, Jones D, Tulloch AJ (2005), “Prevalence of cognitive impairment: results from the MRC trial of assessment and management of older people in the community.” Age Ageing 34(3):242-8 Details

Spiers NA, Matthews RJ, Jagger C, Matthews FE, Boult C, Robinson TG, Brayne C (2005), “Diseases and impairments as risk factors for onset of disability in the older population in England and Wales: findings from the Medical Research Council Cognitive Function and Ageing Study.” J Gerontol A Biol Sci Med Sci 60(2):248-54 Details

Syed A, Chatfield M, Matthews F, Harrison P, Brayne C, Esiri MM (2005), “Depression in the elderly: pathological study of raphe and locus ceruleus.” Neuropathol Appl Neurobiol 31(4):405-13 Details

Williams J, Scott F, Stott C, Allison C, Bolton P, Baron-Cohen S, Brayne C (2005), “The CAST (Childhood Asperger Syndrome Test): test accuracy.” Autism 9(1):45-68 Details

Zaccai J, McCracken C, Brayne C (2005), “A systematic review of prevalence and incidence studies of dementia with Lewy bodies.” Age Ageing 34(6):561-6 Details

2004

Cook LJ, Ho LW, Taylor AE, Brayne C, Evans JG, Xuereb J, Cairns NJ, Pritchard A, Lemmon H, Mann D, St Clair D, Turic D, Hollingworth P, Moore PJ, Jehu L, Archer N, Walter S, Foy C, Edmondson A, Powell J, Lovestone S, Owen MJ, Williams J, Lendon C, Rubinsztein DC (2004), “Candidate gene association studies of the alpha 4 (CHRNA4) and beta 2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease.” Neurosci Lett 358(2):142-6 Details

Dufouil C, Brayne C, Clayton D (2004), “Analysis of longitudinal studies with death and drop-out: a case study.” Stat Med 23(14):2215-26 Details

Foltynie T, Brayne CE, Robbins TW, Barker RA (2004), “The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study.” Brain 127(Pt 3):550-60 Details

Matthews FE, Chatfield M, Freeman C, McCracken C, Brayne C, MRC CFAS (2004), “Attrition and bias in the MRC cognitive function and ageing study: an epidemiological investigation.” BMC Public Health 4:12 Details

Ott A, Andersen K, Dewey ME, Letenneur L, Brayne C, Copeland JR, Dartigues JF, Kragh-Sorensen P, Lobo A, Martinez-Lage JM, Stijnen T, Hofman A, Launer LJ, EURODEM Incidence Research Group (2004), “Effect of smoking on global cognitive function in nondemented elderly.” Neurology 62(6):920-4 Details

Pinto EM, Huppert FA, Morgan K, Mrc Cfas, Brayne C (2004), “Neutrophil counts, monocyte counts and cardiovascular disease in the elderly.” Exp Gerontol 39(4):615-9 Details

2003

Huppert FA, Pinto EM, Morgan K, Brayne C (2003), “Survival in a population sample is predicted by proportions of lymphocyte subsets.” Mech Ageing Dev 124(4):449-51 Details

Surtees P, Wainwright N, Day N, Brayne C, Luben R, Khaw KT (2003), “Adverse experience in childhood as a developmental risk factor for altered immune status in adulthood.” Int J Behav Med 10(3):251-68 Details

Surtees P, Wainwright N, Day N, Luben R, Brayne C, Khaw KT (2003), “Association of depression with peripheral leukocyte counts in EPIC-Norfolk--role of sex and cigarette smoking.” J Psychosom Res 54(4):303-6 Details

1998

Richards M, Abas M, Carter J, Osagie A, Levy R, Brayne C, Forde C (1998), “Social support and activities of daily living in older Afro-Caribbean and white UK residents.” Age Ageing 27(2):252-3 Details