Professor Barbara Sahakian FMedSci DSc University positionProfessor Professor Barbara Sahakian FMedSci DSc is pleased to consider applications from prospective PhD students. DepartmentsInstitutesBehavioural and Clinical Neuroscience Institute, Cambridge Centre for Brain Repair and Wolfson Brain Imaging Centre Home pagehttp://www.psychiatry.cam.ac.uk/pages/p... (personal home page) Research ThemesInterestsMy research is aimed at understanding the neural basis of cognitive, emotional and behavioural dysfunction in order to develop more effective pharmacological and psychological treatments. The focus of my lab is on early detection, differential diagnosis and proof of concept studies using cognitive enhancing drugs. This research utilises neuropsychological tests, such as the CANTAB tests, which I co-invented and a focus remains on the development of novel tests. Current study participants include healthy volunteers and patient groups with brain injury, Alzheimer’s disease, attention deficit hyperactivity disorder (ADHD), obsessive compulsive disorder, substance abuse, depression and mania. Techniques used include psychopharmacological, neuropsychological, neuroimaging (fMRI and PET) and genetic ones. Results from recent studies of ecstasy use and cognitive enhancement using methylphenidate, modafinil and atomoxetine have led to an interest in pharmacogenomics and neuroethics. Research Focus
EquipmentBehavioural analysis Magnetic resonance imaging (MRI) Neuropsychological testing Positron Emission Tomography (PET) Proof of concept trials Psychopharmacology Randomised control trials Collaborators
Associated News Items
Key publicationsChamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006), “Neurochemical Modulation of Response Inhibition and Probabilistic Learning in Humans” Science 311(5762):861-863 Details Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ (2003), “Cognitive enhancing effects of modafinil in healthy volunteers” Psychopharmacology 165(3):260-269 Swainson R, Galton CJ, Hodges JR, Michael A, Semple J, Dunn BD, Jefferies MC, Iddon JL, Robbins TW, Sahakian BJ (2001), “Early detection and differential diagnosis of Alzheimer’s disease and depression with neuropsychological tasks” Dementia and Geriatric Cognitive Disorders 12:265-280 Publications2014Clark-Elford R, Nathan PJ, Auyeung B, Voon V, Sule A, Müller U, Dudas R, Sahakian BJ, Phan KL, Baron-Cohen S (2014), “The effects of oxytocin on social reward learning in humans.” Int J Neuropsychopharmacol 17(2):199-209 Details Fineberg NA, Chamberlain SR, Goudriaan AE, Stein DJ, Vanderschuren LJ, Gillan CM, Shekar S, Gorwood PA, Voon V, Morein-Zamir S, Denys D, Sahakian BJ, Moeller FG, Robbins TW, Potenza MN (2014), “New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity.” CNS Spectr 19(1):69-89 Details Gillan CM, Morein-Zamir S, Durieux AM, Fineberg NA, Sahakian BJ, Robbins TW (2014), “Obsessive-compulsive disorder patients have a reduced sense of control on the illusion of control task.” Front Psychol 5:204 Details Kehagia AA, Housden CR, Regenthal R, Barker RA, Müller U, Rowe J, Sahakian BJ, Robbins TW (2014), “Targeting impulsivity in Parkinson's disease using atomoxetine.” Brain 137(Pt 7):1986-97 Details Owens M, Herbert J, Jones PB, Sahakian BJ, Wilkinson PO, Dunn VJ, Croudace TJ, Goodyer IM (2014), “Elevated morning cortisol is a stratified population-level biomarker for major depression in boys only with high depressive symptoms.” Proc Natl Acad Sci U S A Details Pulcu E, Zahn R, Moll J, Trotter PD, Thomas EJ, Juhasz G, Deakin JF, Anderson IM, Sahakian BJ, Elliott R (2014), “Enhanced subgenual cingulate response to altruistic decisions in remitted major depressive disorder.” Neuroimage Clin 4:701-10 Details Sahakian BJ (2014), “What do experts think we should do to achieve brain health?” Neurosci Biobehav Rev 43:240-58 Details Voon V, Derbyshire K, Rück C, Irvine MA, Worbe Y, Enander J, Schreiber LR, Gillan C, Fineberg NA, Sahakian BJ, Robbins TW, Harrison NA, Wood J, Daw ND, Dayan P, Grant JE, Bullmore ET (2014), “Disorders of compulsivity: a common bias towards learning habits.” Mol Psychiatry Details Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014), “Improving Response Inhibition in Parkinson's Disease with Atomoxetine.” Biol Psychiatry Details Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014), “Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease.” Brain 137(Pt 4):1145-55 Details 2013Als LC, Nadel S, Cooper M, Pierce CM, Sahakian BJ, Garralda ME (2013), “Neuropsychologic function three to six months following admission to the PICU with meningoencephalitis, sepsis, and other disorders: a prospective study of school-aged children.” Crit Care Med 41(4):1094-103 Details Barker RA, Mason SL, Harrower TP, Swain RA, Ho AK, Sahakian BJ, Mathur R, Elneil S, Thornton S, Hurrelbrink C, Armstrong RJ, Tyers P, Smith E, Carpenter A, Piccini P, Tai YF, Brooks DJ, Pavese N, Watts C, Pickard JD, Rosser AE, Dunnett SB, NEST-UK collaboration (2013), “The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease.” J Neurol Neurosurg Psychiatry 84(6):657-65 Details Breitberg A, Drevets WC, Wood SE, Mah L, Schulkin J, Sahakian BJ, Erickson K (2013), “Hydrocortisone infusion exerts dose- and sex-dependent effects on attention to emotional stimuli.” Brain Cogn 81(2):247-55 Details del Campo N, Fryer TD, Hong YT, Smith R, Brichard L, Acosta-Cabronero J, Chamberlain SR, Tait R, Izquierdo D, Regenthal R, Dowson J, Suckling J, Baron JC, Aigbirhio FI, Robbins TW, Sahakian BJ, Müller U (2013), “A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.” Brain 136(Pt 11):3252-70 Details Fineberg NA, Haddad PM, Carpenter L, Gannon B, Sharpe R, Young AH, Joyce E, Rowe J, Wellsted D, Nutt DJ, Sahakian BJ (2013), “The size, burden and cost of disorders of the brain in the UK.” J Psychopharmacol 27(9):761-70 Details Gillan CM, Morein-Zamir S, Kaser M, Fineberg NA, Sule A, Sahakian BJ, Cardinal RN, Robbins TW (2013), “Counterfactual Processing of Economic Action-Outcome Alternatives in Obsessive-Compulsive Disorder: Further Evidence of Impaired Goal-Directed Behavior.” Biol Psychiatry Details Gillan CM, Morein-Zamir S, Urcelay GP, Sule A, Voon V, Apergis-Schoute AM, Fineberg NA, Sahakian BJ, Robbins TW (2013), “Enhanced Avoidance Habits in Obsessive-Compulsive Disorder.” Biol Psychiatry Details Goss AJ, Kaser M, Costafreda SG, Sahakian BJ, Fu CH (2013), “Modafinil augmentation therapy in unipolar and bipolar depression: a systematic review and meta-analysis of randomized controlled trials.” J Clin Psychiatry 74(11):1101-7 Details Hagan CC, Graham JM, Widmer B, Holt RJ, Ooi C, van Nieuwenhuizen AO, Fonagy P, Reynolds S, Target M, Kelvin R, Wilkinson PO, Bullmore ET, Lennox BR, Sahakian BJ, Goodyer I, Suckling J (2013), “Magnetic resonance imaging of a randomized controlled trial investigating predictors of recovery following psychological treatment in adolescents with moderate to severe unipolar depression: study protocol for Magnetic Resonance-Improving Mood with Psychoanalytic and Cognitive Therapies (MR-IMPACT).” BMC Psychiatry 13:247 Details Insel TR, Voon V, Nye JS, Brown VJ, Altevogt BM, Bullmore ET, Goodwin GM, Howard RJ, Kupfer DJ, Malloch G, Marston HM, Nutt DJ, Robbins TW, Stahl SM, Tricklebank MD, Williams JH, Sahakian BJ (2013), “Innovative solutions to novel drug development in mental health.” Neurosci Biobehav Rev 37(10 Pt 1):2438-44 Details Morein-Zamir S, Papmeyer M, Durieux A, Fineberg NA, Sahakian BJ, Robbins TW (2013), “Investigation of attentional bias in obsessive compulsive disorder with and without depression in visual search.” PLoS One 8(11):e80118 Details Morein-Zamir S, Papmeyer M, Gillan CM, Crockett MJ, Fineberg NA, Sahakian BJ, Robbins TW (2013), “Punishment promotes response control deficits in obsessive-compulsive disorder: evidence from a motivational go/no-go task.” Psychol Med 43(2):391-400 Details Morein-Zamir S, Papmeyer M, Pertusa A, Chamberlain SR, Fineberg NA, Sahakian BJ, Mataix-Cols D, Robbins TW (2013), “The profile of executive function in OCD hoarders and hoarding disorder.” Psychiatry Res Details Müller U, Rowe JB, Rittman T, Lewis C, Robbins TW, Sahakian BJ (2013), “Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers.” Neuropharmacology 64:490-5 Details Nutt D, Gispen-de Wied CC, Arango C, Keefe RS, Penadés R, Murphy DG, Robbins TW, Sahakian BJ (2013), “Cognition in schizophrenia: Summary Nice Consultation Meeting 2012.” Eur Neuropsychopharmacol 23(8):769-78 Details Pironti VA, Lai MC, Müller U, Dodds CM, Suckling J, Bullmore ET, Sahakian BJ (2013), “Neuroanatomical Abnormalities and Cognitive Impairments Are Shared by Adults with Attention-Deficit/Hyperactivity Disorder and Their Unaffected First-Degree Relatives.” Biol Psychiatry Details Pulcu E, Trotter PD, Thomas EJ, McFarquhar M, Juhasz G, Sahakian BJ, Deakin JF, Zahn R, Anderson IM, Elliott R (2013), “Temporal discounting in major depressive disorder.” Psychol Med :1-10 Details Roiser JP, Sahakian BJ (2013), “Hot and cold cognition in depression.” CNS Spectr 18(3):139-49 Details Scoriels L, Jones PB, Sahakian BJ (2013), “Modafinil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain.” Neuropharmacology 64:168-84 Details 2012Clark L, Boxer O, Sahakian BJ, Bilder RM (2012), “Research methods: cognitive neuropsychological methods.” Handb Clin Neurol 106:75-87 Details Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools R, Chase HW, Ouden Hd, Apergis-Schoute A, Campbell-Meiklejohn D, Seymour B, Sahakian BJ, Rogers RD, Robbins TW (2012), “Converging evidence for central 5-HT effects in acute tryptophan depletion.” Mol Psychiatry 17(2):121-3 Details de Wit S, Standing HR, Devito EE, Robinson OJ, Ridderinkhof KR, Robbins TW, Sahakian BJ (2012), “Reliance on habits at the expense of goal-directed control following dopamine precursor depletion.” Psychopharmacology (Berl) 219(2):621-31 Details Del Campo N, Müller U, Sahakian BJ (2012), “Neural and behavioral endophenotypes in ADHD.” Curr Top Behav Neurosci 11:65-91 Details Insel TR, Sahakian BJ (2012), “Drug research: a plan for mental illness.” Nature 483(7389):269 Details Maalouf FT, Clark L, Tavitian L, Sahakian BJ, Brent D, Phillips ML (2012), “Bias to negative emotions: a depression state-dependent marker in adolescent major depressive disorder.” Psychiatry Res 198(1):28-33 Details Mohamed AD, Sahakian BJ (2012), “The ethics of elective psychopharmacology.” Int J Neuropsychopharmacol 15(4):559-71 Details Murphy FC, Michael A, Sahakian BJ (2012), “Emotion modulates cognitive flexibility in patients with major depression.” Psychol Med 42(7):1373-82 Details Owens M, Goodyer IM, Wilkinson P, Bhardwaj A, Abbott R, Croudace T, Dunn V, Jones PB, Walsh ND, Ban M, Sahakian BJ (2012), “5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence.” PLoS One 7(11):e48482 Details Robinson OJ, Cools R, Carlisi CO, Sahakian BJ, Drevets WC (2012), “Ventral striatum response during reward and punishment reversal learning in unmedicated major depressive disorder.” Am J Psychiatry 169(2):152-9 Details Robinson OJ, Cools R, Sahakian BJ (2012), “Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience.” Psychopharmacology (Berl) 219(2):599-605 Details Roiser JP, Elliott R, Sahakian BJ (2012), “Cognitive mechanisms of treatment in depression.” Neuropsychopharmacology 37(1):117-36 Details Roiser JP, Levy J, Fromm SJ, Goldman D, Hodgkinson CA, Hasler G, Sahakian BJ, Drevets WC (2012), “Serotonin transporter genotype differentially modulates neural responses to emotional words following tryptophan depletion in patients recovered from depression and healthy volunteers.” J Psychopharmacol 26(11):1434-42 Details Scoriels L, Barnett JH, Soma PK, Sahakian BJ, Jones PB (2012), “Effects of modafinil on cognitive functions in first episode psychosis.” Psychopharmacology (Berl) 220(2):249-58 Details Sugden C, Housden CR, Aggarwal R, Sahakian BJ, Darzi A (2012), “Effect of pharmacological enhancement on the cognitive and clinical psychomotor performance of sleep-deprived doctors: a randomized controlled trial.” Ann Surg 255(2):222-7 Details Szanto K, Dombrovski AY, Sahakian BJ, Mulsant BH, Houck PR, Reynolds CF 3rd, Clark L (2012), “Social emotion recognition, social functioning, and attempted suicide in late-life depression.” Am J Geriatr Psychiatry 20(3):257-65 Details 2011Cannon DM, Klaver JK, Gandhi SK, Solorio G, Peck SA, Erickson K, Akula N, Savitz J, Eckelman WC, Furey ML, Sahakian BJ, McMahon FJ, Drevets WC (2011), “Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder.” Mol Psychiatry 16(4):407-18 Details Chamberlain SR, Blackwell AD, Nathan PJ, Hammond G, Robbins TW, Hodges JR, Michael A, Semple JM, Bullmore ET, Sahakian BJ (2011), “Differential cognitive deterioration in dementia: a two year longitudinal study.” J Alzheimers Dis 24(1):125-36 Details Chamberlain SR, Robbins TW, Winder-Rhodes S, Müller U, Sahakian BJ, Blackwell AD, Barnett JH (2011), “Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery.” Biol Psychiatry 69(12):1192-203 Details Chase HW, Crockett MJ, Msetfi RM, Murphy RA, Clark L, Sahakian BJ, Robbins TW (2011), “5-HT modulation by acute tryptophan depletion of human instrumental contingency judgements.” Psychopharmacology (Berl) 213(2-3):615-23 Details Clark L, Dombrovski AY, Siegle GJ, Butters MA, Shollenberger CL, Sahakian BJ, Szanto K (2011), “Impairment in risk-sensitive decision-making in older suicide attempters with depression.” Psychol Aging 26(2):321-30 Details Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS, Scientific Advisory Board and the Executive Committee of the Grand Challenges on Global Mental Health, Anderson W, Dhansay MA, Phillips A, Shurin S, Walport M, Ewart W, Savill SJ, Bordin IA, Costello EJ, Durkin M, Fairburn C, Glass RI, Hall W, Huang Y, Hyman SE, Jamison K, Kaaya S, Kapur S, Kleinman A, Ogunniyi A, Otero-Ojeda A, Poo MM, Ravindranath V, Sahakian BJ, Saxena S, Singer PA, Stein DJ (2011), “Grand challenges in global mental health.” Nature 475(7354):27-30 Details de Rover M, Pironti VA, McCabe JA, Acosta-Cabronero J, Arana FS, Morein-Zamir S, Hodges JR, Robbins TW, Fletcher PC, Nestor PJ, Sahakian BJ (2011), “Hippocampal dysfunction in patients with mild cognitive impairment: a functional neuroimaging study of a visuospatial paired associates learning task.” Neuropsychologia 49(7):2060-70 Details Del Campo N, Chamberlain SR, Sahakian BJ, Robbins TW (2011), “The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder.” Biol Psychiatry 69(12):e145-57 Details del Campo N, Tait RJ, Acosta-Cabronero J, Hong YT, Izquierdo-Garcia D, Smith R, Aigbirhio FI, Sahakian BJ, Müller U, Robbins TW, Fryer TD (2011), “Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.” Neuroimage 55(1):101-12 Details Ersche KD, Roiser JP, Abbott S, Craig KJ, Müller U, Suckling J, Ooi C, Shabbir SS, Clark L, Sahakian BJ, Fineberg NA, Merlo-Pich EV, Robbins TW, Bullmore ET (2011), “Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist.” Biol Psychiatry 70(8):754-62 Details Gillan CM, Papmeyer M, Morein-Zamir S, Sahakian BJ, Fineberg NA, Robbins TW, de Wit S (2011), “Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder.” Am J Psychiatry 168(7):718-26 Details Gorodetzky H, Sahakian BJ, Robbins TW, Ersche KD (2011), “Differences in self-reported decision-making styles in stimulant-dependent and opiate-dependent individuals.” Psychiatry Res 186(2-3):437-40 Details Kasahara M, Menon DK, Salmond CH, Outtrim JG, Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2011), “Traumatic brain injury alters the functional brain network mediating working memory.” Brain Inj 25(12):1170-87 Details Maalouf FT, Brent D, Clark L, Tavitian L, McHugh RM, Sahakian BJ, Phillips ML (2011), “Neurocognitive impairment in adolescent major depressive disorder: state vs. trait illness markers.” J Affect Disord 133(3):625-32 Details Newcombe VF, Outtrim JG, Chatfield DA, Manktelow A, Hutchinson PJ, Coles JP, Williams GB, Sahakian BJ, Menon DK (2011), “Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury.” Brain 134(Pt 3):759-68 Details Sahakian BJ, Morein-Zamir S (2011), “Neuroethical issues in cognitive enhancement.” J Psychopharmacol 25(2):197-204 Details Scoriels L, Barnett JH, Murray GK, Cherukuru S, Fielding M, Cheng F, Lennox BR, Sahakian BJ, Jones PB (2011), “Effects of modafinil on emotional processing in first episode psychosis.” Biol Psychiatry 69(5):457-64 Details 2010Barnett JH, Robbins TW, Leeson VC, Sahakian BJ, Joyce EM, Blackwell AD (2010), “Assessing cognitive function in clinical trials of schizophrenia.” Neurosci Biobehav Rev 34(8):1161-77 Details Chamberlain SR, Grant JE, Costa A, Müller U, Sahakian BJ (2010), “Effects of acute modafinil on cognition in trichotillomania.” Psychopharmacology (Berl) 212(4):597-601 Details Chamberlain SR, Hampshire A, Menzies LA, Garyfallidis E, Grant JE, Odlaug BL, Craig K, Fineberg N, Sahakian BJ (2010), “Reduced brain white matter integrity in trichotillomania: a diffusion tensor imaging study.” Arch Gen Psychiatry 67(9):965-71 Details Chase HW, Camille N, Michael A, Bullmore ET, Robbins TW, Sahakian BJ (2010), “Regret and the negative evaluation of decision outcomes in major depression.” Cogn Affect Behav Neurosci 10(3):406-13 Details Chase HW, Frank MJ, Michael A, Bullmore ET, Sahakian BJ, Robbins TW (2010), “Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia.” Psychol Med 40(3):433-40 Details Chase HW, Michael A, Bullmore ET, Sahakian BJ, Robbins TW (2010), “Paradoxical enhancement of choice reaction time performance in patients with major depression.” J Psychopharmacol 24(4):471-9 Details Dombrovski AY, Clark L, Siegle GJ, Butters MA, Ichikawa N, Sahakian BJ, Szanto K (2010), “Reward/Punishment reversal learning in older suicide attempters.” Am J Psychiatry 167(6):699-707 Details Ersche KD, Bullmore ET, Craig KJ, Shabbir SS, Abbott S, Müller U, Ooi C, Suckling J, Barnes A, Sahakian BJ, Merlo-Pich EV, Robbins TW (2010), “Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence.” Arch Gen Psychiatry 67(6):632-44 Details Fineberg NA, Potenza MN, Chamberlain SR, Berlin HA, Menzies L, Bechara A, Sahakian BJ, Robbins TW, Bullmore ET, Hollander E (2010), “Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review.” Neuropsychopharmacology 35(3):591-604 Details Kasahara M, Menon DK, Salmond CH, Outtrim JG, Taylor Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2010), “Altered functional connectivity in the motor network after traumatic brain injury.” Neurology 75(2):168-76 Details Maalouf FT, Klein C, Clark L, Sahakian BJ, Labarbara EJ, Versace A, Hassel S, Almeida JR, Phillips ML (2010), “Impaired sustained attention and executive dysfunction: bipolar disorder versus depression-specific markers of affective disorders.” Neuropsychologia 48(6):1862-8 Details Morein-Zamir S, Craig KJ, Ersche KD, Abbott S, Muller U, Fineberg NA, Bullmore ET, Sahakian BJ, Robbins TW (2010), “Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation.” Psychopharmacology (Berl) 212(3):357-67 Details Morein-Zamir S, Fineberg NA, Robbins TW, Sahakian BJ (2010), “Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?” Psychol Med 40(2):263-72 Details Morein-Zamir S, Sahakian BJ (2010), “Neuroethics and public engagement training needed for neuroscientists.” Trends Cogn Sci 14(2):49-51 Details Murthy NV, Selvaraj S, Cowen PJ, Bhagwagar Z, Riedel WJ, Peers P, Kennedy JL, Sahakian BJ, Laruelle MA, Rabiner EA, Grasby PM (2010), “Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain.” Neuroimage 52(1):50-4 Details Robinson OJ, Cools R, Crockett MJ, Sahakian BJ (2010), “Mood state moderates the role of serotonin in cognitive biases.” J Psychopharmacol 24(4):573-83 Details Robinson OJ, Frank MJ, Sahakian BJ, Cools R (2010), “Dissociable responses to punishment in distinct striatal regions during reversal learning.” Neuroimage 51(4):1459-67 Details Robinson OJ, Standing HR, DeVito EE, Cools R, Sahakian BJ (2010), “Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males.” Psychopharmacology (Berl) 211(2):187-95 Details Sahakian BJ, Malloch G, Kennard C, Mental Health Review Group (2010), “A UK strategy for mental health and wellbeing.” Lancet 375(9729):1854-5 Details Smith NJ, Marcus RE, Sahakian BJ, Kapur N, Cox TM (2010), “Haematopoietic stem cell transplantation does not retard disease progression in the psycho-cognitive variant of late-onset metachromatic leukodystrophy.” J Inherit Metab Dis 33 Suppl 3:S471-5 Details Sugden C, Aggarwal R, Housden C, Sahakian BJ, Darzi A (2010), “Pharmacological enhancement of performance in doctors.” BMJ 340:c2542 Details Winder-Rhodes SE, Chamberlain SR, Idris MI, Robbins TW, Sahakian BJ, Müller U (2010), “Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers.” J Psychopharmacol 24(11):1649-57 Details 2009Chamberlain SR, Hampshire A, Müller U, Rubia K, Del Campo N, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ (2009), “Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study.” Biol Psychiatry 65(7):550-5 Details Clark L, Chamberlain SR, Sahakian BJ (2009), “Neurocognitive mechanisms in depression: implications for treatment.” Annu Rev Neurosci 32:57-74 Details Clark L, Roiser JP, Robbins TW, Sahakian BJ (2009), “Disrupted 'reflection' impulsivity in cannabis users but not current or former ecstasy users.” J Psychopharmacol 23(1):14-22 Details DeVito EE, Blackwell AD, Clark L, Kent L, Dezsery AM, Turner DC, Aitken MR, Sahakian BJ (2009), “Methylphenidate improves response inhibition but not reflection-impulsivity in children with attention deficit hyperactivity disorder (ADHD).” Psychopharmacology (Berl) 202(1-3):531-9 Details Lawrence AJ, Luty J, Bogdan NA, Sahakian BJ, Clark L (2009), “Impulsivity and response inhibition in alcohol dependence and problem gambling.” Psychopharmacology (Berl) 207(1):163-72 Details Lawrence AJ, Luty J, Bogdan NA, Sahakian BJ, Clark L (2009), “Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals.” Addiction 104(6):1006-15 Details Robinson OJ, Sahakian BJ (2009), “Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletion.” Psychopharmacology (Berl) 205(2):227-35 Details Robinson OJ, Sahakian BJ (2009), “A double dissociation in the roles of serotonin and mood in healthy subjects.” Biol Psychiatry 65(1):89-92 Details Roiser JP, Cannon DM, Gandhi SK, Taylor Tavares J, Erickson K, Wood S, Klaver JM, Clark L, Zarate CA Jr, Sahakian BJ, Drevets WC (2009), “Hot and cold cognition in unmedicated depressed subjects with bipolar disorder.” Bipolar Disord 11(2):178-89 Details Roiser JP, Levy J, Fromm SJ, Nugent AC, Talagala SL, Hasler G, Henn FA, Sahakian BJ, Drevets WC (2009), “The effects of tryptophan depletion on neural responses to emotional words in remitted depression.” Biol Psychiatry 66(5):441-50 Details Sahakian BJ, Morein-Zamir S (2009), “Neuroscientists need neuroethics teaching.” Science 325(5937):147 Details Slawik H, Salmond CH, Taylor-Tavares JV, Williams GB, Sahakian BJ, Tasker RC (2009), “Frontal cerebral vulnerability and executive deficits from raised intracranial pressure in child traumatic brain injury.” J Neurotrauma 26(11):1891-903 Details 2008Beddington J, Cooper CL, Field J, Goswami U, Huppert FA, Jenkins R, Jones HS, Kirkwood TB, Sahakian BJ, Thomas SM (2008), “The mental wealth of nations.” Nature 455(7216):1057-60 Details Blackwell AD, Paterson NS, Barker RA, Robbins TW, Sahakian BJ (2008), “The effects of modafinil on mood and cognition in Huntington's disease.” Psychopharmacology (Berl) 199(1):29-36 Details Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N, Aitken M, Craig K, Owen AM, Bullmore ET, Robbins TW, Sahakian BJ (2008), “Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.” Science 321(5887):421-2 Details Chamberlain SR, Menzies LA, Fineberg NA, Del Campo N, Suckling J, Craig K, Müller U, Robbins TW, Bullmore ET, Sahakian BJ (2008), “Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study.” Br J Psychiatry 193(3):216-21 Details Chase HW, Clark L, Myers CE, Gluck MA, Sahakian BJ, Bullmore ET, Robbins TW (2008), “The role of the orbitofrontal cortex in human discrimination learning.” Neuropsychologia 46(5):1326-37 Details Chase HW, Clark L, Sahakian BJ, Bullmore ET, Robbins TW (2008), “Dissociable roles of prefrontal subregions in self-ordered working memory performance.” Neuropsychologia 46(11):2650-61 Details Clark L, Bechara A, Damasio H, Aitken MR, Sahakian BJ, Robbins TW (2008), “Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making.” Brain 131(Pt 5):1311-22 Details Clark L, Sahakian BJ (2008), “Cognitive neuroscience and brain imaging in bipolar disorder.” Dialogues Clin Neurosci 10(2):153-63 Details DeVito EE, Blackwell AD, Kent L, Ersche KD, Clark L, Salmond CH, Dezsery AM, Sahakian BJ (2008), “The effects of methylphenidate on decision making in attention-deficit/hyperactivity disorder.” Biol Psychiatry 64(7):636-9 Details Ersche KD, Roiser JP, Robbins TW, Sahakian BJ (2008), “Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans.” Psychopharmacology (Berl) 197(3):421-31 Details Holmes MK, Erickson K, Luckenbaugh DA, Drevets WC, Bain EE, Cannon DM, Snow J, Sahakian BJ, Manji HK, Zarate CA Jr (2008), “A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression.” Bipolar Disord 10(7):806-15 Details Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET (2008), “Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited.” Neurosci Biobehav Rev 32(3):525-49 Details Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, Sahakian BJ, Robbins TW, Bullmore ET (2008), “White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives.” Am J Psychiatry 165(10):1308-15 Details Ornstein TJ, Sahakian BJ, McKenna PJ (2008), “Memory and executive impairment in schizophrenia: comparison with frontal and temporal brain damage.” Psychol Med 38(6):833-42 Details Robinson OJ, Sahakian BJ (2008), “Recurrence in major depressive disorder: a neurocognitive perspective.” Psychol Med 38(3):315-8 Details Roiser JP, Levy J, Fromm SJ, Wang H, Hasler G, Sahakian BJ, Drevets WC (2008), “The effect of acute tryptophan depletion on the neural correlates of emotional processing in healthy volunteers.” Neuropsychopharmacology 33(8):1992-2006 Details Taylor Tavares JV, Clark L, Furey ML, Williams GB, Sahakian BJ, Drevets WC (2008), “Neural basis of abnormal response to negative feedback in unmedicated mood disorders.” Neuroimage 42(3):1118-26 Details 2007Barnett JH, Croudace TJ, Jaycock S, Blackwell C, Hynes F, Sahakian BJ, Joyce EM, Jones PB (2007), “Improvement and decline of cognitive function in schizophrenia over one year: a longitudinal investigation using latent growth modelling.” BMC Psychiatry 7:16 Details Chamberlain SR, Del Campo N, Dowson J, Müller U, Clark L, Robbins TW, Sahakian BJ (2007), “Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder.” Biol Psychiatry 62(9):977-84 Details Chamberlain SR, Fineberg NA, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2007), “A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania.” Neuropsychologia 45(4):654-62 Details Chamberlain SR, Fineberg NA, Menzies LA, Blackwell AD, Bullmore ET, Robbins TW, Sahakian BJ (2007), “Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder.” Am J Psychiatry 164(2):335-8 Details Chamberlain SR, Menzies L, Sahakian BJ, Fineberg NA (2007), “Lifting the veil on trichotillomania.” Am J Psychiatry 164(4):568-74 Details Chamberlain SR, Müller U, Cleary S, Robbins TW, Sahakian BJ (2007), “Atomoxetine increases salivary cortisol in healthy volunteers.” J Psychopharmacol 21(5):545-9 Details Chamberlain SR, Müller U, Deakin JB, Corlett PR, Dowson J, Cardinal RN, Aitken MR, Robbins TW, Sahakian BJ (2007), “Lack of deleterious effects of buspirone on cognition in healthy male volunteers.” J Psychopharmacol 21(2):210-5 Details Chamberlain SR, Robbins TW, Sahakian BJ (2007), “The neurobiology of attention-deficit/hyperactivity disorder.” Biol Psychiatry 61(12):1317-9 Details Chamberlain SR, Sahakian BJ (2007), “The neuropsychiatry of impulsivity.” Curr Opin Psychiatry 20(3):255-61 Details Clark L, Blackwell AD, Aron AR, Turner DC, Dowson J, Robbins TW, Sahakian BJ (2007), “Association between response inhibition and working memory in adult ADHD: a link to right frontal cortex pathology?” Biol Psychiatry 61(12):1395-401 Details DeVito EE, Salmond CH, Owler BK, Sahakian BJ, Pickard JD (2007), “Caudate structural abnormalities in idiopathic normal pressure hydrocephalus.” Acta Neurol Scand 116(5):328-32 Details Dowson JH, Blackwell AD, Turner DC, Harvey E, Malhotra T, Robbins TW, Sahakian BJ (2007), “Questionnaire ratings of attention-deficit/hyperactivity disorder (ADHD) in adults are associated with spatial working memory.” Eur Psychiatry 22(4):256-63 Details Ersche KD, Sahakian BJ (2007), “The neuropsychology of amphetamine and opiate dependence: implications for treatment.” Neuropsychol Rev 17(3):317-36 Details Lawrence AJ, Blackwell AD, Barker RA, Spagnolo F, Clark L, Aitken MR, Sahakian BJ (2007), “Predictors of punding in Parkinson's disease: results from a questionnaire survey.” Mov Disord 22(16):2339-45 Details Menzies L, Achard S, Chamberlain SR, Fineberg N, Chen CH, del Campo N, Sahakian BJ, Robbins TW, Bullmore E (2007), “Neurocognitive endophenotypes of obsessive-compulsive disorder.” Brain 130(Pt 12):3223-36 Details Morein-Zamir S, Turner DC, Sahakian BJ (2007), “A review of the effects of modafinil on cognition in schizophrenia.” Schizophr Bull 33(6):1298-306 Details Potter GG, Blackwell AD, McQuoid DR, Payne ME, Steffens DC, Sahakian BJ, Welsh-Bohmer KA, Krishnan KR (2007), “Prefrontal white matter lesions and prefrontal task impersistence in depressed and nondepressed elders.” Neuropsychopharmacology 32(10):2135-42 Details Roiser JP, Müller U, Clark L, Sahakian BJ (2007), “The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention.” Int J Neuropsychopharmacol 10(4):449-61 Details Roiser JP, Rogers RD, Sahakian BJ (2007), “Neuropsychological function in ecstasy users: a study controlling for polydrug use.” Psychopharmacology (Berl) 189(4):505-16 Details Taylor Tavares JV, Clark L, Cannon DM, Erickson K, Drevets WC, Sahakian BJ (2007), “Distinct profiles of neurocognitive function in unmedicated unipolar depression and bipolar II depression.” Biol Psychiatry 62(8):917-24 Details 2006Barnett JH, Salmond CH, Jones PB, Sahakian BJ (2006), “Cognitive reserve in neuropsychiatry.” Psychol Med 36(8):1053-64 Details Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2006), “Strategy implementation in obsessive-compulsive disorder and trichotillomania.” Psychol Med 36(1):91-7 Details Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania.” Am J Psychiatry 163(7):1282-4 Details Chamberlain SR, Müller U, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Noradrenergic modulation of working memory and emotional memory in humans.” Psychopharmacology (Berl) 188(4):397-407 Details Chamberlain SR, Müller U, Robbins TW, Sahakian BJ (2006), “Neuropharmacological modulation of cognition.” Curr Opin Neurol 19(6):607-12 Details Chamberlain SR, Sahakian BJ (2006), “The neuropsychology of mood disorders.” Curr Psychiatry Rep 8(6):458-63 Details Clark L, Robbins TW, Ersche KD, Sahakian BJ (2006), “Reflection impulsivity in current and former substance users.” Biol Psychiatry 60(5):515-22 Details Ersche KD, Clark L, London M, Robbins TW, Sahakian BJ (2006), “Profile of executive and memory function associated with amphetamine and opiate dependence.” Neuropsychopharmacology 31(5):1036-47 Details Ersche KD, Fletcher PC, Roiser JP, Fryer TD, London M, Robbins TW, Sahakian BJ (2006), “Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers.” Psychopharmacology (Berl) 188(3):364-73 Details Fowler L, Blackwell A, Jaffa A, Palmer R, Robbins TW, Sahakian BJ, Dowson JH (2006), “Profile of neurocognitive impairments associated with female in-patients with anorexia nervosa.” Psychol Med 36(4):517-27 Details Kaplan JS, Erickson K, Luckenbaugh DA, Weiland-Fiedler P, Geraci M, Sahakian BJ, Charney D, Drevets WC, Neumeister A (2006), “Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive Disorder.” J Affect Disord 95(1-3):165-71 Details Rahman S, Robbins TW, Hodges JR, Mehta MA, Nestor PJ, Clark L, Sahakian BJ (2006), “Methylphenidate ('Ritalin') can ameliorate abnormal risk-taking behavior in the frontal variant of frontotemporal dementia.” Neuropsychopharmacology 31(3):651-8 Details Roiser JP, Blackwell AD, Cools R, Clark L, Rubinsztein DC, Robbins TW, Sahakian BJ (2006), “Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion.” 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disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers.” Neurosci Biobehav Rev 29(3):399-419 Details Clark L, Roiser JP, Cools R, Rubinsztein DC, Sahakian BJ, Robbins TW (2005), “Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity.” Psychopharmacology (Berl) 182(4):570-8 Details De Jager C, Blackwell AD, Budge MM, Sahakian BJ (2005), “Predicting cognitive decline in healthy older adults.” Am J Geriatr Psychiatry 13(8):735-40 Details Devito EE, Pickard JD, Salmond CH, Iddon JL, Loveday C, Sahakian BJ (2005), “The neuropsychology of normal pressure hydrocephalus (NPH).” Br J Neurosurg 19(3):217-24 Details Erickson K, Drevets WC, Clark L, Cannon DM, Bain EE, Zarate CA Jr, Charney DS, Sahakian BJ (2005), “Mood-congruent bias in affective go/no-go performance of unmedicated patients with major 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right frontal cortex.” Brain 127(Pt 7):1561-73 Details Blackwell AD, Sahakian BJ, Vesey R, Semple JM, Robbins TW, Hodges JR (2004), “Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease.” Dement Geriatr Cogn Disord 17(1-2):42-8 Details Chamberlain SR, Sahakian BJ (2004), “Cognition in mania and depression: psychological models and clinical implications.” Curr Psychiatry Rep 6(6):451-8 Details Deakin J, Aitken M, Robbins T, Sahakian BJ (2004), “Risk taking during decision-making in normal volunteers changes with age.” J Int Neuropsychol Soc 10(4):590-8 Details Deakin JB, Aitken MR, Dowson JH, Robbins TW, Sahakian BJ (2004), “Diazepam produces disinhibitory cognitive effects in male volunteers.” Psychopharmacology (Berl) 173(1-2):88-97 Details Deakin JB, Rahman S, Nestor PJ, Hodges JR, Sahakian BJ (2004), “Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial.” 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Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES, Sahakian BJ (2001), “Decision-making cognition in mania and depression.” Psychol Med 31(4):679-93 Details Murphy FC, Sahakian BJ (2001), “Neuropsychology of bipolar disorder.” Br J Psychiatry Suppl 41:s120-7 Details Murphy FC, Sahakian BJ (2001), “Neuropsychology of bipolar disorder.” Br J Psychiatry 178(Suppl 41):S120-7 Details Rubinsztein JS, Fletcher PC, Rogers RD, Ho LW, Aigbirhio FI, Paykel ES, Robbins TW, Sahakian BJ (2001), “Decision-making in mania: a PET study.” Brain 124(Pt 12):2550-63 Details Rubinsztein JS, Rogers RD, Riedel WJ, Mehta MA, Robbins TW, Sahakian BJ (2001), “Acute dietary tryptophan depletion impairs maintenance of "affective set" and delayed visual recognition in healthy volunteers.” Psychopharmacology (Berl) 154(3):319-26 Details Swainson R, Hodges JR, Galton CJ, Semple J, Michael A, Dunn BD, Iddon JL, Robbins TW, Sahakian BJ (2001), “Early detection and differential diagnosis of Alzheimer's disease and depression with neuropsychological tasks.” Dement Geriatr Cogn Disord 12(4):265-80 Details 2000Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ (2000), “Selective attention to emotional stimuli in a verbal go/no-go task: an fMRI study.” Neuroreport 11(8):1739-44 Details Lawrence AD, Watkins LH, Sahakian BJ, Hodges JR, Robbins TW (2000), “Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits.” Brain 123 ( Pt 7):1349-64 Details Mavaddat N, Kirkpatrick PJ, Rogers RD, Sahakian BJ (2000), “Deficits in decision-making in patients with aneurysms of the anterior communicating artery.” Brain 123 ( Pt 10):2109-17 Details Mehta MA, Calloway P, Sahakian BJ (2000), “Amelioration of specific working memory deficits by methylphenidate in a case of adult attention deficit/hyperactivity disorder.” J Psychopharmacol 14(3):299-302 Details Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD, Robbins TW (2000), “Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain.” J Neurosci 20(6):RC65 Details Ornstein TJ, Iddon JL, Baldacchino AM, Sahakian BJ, London M, Everitt BJ, Robbins TW (2000), “Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers.” Neuropsychopharmacology 23(2):113-26 Details Robbins TW, Mehta MA, Sahakian BJ (2000), “Neuroscience. Boosting working memory.” Science 290(5500):2275-6 Details Rubinsztein JS, Michael A, Paykel ES, Sahakian BJ (2000), “Cognitive impairment in remission in bipolar affective disorder.” Psychol Med 30(5):1025-36 Details Swainson R, Rogers RD, Sahakian BJ, Summers BA, Polkey CE, Robbins TW (2000), “Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication.” Neuropsychologia 38(5):596-612 Details Watkins LH, Rogers RD, Lawrence AD, Sahakian BJ, Rosser AE, Robbins TW (2000), “Impaired planning but intact decision making in early Huntington's disease: implications for specific fronto-striatal pathology.” Neuropsychologia 38(8):1112-25 Details Williams D, Stott CM, Goodyer IM, Sahakian BJ (2000), “Specific language impairment with or without hyperactivity: neuropsychological evidence for frontostriatal dysfunction.” Dev Med Child Neurol 42(6):368-75 Details 1999Iddon JL, Pickard JD, Cross JJ, Griffiths PD, Czosnyka M, Sahakian BJ (1999), “Specific patterns of cognitive impairment in patients with idiopathic normal pressure hydrocephalus and Alzheimer's disease: a pilot study.” J Neurol Neurosurg Psychiatry 67(6):723-32 Details Lawrence AD, Sahakian BJ, Rogers RD, Hodge JR, Robbins TW (1999), “Discrimination, reversal, and shift learning in Huntington's disease: mechanisms of impaired response selection.” Neuropsychologia 37(12):1359-74 Details Mavaddat N, Sahakian BJ, Hutchinson PJ, Kirkpatrick PJ (1999), “Cognition following subarachnoid hemorrhage from anterior communicating artery aneurysm: relation to timing of surgery.” J Neurosurg 91(3):402-7 Details Mehta MA, Sahakian BJ, McKenna PJ, Robbins TW (1999), “Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson's disease.” Psychopharmacology (Berl) 146(2):162-74 Details Middleton HC, Sharma A, Agouzoul D, Sahakian BJ, Robbins TW (1999), “Idazoxan potentiates rather than antagonizes some of the cognitive effects of clonidine.” Psychopharmacology (Berl) 145(4):401-11 Details Middleton HC, Sharma A, Agouzoul D, Sahakian BJ, Robbins TW (1999), “Contrasts between the cardiovascular concomitants of tests of planning and attention.” Psychophysiology 36(5):610-8 Details Murphy FC, Sahakian BJ, Rubinsztein JS, Michael A, Rogers RD, Robbins TW, Paykel ES (1999), “Emotional bias and inhibitory control processes in mania and depression.” Psychol Med 29(6):1307-21 Details Owen AM, Herrod NJ, Menon DK, Clark JC, Downey SP, Carpenter TA, Minhas PS, Turkheimer FE, Williams EJ, Robbins TW, Sahakian BJ, Petrides M, Pickard JD (1999), “Redefining the functional organization of working memory processes within human lateral prefrontal cortex.” Eur J Neurosci 11(2):567-74 Details Rahman S, Robbins TW, Sahakian BJ (1999), “Comparative cognitive neuropsychological studies of frontal lobe function: implications for therapeutic strategies in frontal variant frontotemporal dementia.” Dement Geriatr Cogn Disord 10 Suppl 1:15-28 Details Rahman S, Sahakian BJ, Hodges JR, Rogers RD, Robbins TW (1999), “Specific cognitive deficits in mild frontal variant frontotemporal dementia.” Brain 122 ( Pt 8):1469-93 Details Rogers RD, Blackshaw AJ, Middleton HC, Matthews K, Hawtin K, Crowley C, Hopwood A, Wallace C, Deakin JF, Sahakian BJ, Robbins TW (1999), “Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour.” Psychopharmacology (Berl) 146(4):482-91 Details Rogers RD, Everitt BJ, Baldacchino A, Blackshaw AJ, Swainson R, Wynne K, Baker NB, Hunter J, Carthy T, Booker E, London M, Deakin JF, Sahakian BJ, Robbins TW (1999), “Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms.” Neuropsychopharmacology 20(4):322-39 Details Rogers RD, Owen AM, Middleton HC, Williams EJ, Pickard JD, Sahakian BJ, Robbins TW (1999), “Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex.” J Neurosci 19(20):9029-38 Details Young AH, Sahakian BJ, Robbins TW, Cowen PJ (1999), “The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers.” Psychopharmacology (Berl) 145(3):260-6 Details 1998Elliott R, Sahakian BJ, Michael A, Paykel ES, Dolan RJ (1998), “Abnormal neural response to feedback on planning and guessing tasks in patients with unipolar depression.” Psychol Med 28(3):559-71 Details Iddon JL, McKenna PJ, Sahakian BJ, Robbins TW (1998), “Impaired generation and use of strategy in schizophrenia: evidence from visuospatial and verbal tasks.” Psychol Med 28(5):1049-62 Details Lawrence AD, Hodges JR, Rosser AE, Kershaw A, ffrench-Constant C, Rubinsztein DC, Robbins TW, Sahakian BJ (1998), “Evidence for specific cognitive deficits in preclinical Huntington's disease.” Brain 121 ( Pt 7):1329-41 Details Lawrence AD, Sahakian BJ (1998), “The cognitive psychopharmacology of Alzheimer's disease: focus on cholinergic systems.” Neurochem Res 23(5):787-94 Details Lawrence AD, Sahakian BJ, Robbins TW (1998), “Cognitive functions and corticostriatal circuits: insights from Huntington's disease.” Trends Cogn Sci 2(10):379-88 Details Lawrence AD, Weeks RA, Brooks DJ, Andrews TC, Watkins LH, Harding AE, Robbins TW, Sahakian BJ (1998), “The relationship between striatal dopamine receptor binding and cognitive performance in Huntington's disease.” Brain 121 ( Pt 7):1343-55 Details Robbins TW, James M, Owen AM, Sahakian BJ, Lawrence AD, McInnes L, Rabbitt PM (1998), “A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: implications for theories of executive functioning and cognitive aging. Cambridge Neuropsychological Test Automated Battery.” J Int Neuropsychol Soc 4(5):474-90 Details Rogers RD, Sahakian BJ, Hodges JR, Polkey CE, Kennard C, Robbins TW (1998), “Dissociating executive mechanisms of task control following frontal lobe damage and Parkinson's disease.” Brain 121 ( Pt 5):815-42 Details 1997Elliott R, Baker SC, Rogers RD, O'Leary DA, Paykel ES, Frith CD, Dolan RJ, Sahakian BJ (1997), “Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography.” Psychol Med 27(4):931-42 Details Elliott R, Sahakian BJ, Herrod JJ, Robbins TW, Paykel ES (1997), “Abnormal response to negative feedback in unipolar depression: evidence for a diagnosis specific impairment.” J Neurol Neurosurg Psychiatry 63(1):74-82 Details Elliott R, Sahakian BJ, Matthews K, Bannerjea A, Rimmer J, Robbins TW (1997), “Effects of methylphenidate on spatial working memory and planning in healthy young adults.” Psychopharmacology (Berl) 131(2):196-206 Details Iddon JL, Sahakian BJ, Kirkpatrick PJ (1997), “Uncomplicated carotid endarterectomy is not associated with neuropsychological impairment.” Pharmacol Biochem Behav 56(4):781-7 Details 1996Beats BC, Sahakian BJ, Levy R (1996), “Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed.” Psychol Med 26(3):591-603 Details Coull JT, Sahakian BJ, Hodges JR (1996), “The alpha(2) antagonist idazoxan remediates certain attentional and executive dysfunction in patients with dementia of frontal type.” Psychopharmacology (Berl) 123(3):239-49 Details Elliott R, Sahakian BJ, McKay AP, Herrod JJ, Robbins TW, Paykel ES (1996), “Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance.” Psychol Med 26(5):975-89 Details Iddon JL, Morgan DJ, Sahakian BJ (1996), “Cognitive dysfunction in patients with congenital hydrocephalus and spina bifida: evidence for a dysexecutive syndrome?” Eur J Pediatr Surg 6 Suppl 1:41 Details Lawrence AD, Sahakian BJ, Hodges JR, Rosser AE, Lange KW, Robbins TW (1996), “Executive and mnemonic functions in early Huntington's disease.” Brain 119 ( Pt 5):1633-45 Details Owen AM, Morris RG, Sahakian BJ, Polkey CE, Robbins TW (1996), “Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man.” Brain 119 ( Pt 5):1597-615 Details Robbins TW, Elliott R, Sahakian BJ (1996), “Neuropsychology--dementia and affective disorders.” Br Med Bull 52(3):627-43 Details Veale DM, Sahakian BJ, Owen AM, Marks IM (1996), “Specific cognitive deficits in tests sensitive to frontal lobe dysfunction in obsessive-compulsive disorder.” Psychol Med 26(6):1261-9 Details 1995Almeida OP, Howard RJ, Levy R, David AS, Morris RG, Sahakian BJ (1995), “Clinical and cognitive diversity of psychotic states arising in late life (late paraphrenia).” Psychol Med 25(4):699-714 Details Almeida OP, Howard RJ, Levy R, David AS, Morris RG, Sahakian BJ (1995), “Cognitive features of psychotic states arising in late life (late paraphrenia).” Psychol Med 25(4):685-98 Details Coull JT, Middleton HC, Robbins TW, Sahakian BJ (1995), “Clonidine and diazepam have differential effects on tests of attention and learning.” Psychopharmacology (Berl) 120(3):322-32 Details Coull JT, Middleton HC, Robbins TW, Sahakian BJ (1995), “Contrasting effects of clonidine and diazepam on tests of working memory and planning.” Psychopharmacology (Berl) 120(3):311-21 Details Coull JT, Sahakian BJ, Middleton HC, Young AH, Park SB, McShane RH, Cowen PJ, Robbins TW (1995), “Differential effects of clonidine, haloperidol, diazepam and tryptophan depletion on focused attention and attentional search.” Psychopharmacology (Berl) 121(2):222-30 Details Elliott R, McKenna PJ, Robbins TW, Sahakian BJ (1995), “Neuropsychological evidence for frontostriatal dysfunction in schizophrenia.” Psychol Med 25(3):619-30 Details Elliott R, Sahakian BJ (1995), “The neuropsychology of schizophrenia: relations with clinical and neurobiological dimensions.” Psychol Med 25(3):581-94 Details Lange KW, Sahakian BJ, Quinn NP, Marsden CD, Robbins TW (1995), “Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia.” J Neurol Neurosurg Psychiatry 58(5):598-606 Details Lawrence AD, Sahakian BJ (1995), “Alzheimer disease, attention, and the cholinergic system.” Alzheimer Dis Assoc Disord 9 Suppl 2:43-9 Details Owen AM, Sahakian BJ, Semple J, Polkey CE, Robbins TW (1995), “Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalo-hippocampectomy in man.” Neuropsychologia 33(1):1-24 Details Sahakian BJ, Elliott R, Low N, Mehta M, Clark RT, Pozniak AL (1995), “Neuropsychological deficits in tests of executive function in asymptomatic and symptomatic HIV-1 seropositive men.” Psychol Med 25(6):1233-46 Details 1994Middleton HC, Coull JT, Sahakian BJ, Robbins TW (1994), “Clonidine-induced changes in the spectral distribution of heart rate variability correlate with performance on a test of sustained attention.” J Psychopharmacol 8(1):1-7 Details Park SB, Coull JT, McShane RH, Young AH, Sahakian BJ, Robbins TW, Cowen PJ (1994), “Tryptophan depletion in normal volunteers produces selective impairments in learning and memory.” Neuropharmacology 33(3-4):575-88 Details Robbins TW, James M, Owen AM, Sahakian BJ, McInnes L, Rabbitt P (1994), “Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers.” Dementia 5(5):266-81 Details Sahakian BJ, Coull JJ, Hodges JR (1994), “Selective enhancement of executive function by idazoxan in a patient with dementia of the frontal lobe type.” J Neurol Neurosurg Psychiatry 57(1):120-1 Details 1993O'Brien JT, Sahakian BJ, Checkley SA (1993), “Cognitive impairments in patients with seasonal affective disorder.” Br J Psychiatry 163:338-43 Details Owen AM, Beksinska M, James M, Leigh PN, Summers BA, Marsden CD, Quinn NP, Sahakian BJ, Robbins TW (1993), “Visuospatial memory deficits at different stages of Parkinson's disease.” Neuropsychologia 31(7):627-44 Details Sahakian BJ, Coull JT (1993), “Tetrahydroaminoacridine (THA) in Alzheimer's disease: an assessment of attentional and mnemonic function using CANTAB.” Acta Neurol Scand Suppl 149:29-35 Details Sahakian BJ, Owen AM, Morant NJ, Eagger SA, Boddington S, Crayton L, Crockford HA, Crooks M, Hill K, Levy R (1993), “Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB.” Psychopharmacology (Berl) 110(4):395-401 Details 1992Eagger SA, Levy R, Sahakian BJ (1992), “Tacrine in Alzheimer's disease.” Acta Neurol Scand Suppl 139:75-80 Details Jones GM, Sahakian BJ, Levy R, Warburton DM, Gray JA (1992), “Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in Alzheimer's disease.” Psychopharmacology (Berl) 108(4):485-94 Details O'Brien JT, Eagger S, Syed GM, Sahakian BJ, Levy R (1992), “A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease.” J Neurol Neurosurg Psychiatry 55(12):1182-7 Details Sahakian BJ, Owen AM (1992), “Computerized assessment in neuropsychiatry using CANTAB: discussion paper.” J R Soc Med 85(7):399-402 Details 1991Eagger SA, Levy R, Sahakian BJ (1991), “Tacrine in Alzheimer's disease.” Lancet 338(8758):50-1 Details Eagger SA, Levy R, Sahakian BJ (1991), “Tacrine in Alzheimer's disease.” Lancet 337(8748):989-92 Details Orrell MW, Sahakian BJ (1991), “Dementia of frontal lobe type.” Psychol Med 21(3):553-6 Details Owen AM, Roberts AC, Polkey CE, Sahakian BJ, Robbins TW (1991), “Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man.” Neuropsychologia 29(10):993-1006 Details 1990Abas MA, Sahakian BJ, Levy R (1990), “Neuropsychological deficits and CT scan changes in elderly depressives.” Psychol Med 20(3):507-20 Details Owen AM, Downes JJ, Sahakian BJ, Polkey CE, Robbins TW (1990), “Planning and spatial working memory following frontal lobe lesions in man.” Neuropsychologia 28(10):1021-34 Details Robbins TW, Giardini V, Jones GH, Reading P, Sahakian BJ (1990), “Effects of dopamine depletion from the caudate-putamen and nucleus accumbens septi on the acquisition and performance of a conditional discrimination task.” Behav Brain Res 38(3):243-61 Details Sahakian BJ, Downes JJ, Eagger S, Evenden JL, Levy R, Philpot MP, Roberts AC, Robbins TW (1990), “Sparing of attentional relative to mnemonic function in a subgroup of patients with dementia of the Alzheimer type.” Neuropsychologia 28(11):1197-213 Details 1989Downes JJ, Roberts AC, Sahakian BJ, Evenden JL, Morris RG, Robbins TW (1989), “Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: evidence for a specific attentional dysfunction.” Neuropsychologia 27(11-12):1329-43 Details Orrell MW, Sahakian BJ, Bergmann K (1989), “Self-neglect and frontal lobe dysfunction.” Br J Psychiatry 155:101-5 Details 1988Morris RG, Downes JJ, Sahakian BJ, Evenden JL, Heald A, Robbins TW (1988), “Planning and spatial working memory in Parkinson's disease.” J Neurol Neurosurg Psychiatry 51(6):757-66 Details Sahakian BJ, Morris RG, Evenden JL, Heald A, Levy R, Philpot M, Robbins TW (1988), “A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease.” Brain 111 ( Pt 3):695-718 Details 1987Jones GM, Reith M, Philpot MP, Sahakian BJ (1987), “Smoking and dementia of Alzheimer type.” J Neurol Neurosurg Psychiatry 50(10):1383 Details Levy R, Sahakian BJ (1987), “Sub-cortical dementia.” Br J Psychiatry 150:559-60 Details 1986Hutson PH, Sarna GS, Sahakian BJ, Dourish CT, Curzon G (1986), “Monitoring 5HT metabolism in the brain of the freely moving rat.” Ann N Y Acad Sci 473:321-36 Details Sahakian BJ, Sarna GS, Kantamaneni DB, Jackson A, Hutson PH, Curzon G (1986), “CSF tryptophan and transmitter amine turnover may predict social behaviour in the normal rat.” Brain Res 399(1):162-6 Details 1985Curzon G, Hutson PH, Kantamaneni BD, Sahakian BJ, Sarna GS (1985), “3,4-Dihydroxyphenylethylamine and 5-hydroxytryptamine metabolism in the rat: acidic metabolites in cisternal cerebrospinal fluid before and after giving probenecid.” J Neurochem 45(2):508-13 Details Sahakian BJ, Sarna GS, Kantamaneni BD, Jackson A, Hutson PH, Curzon G (1985), “Association between learning and cortical catecholamines in non-drug-treated rats.” Psychopharmacology (Berl) 86(3):339-43 Details 1983Keymer A, Crompton DW, Sahakian BJ (1983), “Parasite-induced learned taste aversion involving Nippostrongylus in rats.” Parasitology 86 (Pt 3):455-60 Details Sahakian BJ, Trayhurn P, Wallace M, Deeley R, Winn P, Robbins TW, Everitt BJ (1983), “Increased weight gain and reduced activity in brown adipose tissue produced by depletion of hypothalamic noradrenaline.” Neurosci Lett 39(3):321-6 Details Sahakian BJ, Winn P, Robbins TW, Deeley RJ, Everitt BJ, Dunn LT, Wallace M, James WP (1983), “Changes in body weight and food-related behaviour induced by destruction of the ventral or dorsal noradrenergic bundle in the rat.” Neuroscience 10(4):1405-20 Details 1982Dyme IZ, Sahakian BJ, Golinko BE, Rabe EF (1982), “Perseveration induced by methylphenidate in children: preliminary findings.” Prog Neuropsychopharmacol Biol Psychiatry 6(3):269-73 Details Sahakian BJ (1982), “The interaction of psychological and metabolic factors in the control of eating and obesity.” Hum Nutr Appl Nutr 36A(4):262-71 Details Sahakian BJ (1982), “The interaction of psychological and metabolic factors in the control of eating and obesity.” Scand J Psychol Suppl 1:48-60 Details Sahakian BJ, Burdess C, Luckhurst H, Trayhurn P (1982), “Hyperactivity and obesity: the interaction of social isolation and cafeteria feeding.” Physiol Behav 28(1):117-24 Details 1981James WP, Sahakian BJ (1981), “Overgrowth: energetic significance in relation to obesity.” Prog Clin Biol Res 61:25-53 Details Sahakian BJ, Lean ME, Robbins TW, James WP (1981), “Salivation and insulin secretion in response to food in non-obese men and women.” Appetite 2(3):209-16 Details 1980Drachman DA, Noffsinger D, Sahakian BJ, Kurdziel S, Fleming P (1980), “Aging, memory, and the cholinergic system: a study of dichotic listening.” Neurobiol Aging 1(1):39-43 Details Drachman DA, Sahakian BJ (1980), “Memory and cognitive function in the elderly. A preliminary trial of physostigmine.” Arch Neurol 37(10):674-5 Details Fray PJ, Sahakian BJ, Robbins TW, Koob GF, Iversen SD (1980), “An observational method for quantifying the behavioural effects of dopamine agonists: contrasting effects of d-amphetamine and apomorphine.” Psychopharmacology (Berl) 69(3):253-9 Details Hefti F, Melamed E, Sahakian BJ, Wurtman RJ (1980), “Circling behavior in rats with partial, unilateral nigro-striatal lesions: effect of amphetamine, apomorphine, and DOPA.” Pharmacol Biochem Behav 12(2):185-8 Details Sahakian BJ, Carlson KR, DeGirolami U, Bhawan J (1980), “Functional and structural consequences of long-term dietary L-dopa treatment in mice.” Commun Psychopharmacol 4(2):169-76 Details 1979Drachman DA, Sahakian BJ, Fleming P, Noffsinger D, Kurdziel S (1979), “Aging, memory, and the cholinergic system: a study of dichotic listening.” Trans Am Neurol Assoc 104:165-8 Details Einon DF, Sahakian BJ (1979), “Environmentally induced differences in susceptibility of rats to CNS stimulants and CNS depressants: evidence against a unitary explanation.” Psychopharmacology (Berl) 61(3):299-307 Details Robbins TW, Sahakian BJ (1979), “"Paradoxical" effects of psychomotor stimulant drugs in hyperactive children from the standpoint of behavioural pharmacology.” Neuropharmacology 18(12):931-50 Details Sahakian BJ, Wurtman RJ, Barr JK, Millington WR, Chiel HJ (1979), “Low tryptophan diet decreases brain serotonin and alters response to apomorphine.” Nature 279(5715):731-2 Details 1978Sahakian BJ, Growdon JH, Millington WR, Barr JK, Wurtman RJ (1978), “The effects of cholinergic agonists on apomorphine-induced stereotyped behavior in the rat.” Commun Psychopharmacol 2(3):255-62 Details Sahakian BJ, Koob GF (1978), “The relationship between pipradrol-induced responding for electrical brain stimulation, stereotyped behaviour and locomotor activity.” Neuropharmacology 17(6):363-6 Details 1977Robbins TW, Phillips AG, Sahakian BJ (1977), “Effects of chlordiazepoxide on tail pinch-induced eating in rats.” Pharmacol Biochem Behav 6(3):297-302 Details Sahakian BJ, Robbins TW (1977), “Are the effects of psychomotor stimulant drugs on hyperactive children really paradoxical?” Med Hypotheses 3(4):154-8 Details Sahakian BJ, Robbins TW (1977), “Isolation-rearing enhances tail pinch-induced oral behavior in rats.” Physiol Behav 18(1):53-8 Details 1976Oscar-Berman M, Sahakian BJ (1976), “Spatial probability learning by alcoholic Korsakoff patients.” J Exp Psychol Hum Learn 2(2):215-22 Details Sahakian BJ, Robbins TW, Iversen SD (1976), “Alpha-flupenthixol-induced hyperactivity by chronic dosing in rats.” Eur J Pharmacol 37(1):169-78 Details 1975Einon D, Morgan MJ, Sahakian BJ (1975), “The development of intersession habituation and emergence in socially reared and isolated rats.” Dev Psychobiol 8(6):553-9 Details Sahakian BJ, Robbins TW (1975), “Potentiation of locomotor activity and modification of sterotypy by starvation in adomorphine treated rats.” Neuropharmacology 14(4):251-7 Details Sahakian BJ, Robbins TW, Morgan MJ, Iversen SD (1975), “The effects of psychomotor stimulants on stereotypy and locomotor activity in socially-deprived and control rats.” Brain Res 84(2):195-205 Details 1972Sahakian WS, Sahakian BJ (1972), “Logotherapy as a personaltiy theory.” Isr Ann Psychiatr Relat Discip 10(3):230-44 Details |