Professor Alastair Compston University positionProfessor Emeritus of Neurology DepartmentsDepartment of Clinical Neurosciences Institutesalastair.compston@medschl.cam.ac.uk Home pagehttp://www-neurosciences.medschl.cam.ac.uk/ Research ThemesInterestsMy research interests focus on clinical and experimental demyelinating disease with an emphasis on multiple sclerosis - the commonest potentially disabling disease of young adults. The research group has a broad set of interests: we work on the aetiology with international collaborations in genetics involving large-scale whole genome screens for factors that confer susceptibility and influence disease progression; in neurobiology, we study interactions between glia and axons, and the potential role of human stem cells as 'medicines' for limiting and the repairing the damage; our work in therapeutic immunology has used the monoclonal antibody Campath-1H (Alemtuzimab) both to treat patients and to understand mechanisms of tissue injury that determine the clinical course of the disease. I no longer accept PhD applications.  Genetic associations implicate T cell driven immune pathways in the pathogenesis of multiple sclerosis Click image to view full-size Research Focus
EquipmentCell culture Cellular immunology Cross-sectional and cohort studies Electrophysiological recording techniques Epidemiology Fluorescence microscopy Genetics Immunohistochemistry Magnetic resonance imaging (MRI) Randomised control trials Collaborators
Associated News Items
Key publicationsJones JL, Phuah CL, Cox AL, Thompson SA, Ban M, Shawcross J, Walton A, Sawcer SJ, Compston A, Coles AJ (2009), “IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H).” J Clin Invest 119(7):2052-61 Details CAMMS223 Trial Investigators, Coles AJ, Compston DA, Selmaj KW, Lake SL, Moran S, Margolin DH, Norris K, Tandon PK (2008), “Alemtuzumab vs. interferon beta-1a in early multiple sclerosis.” N Engl J Med 359(17):1786-801 Details International Multiple Sclerosis Genetics Consortium, Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL (2007), “Risk alleles for multiple sclerosis identified by a genomewide study.” N Engl J Med 357(9):851-62 Details Publications2014Andreassen OA, Harbo HF, Wang Y, Thompson WK, Schork AJ, Mattingsdal M, Zuber V, Bettella F, Ripke S, Kelsoe JR, Kendler KS, O'Donovan MC, Sklar P, The Psychiatric Genomics Consortium (PGC) Bipolar Disorder and Schizophrenia Work Groups, The International Multiple Sclerosis Genetics Consortium (IMSGC), McEvoy LK, Desikan RS, Lie BA, Djurovic S, Dale AM (2014), “Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci.” Mol Psychiatry Details Coles AJ, Compston A, 70 signatories (2014), “Product licences for alemtuzumab and multiple sclerosis.” Lancet 383(9920):867-8 Details Compston A (2014), “Dorsal column. From the archives.” Brain 137(Pt 4):1266-71 Details Compston A (2014), “From the archives.” Brain 137(Pt 2):640-4 Details Compston A (2014), “Dorsal column. From the archives.” Brain 137(Pt 5):1565-7 Details Damotte V, Guillot-Noel L, Patsopoulos NA, Madireddy L, El Behi M, International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, De Jager PL, Baranzini SE, Cournu-Rebeix I, Fontaine B (2014), “A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility.” Genes Immun 15(2):126-32 Details Goris A, van Setten J, Diekstra F, Ripke S, Patsopoulos NA, Sawcer SJ, International Multiple Sclerosis Genetics Consortium, van Es M, Australia and New Zealand MS Genetics Consortium, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown RH Jr, Shatunov A, Leigh N, Al-Chalabi A, Shaw CE, Traynor BJ, Chiò A, Restagno G, Mora G, Ophoff RA, Oksenberg JR, Van Damme P, Compston A, Robberecht W, Dubois B, van den Berg LH, De Jager PL, Veldink JH, de Bakker PI (2014), “No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.” Hum Mol Genet 23(7):1916-22 Details Kemppinen A, Baker A, Liao W, Fiddes B, Jones J, Compston A, Ban M, Sawcer S (2014), “Exome sequencing in single cells from the cerebrospinal fluid in multiple sclerosis.” Mult Scler Details Kousin-Ezewu O, Azzopardi L, Parker RA, Tuohy O, Compston A, Coles A, Jones J (2014), “Accelerated lymphocyte recovery after alemtuzumab does not predict multiple sclerosis activity.” Neurology Details Sundqvist E, Buck D, Warnke C, Albrecht E, Gieger C, Khademi M, Lima Bomfim I, Fogdell-Hahn A, Link J, Alfredsson L, Søndergaard HB, Hillert J, International Multiple Sclerosis Genetics Consortium, Oturai AB, Hemme B, Kockum I, Olsson T (2014), “JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.” PLoS Pathog 10(4):e1004084 Details Tuohy O, Costelloe L, Hill-Cawthorne G, Bjornson I, Harding K, Robertson N, May K, Button T, Azzopardi L, Kousin-Ezewu O, Jones J, Compston DA, Coles A (2014), “Alemtuzumab treatment of multiple sclerosis: long-term safety and efficacy.” J Neurol Neurosurg Psychiatry Details 2013Azzopardi L, Thompson SA, Harding KE, Cossburn M, Robertson N, Compston A, Coles AJ, Jones JL (2013), “Predicting autoimmunity after alemtuzumab treatment of multiple sclerosis.” J Neurol Neurosurg Psychiatry Details Ban M, Caillier S, Mero IL, Myhr KM, Celius EG, Aarseth J, Torkildsen Ø, Harbo HF, Oksenberg J, Hauser SL, Sawcer S, Compston A (2013), “No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis.” Ann Neurol 73(3):430-2 Details Blakely EL, Yarham JW, Alston CL, Craig K, Poulton J, Brierley C, Park SM, Dean A, Xuereb JH, Anderson KN, Compston A, Allen C, Sharif S, Enevoldson P, Wilson M, Hammans SR, Turnbull DM, McFarland R, Taylor RW (2013), “Pathogenic mitochondrial tRNA point mutations: nine novel mutations affirm their importance as a cause of mitochondrial disease.” Hum Mutat 34(9):1260-8 Details Button T, Altmann D, Tozer D, Dalton C, Hunter K, Compston A, Coles A, Miller D (2013), “Magnetization transfer imaging in multiple sclerosis treated with alemtuzumab.” Mult Scler 19(2):241-4 Details Compston A (2013), “Brain. Editorial.” Brain 136(Pt 12):3515-9 Details Compston A (2013), “From the archives.” Brain 136(Pt 10):2928-32 Details Compston A (2013), “Down the ages, physicians have observed the evolution of disease over time.” Brain 136(Pt 11):3205-8 Details Compston A (2013), “A new familial infantile form of diffuse brain-sclerosis.” Brain 136(Pt 9):2649-51 Details Compston A (2013), “Brain editorial.” Brain 136(Pt 10):2925-7 Details Compston A (2013), “From the archives. A contribution to the study of apraxia with a review of the literature.” Brain 136(Pt 8):2331-5 Details Compston A (2013), “Brain. Editorial.” Brain 136(Pt 9):2645-8 Details Compston A (2013), “From the archives.” Brain 136(Pt 7):2011-4 Details Compston A (2013), “War-neurasthenia, acute and chronic. By DW Carmalt Jones MD FRCP, Physician to Westminster Hospital; sometime Medical Officer-in-charge Medical Division, No. 4 Stationary Hospital, British Expeditionary Force (Neurological centre), and Consultant Physician, Egyptian Expeditionary Force. Brain 1919; 42: 171-213.” Brain 136(Pt 6):1681-6 Details Compston A (2013), “Brain. Editorial.” Brain 136(Pt 8):2327-30 Details Compston A (2013), “Brain. Editorial.” Brain 136(Pt 7):2007-10 Details Compston A (2013), “Brain. Editorial.” Brain 136(Pt 6):1677-80 Details Compston A (2013), “From the archives.” Brain 136(Pt 4):990-3 Details Compston A (2013), “Brain. Editorial.” Brain 136(Pt 5):1333-5 Details Compston A (2013), “Brain. Editorial.” Brain 136(Pt 4):987-9 Details Compston A (2013), “From the archives. The cerebral arterial supply. By Charles E Beevor MD, FRCP. Brain 1908; 30: 403–25.” Brain 136(Pt 2):362-7 Details Compston A (2013), “From the archives. Anatomical and physiological observations on lesions in the cerebellar nuclei in Macacus rhesus (preliminary report). By Ernest Sachs and Edgar F. Fincher. Brain 1927, 50: 350-356; with The subpial resection of the cortex in the treatment of Jacksonian epilepsy (Horsley operation); with observations on areas 4 and 6. By Ernest Sachs. Brain 1935, 58: 492-503; with Observations on the pathways transmitting the sensation of taste. By Henry G. Schwartz and Graham Weddell. Brain 1938, 61: 99-115.” Brain 136(Pt 1):5-8 Details Compston A (2013), “Editorial.” Brain 136(Pt 3):685-7 Details Compston A (2013), “Brain. Editorial.” Brain 136(Pt 2):359-61 Details Compston A (2013), “Brain. Editorial.” Brain 136(Pt 1):1-4 Details Fiddes B, Wason J, Kemppinen A, Ban M, Compston A, Sawcer S (2013), “Confounding underlies the apparent month of birth effect in multiple sclerosis.” Ann Neurol 73(6):714-20 Details Hunt KA, Mistry V, Bockett NA, Ahmad T, Ban M, Barker JN, Barrett JC, Blackburn H, Brand O, Burren O, Capon F, Compston A, Gough SC, Jostins L, Kong Y, Lee JC, Lek M, MacArthur DG, Mansfield JC, Mathew CG, Mein CA, Mirza M, Nutland S, Onengut-Gumuscu S, Papouli E, Parkes M, Rich SS, Sawcer S, Satsangi J, Simmonds MJ, Trembath RC, Walker NM, Wozniak E, Todd JA, Simpson MA, Plagnol V, van Heel DA (2013), “Negligible impact of rare autoimmune-locus coding-region variants on missing heritability.” Nature 498(7453):232-5 Details International Multiple Sclerosis Genetics Consortium (2013), “Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls.” Am J Hum Genet 92(6):854-65 Details International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, Oturai A, Saarela J, Fontaine B, Hemmer B, Martin C, Zipp F, D'Alfonso S, Martinelli-Boneschi F, Taylor B, Harbo HF, Kockum I, Hillert J, Olsson T, Ban M, Oksenberg JR, Hintzen R, Barcellos LF, Wellcome Trust Case Control Consortium 2 (WTCCC2), International IBD Genetics Consortium (IIBDGC), Agliardi C, Alfredsson L, Alizadeh M, Anderson C, Andrews R, Søndergaard HB, Baker A, Band G, Baranzini SE, Barizzone N, Barrett J, Bellenguez C, Bergamaschi L, Bernardinelli L, Berthele A, Biberacher V, Binder TM, Blackburn H, Bomfim IL, Brambilla P, Broadley S, Brochet B, Brundin L, Buck D, Butzkueven H, Caillier SJ, Camu W, Carpentier W, Cavalla P, Celius EG, Coman I, Comi G, Corrado L, Cosemans L, Cournu-Rebeix I, Cree BA, Cusi D, Damotte V, Defer G, Delgado SR, Deloukas P, di Sapio A, Dilthey AT, Donnelly P, Dubois B, Duddy M, Edkins S, Elovaara (2013), “Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.” Nat Genet 45(11):1353-60 Details Ismail A, Cooper-Knock J, Highley JR, Milano A, Kirby J, Goodall E, Lowe J, Scott I, Constantinescu CS, Walters SJ, Price S, McDermott CJ, Sawcer S, Compston DA, Sharrack B, Shaw PJ (2013), “Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72.” J Neurol Neurosurg Psychiatry 84(1):79-87 Details Isobe N, Damotte V, Lo Re V, Ban M, Pappas D, Guillot-Noel L, Rebeix I, Compston A, Mack T, Cozen W, Fontaine B, Hauser SL, Oksenberg JR, Sawcer S, Gourraud PA (2013), “Genetic burden in multiple sclerosis families.” Genes Immun 14(7):434-40 Details Jones JL, Thompson SA, Loh P, Davies JL, Tuohy OC, Curry AJ, Azzopardi L, Hill-Cawthorne G, Fahey MT, Compston A, Coles AJ (2013), “Human autoimmunity after lymphocyte depletion is caused by homeostatic T-cell proliferation.” Proc Natl Acad Sci U S A 110(50):20200-5 Details McCarthy CL, Tuohy O, Compston DA, Kumararatne DS, Coles AJ, Jones JL (2013), “Immune competence after alemtuzumab treatment of multiple sclerosis.” Neurology 81(10):872-6 Details Mechelli R, Umeton R, Policano C, Annibali V, Coarelli G, Ricigliano VA, Vittori D, Fornasiero A, Buscarinu MC, International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium,2, Romano S, Salvetti M, Ristori G (2013), “A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis.” PLoS One 8(5):e63300 Details Mero IL, Gustavsen MW, Sæther HS, Flåm ST, Berg-Hansen P, Søndergaard HB, Jensen PE, Berge T, Bjølgerud A, Muggerud A, Aarseth JH, International Multiple Sclerosis Genetics Consortium, Myhr KM, Celius EG, Sellebjerg F, Hillert J, Alfredsson L, Olsson T, Oturai AB, Kockum I, Lie BA, Andreassen BK, Harbo HF (2013), “Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles.” PLoS One 8(3):e58352 Details Patsopoulos NA, Barcellos LF, Hintzen RQ, Schaefer C, van Duijn CM, Noble JA, Raj T, IMSGC, ANZgene, Gourraud PA, Stranger BE, Oksenberg J, Olsson T, Taylor BV, Sawcer S, Hafler DA, Carrington M, De Jager PL, de Bakker PI (2013), “Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.” PLoS Genet 9(11):e1003926 Details Pfeffer G, Burke A, Yu-Wai-Man P, Compston DA, Chinnery PF (2013), “Clinical features of MS associated with Leber hereditary optic neuropathy mtDNA mutations.” Neurology 81(24):2073-81 Details Stacpoole SR, Spitzer S, Bilican B, Compston A, Karadottir R, Chandran S, Franklin RJ (2013), “High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology.” Stem Cell Reports 1(5):437-50 Details Stacpoole SR, Webber DJ, Bilican B, Compston A, Chandran S, Franklin RJ (2013), “Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation.” Stem Cells Transl Med 2(6):464-72 Details 2012Cohen JA, Coles AJ, Arnold DL, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Fisher E, Brinar VV, Giovannoni G, Stojanovic M, Ertik BI, Lake SL, Margolin DH, Panzara MA, Compston DA, CARE-MS I investigators (2012), “Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial.” Lancet 380(9856):1819-28 Details Coles AJ, Fox E, Vladic A, Gazda SK, Brinar V, Selmaj KW, Skoromets A, Stolyarov I, Bass A, Sullivan H, Margolin DH, Lake SL, Moran S, Palmer J, Smith MS, Compston DA (2012), “Alemtuzumab more effective than interferon ?-1a at 5-year follow-up of CAMMS223 clinical trial.” Neurology 78(14):1069-78 Details Coles AJ, Twyman CL, Arnold DL, Cohen JA, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Miller T, Fisher E, Sandbrink R, Lake SL, Margolin DH, Oyuela P, Panzara MA, Compston DA, CARE-MS II investigators (2012), “Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial.” Lancet 380(9856):1829-39 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 12):3517-20 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 11):3193-5 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 10):2897-9 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 9):2573-5 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 8):2301-3 Details Compston A (2012), “The lipidoses and the central nervous system. 1948.” Brain 135(Pt 6):1658-62 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 7):1995-7 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 6):1655-7 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 5):1337-9 Details Compston A (2012), “The benign form of multiple sclerosis. A study based on 241 cases seen within three years of onset and followed up until the tenth year or more of the disease. By Douglas McAlpine. From the Institute of Clinical Research, The Middlesex Hospital Medical School, London W1. Brain 1961: 84; 186-203.” Brain 135(Pt 3):648-51 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 3):645-7 Details Compston A (2012), “Brain Editorial.” Brain 135(Pt 2):305-7 Details Compston A (2012), “Brain. Editorial.” Brain 135(Pt 1):1-3 Details Connick P, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S (2012), “Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study.” Lancet Neurol 11(2):150-6 Details Hill-Cawthorne GA, Button T, Tuohy O, Jones JL, May K, Somerfield J, Green A, Giovannoni G, Compston DA, Fahey MT, Coles AJ (2012), “Long term lymphocyte reconstitution after alemtuzumab treatment of multiple sclerosis.” J Neurol Neurosurg Psychiatry 83(3):298-304 Details Sajic M, Hunt DP, Lee W, Compston DA, Schweimer JV, Gregson NA, Chandran S, Smith KJ (2012), “Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation.” PLoS One 7(2):e30708 Details Wellcome Trust Case Control Consortium, Maller JB, McVean G, Byrnes J, Vukcevic D, Palin K, Su Z, Howson JM, Auton A, Myers S, Morris A, Pirinen M, Brown MA, Burton PR, Caulfield MJ, Compston A, Farrall M, Hall AS, Hattersley AT, Hill AV, Mathew CG, Pembrey M, Satsangi J, Stratton MR, Worthington J, Craddock N, Hurles M, Ouwehand W, Parkes M, Rahman N, Duncanson A, Todd JA, Kwiatkowski DP, Samani NJ, Gough SC, McCarthy MI, Deloukas P, Donnelly P (2012), “Bayesian refinement of association signals for 14 loci in 3 common diseases.” Nat Genet 44(12):1294-301 Details 2011Asbury AK, King RH, Reilly MM, Dyck PJ, Said G, Compston A (2011), “Professor P. K. Thomas: clinician, investigator, editor and leader--a retrospective appreciation.” Brain 134(Pt 2):618-26 Details Coles AJ, Fox E, Vladic A, Gazda SK, Brinar V, Selmaj KW, Bass AD, Wynn DR, Margolin DH, Lake SL, Moran S, Palmer J, Smith MS, Compston DA (2011), “Alemtuzumab versus interferon ?-1a in early relapsing-remitting multiple sclerosis: post-hoc and subset analyses of clinical efficacy outcomes.” Lancet Neurol 10(4):338-48 Details Compston A (2011), “Neurology: quo vadis?” Clin Med 11(6):589-90 Details Compston A (2011), “On diabetic neuritis, with a clinical and pathological description of three cases of diabetic pseudo-tabes. By T. Davies Pryce MRCS, consulting surgeon to the Nottingham General Dispensary. Brain 1893: 16; 416-424. With Diabetic neuropathy. A clinical study of 150 cases. By M. Mencer Martin. From the Department of Diabetes, King's College Hospital, Denmark Hill, London, S.E., UK. Brain 1953: 76; 594-624.” Brain 134(Pt 11):3137-40 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 12):3421-3 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 11):3135-6 Details Compston A (2011), “Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. By John R. Hodges, Karalyn Patterson, Susan Oxbury and Elaine Furnell. From The Archives.” Brain 134(Pt 9):2444-6 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 10):2791-4 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 9):2441-3 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 8):2187-9 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 7):1869-71 Details Compston A (2011), “William Ian McDonald: 1933-2006.” Brain 134(Pt 7):2158-76 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 6):1577-9 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 5):1251-3 Details Compston A (2011), “The anatomy and physiology of cutaneous sensibility: a critical review. By FMR Walshe. Brain 1942: 65; 48–112.” Brain 134(Pt 4):920-3 Details Compston A (2011), “From the archives. Disturbances of vision from cerebral lesions, with special reference to the cortical representation of the macula. By Gordon Holmes and W. T. Lister (Consulting Ophthalmic Surgeon, BEF). Brain 1916: 39; 34-73; with A contribution to the cortical representation of vision. By Gordon Holmes. Brain 1931: 54; 470-479.” Brain 134(Pt 3):634-7 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 4):917-9 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 3):631-3 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 2):323-5 Details Compston A (2011), “Brain. Editorial.” Brain 134(Pt 1):1-3 Details Connick P, Kolappan M, Patani R, Scott MA, Crawley C, He XL, Richardson K, Barber K, Webber DJ, Wheeler-Kingshott CA, Tozer DJ, Samson RS, Thomas DL, Du MQ, Luan SL, Michell AW, Altmann DR, Thompson AJ, Miller DH, Compston A, Chandran S (2011), “The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments.” Trials 12:62 Details Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC, Bhaw-Rosun L, Bockett NA, Brand OJ, Brouwer E, Concannon P, Cooper JD, Dias KR, van Diemen CC, Dubois PC, Edkins S, Fölster-Holst R, Fransen K, Glass DN, Heap GA, Hofmann S, Huizinga TW, Hunt S, Langford C, Lee J, Mansfield J, Marrosu MG, Mathew CG, Mein CA, Müller-Quernheim J, Nutland S, Onengut-Gumuscu S, Ouwehand W, Pearce K, Prescott NJ, Posthumus MD, Potter S, Rosati G, Sambrook J, Satsangi J, Schreiber S, Shtir C, Simmonds MJ, Sudman M, Thompson SD, Toes R, Trynka G, Vyse TJ, Walker NM, Weidinger S, Zhernakova A, Zoledziewska M, Type 1 Diabetes Genetics Consortium, UK Inflammatory Bowel Disease (IBD) Genetics Consortium, Wellcome Trust Case Control Consortium, Weersma RK, Gough SC, Sawcer S, Wijmenga C, Parkes M, Cucca F, Franke A, Deloukas P, Rich SS, Todd JA, van Heel DA (2011), “Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.” Nat Genet 44(1):3-5 Details International Multiple Sclerosis Genetics Consortium (2011), “The genetic association of variants in CD6, TNFRSF1A and IRF8 to multiple sclerosis: a multicenter case-control study.” PLoS One 6(4):e18813 Details International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2, Sawcer S, Hellenthal G, Pirinen M, Spencer CC, Patsopoulos NA, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt SE, Edkins S, Gray E, Booth DR, Potter SC, Goris A, Band G, Oturai AB, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B, Gwilliam R, Zipp F, Jayakumar A, Martin R, Leslie S, Hawkins S, Giannoulatou E, D'alfonso S, Blackburn H, Boneschi FM, Liddle J, Harbo HF, Perez ML, Spurkland A, Waller MJ, Mycko MP, Ricketts M, Comabella M, Hammond N, Kockum I, McCann OT, Ban M, Whittaker P, Kemppinen A, Weston P, Hawkins C, Widaa S, Zajicek J, Dronov S, Robertson N, Bumpstead SJ, Barcellos LF, Ravindrarajah R, Abraham R, Alfredsson L, Ardlie K, Aubin C, Baker A, Baker K, Baranzini SE, Bergamaschi L, Bergamaschi R, Bernstein A, Berthele A, Boggild M, Bradfield JP, Brassat D, Broadley SA, Buck D, Butzkueven H, Capra R, Carroll WM, Cavalla P, Celius EG, Cepok S, Chiavacci R, Clerget-Darpoux F, Clysters (2011), “Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.” Nature 476(7359):214-9 Details Kemppinen A, Sawcer S, Compston A (2011), “Genome-wide association studies in multiple sclerosis: lessons and future prospects.” Brief Funct Genomics 10(2):61-70 Details Mero IL, Ban M, Lorentzen ÅR, Smestad C, Celius EG, Sæther H, Saeedi H, Viken MK, Skinningsrud B, Undlien DE, Aarseth J, Myhr KM, Granum S, Spurkland A, Sawcer S, Compston A, Lie BA, Harbo HF (2011), “Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.” Genes Immun 12(3):191-8 Details Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Alvarez S, de Lera AR, Wyllie DJ, Compston DA, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S (2011), “Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state.” Nat Commun 2:214 Details Patsopoulos NA, Bayer Pharma MS Genetics Working Group, Steering Committees of Studies Evaluating IFN?-1b and a CCR1-Antagonist, ANZgene Consortium, GeneMSA, International Multiple Sclerosis Genetics Consortium, Esposito F, Reischl J, Lehr S, Bauer D, Heubach J, Sandbrink R, Pohl C, Edan G, Kappos L, Miller D, Montalbán J, Polman CH, Freedman MS, Hartung HP, Arnason BG, Comi G, Cook S, Filippi M, Goodin DS, Jeffery D, O'Connor P, Ebers GC, Langdon D, Reder AT, Traboulsee A, Zipp F, Schimrigk S, Hillert J, Bahlo M, Booth DR, Broadley S, Brown MA, Browning BL, Browning SR, Butzkueven H, Carroll WM, Chapman C, Foote SJ, Griffiths L, Kermode AG, Kilpatrick TJ, Lechner-Scott J, Marriott M, Mason D, Moscato P, Heard RN, Pender MP, Perreau VM, Perera D, Rubio JP, Scott RJ, Slee M, Stankovich J, Stewart GJ, Taylor BV, Tubridy N, Willoughby E, Wiley J, Matthews P, Boneschi FM, Compston A, Haines J, Hauser SL, McCauley J, Ivinson A, Oksenberg JR, Pericak-Vance M, Sawcer SJ, De Jager PL, Hafler DA, de Bakker PI (2011), “Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.” Ann Neurol 70(6):897-912 Details Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, Burnett MS, Devaney JM, Knouff CW, Thompson JR, Horne BD, Stewart AF, Assimes TL, Wild PS, Allayee H, Nitschke PL, Patel RS, Myocardial Infarction Genetics Consortium, Wellcome Trust Case Control Consortium, Martinelli N, Girelli D, Quyyumi AA, Anderson JL, Erdmann J, Hall AS, Schunkert H, Quertermous T, Blankenberg S, Hazen SL, Roberts R, Kathiresan S, Samani NJ, Epstein SE, Rader DJ (2011), “Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.” Lancet 377(9763):383-92 Details Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S (2011), “Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.” Nat Protoc 6(8):1229-40 Details Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S (2011), “Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation.” Cell Death Differ 18(6):1016-23 Details Zuvich RL, Bush WS, McCauley JL, Beecham AH, De Jager PL, International Multiple Sclerosis Genetics Consortium, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Sawcer SJ, Pericak-Vance MA, Barcellos LF, Mortlock DP, Haines JL (2011), “Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.” Hum Mol Genet 20(17):3517-24 Details 2010Ban M, McCauley JL, Zuvich R, Baker A, Bergamaschi L, Cox M, Kemppinen A, D'Alfonso S, Guerini FR, Lechner-Scott J, Dudbridge F, Wason J, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, Sexton D, Oksenberg JR, Hauser SL, Pericak-Vance MA, Haines J, Compston A, Sawcer S (2010), “A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.” Genes Immun 11(8):660-4 Details Briggs FB, Bartlett SE, Goldstein BA, Wang J, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, International Multiple Sclerosis Genetics Consortium, Barcellos LF (2010), “Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals.” Hum Mol Genet 19(21):4286-95 Details Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium (2010), “Variation within DNA repair pathway genes and risk of multiple sclerosis.” Am J Epidemiol 172(2):217-24 Details Bronson PG, Caillier S, Ramsay PP, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Sawcer SJ, Pericak-Vance MA, Haines JL, International Multiple Sclerosis Genetics Consortium, Hauser SL, Oksenberg JR, Barcellos LF (2010), “CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.” Hum Mol Genet 19(11):2331-40 Details Compston A (2010), “Brain. Editorial.” Brain 133(Pt 12):3487-8 Details Compston A (2010), “Brain. Editorial.” Brain 133(11):3157-9 Details Compston A (2010), “Aids to the investigation of peripheral nerve injuries. Medical Research Council: Nerve Injuries Research Committee. His Majesty's Stationery Office: 1942; pp. 48 (iii) and 74 figures and 7 diagrams; with aids to the examination of the peripheral nervous system. By Michael O'Brien for the Guarantors of Brain. Saunders Elsevier: 2010; pp. [8] 64 and 94 Figures.” Brain 133(10):2838-44 Details Compston A (2010), “Brain. Editorial.” Brain 133(10):2835-7 Details Compston A (2010), “Brain. Editorial.” Brain 133(Pt 8):2173-5 Details Compston A (2010), “The hippocampus and the sense of smell. A review, by Alf Brodal. Brain 1947: 70; 179-222.” Brain 133(9):2509-13 Details Compston A (2010), “Brain. Editorial.” Brain 133(9):2507-8 Details Compston A (2010), “From the archives. Corticobasal degeneration. By WRG Gibb, PJ Luther and CD Marsden. Brain 1989: 112; 1171-1192 with Corticobasal degeneration. A clinical study of 36 cases. By JO Rinne, MS Lee, PD Thompson and CD Marsden. Brain 1994: 117; 1183-1196.” Brain 133(Pt 7):1860-2 Details Compston A (2010), “Brain. Editorial.” Brain 133(Pt 7):1857-9 Details Compston A (2010), “Commentary: Scheme has benefited patients.” BMJ 340:c2707 Details Compston A (2010), “Brain. Editorial.” Brain 133(Pt 6):1571-2 Details Compston A (2010), “Brain. Editorial.” Brain 133(Pt 5):1289-91 Details Compston A (2010), “Dr. Sigmund Freud. Editorial.” Brain 133(Pt 4):947-9 Details Compston A (2010), “What got me into neurology (and did it work out?).” Pract Neurol 10(2):107-8 Details Compston A (2010), “Brain. Editorial.” Brain 133(Pt 3):643-4 Details Compston A (2010), “Dr Macdonald Critchley (1900-97).” Brain 133(Pt 2):311-3 Details Compston A (2010), “The Berger rhythm: potential changes from the occipital lobes in man.” Brain 133(Pt 1):3-6 Details Compston A (2010), “A clear case of possession. Editorial.” Brain 133(Pt 1):1-2 Details Cree BA, Rioux JD, McCauley JL, Gourraud PA, Goyette P, McElroy J, De Jager P, Santaniello A, Vyse TJ, Gregersen PK, Mirel D, Hafler DA, Haines JL, Pericak-Vance MA, Compston A, Sawcer SJ, Oksenberg JR, Hauser SL, IMAGEN, IMSGC (2010), “A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01.” PLoS One 5(6):e11296 Details Grozeva D, Kirov G, Ivanov D, Jones IR, Jones L, Green EK, St Clair DM, Young AH, Ferrier N, Farmer AE, McGuffin P, Holmans PA, Owen MJ, O'Donovan MC, Craddock N, Wellcome Trust Case Control Consortium (2010), “Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia.” Arch Gen Psychiatry 67(4):318-27 Details Hunt DP, Sajic M, Phillips H, Henderson D, Compston A, Smith K, Chandran S (2010), “Origins of gliogenic stem cell populations within adult skin and bone marrow.” Stem Cells Dev 19(7):1055-65 Details International Multiple Sclerosis Genetics Consortium (IMSGC) (2010), “Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.” Hum Mol Genet 19(5):953-62 Details International Multiple Sclerosis Genetics Consortium (IMSGC), Booth DR, Heard RN, Stewart GJ, Cox M, Scott RJ, Lechner-Scott J, Goris A, Dobosi R, Dubois B, Saarela J, Leppä V, Peltonen L, Pirttila T, Cournu-Rebeix I, Fontaine B, Bergamaschi L, D'Alfonso S, Leone M, Lorentzen AR, Harbo HF, Celius EG, Spurkland A, Link J, Kockum I, Olsson T, Hillert J, Ban M, Baker A, Kemppinen A, Sawcer S, Compston A, Robertson NP, De Jager PL, Hafler DA, Barcellos LF, Ivinson AJ, McCauley JL, Pericak-Vance MA, Oksenberg JR, Hauser SL, Sexton D, Haines J (2010), “Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.” Nat Genet 42(6):469-70; author reply 470-1 Details International Multiple Sclerosis Genetics Conssortium (IMSGC) (2010), “IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci.” Genes Immun 11(5):397-405 Details Jones JL, Anderson JM, Phuah CL, Fox EJ, Selmaj K, Margolin D, Lake SL, Palmer J, Thompson SJ, Wilkins A, Webber DJ, Compston DA, Coles AJ (2010), “Improvement in disability after alemtuzumab treatment of multiple sclerosis is associated with neuroprotective autoimmunity.” Brain 133(Pt 8):2232-47 Details Saiki M, Baker A, Williams-Gray CH, Foltynie T, Goodman RS, Taylor CJ, Compston DA, Barker RA, Sawcer SJ, Goris A (2010), “Association of the human leucocyte antigen region with susceptibility to Parkinson's disease.” J Neurol Neurosurg Psychiatry 81(8):890-1 Details Somerfield J, Hill-Cawthorne GA, Lin A, Zandi MS, McCarthy C, Jones JL, Willcox M, Shaw D, Thompson SA, Compston AS, Hale G, Waldmann H, Coles AJ (2010), “A novel strategy to reduce the immunogenicity of biological therapies.” J Immunol 185(1):763-8 Details Thompson SA, Jones JL, Cox AL, Compston DA, Coles AJ (2010), “B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis.” J Clin Immunol 30(1):99-105 Details Wellcome Trust Case Control Consortium, Craddock N, Hurles ME, Cardin N, Pearson RD, Plagnol V, Robson S, Vukcevic D, Barnes C, Conrad DF, Giannoulatou E, Holmes C, Marchini JL, Stirrups K, Tobin MD, Wain LV, Yau C, Aerts J, Ahmad T, Andrews TD, Arbury H, Attwood A, Auton A, Ball SG, Balmforth AJ, Barrett JC, Barroso I, Barton A, Bennett AJ, Bhaskar S, Blaszczyk K, Bowes J, Brand OJ, Braund PS, Bredin F, Breen G, Brown MJ, Bruce IN, Bull J, Burren OS, Burton J, Byrnes J, Caesar S, Clee CM, Coffey AJ, Connell JM, Cooper JD, Dominiczak AF, Downes K, Drummond HE, Dudakia D, Dunham A, Ebbs B, Eccles D, Edkins S, Edwards C, Elliot A, Emery P, Evans DM, Evans G, Eyre S, Farmer A, Ferrier IN, Feuk L, Fitzgerald T, Flynn E, Forbes A, Forty L, Franklyn JA, Freathy RM, Gibbs P, Gilbert P, Gokumen O, Gordon-Smith K, Gray E, Green E, Groves CJ, Grozeva D, Gwilliam R, Hall A, Hammond N, Hardy M, Harrison P, Hassanali N, Hebaishi H, Hines S, Hinks A, Hitman GA, Hocking L, Howard E, Howard P, Howson JM, Hughes D, Hunt S, I (2010), “Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.” Nature 464(7289):713-20 Details Wilkins A, Kondo Y, Song J, Liu S, Compston A, Black JA, Waxman SG, Duncan ID (2010), “Slowly progressive axonal degeneration in a rat model of chronic, nonimmune-mediated demyelination.” J Neuropathol Exp Neurol 69(12):1256-69 Details Zuvich RL, McCauley JL, Oksenberg JR, Sawcer SJ, De Jager PL, International Multiple Sclerosis Genetics Consortium, Aubin C, Cross AH, Piccio L, Aggarwal NT, Evans D, Hafler DA, Compston A, Hauser SL, Pericak-Vance MA, Haines JL (2010), “Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility.” Hum Genet 127(5):525-35 Details 2009Anderson JM, Patani R, Reynolds R, Nicholas R, Compston A, Spillantini MG, Chandran S (2009), “Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis.” Acta Neuropathol 117(5):583-9 Details Ban M, Goris A, Lorentzen AR, Baker A, Mihalova T, Ingram G, Booth DR, Heard RN, Stewart GJ, Bogaert E, Dubois B, Harbo HF, Celius EG, Spurkland A, Strange R, Hawkins C, Robertson NP, Dudbridge F, Wason J, De Jager PL, Hafler D, Rioux JD, Ivinson AJ, McCauley JL, Pericak-Vance M, Oksenberg JR, Hauser SL, Sexton D, Haines J, Sawcer S, Wellcome Trust Case-Control Consortium (WTCCC), Compston A (2009), “Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor.” Eur J Hum Genet 17(10):1309-13 Details Compston A (2009), “Was Charles Darwin interested in the brain?” Brain 132(Pt 12):3191-2 Details Compston A (2009), “A human experiment in nerve division by W.H.R. Rivers MD FRS, Fellow of St John's College, Cambridge and Henry Head MD FRS, Physician to the London Hospital, Brain 1908: 31; 323-450.” Brain 132(Pt 11):2903-5 Details Compston A (2009), “Brain. Editorial.” Brain 132(Pt 11):2901-2 Details Compston A (2009), “Balanced and responsible journalism.” Brain 132(Pt 10):2621-2 Details Compston A (2009), “Lord Campbell's account of Shakespeare's legal knowledge stimulated Sir John (Charles) Bucknill to interpret the bard's words and phrases of medical significance for the general reader. Editorial.” Brain 132(Pt 9):2301-2 Details Compston A (2009), “Progressive lenticular degeneration: a familial nervous disease associated with cirrhosis of the liver, by S. A. Kinnier Wilson, (From the National Hospital, and the Laboratory of the National Hospital, Queen Square, London) Brain 1912: 34; 295-509.” Brain 132(Pt 8):1997-2001 Details Compston A (2009), “'Primary sensory neuropathy with muscular changes associated with carcinoma'. Editorial.” Brain 132(Pt 8):1995-6 Details Compston A (2009), “Measurements come in all shapes and sizes.” Brain 132(Pt 7):1683-4 Details Compston A (2009), “Editorial. 'The muddle of embodiment'.” Brain 132(Pt 6):1411-2 Details Compston A (2009), “Editorial. Sarcasm, risk taking, callous unemotional responses, confabulation, telling lies, gambling, fear-conditioning and compulsive activity.” Brain 132(Pt 5):1119-20 Details Compston A (2009), “The cervical portion of the vertebral artery: a clinico-pathological study, by E. C. Hutchinson and P. O. Yates (from the Department of Neurology and Neuro-pathology, the Manchester Royal Infirmary) Brain 1956: 79; 319-31 and Arterial occlusions in the vertebro-basilar system: a study of 44 patients with post-mortem data, by P. Castaigne, F. Lhermitte, J. C. Gautier, R. Escourolle, C. Derouesné, P. Der Agopian and C. Popa (from Hôpital de la Salpêtrière, 47 Bd de l'ôpital, Paris, 13), Brain 1973: 96; 133-154.” Brain 132(Pt 4):827-30 Details Compston A (2009), “Sensory history.” Brain 132(Pt 4):825-6 Details Compston A (2009), “Many organizations and institutions will celebrate the bicentenary of the birth of Charles Darwin. Editorial.” Brain 132(Pt 3):563-4 Details Compston A (2009), “It is part of the art of medicine that, despite its origins in organ based pathological anatomy, the concept of 'disease' is constantly adjusted by evolving societal concepts of what does and does not constitute illness.” Brain 132(Pt 2):279-81 Details Compston A (2009), “Doctors who write literature may be considered to have crossed from science to the humanities obtaining release from the rigid constraints of logic, experiment and fact, and gaining the freedoms of imagination, metaphor and fiction.” Brain 132(Pt 1):1-2 Details De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA (2009), “The role of the CD58 locus in multiple sclerosis.” Proc Natl Acad Sci U S A 106(13):5264-9 Details De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, International MS Genetics Consortium, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR (2009), “Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.” Nat Genet 41(7):776-82 Details Dehghan A, Yang Q, Peters A, Basu S, Bis JC, Rudnicka AR, Kavousi M, Chen MH, Baumert J, Lowe GD, McKnight B, Tang W, de Maat M, Larson MG, Eyhermendy S, McArdle WL, Lumley T, Pankow JS, Hofman A, Massaro JM, Rivadeneira F, Kolz M, Taylor KD, van Duijn CM, Kathiresan S, Illig T, Aulchenko YS, Volcik KA, Johnson AD, Uitterlinden AG, Tofler GH, Gieger C, Wellcome Trust Case Control Consortium, Psaty BM, Couper DJ, Boerwinkle E, Koenig W, O'Donnell CJ, Witteman JC, Strachan DP, Smith NL, Folsom AR (2009), “Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.” Circ Cardiovasc Genet 2(2):125-33 Details Hirst C, Ingram G, Pickersgill T, Swingler R, Compston DA, Robertson NP (2009), “Increasing prevalence and incidence of multiple sclerosis in South East Wales.” J Neurol Neurosurg Psychiatry 80(4):386-91 Details International MHC and Autoimmunity Genetics Network, Rioux JD, Goyette P, Vyse TJ, Hammarström L, Fernando MM, Green T, De Jager PL, Foisy S, Wang J, de Bakker PI, Leslie S, McVean G, Padyukov L, Alfredsson L, Annese V, Hafler DA, Pan-Hammarström Q, Matell R, Sawcer SJ, Compston AD, Cree BA, Mirel DB, Daly MJ, Behrens TW, Klareskog L, Gregersen PK, Oksenberg JR, Hauser SL (2009), “Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.” Proc Natl Acad Sci U S A 106(44):18680-5 Details International Multiple Sclerosis Genetics Consortium (IMSGC) (2009), “The expanding genetic overlap between multiple sclerosis and type I diabetes.” Genes Immun 10(1):11-4 Details Jallow M, Teo YY, Small KS, Rockett KA, Deloukas P, Clark TG, Kivinen K, Bojang KA, Conway DJ, Pinder M, Sirugo G, Sisay-Joof F, Usen S, Auburn S, Bumpstead SJ, Campino S, Coffey A, Dunham A, Fry AE, Green A, Gwilliam R, Hunt SE, Inouye M, Jeffreys AE, Mendy A, Palotie A, Potter S, Ragoussis J, Rogers J, Rowlands K, Somaskantharajah E, Whittaker P, Widden C, Donnelly P, Howie B, Marchini J, Morris A, SanJoaquin M, Achidi EA, Agbenyega T, Allen A, Amodu O, Corran P, Djimde A, Dolo A, Doumbo OK, Drakeley C, Dunstan S, Evans J, Farrar J, Fernando D, Hien TT, Horstmann RD, Ibrahim M, Karunaweera N, Kokwaro G, Koram KA, Lemnge M, Makani J, Marsh K, Michon P, Modiano D, Molyneux ME, Mueller I, Parker M, Peshu N, Plowe CV, Puijalon O, Reeder J, Reyburn H, Riley EM, Sakuntabhai A, Singhasivanon P, Sirima S, Tall A, Taylor TE, Thera M, Troye-Blomberg M, Williams TN, Wilson M, Kwiatkowski DP, Wellcome Trust Case Control Consortium, Malaria Genomic Epidemiology Network (2009), “Genome-wide and fine-resolution association analysis of malaria in West Africa.” Nat Genet 41(6):657-65 Details Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, International Multiple Sclerosis Genetics Consortium, De Jager PL, Wicker LS, Todd JA, Hafler DA (2009), “IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.” PLoS Genet 5(1):e1000322 Details Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, Papadakis K, Voight BF, Scott LJ, Zhang F, Farrall M, Tanaka T, Wallace C, Chambers JC, Khaw KT, Nilsson P, van der Harst P, Polidoro S, Grobbee DE, Onland-Moret NC, Bots ML, Wain LV, Elliott KS, Teumer A, Luan J, Lucas G, Kuusisto J, Burton PR, Hadley D, McArdle WL, Wellcome Trust Case Control Consortium, Brown M, Dominiczak A, Newhouse SJ, Samani NJ, Webster J, Zeggini E, Beckmann JS, Bergmann S, Lim N, Song K, Vollenweider P, Waeber G, Waterworth DM, Yuan X, Groop L, Orho-Melander M, Allione A, Di Gregorio A, Guarrera S, Panico S, Ricceri F, Romanazzi V, Sacerdote C, Vineis P, Barroso I, Sandhu MS, Luben RN, Crawford GJ, Jousilahti P, Perola M, Boehnke M, Bonnycastle LL, Collins FS, Jackson AU, Mohlke KL, Stringham HM, Valle TT, Willer CJ, Bergman RN, Morken MA, Döring A, Gieger C, Illig T, Meitinger T, Org E, Pfeufer A, Wichmann HE, Kathiresan S, Marrugat J, O'Donnell CJ, Schwartz SM, Siscovick DS (2009), “Genome-wide association study identifies eight loci associated with blood pressure.” Nat Genet 41(6):666-76 Details Orozco G, Hinks A, Eyre S, Ke X, Gibbons LJ, Bowes J, Flynn E, Martin P, Wellcome Trust Case Control Consortium, YEAR consortium, Wilson AG, Bax DE, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Thomson W, Barton A, Worthington J (2009), “Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.” Hum Mol Genet 18(14):2693-9 Details Patani R, Compston A, Puddifoot CA, Wyllie DJ, Hardingham GE, Allen ND, Chandran S (2009), “Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.” PLoS One 4(10):e7327 Details Williams-Gray C, Goris A, Foltynie T, Compston A, Sawcer S, Barker RA (2009), “No evidence for association between an MAOA functional polymorphism and susceptibility to Parkinson's disease.” J Neurol 256(1):132-3 Details Williams-Gray CH, Goris A, Saiki M, Foltynie T, Compston DA, Sawcer SJ, Barker RA (2009), “Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson's disease.” J Neurol 256(3):493-8 Details 2008Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S (2008), “Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.” Brain 131(Pt 7):1736-48 Details Ban M, Elson J, Walton A, Turnbull D, Compston A, Chinnery P, Sawcer S (2008), “Investigation of the role of mitochondrial DNA in multiple sclerosis susceptibility.” PLoS One 3(8):e2891 Details Barcellos LF, Ramsay PP, Caillier SJ, Sawcer S, Haines J, Schmidt S, Pericak-Vance M, Compston DA, Gabatto P, Hauser SL, Oksenberg JR (2008), “Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis.” Genes Immun 9(6):493-500 Details Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, Gibbons L, Plant D, Wellcome Trust Case Control Consortium, Wilson AG, Marinou I, Morgan A, Emery P, YEAR consortium, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Worthington J (2008), “Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.” Hum Mol Genet 17(15):2274-9 Details Barton A, Thomson W, Ke X, Eyre S, Hinks A, Bowes J, Plant D, Gibbons LJ, Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC Consortium, Wilson AG, Bax DE, Morgan AW, Emery P, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Worthington J (2008), “Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.” Nat Genet 40(10):1156-9 Details Bilican B, Fiore-Heriche C, Compston A, Allen ND, Chandran S (2008), “Induction of Olig2 precursors by FGF involves BMP signalling blockade at the Smad level.” PLoS One 3(8):e2863 Details Chandran S, Hunt D, Joannides A, Zhao C, Compston A, Franklin RJ (2008), “Myelin repair: the role of stem and precursor cells in multiple sclerosis.” Philos Trans R Soc Lond B Biol Sci 363(1489):171-83 Details Compston A (2008), “Misrepresentation of the outside world or self may follow damage to the nervous system.” Brain 131(Pt 12):3109-10 Details Compston A (2008), “Brain. Editorial.” Brain 131(Pt 11):2803-4 Details Compston A (2008), “Brain. Editorial.” Brain 131(Pt 10):2529-31 Details Compston A (2008), “Most intact human nervous systems know whether they are vertical or tilted, to around 4 degrees of accuracy between the perceived and real displacement.” Brain 131(Pt 9):2235-6 Details Compston A (2008), “Deceptively amorphous macroscopic appearance of the brain conceals untold complexities of regional specification.” Brain 131(Pt 8):1961-2 Details Compston A (2008), “Science and religion traditionally part company around the issue of evidence.” Brain 131(Pt 7):1675-6 Details Compston A (2008), “Brain. Editorial.” Brain 131(Pt 5):1163-4 Details Compston A (2008), “Brain. Editorial.” Brain 131(Pt 4):895-6 Details Compston A, Coles A (2008), “Multiple sclerosis.” Lancet 372(9648):1502-17 Details Dean G, Yeo TW, Goris A, Taylor CJ, Goodman RS, Elian M, Galea-Debono A, Aquilina A, Felice A, Vella M, Sawcer S, Compston DA (2008), “HLA-DRB1 and multiple sclerosis in Malta.” Neurology 70(2):101-5 Details Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, Nimmo ER, Massey D, Berzuini C, Johnson C, Barrett JC, Cummings FR, Drummond H, Lees CW, Onnie CM, Hanson CE, Blaszczyk K, Inouye M, Ewels P, Ravindrarajah R, Keniry A, Hunt S, Carter M, Watkins N, Ouwehand W, Lewis CM, Cardon L, Wellcome Trust Case Control Consortium, Lobo A, Forbes A, Sanderson J, Jewell DP, Mansfield JC, Deloukas P, Mathew CG, Parkes M, Satsangi J (2008), “Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.” Nat Genet 40(6):710-2 Details Goris A, Walton A, Ban M, Dubois B, Compston A, Sawcer S (2008), “A Taqman assay for high-throughput genotyping of the multiple sclerosis-associated HLA-DRB1*1501 allele.” Tissue Antigens 72(4):401-3 Details Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJ, Baker D, Chandran S (2008), “An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.” J Neuroimmunol 201-202:200-11 Details Hirst C, Ingram G, Swingler R, Compston DA, Pickersgill T, Robertson NP (2008), “Change in disability in patients with multiple sclerosis: a 20-year prospective population-based analysis.” J Neurol Neurosurg Psychiatry 79(10):1137-43 Details Hirst C, Swingler R, Compston DA, Ben-Shlomo Y, Robertson NP (2008), “Survival and cause of death in multiple sclerosis: a prospective population-based study.” J Neurol Neurosurg Psychiatry 79(9):1016-21 Details Hunt DP, Irvine KA, Webber DJ, Compston DA, Blakemore WF, Chandran S (2008), “Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord.” Cell Transplant 17(7):865-73 Details Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S (2008), “A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin.” Stem Cells 26(1):163-72 Details International Multiple Sclerosis Genetics Consortium (IMSGC) (2008), “Refining genetic associations in multiple sclerosis.” Lancet Neurol 7(7):567-9 Details Moyes DL, Goris A, Ban M, Compston A, Griffiths DJ, Sawcer S, Venables PJ (2008), “HERV-K113 is not associated with multiple sclerosis in a large family-based study.” AIDS Res Hum Retroviruses 24(3):363-5 Details 2007Ban M, Walton A, Goris A, Gray J, Compston A, Sawcer S (2007), “Polymorphisms in the neuromyelitis optica auto-antigen AQP4 and susceptibility to multiple sclerosis.” J Neurol 254(3):398-9 Details Compston A (2007), “Complexity and heterogeneity in demyelinating disease.” Brain 130(Pt 5):1178-80 Details Goris A, Williams-Gray CH, Clark GR, Foltynie T, Lewis SJ, Brown J, Ban M, Spillantini MG, Compston A, Burn DJ, Chinnery PF, Barker RA, Sawcer SJ (2007), “Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.” Ann Neurol 62(2):145-53 Details Goris A, Williams-Gray CH, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Barker RA, Sawcer SJ (2007), “Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson's disease.” J Neurol 254(7):846-8 Details Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL, Multiple Sclerosis Genetics Group (2007), “Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.” Nat Genet 39(9):1083-91 Details Hensiek AE, Seaman SR, Barcellos LF, Oturai A, Eraksoi M, Cocco E, Vecsei L, Stewart G, Dubois B, Bellman-Strobl J, Leone M, Andersen O, Bencsik K, Booth D, Celius EG, Harbo HF, Hauser SL, Heard R, Hillert J, Myhr KM, Marrosu MG, Oksenberg JR, Rajda C, Sawcer SJ, Sørensen PS, Zipp F, Compston DA (2007), “Familial effects on the clinical course of multiple sclerosis.” Neurology 68(5):376-83 Details Jaros E, Mahad DJ, Hudson G, Birchall D, Sawcer SJ, Griffiths PG, Sunter J, Compston DA, Perry RH, Chinnery PF (2007), “Primary spinal cord neurodegeneration in Leber hereditary optic neuropathy.” Neurology 69(2):214-6 Details Joannides AJ, Fiore-Hériché C, Battersby AA, Athauda-Arachchi P, Bouhon IA, Williams L, Westmore K, Kemp PJ, Compston A, Allen ND, Chandran S (2007), “A scaleable and defined system for generating neural stem cells from human embryonic stem cells.” Stem Cells 25(3):731-7 Details Webber DJ, Compston A, Chandran S (2007), “Minimally manipulated oligodendrocyte precursor cells retain exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus.” Eur J Neurosci 26(7):1791-800 Details Wellcome Trust Case Control Consortium (2007), “Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.” Nature 447(7145):661-78 Details Wellcome Trust Case Control Consortium, Australo-Anglo-American Spondylitis Consortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Marchini JL, Morris AP, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, Stevens HE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL, Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskivina V, Nikolov I, O'Donovan MC, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, Barrett JH, Bishop TD, Iles MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ, Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H (2007), “Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.” Nat Genet 39(11):1329-37 Details Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A, Fenoglio C, Ban M, Taylor CJ, Goodman RS, Walsh E, Wolfish CS, Horton R, Traherne J, Beck S, Trowsdale J, Caillier SJ, Ivinson AJ, Green T, Pobywajlo S, Lander ES, Pericak-Vance MA, Haines JL, Daly MJ, Oksenberg JR, Hauser SL, Compston A, Hafler DA, Rioux JD, Sawcer S (2007), “A second major histocompatibility complex susceptibility locus for multiple sclerosis.” Ann Neurol 61(3):228-36 Details 2006Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F, Cree BC, Begovich AB, Villoslada P, Montalban X, Uccelli A, Savettieri G, Lincoln RR, DeLoa C, Haines JL, Pericak-Vance MA, Compston A, Hauser SL, Oksenberg JR (2006), “Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis.” Hum Mol Genet 15(18):2813-24 Details Burwick RM, Ramsay PP, Haines JL, Hauser SL, Oksenberg JR, Pericak-Vance MA, Schmidt S, Compston A, Sawcer S, Cittadella R, Savettieri G, Quattrone A, Polman CH, Uitdehaag BM, Zwemmer JN, Hawkins CP, Ollier WE, Weatherby S, Enzinger C, Fazekas F, Schmidt H, Schmidt R, Hillert J, Masterman T, Hogh P, Niino M, Kikuchi S, Maciel P, Santos M, Rio ME, Kwiecinski H, Zakrzewska-Pniewska B, Evangelou N, Palace J, Barcellos LF (2006), “APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers.” Neurology 66(9):1373-83 Details Coles AJ, Cox A, Le Page E, Jones J, Trip SA, Deans J, Seaman S, Miller DH, Hale G, Waldmann H, Compston DA (2006), “The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy.” J Neurol 253(1):98-108 Details Compston A (2006), “The basis for treatment in multiple sclerosis.” Acta Neurol Scand Suppl 183:41-7 Details Compston A (2006), “Making progress on the natural history of multiple sclerosis.” Brain 129(Pt 3):561-3 Details De Jager PL, Graham R, Farwell L, Sawcer S, Richardson A, Behrens TW, Compston A, Hafler DA, Kere J, Vyse TJ, Rioux JD (2006), “The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus.” Genes Immun 7(4):327-34 Details De Jager PL, Sawcer S, Waliszewska A, Farwell L, Wild G, Cohen A, Langelier D, Bitton A, Compston A, Hafler DA, Rioux JD (2006), “Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis.” Eur J Hum Genet 14(3):317-21 Details Fenoglio C, Galimberti D, Ban M, Maranian M, Scalabrini D, Venturelli E, Piccio L, De Riz M, Yeo TW, Goris A, Gray J, Bresolin N, Scarpini E, Compston A, Sawcer S (2006), “SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis.” Neurosci Lett 394(2):92-6 Details Games Collaborative Group, Ban M, Booth D, Heard R, Stewart G, Goris A, Vandenbroeck K, Dubois B, Laaksonen M, Ilonen J, Alizadeh M, Edan G, Babron MC, Brassat D, Clanet M, Cournu-Rebeix I, Fontaine B, Semana G, Goedde R, Epplen J, Weber A, Infante-Duarte C, Zipp F, Rajda C, Bencsik K, Vécsei L, Heggarty S, Graham C, Hawkins S, Liguori M, Momigliano-Richiardi P, Caputo D, Grimaldi LM, Leone M, Massacesi L, Milanese C, Salvetti M, Savettieri G, Trojano M, Bielecki B, Mycko MP, Selmaj K, Santos M, Maciel P, Pereira C, Silva A, Silva BM, Coraddu F, Marrosu MG, Akesson E, Hillert J, Datta P, Oturai A, Harbo HF, Spurkland A, Goertsches R, Villoslada P, Eraksoy M, Hensiek A, Compston A, Setakis E, Gray J, Yeo TW, Sawcer S (2006), “Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans.” J Neuroimmunol 179(1-2):108-16 Details Gaughwin PM, Caldwell MA, Anderson JM, Schwiening CJ, Fawcett JW, Compston DA, Chandran S (2006), “Astrocytes promote neurogenesis from oligodendrocyte precursor cells.” Eur J Neurosci 23(4):945-56 Details Goris A, Maranian M, Walton A, Yeo TW, Ban M, Gray J, Compston A, Sawcer S (2006), “No evidence for association of a European-specific chromosome 17 inversion with multiple sclerosis.” Eur J Hum Genet 14(10):1064 Details Goris A, Maranian M, Walton A, Yeo TW, Ban M, Gray J, Dubois B, Compston A, Sawcer S (2006), “CD24 Ala/Val polymorphism and multiple sclerosis.” J Neuroimmunol 175(1-2):200-2 Details Goris A, Williams-Gray CH, Foltynie T, Compston DA, Barker RA, Sawcer SJ (2006), “No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening.” Am J Hum Genet 78(6):1088-90; author reply 1092-4 Details Goris A, Yeo TW, Maranian M, Walton A, Ban M, Gray J, Compston A, Sawcer S (2006), “Novel Olig 1-coding variants and susceptibility to multiple sclerosis.” J Neurol Neurosurg Psychiatry 77(11):1296-7 Details Joannides A, Fiore-Hériché C, Westmore K, Caldwell M, Compston A, Allen N, Chandran S (2006), “Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion.” Stem Cells 24(2):230-5 Details Majed HH, Chandran S, Niclou SP, Nicholas RS, Wilkins A, Wing MG, Rhodes KE, Spillantini MG, Compston A (2006), “A novel role for Sema3A in neuroprotection from injury mediated by activated microglia.” J Neurosci 26(6):1730-8 Details McKnight AJ, Maxwell AP, Sawcer S, Compston A, Setakis E, Patterson CC, Brady HR, Savage DA (2006), “A genome-wide DNA microsatellite association screen to identify chromosomal regions harboring candidate genes in diabetic nephropathy.” J Am Soc Nephrol 17(3):831-6 Details Roxburgh RH, Sawcer S, Maranian M, Seaman S, Hensiek A, Yeo T, Deans J, Compston A (2006), “No evidence of a significant role for CTLA-4 in multiple sclerosis.” J Neuroimmunol 171(1-2):193-7 Details Sawcer S, Compston A (2006), “Multiple sclerosis: light at the end of the tunnel.” Eur J Hum Genet 14(3):257-8 Details Schmidt S, Pericak-Vance MA, Sawcer S, Barcellos LF, Hart J, Sims J, Prokop AM, van der Walt J, DeLoa C, Lincoln RR, Oksenberg JR, Compston A, Hauser SL, Haines JL, Gregory SG, Multiple Sclerosis Genetics Group (2006), “Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis.” Genes Immun 7(5):384-92 Details Traherne JA, Barcellos LF, Sawcer SJ, Compston A, Ramsay PP, Hauser SL, Oksenberg JR, Trowsdale J (2006), “Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15.” Hum Mol Genet 15(1):155-61 Details Williams-Gray CH, Goris A, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Sawcer SJ, Barker RA (2006), “Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson's disease cohort.” J Neurol Neurosurg Psychiatry 77(5):665-7 Details Williams-Gray CH, Goris A, Foltynie T, Brown J, Maranian M, Walton A, Compston DA, Sawcer SJ, Barker RA (2006), “No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson's disease.” Mov Disord 21(5):731-2 Details 2005Ban M, Maranian M, Wai Yeo T, Gray J, Compston A, Sawcer S (2005), “Cis acting expression loci in multiple sclerosis.” J Neuroimmunol 162(1-2):3-4 Details Ban M, Maranian M, Yeo TW, Gray J, Compston A, Sawcer S (2005), “Ultraconserved regions in multiple sclerosis.” Eur J Hum Genet 13(9):998-9 Details Ban M, Maranian M, Yeo TW, Gray J, Compston A, Sawcer S (2005), “No evidence for association of the protein kinase C alpha gene with multiple sclerosis.” J Neurol 252(5):619-20 Details Chandran S, Compston A (2005), “Neural stem cells as a potential source of oligodendrocytes for myelin repair.” J Neurol Sci 233(1-2):179-81 Details Compston A (2005), “From the archives. 'Visual field changes following anterior temporal lobectomy: their significance in relation to "Meyer's loop" of the optic radiation' and 'The architecture of the optic radiation in the temporal lobe of man'.” Brain 128(Pt 9):1959-61 Details Compston A (2005), “From the archives. Problems of life and mind.” Brain 128(Pt 8):1743-4 Details Compston A (2005), “Decade of the brain.” Brain 128(Pt 8):1741-2 Details Compston A (2005), “Facial reflexes.” Brain 128(Pt 2):235-6 Details Compston A (2005), “Brain. Editorial.” Brain 128(Pt 2):233-4 Details Compston A (2005), “Brain. Editorial.” Brain 128(Pt 1):1-2 Details Cox A, Coles A, Antoun N, Malik O, Lucchinnetti C, Compston A (2005), “Recurrent myelitis and optic neuritis in a 29-year-old woman.” Lancet Neurol 4(8):510-6 Details Cox AL, Thompson SA, Jones JL, Robertson VH, Hale G, Waldmann H, Compston DA, Coles AJ (2005), “Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis.” Eur J Immunol 35(11):3332-42 Details Foltynie T, Hicks A, Sawcer S, Jonasdottir A, Setakis E, Maranian M, Yeo T, Lewis S, Brayne C, Stefansson K, Compston A, Gulcher J, Barker RA (2005), “A genome wide linkage disequilibrium screen in Parkinson's disease.” J Neurol 252(5):597-602 Details Lindquist S, Schott BH, Ban M, Compston DA, Sawcer S, Sailer M (2005), “The BDNF-Val66Met polymorphism: implications for susceptibility to multiple sclerosis and severity of disease.” J Neuroimmunol 167(1-2):183-5 Details Roxburgh RH, Seaman SR, Masterman T, Hensiek AE, Sawcer SJ, Vukusic S, Achiti I, Confavreux C, Coustans M, le Page E, Edan G, McDonnell GV, Hawkins S, Trojano M, Liguori M, Cocco E, Marrosu MG, Tesser F, Leone MA, Weber A, Zipp F, Miterski B, Epplen JT, Oturai A, Sørensen PS, Celius EG, Lara NT, Montalban X, Villoslada P, Silva AM, Marta M, Leite I, Dubois B, Rubio J, Butzkueven H, Kilpatrick T, Mycko MP, Selmaj KW, Rio ME, Sá M, Salemi G, Savettieri G, Hillert J, Compston DA (2005), “Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity.” Neurology 64(7):1144-51 Details Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL, International Multiple Sclerosis Genetics Consortium (2005), “A high-density screen for linkage in multiple sclerosis.” Am J Hum Genet 77(3):454-67 Details Wilkins A, Compston A (2005), “Trophic factors attenuate nitric oxide mediated neuronal and axonal injury in vitro: roles and interactions of mitogen-activated protein kinase signalling pathways.” J Neurochem 92(6):1487-96 Details 2004Chandran S, Compston A, Jauniaux E, Gilson J, Blakemore W, Svendsen C (2004), “Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors.” Glia 47(4):314-24 Details Coles A, Deans J, Compston A (2004), “Campath-1H treatment of multiple sclerosis: lessons from the bedside for the bench.” Clin Neurol Neurosurg 106(3):270-4 Details Compston A (2004), “Mechanisms of axon-glial injury of the optic nerve.” Eye (Lond) 18(11):1182-7 Details Compston A (2004), “'The marvellous harmony of the nervous parts': the origins of multiple sclerosis.” Clin Med 4(4):346-54 Details Compston A (2004), “The pathogenesis and basis for treatment in multiple sclerosis.” Clin Neurol Neurosurg 106(3):246-8 Details Harbo HF, Lie BA, Sawcer S, Celius EG, Dai KZ, Oturai A, Hillert J, Lorentzen AR, Laaksonen M, Myhr KM, Ryder LP, Fredrikson S, Nyland H, Sørensen PS, Sandberg-Wollheim M, Andersen O, Svejgaard A, Edland A, Mellgren SI, Compston A, Vartdal F, Spurkland A (2004), “Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis.” Tissue Antigens 63(3):237-47 Details Joannides A, Gaughwin P, Schwiening C, Majed H, Sterling J, Compston A, Chandran S (2004), “Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells.” Lancet 364(9429):172-8 Details Sawcer SJ, Maranian M, Singlehurst S, Yeo T, Compston A, Daly MJ, De Jager PL, Gabriel S, Hafler DA, Ivinson AJ, Lander ES, Rioux JD, Walsh E, Gregory SG, Schmidt S, Pericak-Vance MA, Barcellos L, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL (2004), “Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping.” Hum Mol Genet 13(17):1943-9 Details Tait KF, Collins JE, Heward JM, Eaves I, Snook H, Franklyn JA, Barnett AH, Todd JA, Maranian M, Compston A, Sawcer S, Gough SC (2004), “Evidence for a Type 1 diabetes-specific mechanism for the insulin gene-associated IDDM2 locus rather than a general influence on autoimmunity.” Diabet Med 21(3):267-70 Details Wilkins A, Nikodemova M, Compston A, Duncan I (2004), “Minocycline attenuates nitric oxide-mediated neuronal and axonal destruction in vitro.” Neuron Glia Biol 1(3):297-305 Details Yeo TW, Maranian M, Singlehurst S, Gray J, Compston A, Sawcer S (2004), “Four single nucleotide polymorphisms from the vitamin D receptor gene in UK multiple sclerosis.” J Neurol 251(6):753-4 Details 2003Akesson E, Coraddu F, Marrosu MG, Massacesi L, Hensiek A, Harbo HF, Oturai A, Trojano M, Momigliano-Richiardi P, Cocco E, Murru R, Hillert J, Compston A, Sawcer S (2003), “Refining the linkage analysis on chromosome 10 in 449 sib-pairs with multiple sclerosis.” J Neuroimmunol 143(1-2):31-8 Details Alizadeh M, Génin E, Babron MC, Birebent B, Cournu-Rebeix I, Yaouanq J, Dréano S, Sawcer S, Compston A, Clanet M, Edan G, Fontaine B, Clerget-Darpoux F, Semana G, French Multiple Sclerosis Genetics Group (2003), “Genetic analysis of multiple sclerosis in Europeans: French data.” J Neuroimmunol 143(1-2):74-8 Details Ban M, Sawcer SJ, Heard RN, Bennetts BH, Adams S, Booth D, Perich V, Setakis E, Compston A, Stewart GJ (2003), “A genome-wide screen for linkage disequilibrium in Australian HLA-DRB1*1501 positive multiple sclerosis patients.” J Neuroimmunol 143(1-2):60-4 Details Bielecki B, Mycko MP, Tronczy?ska E, Bieniek M, Sawcer S, Setakis E, Benediktsson K, Compston A, Selmaj KW (2003), “A whole genome screen for association in Polish multiple sclerosis patients.” J Neuroimmunol 143(1-2):107-11 Details Chandran S, Kato H, Gerreli D, Compston A, Svendsen CN, Allen ND (2003), “FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway.” Development 130(26):6599-609 Details Coles A, Mukherjee M, Compston A (2003), “Case reports in The Lancet.” Lancet 361(9364):1230 Details Compston A (2003), “Revisiting The pathogenesis of multiple sclerosis revisited.” Int MS J 10(1):29-31 Details Coraddu F, Lai M, Mancosu C, Cocco E, Sawcer S, Setakis E, Compston A, Marrosu MG (2003), “A genome-wide screen for linkage disequilibrium in Sardinian multiple sclerosis.” J Neuroimmunol 143(1-2):120-3 Details Eraksoy M, Hensiek A, Kurtuncu M, Akman-Demir G, Kilinc M, Gedizlioglu M, Petek-Balci B, Anlar O, Kutlu C, Saruhan-Direskeneli G, Idrisoglu HA, Setakis E, Compston A, Sawcer S, Turkish Multiple Sclerosis Genetics Study Group (2003), “A genome screen for linkage disequilibrium in Turkish multiple sclerosis.” J Neuroimmunol 143(1-2):129-32 Details Eraksoy M, Kurtuncu M, Akman-Demir G, Kilinc M, Gedizlioglu M, Mirza M, Anlar O, Kutlu C, Demirkiran M, Idrisoglu HA, Compston A, Sawcer S, Turkish Multiple Sclerosis Genetics Study Group (2003), “A whole genome screen for linkage in Turkish multiple sclerosis.” J Neuroimmunol 143(1-2):17-24 Details Goertsches R, Villoslada P, Comabella M, Montalban X, Navarro A, de la Concha EG, Arroyo R, Lopez de Munain A, Otaegui D, Palacios R, Perez-Tur J, Jonasdottir A, Benediktsson K, Fossdal R, Sawcer S, Setakis E, Compston A, Spanish MS Genetics Group (2003), “A genomic screen of Spanish multiple sclerosis patients reveals multiple loci associated with the disease.” J Neuroimmunol 143(1-2):124-8 Details Golde S, Coles A, Lindquist JA, Compston A (2003), “Decreased iNOS synthesis mediates dexamethasone-induced protection of neurons from inflammatory injury in vitro.” Eur J Neurosci 18(9):2527-37 Details Goris A, Sawcer S, Vandenbroeck K, Carton H, Billiau A, Setakis E, Compston A, Dubois B (2003), “New candidate loci for multiple sclerosis susceptibility revealed by a whole genome association screen in a Belgian population.” J Neuroimmunol 143(1-2):65-9 Details Harbo HF, Datta P, Oturai A, Ryder LP, Sawcer S, Setakis E, Akesson E, Celius EG, Modin H, Sandberg-Wollheim M, Myhr KM, Andersen O, Hillert J, Sorensen PS, Svejgaard A, Compston A, Vartdal F, Spurkland A (2003), “Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients.” J Neuroimmunol 143(1-2):101-6 Details Heggarty S, Sawcer S, Hawkins S, McDonnell G, Droogan A, Vandenbroeck K, Hutchinson M, Setakis E, Compston A, Graham C (2003), “A genome wide scan for association with multiple sclerosis in a N. Irish case control population.” J Neuroimmunol 143(1-2):93-6 Details Hensiek AE, Roxburgh R, Meranian M, Seaman S, Yeo T, Compston DA, Sawcer SJ (2003), “Osteopontin gene and clinical severity of multiple sclerosis.” J Neurol 250(8):943-7 Details Hensiek AE, Roxburgh R, Smilie B, Coraddu F, Akesson E, Holmans P, Sawcer SJ, Compston DA (2003), “Updated results of the United Kingdom linkage-based genome screen in multiple sclerosis.” J Neuroimmunol 143(1-2):25-30 Details Hensiek AE, Sawcer SJ, Compston DA (2003), “Searching for needles in haystacks-the genetics of multiple sclerosis and other common neurological diseases.” Brain Res Bull 61(3):229-34 Details Joannides A, Gaughwin P, Scott M, Watt S, Compston A, Chandran S (2003), “Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells.” J Hematother Stem Cell Res 12(6):681-8 Details Jonasdottir A, Thorlacius T, Fossdal R, Jonasdottir A, Benediktsson K, Benedikz J, Jonsson HH, Sainz J, Einarsdottir H, Sigurdardottir S, Kristjansdottir G, Sawcer S, Compston A, Stefansson K, Gulcher J (2003), “A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers.” J Neuroimmunol 143(1-2):88-92 Details Laaksonen M, Jonasdottir A, Fossdal R, Ruutiainen J, Sawcer S, Compston A, Benediktsson K, Thorlacius T, Gulcher J, Ilonen J (2003), “A whole genome association study in Finnish multiple sclerosis patients with 3669 markers.” J Neuroimmunol 143(1-2):70-3 Details Liguori M, Sawcer S, Setakis E, Compston A, Giordano M, D'Alfonso S, Mellai M, Malferrari G, Trojano M, Livrea P, De Robertis F, Massacesi L, Repice A, Ballerini C, Biagioli T, Bomprezzi R, Cannoni S, Ristori G, Salvetti M, Grimaldi LM, Biunno I, Comi G, Leone M, Ferro I, Naldi P, Milanese C, Gellera C, Loredana LM, Savettieri G, Salemi G, Aridon P, Caputo D, Rosa Guerini F, Ferrante P, Momigliano-Richiardi P (2003), “A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population.” J Neuroimmunol 143(1-2):97-100 Details Martins Silva B, Thorlacius T, Benediktsson K, Pereira C, Fossdal R, Jonsson HH, Silva A, Leite I, Cerqueira J, Costa PP, Marta M, Foltynie T, Sawcer S, Compston A, Jonasdottir A (2003), “A whole genome association study in multiple sclerosis patients from north Portugal.” J Neuroimmunol 143(1-2):116-9 Details Muzaimi MB, Wiles CM, Robertson NP, Ravine D, Compston DA (2003), “Task specific focal dystonia: a presentation of spinocerebellar ataxia type 6.” J Neurol Neurosurg Psychiatry 74(10):1444-5 Details Nicholas R, Stevens S, Wing M, Compston A (2003), “Oligodendroglial-derived stress signals recruit microglia in vitro.” Neuroreport 14(7):1001-5 Details Rajda C, Bencsik K, Seres E, Jonasdottir A, Foltynie T, Sawcer S, Benediktsson K, Fossdal R, Setakis E, Compston A, Vécsei L (2003), “A genome-wide screen for association in Hungarian multiple sclerosis.” J Neuroimmunol 143(1-2):84-7 Details Santos M, Pinto-Basto J, Rio ME, Sá MJ, Valença A, Sá A, Dinis J, Figueiredo J, Bigotte de Almeida L, Coelho I, Sawcer S, Setakis E, Compston A, Sequeiros J, Maciel P (2003), “A whole genome screen for association with multiple sclerosis in Portuguese patients.” J Neuroimmunol 143(1-2):112-5 Details Sawcer S, Compston A (2003), “The genetic analysis of multiple sclerosis in Europeans: concepts and design.” J Neuroimmunol 143(1-2):13-6 Details Sawcer S, Maranian M, Hensiek A, Roxburgh R, Gray J, Compston A (2003), “Crohn's associated NOD2 gene variants are not involved in determining susceptibility to multiple sclerosis.” J Neurol Neurosurg Psychiatry 74(8):1157 Details Weber A, Infante-Duarte C, Sawcer S, Setakis E, Bellmann-Strobl J, Hensiek A, Rueckert S, Schoenemann C, Benediktsson K, Compston A, Zipp F (2003), “A genome-wide German screen for linkage disequilibrium in multiple sclerosis.” J Neuroimmunol 143(1-2):79-83 Details Wilkins A, Majed H, Layfield R, Compston A, Chandran S (2003), “Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor.” J Neurosci 23(12):4967-74 Details Yeo TW, Roxburgh R, Maranian M, Singlehurst S, Gray J, Hensiek A, Setakis E, Compston A, Sawcer S (2003), “Refining the analysis of a whole genome linkage disequilibrium association map: the United Kingdom results.” J Neuroimmunol 143(1-2):53-9 Details Zarei M, Chandran S, Compston A, Hodges J (2003), “Cognitive presentation of multiple sclerosis: evidence for a cortical variant.” J Neurol Neurosurg Psychiatry 74(7):872-7 Details 2002Akesson E, Oturai A, Berg J, Fredrikson S, Andersen O, Harbo HF, Laaksonen M, Myhr KM, Nyland HI, Ryder LP, Sandberg-Wollheim M, Sorensen PS, Spurkland A, Svejgaard A, Holmans P, Compston A, Hillert J, Sawcer S (2002), “A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis.” Genes Immun 3(5):279-85 Details Ban M, Stewart GJ, Bennetts BH, Heard R, Simmons R, Maranian M, Compston A, Sawcer SJ (2002), “A genome screen for linkage in Australian sibling-pairs with multiple sclerosis.” Genes Immun 3(8):464-9 Details Compston A, Coles A (2002), “Multiple sclerosis.” Lancet 359(9313):1221-31 Details Compston A, Davis JN (2002), “Brain denies being forbidding and insensitive to change.” BMJ 324(7345):1101 Details Compston A, Sawcer S (2002), “Genetic analysis of multiple sclerosis.” Curr Neurol Neurosci Rep 2(3):259-66 Details Goedde R, Sawcer S, Boehringer S, Miterski B, Sindern E, Haupts M, Schimrigk S, Compston A, Epplen JT (2002), “A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666 microsatellite markers.” Hum Genet 111(3):270-7 Details Golde S, Chandran S, Brown GC, Compston A (2002), “Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression.” J Neurochem 82(2):269-82 Details Hensiek AE, Sawcer SJ, Feakes R, Deans J, Mander A, Akesson E, Roxburgh R, Coraddu F, Smith S, Compston DA (2002), “HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis.” J Neurol Neurosurg Psychiatry 72(2):184-7 Details Hickman SJ, Brierley CM, Brex PA, MacManus DG, Scolding NJ, Compston DA, Miller DH (2002), “Continuing optic nerve atrophy following optic neuritis: a serial MRI study.” Mult Scler 8(4):339-42 Details Nicholas RS, Stevens S, Wing MG, Compston DA (2002), “Microglia-derived IGF-2 prevents TNFalpha induced death of mature oligodendrocytes in vitro.” J Neuroimmunol 124(1-2):36-44 Details Sawcer S, Maranian M, Setakis E, Curwen V, Akesson E, Hensiek A, Coraddu F, Roxburgh R, Sawcer D, Gray J, Deans J, Goodfellow PN, Walker N, Clayton D, Compston A (2002), “A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility.” Brain 125(Pt 6):1337-47 Details Zarei M, Collins VP, Chandran S, Valler D, Higgins JN, Compston DA, Yates JR (2002), “Tuberous sclerosis presenting in late adult life.” J Neurol Neurosurg Psychiatry 73(4):436-8 Details 2001Brierley CM, Crang AJ, Iwashita Y, Gilson JM, Scolding NJ, Compston DA, Blakemore WF (2001), “Remyelination of demyelinated CNS axons by transplanted human schwann cells: the deleterious effect of contaminating fibroblasts.” Cell Transplant 10(3):305-15 Details Broadley S, Sawcer S, D'Alfonso S, Hensiek A, Coraddu F, Gray J, Roxburgh R, Clayton D, Buttinelli C, Quattrone A, Trojano M, Massacesi L, Compston A (2001), “A genome screen for multiple sclerosis in Italian families.” Genes Immun 2(4):205-10 Details Broadley SA, Sawcer SJ, Chataway SJ, Coraddu F, Coles A, Gray J, Roxburgh R, Clayton D, Compston DA (2001), “No association between multiple sclerosis and the Notch3 gene responsible for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).” J Neurol Neurosurg Psychiatry 71(1):97-9 Details Chataway J, Mander A, Robertson N, Sawcer S, Deans J, Fraser M, Broadley S, Clayton D, Compston A (2001), “Multiple sclerosis in sibling pairs: an analysis of 250 families.” J Neurol Neurosurg Psychiatry 71(6):757-61 Details Coraddu F, Sawcer S, D'Alfonso S, Lai M, Hensiek A, Solla E, Broadley S, Mancosu C, Pugliatti M, Marrosu MG, Compston A (2001), “A genome screen for multiple sclerosis in Sardinian multiplex families.” Eur J Hum Genet 9(8):621-6 Details Hickman SJ, Brex PA, Brierley CM, Silver NC, Barker GJ, Scolding NJ, Compston DA, Moseley IF, Plant GT, Miller DH (2001), “Detection of optic nerve atrophy following a single episode of unilateral optic neuritis by MRI using a fat-saturated short-echo fast FLAIR sequence.” Neuroradiology 43(2):123-8 Details Hickman SJ, Brierley CM, Silver NC, Moseley IF, Scolding NJ, Compston DA, Miller DH (2001), “Infratentorial hypointense lesion volume on T1-weighted magnetic resonance imaging correlates with disability in patients with chronic cerebellar ataxia due to multiple sclerosis.” J Neurol Sci 187(1-2):35-9 Details Hupperts R, Broadley S, Mander A, Clayton D, Compston DA, Robertson NP (2001), “Patterns of disease in concordant parent-child pairs with multiple sclerosis.” Neurology 57(2):290-5 Details McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, McFarland HF, Paty DW, Polman CH, Reingold SC, Sandberg-Wollheim M, Sibley W, Thompson A, van den Noort S, Weinshenker BY, Wolinsky JS (2001), “Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis.” Ann Neurol 50(1):121-7 Details Merriman TR, Cordell HJ, Eaves IA, Danoy PA, Coraddu F, Barber R, Cucca F, Broadley S, Sawcer S, Compston A, Wordsworth P, Shatford J, Laval S, Jirholt J, Holmdahl R, Theofilopoulos AN, Kono DH, Tuomilehto J, Tuomilehto-Wolf E, Buzzetti R, Marrosu MG, Undlien DE, Rønningen KS, Ionesco-Tirgoviste C, Shield JP, Pociot F, Nerup J, Jacob CO, Polychronakos C, Bain SC, Todd JA (2001), “Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.” Diabetes 50(1):184-94 Details Miller A, Compston A, Martin R (2001), “The 15th Rappaport Symposium. Immune-mediated brain injury and repair: mechanisms and therapies. 15-16 June 2000, Haifa, Israel.” Isr Med Assoc J 3(3):233-6 Details Nicholas RS, Compston A, Brown DR (2001), “Inhibition of tumour necrosis factor-alpha (TNFalpha)-induced NF-kappaB p52 converts the metabolic effects of microglial-derived TNFalpha on mouse cerebellar neurones to neurotoxicity.” J Neurochem 76(5):1431-8 Details Nicholas RS, Wing MG, Compston A (2001), “Nonactivated microglia promote oligodendrocyte precursor survival and maturation through the transcription factor NF-kappa B.” Eur J Neurosci 13(5):959-67 Details Stangel M, Compston A (2001), “Polyclonal immunoglobulins (IVIg) modulate nitric oxide production and microglial functions in vitro via Fc receptors.” J Neuroimmunol 112(1-2):63-71 Details Wilkins A, Chandran S, Compston A (2001), “A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons.” Glia 36(1):48-57 Details 2000Broadley SA, Deans J, Chataway SJ, Sawcer SJ, Compston DA (2000), “Multiple sclerosis and tonsillectomy: no evidence for an influence on the development of disease or clinical phenotype.” Mult Scler 6(2):121-3 Details Broadley SA, Deans J, Sawcer SJ, Clayton D, Compston DA (2000), “Autoimmune disease in first-degree relatives of patients with multiple sclerosis. A UK survey.” Brain 123 ( Pt 6):1102-11 Details Compston A (2000), “The genetics of multiple sclerosis.” J Neurovirol 6 Suppl 2:S5-9 Details Compston A (2000), “The genetics of multiple sclerosis.” Clin Chem Lab Med 38(2):133-5 Details Feakes R, Sawcer S, Broadley S, Coraddu F, Roxburgh R, Gray J, Clayton D, Compston A (2000), “Interleukin 1 receptor antagonist (IL-1ra) in multiple sclerosis.” J Neuroimmunol 105(1):96-101 Details Feakes R, Sawcer S, Smillie B, Chataway J, Broadley S, Compston A (2000), “No evidence for the involvement of interleukin 2 or the immunoglobulin heavy chain gene cluster in determining genetic susceptibility to multiple sclerosis.” J Neurol Neurosurg Psychiatry 68(5):679 Details Stangel M, Compston A, Scolding NJ (2000), “Oligodendroglia are protected from antibody-mediated complement injury by normal immunoglobulins ("IVIg").” J Neuroimmunol 103(2):195-201 Details Stangel M, Joly E, Scolding NJ, Compston DA (2000), “Normal polyclonal immunoglobulins ('IVIg') inhibit microglial phagocytosis in vitro.” J Neuroimmunol 106(1-2):137-44 Details 1999Chataway J, Sawcer S, Coraddu F, Feakes R, Broadley S, Jones HB, Clayton D, Gray J, Goodfellow PN, Compston A (1999), “Evidence that allelic variants of the spinocerebellar ataxia type 2 gene influence susceptibility to multiple sclerosis.” Neurogenetics 2(2):91-6 Details Chataway J, Sawcer S, Feakes R, Coraddu F, Broadley S, Gray J, Compston A (1999), “More evidence that founder effects exist in the European population.” Eur J Hum Genet 7(6):623-4 Details Chataway J, Sawcer S, Feakes R, Coraddu F, Broadley S, Jones HB, Clayton D, Gray J, Goodfellow PN, Compston A (1999), “A screen of candidates from peaks of linkage: evidence for the involvement of myeloperoxidase in multiple sclerosis.” J Neuroimmunol 98(2):208-13 Details Chataway J, Sawcer S, Sherman D, Hobart M, Fernie B, Coraddu F, Feakes R, Broadley S, Gray J, Jones HB, Clayton D, Goodfellow PN, Compston A (1999), “No evidence for association of multiple sclerosis with the complement factors C6 and C7.” J Neuroimmunol 99(1):150-6 Details Coles AJ, Wing M, Smith S, Coraddu F, Greer S, Taylor C, Weetman A, Hale G, Chatterjee VK, Waldmann H, Compston A (1999), “Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis.” Lancet 354(9191):1691-5 Details Coles AJ, Wing MG, Molyneux P, Paolillo A, Davie CM, Hale G, Miller D, Waldmann H, Compston A (1999), “Monoclonal antibody treatment exposes three mechanisms underlying the clinical course of multiple sclerosis.” Ann Neurol 46(3):296-304 Details Compston A (1999), “The pathological anatomy of the lesion in multiple sclerosis.” Brain Res Bull 50(5-6):463-4 Details Compston A (1999), “The genetic epidemiology of multiple sclerosis.” Philos Trans R Soc Lond B Biol Sci 354(1390):1623-34 Details Compston A (1999), “Chance and design.” J Neurol 246(8):653 Details Compston A (1999), “Provision of treatment for multiple sclerosis.” Lancet 353(9165):1710-1 Details Feakes R, Sawcer S, Chataway J, Coraddu F, Broadley S, Gray J, Jones HB, Clayton D, Goodfellow PN, Compston A (1999), “Exploring the dense mapping of a region of potential linkage in complex disease: an example in multiple sclerosis.” Genet Epidemiol 17(1):51-63 Details Hall GL, Girdlestone J, Compston DA, Wing MG (1999), “Recall antigen presentation by gamma-interferon-activated microglia results in T cell activation and propagation of the immune response.” J Neuroimmunol 98(2):105-11 Details Hennessey A, Robertson NP, Swingler R, Compston DA (1999), “Urinary, faecal and sexual dysfunction in patients with multiple sclerosis.” J Neurol 246(11):1027-32 Details Paolillo A, Coles AJ, Molyneux PD, Gawne-Cain M, MacManus D, Barker GJ, Compston DA, Miller DH (1999), “Quantitative MRI in patients with secondary progressive MS treated with monoclonal antibody Campath 1H.” Neurology 53(4):751-7 Details Robertson NP, Compston DA, Kirkpatrick P (1999), “Moyamoya disease presenting as Valsalva related partial seizures.” J Neurol Neurosurg Psychiatry 66(1):111 Details Scolding NJ, Rayner PJ, Compston DA (1999), “Identification of A2B5-positive putative oligodendrocyte progenitor cells and A2B5-positive astrocytes in adult human white matter.” Neuroscience 89(1):1-4 Details Wing MG, Seilly DJ, Nicholas RS, Rahman S, Zajicek J, Lachmann PJ, Compston DA (1999), “Comparison of C1q-receptors on rat microglia and peritoneal macrophages.” J Neuroimmunol 94(1-2):74-81 Details 1998Chandran S, Svendsen C, Compston A, Scolding N (1998), “Regional potential for oligodendrocyte generation in the rodent embryonic spinal cord following exposure to EGF and FGF-2.” Glia 24(4):382-9 Details Chataway J, Feakes R, Coraddu F, Gray J, Deans J, Fraser M, Robertson N, Broadley S, Jones H, Clayton D, Goodfellow P, Sawcer S, Compston A (1998), “The genetics of multiple sclerosis: principles, background and updated results of the United Kingdom systematic genome screen.” Brain 121 ( Pt 10):1869-87 Details Coles AJ, Wing MG, Compston DA (1998), “Disease activity and the immune set in multiple sclerosis: blood markers for immunotherapy.” Mult Scler 4(3):232-8 Details Compston A (1998), “Future options for therapies to limit damage and enhance recovery.” Semin Neurol 18(3):405-14 Details Coraddu F, Reyes-Yanez MP, Parra A, Gray J, Smith SI, Taylor CJ, Compston DA (1998), “HLA associations with multiple sclerosis in the Canary Islands.” J Neuroimmunol 87(1-2):130-5 Details Coraddu F, Sawcer S, Feakes R, Chataway J, Broadley S, Jones HB, Clayton D, Gray J, Smith S, Taylor C, Goodfellow PN, Compston A (1998), “HLA typing in the United Kingdom multiple sclerosis genome screen.” Neurogenetics 2(1):24-33 Details Feakes R, Chataway J, Sawcer S, Jones HB, Clayton D, Goodfellow PN, Compston A (1998), “Susceptibility to multiple sclerosis and the immunoglobulin heavy chain gene cluster.” Ann Neurol 44(6):984 Details Kapoor R, Miller DH, Jones SJ, Plant GT, Brusa A, Gass A, Hawkins CP, Page R, Wood NW, Compston DA, Moseley IF, McDonald WI (1998), “Effects of intravenous methylprednisolone on outcome in MRI-based prognostic subgroups in acute optic neuritis.” Neurology 50(1):230-7 Details Malik O, Compston DA, Scolding NJ (1998), “Interferon-beta inhibits mitogen induced astrocyte proliferation in vitro.” J Neuroimmunol 86(2):155-62 Details O'Riordan JI, Gawne Cain M, Coles A, Wang L, Compston DA, Tofts P, Miller DH (1998), “T1 hypointense lesion load in secondary progressive multiple sclerosis: a comparison of pre versus post contrast loads and of manual versus semi automated threshold techniques for lesion segmentation.” Mult Scler 4(5):408-12 Details Robertson NP, Deans J, Compston DA (1998), “Myasthenia gravis: a population based epidemiological study in Cambridgeshire, England.” J Neurol Neurosurg Psychiatry 65(4):492-6 Details Robertson NP, Shaunak S, Compston DA (1998), “Urgent neurology out-patient referrals from primary health care physicians.” QJM 91(4):309-13 Details Scolding N, Franklin R, Stevens S, Heldin CH, Compston A, Newcombe J (1998), “Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis.” Brain 121 ( Pt 12):2221-8 Details Scolding NJ, Morgan BP, Compston DA (1998), “The expression of complement regulatory proteins by adult human oligodendrocytes.” J Neuroimmunol 84(1):69-75 Details Tubridy N, Coles AJ, Molyneux P, Compston DA, Barkhof F, Thompson AJ, McDonald WI, Miller DH (1998), “Secondary progressive multiple sclerosis: the relationship between short-term MRI activity and clinical features.” Brain 121 ( Pt 2):225-31 Details 1997Buss DC, Marshall RW, Milligan N, McQueen I, Compston DA, Routledge PA (1997), “The effect of intravenous aminophylline on essential tremor.” Br J Clin Pharmacol 43(1):119-21 Details Compston A (1997), “Genetic epidemiology of multiple sclerosis.” J Neurol Neurosurg Psychiatry 62(6):553-61 Details Compston A (1997), “Remyelination in multiple sclerosis: a challenge for therapy. The 1996 European Charcot Foundation Lecture.” Mult Scler 3(2):51-70 Details Compston A, Zajicek J, Sussman J, Webb A, Hall G, Muir D, Shaw C, Wood A, Scolding N (1997), “Glial lineages and myelination in the central nervous system.” J Anat 190 ( Pt 2):161-200 Details Hall GL, Compston A, Scolding NJ (1997), “Beta-interferon and multiple sclerosis.” Trends Neurosci 20(2):63-7 Details Hall GL, Wing MG, Compston DA, Scolding NJ (1997), “beta-Interferon regulates the immunomodulatory activity of neonatal rodent microglia.” J Neuroimmunol 72(1):11-9 Details Robertson NP, O'Riordan JI, Chataway J, Kingsley DP, Miller DH, Clayton D, Compston DA (1997), “Offspring recurrence rates and clinical characteristics of conjugal multiple sclerosis.” Lancet 349(9065):1587-90 Details Sawcer S, Goodfellow PN, Compston A (1997), “The genetic analysis of multiple sclerosis.” Trends Genet 13(6):234-9 Details Sawcer S, Jones HB, Judge D, Visser F, Compston A, Goodfellow PN, Clayton D (1997), “Empirical genomewide significance levels established by whole genome simulations.” Genet Epidemiol 14(3):223-9 Details Williamson AV, Compston DA, Randall AD (1997), “Analysis of the ion channel complement of the rat oligodendrocyte progenitor in a commonly studied in vitro preparation.” Eur J Neurosci 9(4):706-20 Details 1996Compston A (1996), “Calman cometh.” J R Coll Physicians Lond 30(6):587-8 Details Compston A (1996), “Remyelination of the central nervous system.” Mult Scler 1(6):388-92 Details Moreau T, Coles A, Wing M, Isaacs J, Hale G, Waldmann H, Compston A (1996), “Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis.” Brain 119 ( Pt 1):225-37 Details Moreau T, Coles A, Wing M, Thorpe J, Miller D, Moseley I, Issacs J, Hale G, Clayton D, Scolding N, Waldmann H, Compston A (1996), “CAMPATH-IH in multiple sclerosis.” Mult Scler 1(6):357-65 Details Muir DA, Compston DA (1996), “Growth factor stimulation triggers apoptotic cell death in mature oligodendrocytes.” J Neurosci Res 44(1):1-11 Details Robertson N, Deans J, Fraser M, Compston DA (1996), “Multiple sclerosis in south Cambridgeshire: incidence and prevalence based on a district register.” J Epidemiol Community Health 50(3):274-9 Details Robertson NP, Clayton D, Fraser M, Deans J, Compston DA (1996), “Clinical concordance in sibling pairs with multiple sclerosis.” Neurology 47(2):347-52 Details Robertson NP, Fraser M, Deans J, Clayton D, Walker N, Compston DA (1996), “Age-adjusted recurrence risks for relatives of patients with multiple sclerosis.” Brain 119 ( Pt 2):449-55 Details Sawcer S, Jones HB, Feakes R, Gray J, Smaldon N, Chataway J, Robertson N, Clayton D, Goodfellow PN, Compston A (1996), “A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22.” Nat Genet 13(4):464-8 Details Shaw CE, Milner R, Compston AS, ffrench-Constant C (1996), “Analysis of integrin expression on oligodendrocytes during axo-glial interaction by using rat-mouse xenocultures.” J Neurosci 16(3):1163-72 Details Targett MP, Sussman J, Scolding N, O'Leary MT, Compston DA, Blakemore WF (1996), “Failure to achieve remyelination of demyelinated rat axons following transplantation of glial cells obtained from the adult human brain.” Neuropathol Appl Neurobiol 22(3):199-206 Details Thorpe JW, Kidd D, Moseley IF, Thompson AJ, MacManus DG, Compston DA, McDonald WI, Miller DH (1996), “Spinal MRI in patients with suspected multiple sclerosis and negative brain MRI.” Brain 119 ( Pt 3):709-14 Details Wing MG, Moreau T, Greenwood J, Smith RM, Hale G, Isaacs J, Waldmann H, Lachmann PJ, Compston A (1996), “Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells.” J Clin Invest 98(12):2819-26 Details 1995Chalmers RM, Robertson N, Kellar-Wood H, Compston DA, Harding AE (1995), “Sequence of the human homologue of a mitochondrially encoded murine transplantation antigen in patients with multiple sclerosis.” J Neurol 242(5):332-4 Details Compston A (1995), “Beta-Interferon and multiple sclerosis: not a final solution to the problem.” Br J Hosp Med 53(11):547-9, 551, 553 Details Compston A (1995), “Brain repair.” J Intern Med 237(2):127-34 Details Compston DA, Kellar Wood H, Robertson N, Sawcer S, Wood NW (1995), “Genes and susceptibility to multiple sclerosis.” Acta Neurol Scand Suppl 161:43-51 Details Filippi M, Paty DW, Kappos L, Barkhof F, Compston DA, Thompson AJ, Zhao GJ, Wiles CM, McDonald WI, Miller DH (1995), “Correlations between changes in disability and T2-weighted brain MRI activity in multiple sclerosis: a follow-up study.” Neurology 45(2):255-60 Details Kellar-Wood HF, Wood NW, Holmans P, Clayton D, Robertson N, Compston DA (1995), “Multiple sclerosis and the HLA-D region: linkage and association studies.” J Neuroimmunol 58(2):183-90 Details Luxton RW, Zeman A, Holzel H, Harvey P, Wilson J, Kocen R, Morgan-Hughes J, Miller DH, Compston A, Thompson EJ (1995), “Affinity of antigen-specific IgG distinguishes multiple sclerosis from encephalitis.” J Neurol Sci 132(1):11-9 Details Robertson N, Compston A (1995), “Surveying multiple sclerosis in the United Kingdom.” J Neurol Neurosurg Psychiatry 58(1):2-6 Details Robertson N, Deans J, Fraser M, Compston DA (1995), “Multiple sclerosis in the north Cambridgeshire districts of East Anglia.” J Neurol Neurosurg Psychiatry 59(1):71-6 Details Scolding NJ, Compston DA (1995), “Growth factors fail to protect rat oligodendrocytes against humoral injury in vitro.” Neurosci Lett 183(1-2):75-8 Details Scolding NJ, Rayner PJ, Sussman J, Shaw C, Compston DA (1995), “A proliferative adult human oligodendrocyte progenitor.” Neuroreport 6(3):441-5 Details Webb A, Clark P, Skepper J, Compston A, Wood A (1995), “Guidance of oligodendrocytes and their progenitors by substratum topography.” J Cell Sci 108 ( Pt 8):2747-60 Details Wing MG, Waldmann H, Isaacs J, Compston DA, Hale G (1995), “Ex-vivo whole blood cultures for predicting cytokine-release syndrome: dependence on target antigen and antibody isotype.” Ther Immunol 2(4):183-90 Details Wood NW, Sawcer SJ, Kellar-Wood HF, Holmans P, Clayton D, Robertson N, Compston DA (1995), “Susceptibility to multiple sclerosis and the immunoglobulin heavy chain variable region.” J Neurol 242(10):677-82 Details Wood NW, Sawcer SJ, Kellar-Wood HF, Holmans P, Clayton D, Robertson N, Compston DA (1995), “The T-cell receptor beta locus and susceptibility to multiple sclerosis.” Neurology 45(10):1859-63 Details Zajicek J, Compston A (1995), “Mechanisms of damage and repair in multiple sclerosis--a review.” Mult Scler 1(2):61-72 Details Zajicek J, Wing M, Skepper J, Compston A (1995), “Human oligodendrocytes are not sensitive to complement. A study of CD59 expression in the human central nervous system.” Lab Invest 73(1):128-38 Details 1994Compston A (1994), “The epidemiology of multiple sclerosis: principles, achievements, and recommendations.” Ann Neurol 36 Suppl 2:S211-7 Details Compston A (1994), “Brain repair: an overview.” J Neurol 242(1 Suppl 1):S1-4 Details Compston A (1994), “Brain repair.” J R Coll Physicians Lond 28(2):107-20 Details Compston A (1994), “Future prospects for the management of multiple sclerosis.” Ann Neurol 36 Suppl:S146-50 Details Compston A, Kellar-Wood H, Wood N (1994), “Multiple sclerosis.” Baillieres Clin Neurol 3(2):353-71 Details Eoli M, Wood NW, Kellar-Wood HF, Holmans P, Clayton D, Compston DA (1994), “No linkage between multiple sclerosis and the T cell receptor alpha chain locus.” J Neurol Sci 124(1):32-7 Details Ginsberg L, Compston DA (1994), “Acute encephalopathy: diagnosis and outcome in patients at a regional neurological unit.” Q J Med 87(3):169-80 Details Kellar-Wood H, Robertson N, Govan GG, Compston DA, Harding AE (1994), “Leber's hereditary optic neuropathy mitochondrial DNA mutations in multiple sclerosis.” Ann Neurol 36(1):109-12 Details Kellar-Wood HF, Powis SH, Gray J, Compston DA (1994), “MHC-encoded TAP1 and TAP2 dimorphisms in multiple sclerosis.” Tissue Antigens 43(2):129-32 Details Kirk PF, Williams JD, Petersen MM, Compston DA (1994), “The effect of methylprednisolone on monocyte eicosanoid production in patients with multiple sclerosis.” J Neurol 241(7):427-31 Details Milligan NM, Miller DH, Compston DA (1994), “A placebo-controlled trial of isoprinosine in patients with multiple sclerosis.” J Neurol Neurosurg Psychiatry 57(2):164-8 Details Moreau T, Thorpe J, Miller D, Moseley I, Hale G, Waldmann H, Clayton D, Wing M, Scolding N, Compston A (1994), “Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis.” Lancet 344(8918):298-301 Details Mumford CJ, Wood NW, Kellar-Wood H, Thorpe JW, Miller DH, Compston DA (1994), “The British Isles survey of multiple sclerosis in twins.” Neurology 44(1):11-5 Details Roddy J, Clark I, Hazleman BL, Compston DA, Scolding NJ (1994), “Cerebrospinal fluid concentrations of the complement MAC inhibitor CD59 in multiple sclerosis and patients with other neurological disorders.” J Neurol 241(9):557-60 Details Scolding NJ, Zajicek JP, Wood N, Compston DA (1994), “The pathogenesis of demyelinating disease.” Prog Neurobiol 43(2):143-73 Details Sussman J, Compston DA (1994), “Subacute sclerosing panencephalitis in Wales.” Q J Med 87(1):23-34 Details Thorpe JW, Mumford CJ, Compston DA, Kendall BE, MacManus DG, McDonald WI, Miller DH (1994), “British Isles survey of multiple sclerosis in twins: MRI.” J Neurol Neurosurg Psychiatry 57(4):491-6 Details Wood NW, Holmans P, Clayton D, Robertson N, Compston DA (1994), “No linkage or association between multiple sclerosis and the myelin basic protein gene in affected sibling pairs.” J Neurol Neurosurg Psychiatry 57(10):1191-4 Details Zajicek J, Compston A (1994), “Myelination in vitro of rodent dorsal root ganglia by glial progenitor cells.” Brain 117 ( Pt 6):1333-50 Details 1993Compston A (1993), “Limiting and repairing the damage in multiple sclerosis.” Schweiz Med Wochenschr 123(22):1145-52 Details Compston A (1993), “Inflammation and the brain.” Mol Chem Neuropathol 19(1-2):47-64 Details Martyn CN, Cruddas M, Compston DA (1993), “Symptomatic Epstein-Barr virus infection and multiple sclerosis.” J Neurol Neurosurg Psychiatry 56(2):167-8 Details Mumford CJ, Compston A (1993), “Problems with rating scales for multiple sclerosis: a novel approach--the CAMBS score.” J Neurol 240(4):209-15 Details Wood A, Wing MG, Benham CD, Compston DA (1993), “Specific induction of intracellular calcium oscillations by complement membrane attack on oligodendroglia.” J Neurosci 13(8):3319-32 Details 1992Compston A (1992), “Reviewing multiple sclerosis.” Postgrad Med J 68(801):507-16 Details Compston A (1992), “Cellular organisation of the optic nerve and the implications for optic neuritis.” Eye (Lond) 6 ( Pt 2):123-8 Details Compston A, Sadovnick AD (1992), “Epidemiology and genetics of multiple sclerosis.” Curr Opin Neurol Neurosurg 5(2):175-81 Details Confavreux C, Compston DA, Hommes OR, McDonald WI, Thompson AJ (1992), “EDMUS, a European database for multiple sclerosis.” J Neurol Neurosurg Psychiatry 55(8):671-6 Details Harding AE, Sweeney MG, Miller DH, Mumford CJ, Kellar-Wood H, Menard D, McDonald WI, Compston DA (1992), “Occurrence of a multiple sclerosis-like illness in women who have a Leber's hereditary optic neuropathy mitochondrial DNA mutation.” Brain 115 ( Pt 4):979-89 Details Mumford CJ, Fraser MB, Wood NW, Compston DA (1992), “Multiple sclerosis in the Cambridge health district of east Anglia.” J Neurol Neurosurg Psychiatry 55(10):877-82 Details Scolding NJ, Morgan BP, Campbell AK, Compston DA (1992), “The role of calcium in rat oligodendrocyte injury and repair.” Neurosci Lett 135(1):95-8 Details Swingler RJ, Compston DA (1992), “The morbidity of multiple sclerosis.” Q J Med 83(300):325-37 Details Wing MG, Zajicek J, Seilly DJ, Compston DA, Lachmann PJ (1992), “Oligodendrocytes lack glycolipid anchored proteins which protect them against complement lysis. Restoration of resistance to lysis by incorporation of CD59.” Immunology 76(1):140-5 Details Zajicek J, Wing MG, Lachmann PJ, Compston DA (1992), “Mechanisms of oligodendrocyte interaction with normal human serum--defining the role of complement.” J Neurol Sci 108(1):65-72 Details Zajicek JP, Wing M, Scolding NJ, Compston DA (1992), “Interactions between oligodendrocytes and microglia. A major role for complement and tumour necrosis factor in oligodendrocyte adherence and killing.” Brain 115 ( Pt 6):1611-31 Details 1991Compston A (1991), “Limiting and repairing the damage in multiple sclerosis.” J Neurol Neurosurg Psychiatry 54(11):945-8 Details Compston A, Scolding N, Wren D, Noble M (1991), “The pathogenesis of demyelinating disease: insights from cell biology.” Trends Neurosci 14(5):175-82 Details Compston DA, Scolding NJ (1991), “Immune-mediated oligodendrocyte injury.” Ann N Y Acad Sci 633:196-204 Details Jones J, Frith S, Piddlesden S, Morgan BP, Compston DA, Campbell AK, Hallett MB (1991), “Imaging Ca2+ changes in individual oligodendrocytes attacked by T-cell perforin.” Immunology 74(4):572-7 Details Pope FM, Kendall BE, Slapak GI, Kapoor R, McDonald WI, Compston DA, Mitchell R, Hope DT, Millar-Craig MW, Dean JC (1991), “Type III collagen mutations cause fragile cerebral arteries.” Br J Neurosurg 5(6):551-74 Details Scolding NJ, Compston DA (1991), “Oligodendrocyte-macrophage interactions in vitro triggered by specific antibodies.” Immunology 72(1):127-32 Details 1990Compston A (1990), “Risk factors for multiple sclerosis: race or place?” J Neurol Neurosurg Psychiatry 53(10):821-3 Details Compston DA (1990), “The dissemination of multiple sclerosis. The Langdon-Brown lecture 1989.” J R Coll Physicians Lond 24(3):207-18 Details Kirk P, Compston A (1990), “The effect of methylprednisolone on lymphocyte phenotype and function in patients with multiple sclerosis.” J Neuroimmunol 26(1):1-8 Details Scolding NJ, Jones J, Compston DA, Morgan BP (1990), “Oligodendrocyte susceptibility to injury by T-cell perforin.” Immunology 70(1):6-10 Details Scolding NJ, Morgan BP, Campbell AK, Compston DA (1990), “Complement mediated serum cytotoxicity against oligodendrocytes: a comparison with other cells of the oligodendrocyte-type 2 astrocyte lineage.” J Neurol Sci 97(2-3):155-62 Details Swingler RJ, Compston DA (1990), “Demographic characteristics of multiple sclerosis in south east Wales.” Neuroepidemiology 9(2):68-77 Details White AD, Swingler RJ, Compston DA (1990), “Features of multiple sclerosis in older patients in South Wales.” Gerontology 36(3):159-64 Details 1989Campbell AK, Patel A, Houston WA, Scolding NJ, Frith S, Morgan BP, Compston DA (1989), “Photoproteins as indicators of intracellular free Ca2+.” J Biolumin Chemilumin 4(1):463-74 Details Compston DA (1989), “The management of multiple sclerosis.” Q J Med 70(262):93-101 Details Compston DA, Morgan BP, Campbell AK, Wilkins P, Cole G, Thomas ND, Jasani B (1989), “Immunocytochemical localization of the terminal complement complex in multiple sclerosis.” Neuropathol Appl Neurobiol 15(4):307-16 Details Compston DA, Swingler RJ (1989), “Overestimated disease duration.” J Neurol Neurosurg Psychiatry 52(11):1312 Details Hennessy A, Swingler RJ, Compston DA (1989), “The incidence and mortality of multiple sclerosis in south east Wales.” J Neurol Neurosurg Psychiatry 52(9):1085-9 Details Hughes PJ, Kirk PF, Compston DA (1989), “Dual labelling of circulating CD8 cells in patients with multiple sclerosis.” J Neurol Neurosurg Psychiatry 52(1):118-21 Details Huson SM, Compston DA, Clark P, Harper PS (1989), “A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity.” J Med Genet 26(11):704-11 Details Huson SM, Compston DA, Harper PS (1989), “A genetic study of von Recklinghausen neurofibromatosis in south east Wales. II. Guidelines for genetic counselling.” J Med Genet 26(11):712-21 Details Kesselring J, Miller DH, MacManus DG, Johnson G, Milligan NM, Scolding N, Compston DA, McDonald WI (1989), “Quantitative magnetic resonance imaging in multiple sclerosis: the effect of high dose intravenous methylprednisolone.” J Neurol Neurosurg Psychiatry 52(1):14-7 Details Linington C, Lassmann H, Morgan BP, Compston DA (1989), “Immunohistochemical localisation of terminal complement component C9 in experimental allergic encephalomyelitis.” Acta Neuropathol 79(1):78-85 Details Linington C, Morgan BP, Scolding NJ, Wilkins P, Piddlesden S, Compston DA (1989), “The role of complement in the pathogenesis of experimental allergic encephalomyelitis.” Brain 112 ( Pt 4):895-911 Details Lunt PW, Compston DA, Harper PS (1989), “Estimation of age dependent penetrance in facioscapulohumeral muscular dystrophy by minimising ascertainment bias.” J Med Genet 26(12):755-60 Details Scolding N, Linington C, Compston A (1989), “Immune mechanisms in the pathogenesis of demyelinating diseases.” Autoimmunity 4(1-2):131-42 Details Scolding NJ, Frith S, Linington C, Morgan BP, Campbell AK, Compston DA (1989), “Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation.” J Neuroimmunol 22(3):169-76 Details Scolding NJ, Houston WA, Morgan BP, Campbell AK, Compston DA (1989), “Reversible injury of cultured rat oligodendrocytes by complement.” Immunology 67(4):441-6 Details Scolding NJ, Morgan BP, Houston A, Campbell AK, Linington C, Compston DA (1989), “Normal rat serum cytotoxicity against syngeneic oligodendrocytes. Complement activation and attack in the absence of anti-myelin antibodies.” J Neurol Sci 89(2-3):289-300 Details Scolding NJ, Morgan BP, Houston WA, Linington C, Campbell AK, Compston DA (1989), “Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement.” Nature 339(6226):620-2 Details 1988Compston A (1988), “The 150th anniversary of the first depiction of the lesions of multiple sclerosis.” J Neurol Neurosurg Psychiatry 51(10):1249-52 Details Compston A (1988), “Methylprednisolone and multiple sclerosis.” Arch Neurol 45(6):669-70 Details Fox R, Pope FM, Narcisi P, Nicholls AC, Kendall BE, Hourihan MD, Compston DA (1988), “Spontaneous carotid cavernous fistula in Ehlers Danlos syndrome.” J Neurol Neurosurg Psychiatry 51(7):984-6 Details Hughes PJ, Compston DA (1988), “Peripheral blood lymphocyte phenotype and function in multiple sclerosis.” J Neurol Neurosurg Psychiatry 51(9):1187-92 Details Huson SM, Harper PS, Compston DA (1988), “Von Recklinghausen neurofibromatosis. A clinical and population study in south-east Wales.” Brain 111 ( Pt 6):1355-81 Details Panicker R, Bloom AL, Compston DA (1988), “Inflammatory demyelinating polyneuropathy in a haemophiliac associated with human immunodeficiency virus infection, responding to high dose intravenous immunoglobulin.” Postgrad Med J 64(755):699-700 Details Pope FM, Nicholls AC, Narcisi P, Temple A, Chia Y, Fryer P, De Paepe A, De Groote WP, McEwan JR, Compston DA (1988), “Type III collagen mutations in Ehlers Danlos syndrome type IV and other related disorders.” Clin Exp Dermatol 13(5):285-302 Details Swingler RJ, Compston DA (1988), “The prevalence of multiple sclerosis in south east Wales.” J Neurol Neurosurg Psychiatry 51(12):1520-4 Details 1987Alvord EC Jr, Jahnke U, Fischer EH, Kies MW, Driscoll BF, Compston DA (1987), “The multiple causes of multiple sclerosis: the importance of age of infections in childhood.” J Child Neurol 2(4):313-21 Details Compston A (1987), “Selection of patients for clinical trials.” Neuroepidemiology 6(1-2):34-9 Details Compston DA, Milligan NM, Hughes PJ, Gibbs J, McBroom V, Morgan BP, Campbell AK (1987), “A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: 2. Laboratory results.” J Neurol Neurosurg Psychiatry 50(5):517-22 Details Francis DA, Compston DA, Batchelor JR, McDonald WI (1987), “A reassessment of the risk of multiple sclerosis developing in patients with optic neuritis after extended follow-up.” J Neurol Neurosurg Psychiatry 50(6):758-65 Details Hughes PJ, Kirk PF, Dyas J, Munro JA, Welsh KI, Compston DA (1987), “Factors influencing circulating OKT8 cell phenotypes in patients with multiple sclerosis.” J Neurol Neurosurg Psychiatry 50(9):1156-9 Details Milligan NM, Newcombe R, Compston DA (1987), “A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: 1. Clinical effects.” J Neurol Neurosurg Psychiatry 50(5):511-6 Details Swingler RJ, Hughes PJ, Munro JA, Compston DA (1987), “Human T-cell lymphotrophic viruses in patients with multiple sclerosis.” J Neurol 234(6):234 Details Swingler RJ, Kirk PF, Darke C, Compston DA (1987), “HLA and multiple sclerosis in south east Wales.” J Neurol Neurosurg Psychiatry 50(9):1153-5 Details 1986Compston A (1986), “The modern management of multiple sclerosis.” Br J Hosp Med 36(3):200-1, 204-8 Details Compston DA, Morgan BP, Oleesky D, Fifield R, Campbell AK (1986), “Cerebrospinal fluid C9 in demyelinating disease.” Neurology 36(11):1503-6 Details Compston DA, Vakarelis BN, Paul E, McDonald WI, Batchelor JR, Mims CA (1986), “Viral infection in patients with multiple sclerosis and HLA-DR matched controls.” Brain 109 ( Pt 2):325-44 Details Hughes PJ, Kirk PF, Compston DA (1986), “Suppressor T cells in family members of patients with multiple sclerosis.” Brain 109 ( Pt 5):969-85 Details Huson SM, Harper PS, Hourihan MD, Cole G, Weeks RD, Compston DA (1986), “Cerebellar haemangioblastoma and von Hippel-Lindau disease.” Brain 109 ( Pt 6):1297-310 Details Huson SM, Meredith AL, Sarfarazi M, Shaw DJ, Brook D, Compston DA, Harper PS (1986), “Evidence against linkage of von Recklinghausen neurofibromatosis and chromosome 19 markers.” Ann N Y Acad Sci 486:349-53 Details Huson SM, Meredith AL, Sarfarazi M, Shaw DJ, Compston DA, Harper PS (1986), “Linkage analysis of peripheral neurofibromatosis (Von Recklinghausen disease) and chromosome 19 markers linked to myotonic dystrophy.” J Med Genet 23(1):55-7 Details Swingler RJ, Compston D (1986), “The distribution of multiple sclerosis in the United Kingdom.” J Neurol Neurosurg Psychiatry 49(10):1115-24 Details Wroe S, Richens A, Compston A (1986), “Bilateral ballistic movements occurring as a late complication of hemispherectomy and responding to sulpiride.” J Neurol 233(5):315-6 Details 1985Farquharson RG, Compston A, Bloom AL (1985), “Lupus anticoagulant: a place for pre-pregnancy treatment?” Lancet 2(8459):842-3 Details 1984Compston DA, Hughes PJ (1984), “Peripheral blood lymphocyte sub-populations and multiple sclerosis.” J Neuroimmunol 6(2):105-14 Details Morgan BP, Campbell AK, Compston DA (1984), “Terminal component of complement (C9) in cerebrospinal fluid of patients with multiple sclerosis.” Lancet 2(8397):251-4 Details 1983Compston A (1983), “Lymphocyte subpopulations in patients with multiple sclerosis.” J Neurol Neurosurg Psychiatry 46(2):105-14 Details 1982Compston A, Howard S (1982), “HLA typing in multiple sclerosis.” Lancet 2(8299):661 Details Lees AJ, Stern GM, Compston DA (1982), “Histocompatibility antigens and post-encephalitic Parkinsonism.” J Neurol Neurosurg Psychiatry 45(11):1060-1 Details Mertin J, Rudge P, Kremer M, Healey MJ, Knight SC, Compston A, Batchelor JR, Thompson EJ, Halliday AM, Denman M, Medawar PB (1982), “Double-blind controlled trial of immunosuppression in the treatment of multiple sclerosis: final report.” Lancet 2(8294):351-4 Details 1981Compston A (1981), “Multiple sclerosis in the Orkneys.” Lancet 2(8237):98 Details Fielder AH, Batchelor JR, Vakarelis BN, Compston DA, McDonald WI (1981), “Optic neuritis and multiple sclerosis: do factor B alleles influence progression of disease?” Lancet 2(8258):1246-8 Details 1980Compston DA, Vincent A, Newsom-Davis J, Batchelor JR (1980), “Clinical, pathological, HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis.” Brain 103(3):579-601 Details 1978Batchelor JR, Compston A, McDonald WI (1978), “The significance of the association between HLA and multiple sclerosis.” Br Med Bull 34(3):279-84 Details Compston A (1978), “HLA and neurologic disease.” Neurology 28(5):413-4 Details Compston DA, Batchelor JR, Earl CJ, McDonald WI (1978), “Factors influencing the risk of multiple sclerosis developing in patients with optic neuritis.” Brain 101(3):495-511 Details Rees AJ, Peters DK, Compston DA, Batchelor JR (1978), “Strong association between HLA-DRW2 and antibody-mediated Goodpasture's syndrome.” Lancet 1(8071):966-8 Details 1976Compston DA, Batchelor JR, McDonald WI (1976), “B-lymphocyte alloantigens associated with multiple sclerosis.” Lancet 2(7998):1261-5 Details McComish M, Compston A, Jewitt D (1976), “Cardiac abnormalities in chronic progressive external ophthalmoplegia.” Br Heart J 38(5):526-9 Details |