Dr Abhishekh Ashok MBBS PhD![]() University positionAcademic Clinical Fellow DepartmentsInstitutesResearch ThemesInterestsI am an academic clinical fellow in Radiology. My research interest include developing novel neuroimaging techniques to understand the molecular process underlying physiological and pathological states of brain. My research uses novel MRI technique and positron emission tomographic (PET) radioligands in vitro and in vivo. I am working closely with molecular imaging chemistry laboratory of Prof Franklin Aigbirhio. Currently, in collaboration with Prof John O’Brien I am working on a project to investigate molecular mechanisms in dementia. Research Focus
EquipmentMagnetic resonance imaging (MRI) Positron Emission Tomography (PET) Collaborators
Associated News ItemsKey publicationsErritzoe D, Ashok AH, Searle GE, Colasanti A, Turton S, Lewis Y, Huiban M, Moz S, Passchier J, Saleem A, Beaver J, Lingford-Hughes A, Nutt DJ, Howes OD, Gunn RN, Knudsen GM, Rabiner EA (2020), “Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge” Neuropsychopharmacology 45(5):804-810 Marques TR, Ashok AH, Angelescu I, Borgan F, Myers J, Lingford-Hughes A, Nutt DJ, Veronese M, Turkheimer FE, Howes OD (2020), “GABA-A receptor differences in schizophrenia: a positron emission tomography study using [11C]Ro154513” Molecular Psychiatry Ashok AH, Myers J, Reis Marques T, Rabiner EA, Howes OD (2019), “Reduced mu opioid receptor availability in schizophrenia revealed with [11C]-carfentanil positron emission tomographic Imaging. ” Nature Communication 10(1):4493 Ashok AH, Marques TR, Jauhar S, Nour MM, Goodwin GM, Young AH, Howes OD (2017), “The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment” Molecular Psychiatry 22(5):666-679 Ashok AH, Mizuno Y, Volkow ND, Howes OD (2017), “Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-analysis” JAMA Psychiatry 74(5):511-519 Bloomfield MA, Ashok AH, Volkow ND, Howes OD (2016), “The effects of Δ 9-tetrahydrocannabinol on the dopamine system” Nature 539(7629):369-377 Publications2021Ashok AH, Myers J, Frost G, Turton S, Gunn RN, Passchier J, Colasanti A, Marques TR, Nutt D, Lingford-Hughes A, Howes OD, Rabiner EA (2021), “Acute acetate administration increases endogenous opioid levels in the human brain: A [11C]carfentanil molecular imaging study” J Psychopharmacol 35(5):606-610 Rogdaki M, Devroye C, Ciampoli M, Veronese M, Ashok AH, McCutcheon RA, Jauhar S, Bonoldi I, Gudbrandsen M, Daly E, van Amelsvoort T, Van Den Bree M, Owen MJ, Turkheimer F, Papaleo F, Howes OD (2021), “Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study” Mol Psychiatry PMID: 33981004 DOI: 10.1038/s41380-021-01108-y 2019Marques TR, Ashok AH, Pillinger T, Veronese M, Turkheimer FE, Dazzan P, Sommer IEC, Howes OD (2019), “Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies” Psychol Med 49(13):2186-2196 2018Plavén-Sigray P, Matheson GJ, Collste K, Ashok AH, Coughlin JM, Howes OD, Mizrahi R, Pomper MG, Rusjan P, Veronese M, Wang Y, Cervenka S (2018), “Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data” Biol Psychiatry 84(6):433-442 |