Dr Abhishekh Ashok MBBS PhD


University position

Academic Clinical Fellow

Departments

Department of Radiology

Institutes

Wolfson Brain Imaging Centre

Email

aa2185@cam.ac.uk

Research Themes

Clinical and Veterinary Neuroscience

Cellular and Molecular Neuroscience

Interests

I am an academic clinical fellow in Radiology. My research interest include developing novel neuroimaging techniques to understand the molecular process underlying physiological and pathological states of brain. My research uses novel MRI technique and positron emission tomographic (PET) radioligands in vitro and in vivo. I am working closely with molecular imaging chemistry laboratory of Prof Franklin Aigbirhio. Currently, in collaboration with Prof John O’Brien I am working on a project to investigate molecular mechanisms in dementia.

Research Focus

Keywords

Positron emission tomography

MRI

Dementia

Neurosciences

Clinical conditions

Alzheimer's disease

Equipment

Magnetic resonance imaging (MRI)

Positron Emission Tomography (PET)

Collaborators

Cambridge

Franklin Aigbirhio

Ferdia Gallagher

Tomasz Matys

John O'Brien

Associated News Items


    Key publications

    Erritzoe D, Ashok AH, Searle GE, Colasanti A, Turton S, Lewis Y, Huiban M, Moz S, Passchier J, Saleem A, Beaver J, Lingford-Hughes A, Nutt DJ, Howes OD, Gunn RN, Knudsen GM, Rabiner EA (2020), “Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge” Neuropsychopharmacology 45(5):804-810

    Marques TR, Ashok AH, Angelescu I, Borgan F, Myers J, Lingford-Hughes A, Nutt DJ, Veronese M, Turkheimer FE, Howes OD (2020), “GABA-A receptor differences in schizophrenia: a positron emission tomography study using [11C]Ro154513” Molecular Psychiatry

    Ashok AH, Myers J, Reis Marques T, Rabiner EA, Howes OD (2019), “Reduced mu opioid receptor availability in schizophrenia revealed with [11C]-carfentanil positron emission tomographic Imaging. ” Nature Communication 10(1):4493

    Ashok AH, Marques TR, Jauhar S, Nour MM, Goodwin GM, Young AH, Howes OD (2017), “The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment” Molecular Psychiatry 22(5):666-679

    Ashok AH, Mizuno Y, Volkow ND, Howes OD (2017), “Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine: A Systematic Review and Meta-analysis” JAMA Psychiatry 74(5):511-519

    Bloomfield MA, Ashok AH, Volkow ND, Howes OD (2016), “The effects of Δ 9-tetrahydrocannabinol on the dopamine system” Nature 539(7629):369-377

    Publications

    2021

    Ashok AH, Myers J, Frost G, Turton S, Gunn RN, Passchier J, Colasanti A, Marques TR, Nutt D, Lingford-Hughes A, Howes OD, Rabiner EA (2021), “Acute acetate administration increases endogenous opioid levels in the human brain: A [11C]carfentanil molecular imaging study” J Psychopharmacol 35(5):606-610

    Rogdaki M, Devroye C, Ciampoli M, Veronese M, Ashok AH, McCutcheon RA, Jauhar S, Bonoldi I, Gudbrandsen M, Daly E, van Amelsvoort T, Van Den Bree M, Owen MJ, Turkheimer F, Papaleo F, Howes OD (2021), “Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study” Mol Psychiatry PMID: 33981004 DOI: 10.1038/s41380-021-01108-y

    2019

    Marques TR, Ashok AH, Pillinger T, Veronese M, Turkheimer FE, Dazzan P, Sommer IEC, Howes OD (2019), “Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies” Psychol Med 49(13):2186-2196

    2018

    Plavén-Sigray P, Matheson GJ, Collste K, Ashok AH, Coughlin JM, Howes OD, Mizrahi R, Pomper MG, Rusjan P, Veronese M, Wang Y, Cervenka S (2018), “Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data” Biol Psychiatry 84(6):433-442