Systems & Computational
Developmental
Cognitive & Behavioural
Clinical & Veterinary
Cellular & Molecular
Systems & Computational

Computational, theoretical and systems neuroscience has been a recent focus of development for the neuroscience community at Cambridge. Computational neuroscience is an important research strategy of the Cambridge Computational Biology Institute. There are also particular strengths in experimental approaches in this area across a range of departments, including the Department of Applied Mathematics and Theoretical Physics and the Department of Engineering. Systems neuroscience at Cambridge is increasingly dependent on theory to describe and analyse complex systems, as well as beginning to take an evolutionary approach. A wide range of techniques is used in this field and this is set to expand. A new Systems Biology Institute is being developed to provide a focus for genomics, proteomics and bioinformatics.

Principal investigators

  • Dr John Apergis-Schoute
    The psychological link between appetite and emotions is clear. Often enough food consumption is powerfully influenced by emotional cues that are unrelated to energy requirements. As the amygdala and hypothalamus, two neural regions that code for a...
  • Sabine Bahn Professor Sabine Bahn
    The goals of the Bahn Laboratory are to develop molecular diagnostics for schizophrenia and other major neuropsychiatric disorders, to develop and test new hypotheses of the pathological basis of schizophrenia and bipolar affective disorder and to...
  • Philip Barnard Dr Philip Barnard
    My programme of work focuses mainly on Executive Control and Emotional Meanings in Cognitive and Neural systems. Current work is organised under four project headings: [a] Core Theoretical work on Interacting Cognitive Subsystems - a macro-theory...
  • Tristan Bekinschtein Dr Tristan Bekinschtein
    I am interested in non-classic approaches to study the physiology and cognition of consciousness. I have wide Interests in Cognition and neurophysiology. In the last few years I have been mainly concentrating in describing different states of con...
  • Alan Blackwell Dr Alan Blackwell
    I construct and apply models of human behaviour when interacting with technology. These models take a variety of forms, not all drawing on neuroscience, but I have a particular interest in neuroeconomic models of abstraction formation and use. Thi...
  • Clemence Blouet Dr Clemence Blouet
    My work focuses on the characterization of brain nutrient-sensing circuits implicated in the regulation of energy homeostasis. This research is done through 3 main axes: 1. the characterization of molecular mechanisms implicated in brain nutrien...
  • Dr Tiago Branco
    Our goal is to understand how the mouse brain implements the computations that underlie innate behaviours. We aim to provide biophysically detailed descriptions of how sensory inputs and motivational states are integrated to produce behavioural ou...
  • Dennis Bray Dr Dennis Bray
    How do bacteria find distant sources of food, and avoid noxious and potentially damaging environments? We seek answers to these questions by developing computer simulations of swimming bacteria exposed to gradients of different substances. Our pro...
  • Ed Bullmore Professor Ed Bullmore
    I am interested in understanding human brain network organization from neuroimaging data in health and disease. My recent methodological work has focused on graph theory to measure aspects of brain network topology. I am also interested in bette...
  • Malcolm Burrows Professor Malcolm Burrows
    I work on the properties of neurons and the circuits they form to understand how they control behaviour. 1. Motor control. How do nonspiking local interneurons organise motor neurons to generate limb movements? How do spiking interneurons proce...
  • Tim Bussey Professor Tim Bussey
    Lisa Saksida and I are PIs in the Translational Cognitive Neuroscience Lab (TCNLab). The driving force behind all of the work in our lab is exactly as the name suggests: we want to understand the neuroscience of cognition, and to facilitate transl...
  • Dr Paula Buttery
    The application of natural language engineering techniques to augment neuro-imaging analysis and experimental design.
  • Rudolf Cardinal Dr Rudolf Cardinal
    I am interested in computational models of attentional selection and cognition.
  • Roberto Cipolla Professor Roberto Cipolla
    My research in computational vision includes a number of areas, in particular the recovery of shape, object detection and recognition. My group has developed algorithms for reconstructing three-dimensional shapes of objects from multiple images as...
  • Andrew Crawford Professor Andrew Crawford
    I am interested in biophysics and physiology of the vertebrate inner ear , especially the cochlea. My research has focussed on the electrophysiology of cochlear hair cells with a view to understanding how they manage to respond to nanometre dis...
  • Marek Czosnyka Professor Marek Czosnyka
    Brain Physics summarizes physical interactions between volumes, flows and pressures in brain. Measurement, data processing and analysis, forecasting and modeling of various cerebral phenomena as autoregulation of CBF or pressure-volume compensatio...
  • Mario de Bono Dr Mario de Bono
    We seek to understand how neural networks are assembled, function and evolve. C. elegans is a powerful system to study neural circuits. The worm has exactly 302 neurons each of which can be identified. EM reconstructions have identified synapti...
  • Benedetto De Martino Benedetto De Martino
    My research aims to provide a mechanistic understanding on how the brain constructs the values used to guide choice. I approach this complex problem by combining a number of different theoretical frameworks from economics and computational neurosc...
  • Steve Edgley Dr Steve Edgley
    I’m interested in how movements are controlled. Our everyday movements are performed with little conscious thought and are remarkably precise. Despite what the textbooks tell you, the way in which this is accomplished is poorly understood. I work ...
  • Stephen Eglen Dr Stephen Eglen
    I use computational tools to help investigate mechanisms of neural development. In particular, I study the formation of retinotopic maps and retinal mosaics in vertebrate visual systems. In addition, I am interested in the analysis of large-scal...
  • Shuhai Fan Professor Shuhai Fan
    1 Modeling, simulation and optimization of some kinds of artificial neural network with humoral regulation (includes anesthetic, hormone and so on). Apply these kinds of artificial neural network to the quality control system of mass customizatio...
  • Giorgio  Favrin Dr Giorgio Favrin
    The focus of my research is to build and analyze the network of pathways associated with Alzheimer’s disease. We are currently measuring these interaction data in the yeast S. cerevisiae (baker’s yeast). We use these data, in conjunction with fr...
  • Professor Thanasis Fokas PhD-MD
    Analytical algorithms for several medical imaging techniques including PAT, SPECT, MEG, EEG.
  • Dr David Franklin
    I am interested in how we are able to develop models of the external world and use these to adapt our movements to new experiences. I am currently studying the adaptation of humans to novel force fields generated with a 2 degree-of-freedom robotic...
  • Zoubin Ghahramani Professor Zoubin Ghahramani
    My current research interests include Bayesian approaches to machine learning, artificial intelligence, statistics, information retrieval, bioinformatics, and computational motor control. Statistics provides the mathematical foundations for handli...
  • Paloma T Gonzalez-Bellido Dr Paloma T Gonzalez-Bellido
    Given a set of environmental conditions and behavioral limitations, what is the optimal neural strategy and performance for a certain visual task? What adaptations are crucial for it? Are such adaptations widely spread across distantly related sp...
  • Roger Hardie Professor Roger Hardie
    Phototransduction, TRP channels and Calcium signalling in Drosophila Phototransduction in the fruitfly Drosophila is an important model for G-protein coupled signalling and fascinating in its own right. We study the underlying cellular and molecu...
  • Michael Hastings FMedSci Dr Michael Hastings FRS, FMedSci
    Cellular and molecular basis to circadian rhythms in mammals and its relevance to metabolic and neurological disease.
  • Berthold Hedwig Dr Berthold Hedwig
    I analyse the neural mechanisms underlying acoustic communication in insects which use species-specific sounds for mate attraction. I use behavioural, neurophysiological and optical imaging techniques with the aim to understand: 1. The neural mech...
  • Richard Henson Professor Richard (Rik) Henson
    My primary interest concerns how we remember things. Specifically, I use the techniques of functional magnetic resonance imaging (fMRI) and electro- and magneto- encephalography (EEG/MEG) to examine brain activity as healthy volunteers try to reme...
  • Joe Herbert Professor Joe Herbert
    I am interested in the role of the brain in adaptive responses, with particular reference to the reciprocal interaction between hormones and the brain. My experimental work is focussed on the way that neural factors, such as serotonin and glucocor...
  • Sean Holden Dr Sean Holden
    Our research covers assorted issues in both theoretical and applied machine learning. At present we are interested in: - Computational learning theory. How can we better understand the properties of machine learning algorithms in terms of, for ex...
  • Gregory Jefferis Dr Gregory Jefferis
    Our broad goal is to understand how smell turns into behaviour in the fruit fly brain. We use a combination of genetic labelling and manipulation, targeted in vivo whole cell patch clamp recording and high resolution neuroanatomy to study olfactor...
  • Dr Anna Korhonen
    Computational neurolinguistics, the application of natural language processing techniques to aid research in cognitive neuroscience, computational lexical semantics and comceptual structure
  • Zoe Kourtzi Professor Zoe Kourtzi
    My work aims to understand the role of learning and experience in enabling humans of all ages to translate sensory experience into complex decisions and adaptive behaviours. Adaptive cognitive abilities are critical for survival and social interac...
  • Nikolaus Kriegeskorte Dr Nikolaus Kriegeskorte
    - visual object recognition - pattern-information fMRI - computational modelling - species relationships
  • Dina Kronhaus Dr Dina Kronhaus
    My research is focused on studying connectivity and neural re-organisation, in the human brain, using theoretical modelling techniques to complement analysis of experimental data. I aim to identify overlapping yet distinct neural circuits implicat...
  • Markus Kuhn Dr Markus Kuhn
    I am a Computer Scientist and one of my many interests include information-theoretic and signal-processing aspects of neural physiology, in models of human perception and learning, and in computer architectures specifically designed to execute bio...
  • Simon Laughlin Professor Simon Laughlin
    Our group is interested in discovering design principles that govern the structure and function of neurons and neural circuits. We record from well-defined neurons, mainly in flies’ visual systems, to measure the molecular and cellular factors tha...
  • Nicolas Le Novere Dr Nicolas Le Novere
    My scientific interests revolve around signal transduction in neurons, ranging from the molecular structure of membrane proteins involved in neurotransmission to modelling signalling pathways. A strong focus is the molecular and cellular basis of ...
  • Máté Lengyel Dr Máté Lengyel
    I study learning and memory from computational, algorithmic/representational and neurobiological viewpoints. I also maintain an active interest in the possible computational functions of neural oscillations, particularly those present in the hippo...
  • Pietro Lio' Dr Pietro Lio'
    I am a Reader in Computational Biology in the Computer Laboratory which is the department of Computer Science of the University of Cambridge and I am a member of the Artificial Intelligence group of the Computer Laboratory. I hold a PhD in Comple...
  • David MacKay Professor David MacKay FRS
    Bayesian inference and information theory; computation, learning, and memory in neural network models, including probabilistic and spike-timing-based models. Human-computer interfaces based on information theory, especially aimed at disabled peopl...
  • Matthew Mason Dr Matthew Mason
    I investigate the function and evolution of the middle ear apparatus in vertebrates. Comparative anatomy is backed up with more recent techniques, such as micro-CT and laser interferometry, in order to visualise the middle ear structures and exami...
  • Brian McCabe Dr Brian McCabe
    The neural mechanisms of learning and memory, particularly imprinting in the domestic chick. The young of many species, when exposed to a conspicuous object, rapidly learn the object's characteristics and subsequently narrow their social preferenc...
  • Professor John Mollon
    My research interests are in the visual perception of colour, motion, form and depth; the genetic basis for individual variations in perception; the nature of the information carried by the cerebral bus; and the history of neuroscience and of colo...
  • David Parker Dr David Parker
    My lab examines how interactions in neuronal networks generate behaviourally relevant network outputs, using the lamprey spinal cord locomotor network as a model system. We combine electrophysiological, computational, molecular, and anatomical app...
  • Roy Patterson Dr Roy Patterson
    We have developed a computational model of the auditory signal processing that transforms a sound wave into the auditory image you hear in response to that sound wave. We investigate how the cochlea and neural centres in the auditory pathway proce...
  • Stefano Pluchino Dr Stefano Pluchino
    Recent evidence from our own laboratory indicates that the systemic injection of somatic neural stem/precursor cells (NPCs) very efficiently protect the CNS from the chronic degeneration induced by inflammation both in small rodents as well as in ...
  • Taufiq Rahman Dr Taufiq Rahman
    My research interests broadly lie in two categories - structure-function studies of intracellular calcium channels and rational design and development of selective modulators of signalling proteins including ion channels
  • Carl Edward Rasmussen Dr Carl Edward Rasmussen
    I work on probabilistic inference and machine learning. What are the mathematical foundations of learning from experience in biological systems?
  • Akhilesh Reddy Dr Akhilesh Reddy
    My group is interested in circadian rhythms, which are daily cycles of physiology and behaviour that persist when organisms are isolated from the outside world. They represent a fundamental biological mechanism, and are present at all levels of li...
  • Trevor Robbins Professor Trevor Robbins
    Research interests span the areas of cognitive neuroscience, behavioural neuroscience and psychopharmacology. Main work focuses on the functions of the frontal lobes of the brain and their connections with other regions. These brain systems are re...
  • Hugh Robinson Dr Hugh Robinson
    We study synaptic integration in mammalian cortical neurons - encoding of synaptic inputs into patterns of action potentials, or spikes. We are currently interested in - development of advanced electrical stimulation techniques (conductan...
  • James Rowe Dr James Rowe BA BM BCh PhD
    Characterisation and optimisation of prefrontal cortical functions in health and disease. The functions of the prefrontal cortex remain controversial yet they are of great importance to our everyday life, thoughts, actions and self expression. I ...
  • Mikail Rubinov Mikail Rubinov
    I model large-scale human brain anatomy and activity as a complex network of brain regions and interregional associations. I use brain-imaging -- such as magnetic-resonance-imaging -- data sets and computer simulations to model healthy and disease...
  • John Rust Professor John Rust
    The development, evaluation and implementation of psychometric tests and psychometric testing procedures. As Director of The Psychometrics Centre I have been responsible for the UK standardisation of many of the most widely used psychometric tests...
  • Lisa Saksida Dr Lisa Saksida
    We are working toward a better understanding of the psychological processes underlying memory and perception through a programme of theoretically-driven experimental research using both healthy subjects and brain-damaged populations. Research in m...
  • Wolfram Schultz Professor Wolfram Schultz
    Our group is interested to relate the mechanics of brain activity to measurable behaviour. We combine neurophysiological, imaging and behavioural techniques to investigate the neural correlates of goal-directed. We are interested in outcome value ...
  • Christof Schwiening Dr Christof Schwiening
    Electrical activity of neurones is associated with calcium influx through various channels. Most neurones extrude this calcium very rapidly on the plasma-membrane calcium pump (PMCA). Our research shows that this extrusion occurs in exchange for h...
  • Rodolphe Sepulchre Professor Rodolphe Sepulchre
    We use tools from feedback control theory and machine learning to study the modulation and robustness of neuronal circuits. We are particularly interested in the mechanisms that transfer rhythmic activity across a range of temporal and spatial sca...
  • Murray Shanahan Professor Murray Shanahan
    I am primarily interested in cognitive architecture, both as it is found in Nature and as it might be realised artificially. Because I'm committed to the view that cognition and embodiment are initmately related, I also have a strong interest in r...
  • Peter Smielewski Dr Peter Smielewski
    In an established environment of Clinical Neuroscience Dept large quantities of data can be captured from bed-side monitors. Using that data, continuous assessment of changing cerebrovascular haemodynamics and oxygenation is possible but requires ...
  • Ewan Smith Dr Ewan Smith
    The main interest of the Smith lab is to understand the molecular mechanisms by which sensory neurones detect noxious stimuli, so-called nociceptors. We are particularly interested in how acid activates nociceptors in both physiological and pathop...
  • Henning Sprekeler Henning Sprekeler
    The group studies how synaptic plasticity can give rise to learning and memory. To this end, we use computational models to link the cellular and synaptic description level to higher levels such as network dynamics, the development of sensory repr...
  • Emmanuel  A Stamatakis Dr Emmanuel A Stamatakis
    My research aims to decode complex relationships between remote and/or proximal brain regions, which form networks at rest or during goal directed behaviour. This includes work on network adaptive behaviour (reorganisation/plasticity) triggered by...
  • John Suckling John Suckling
    Neuroimaging is a major contributor to the renaissance of experimental psychiatry and psychology. Drawing on the extensive infrastructure of Cambridge Neuroscience and Department of Psychiatry’s close links between research and clinical practice, ...
  • David Tolhurst Dr David Tolhurst
    Visual coding of natural scenes. Information coding in the visual cortex studied by single unit recording, computational models and psychophysical discrimination by human observers. Visual deficits in developmental or acquired visual abnormality.
  • Marco Tripodi Marco Tripodi
    One of the major tasks that the nervous system faces is that of linking perception to action. We perceive the world around us through our senses and we use this information to select the most appropriate set of actions. My lab studies the organiza...
  • Richard Turner Dr Richard Turner
    My research lies at the interface between computer perception (which builds artificial systems for understanding images, sounds and videos), neuroscience (which tries to understand the brain) and machine-learning (which provides a theoretical fram...
  • Gonzalo P. Urcelay Dr Gonzalo P. Urcelay
    I am interested in learning theories and the neurobiological substrates of acquired behaviour. I am currently conducting studies to assess the involvement of the prefrontal cortex in the transition from goal-directed to habitual behaviours and its...
  • Bert Vaux Dr Bert Vaux
    --grounding of phonological learning in a mathematical implementation of evolutionary information theory. --phonological cognition. --implications of selective aphasias, first and second language acquisition phenomena, processing and production ef...
  • Michele Vendruscolo Professor Michele Vendruscolo
    Our research is aimed at understanding the principles governing protein homeostasis - the ability of cells to generate and regulate the levels of proteins in terms of conformations, interactions, concentrations and cellular localisation. We have s...
  • Andrew Welchman Dr Andrew Welchman
    I am interested in how the brain brings together information from the senses to support perception and interaction with the rapidly changing world. Work in my lab integrates psychophysics, movement recording, modelling and brain imaging techniques...
  • Ian Wilkinson Dr Ian Wilkinson
    My research is clinically orientated and centres on the physiology and pharmacology of the cardiovascular system, and particularly the large arteries and endothelial function. As a clinical pharmacologist, I combine detailed physiological measure...
  • Dr Ian Winter
    Primitive neural mechanisms of auditory scene analysis. My research searches for neurophysiological correlates of the cues necessary for the segregation and fusion of auditory objects. This work is carried out in close collaboration with psychop...
  • Daniel Wolpert Professor Daniel Wolpert FMedSci FRS
    The group uses engineering approaches to understand how the human brain controls movement. The work includes both computational modelling and experimental approaches using robotic and virtual reality interfaces. Research areas include motor planni...
  • Steve Young Professor Steve Young
    My primary interest is in adaptive learning in spoken dialogue systems. This currently involves modelling human machine dialogues using the framework of Partially Observable Markov Decision Processes (POMDPs). The research issues addressed incl...
  • Dr Ye Yuan
    Machine learning / System identification Modelling the natural history of neurodegenerative genetic disorder progression