Systems & Computational
Developmental
Cognitive & Behavioural
Clinical & Veterinary
Cellular & Molecular
Clinical & Veterinary

Clinical and veterinary researchers are naturally focused around Clinical School and the School of Veterinary Science. The University recently established a new Department of Clinical Neurosciences to include the former University units of Neurology and Neurosurgery, the Brain Repair Centre and the Wolfson Brain Imaging Centre. Research in this areas has a strong emphasis on clinical application in conditions such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, multiple sclerosis, stroke, brain injury, autism, schizophrenia and depression. There are clear links between clinical and veterinary science, as well as fundamental science research conducted within the School of Biology.

Principal investigators

  • Franklin  Aigbirhio Professor Franklin Aigbirhio
    Research in the development and application of molecular imaging probes, in particular for the in vivo imaging technique of positron emission tomography. Objectives are to design, develop and apply imaging probes that are specific and selective to...
  • Richard Ansorge Dr Richard Ansorge
    My current interests include hardware and software development for various medical imaging modalities, especially PET and MRI. This work is done in close collaboration with the Wolfson Brain Imaging Centre. One particular current project is the d...
  • Topun Austin Dr Topun Austin
    Brain injury in the newborn is a major cause of death and lifelong neurodisability placing an enormous burden on patients, their families and wider society. I lead the Cambridge Centre for Perinatal Neuroscience (CCPN), which includes a dedicated...
  • Roger Barker Professor Roger Barker
    I work on: Clinical aspects of Parkinson's and Huntington's disease including the study of disease heterogeneity using cognitive testing, functional imaging and genetic biomarkers. Examining the value of different biomarkers to assess disease onse...
  • Jean-claude Baron-Cohen Professor Jean-Claude Baron
    My research focuses on the pathophysiology of ischaemic stroke and the mechanisms underlying subsequent deterioration or recovery, including neuronal damage, tissue inflammation and long-term plasticity processes. In terms of methodology, my appro...
  • German Berrios Professor German Berrios
    I am interested in the study of psychiatric symptoms (e.g. hallucinations, delusions, obsessions) appearing in the context of neurological disease. Since the 19th century, the view that 'mental symptoms' seen in the context of neurological diseas...
  • Carol Brayne Professor Carol Brayne
    My research programme is based around longitudinal population based studies of people aged 65 and above, running since 1985. They include collections of blood, and are linked to the Cambridge Brain Bank. Opportunities exist for translation from la...
  • Kevin Brindle Professor Kevin Brindle
    We have developed non-invasive magnetic resonance imaging (MRI) techniques that enable us to track labelled cells that have been implanted in the CNS. This work has been conducted in collaboration with Robin Franklin. In addition we are developi...
  • Raymond Bujdoso Dr Raymond Bujdoso
    Prion diseases such as scrapie of sheep and goats, BSE of cattle and CJD of humans are transmissible neurodegenerative diseases. The research of our prion group is concerned with providing knowledge to try and answer some of the important question...
  • Ed Bullmore Professor Ed Bullmore
    I am interested in understanding human brain network organization from neuroimaging data in health and disease. My recent methodological work has focused on graph theory to measure aspects of brain network topology. I am also interested in bette...
  • Philip Buttery Dr Philip Buttery
    We work on the role of rho family GTPases and their regulators in the plasticity of CNS synapses, as related to brain disease and recovery from brain injury. We are currently focussing on a regulator of the GTPase Rac1 which is upregulated with n...
  • Roger Carpenter Professor Roger Carpenter MA PhD ScD
    I work on the brain mechanisms of human decision. The most common decision we make - two or three times every second - is what to look at next, and the measurement of the time taken to choose to look at a visual target - the saccadic latency - ha...
  • Adrian Carpenter Dr Adrian Carpenter
    Our group develops new techniques for the acquisition and analysis of PET and MR images to improve our understanding of the pathophysiology of disease. We also develop novel instrumentation, for example we are an internationally leading centre d...
  • Samuel Chamberlain Dr Samuel Chamberlain MB/BChir PhD MRCPsych
    My research focuses on the neurochemical and neural substrates of cognition, and psychiatric endophenotypes.
  • Dennis Chan Dr Dennis Chan
    I am interested in identifying alterations in the function of the entorhinal cortex (EC) and hippocampus in early Alzheimer's disease (AD), with the ultimate aim of diagnosing AD prior to symptom onset. EC grid cell and hippocampal place cell fun...
  • Luke  Clark Dr Luke Clark
    My research is directed at the broad interface between psychological disorders and cognitive neuroscience, with a particular focus on the brain mechanisms underlying gambling decisions. Gambling is a popular recreational activity that can also bec...
  • Jonathan Coles Dr Jonathan Coles
    As a clinician specialising within Neurointensive care my research interests are focused on describing the pathophysiology of head injury and optimising patient outcome. Using the combined facilities of the Wolfson Brain Imaging and Neurosciences ...
  • Alasdair Coles Revd Dr Alasdair Coles
    We study people with immunological illnesses of the brain, especially multiple sclerosis. We combine clinical and laboratory work. Our most important work to date has been on alemtuzumab (Campath-1H), a humanised monoclonal antibody made original...
  • Tony Coll Dr Tony Coll
    My current research continues to focus upon the roles of the hypothalamus in the control of energy balance. Our current understanding of the central control of appetite has relied heavily upon mouse models and I continue to utilise the power of b...
  • William Colledge Professor William Colledge
    My research group is interested in the neuroendocrine regulation of mammalian fertility using transgenic mice as a model system. Puberty and the regulation of mammalian fertility is controlled by hormonal signalling within the hypothalamus. My re...
  • Alastair Compston Professor Alastair Compston
    My research interests focus on clinical and experimental demyelinating disease with an emphasis on multiple sclerosis - the commonest potentially disabling disease of young adults. The research group has a broad set of interests: we work on the a...
  • Damian Crowther Dr Damian Crowther
    We use a range of in vitro and in vivo techniques to understand how amyloid protein aggregates: i) mediate their toxic effects and ii) underpin the pathological progression of disorders such as Alzheimer's disease. We are investigating the molecul...
  • Marek Czosnyka Professor Marek Czosnyka
    Brain Physics summarizes physical interactions between volumes, flows and pressures in brain. Measurement, data processing and analysis, forecasting and modeling of various cerebral phenomena as autoregulation of CBF or pressure-volume compensatio...
  • Christopher Dobson Professor Christopher Dobson
    Our group is investigating the molecular origins of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s Disease, that are characterised neuropathologically by the presence of amyloid fibrils. The aim of our research is to understand ...
  • Robert Dudas Dr Robert Dudas
    I have carried out research projects on cognitive impairment in the context of progressive-degenerative dementias and affective symptomatology. My current research focuses on the neurobiology of emotional dysregulation and self-harm in the affect...
  • Karen Ersche Dr Karen Ersche
    My research focuses on the neuropsychological correlates and neurochemical processes underlying addictive behaviour and the translation of this knowledge into therapeutic interventions. This work involves a combination of approaches including neur...
  • Sadaf Farooqi Professor Sadaf Farooqi
    Using a candidate gene approach in patients with severe, early onset obesity recruited to the Genetics Of Obesity Study (GOOS), we have identified patients with mutations in genes encoding leptin, the leptin receptor and targets of leptin action ...
  • Emilio  Fernandez-Egea Dr Emilio Fernandez-Egea
    My research interests are mostly the biological and clinical aspects of chronic schizophrenia. I’m the Clozapine Clinic Lead and the Good Outcome Schizophrenia Clinic lead for the local MH Trust (Cambridgeshire and Peterborough NHS Foundation Trus...
  • Jonathan Gillard Professor Jonathan Gillard
    Development of novel Magnetic Resonance imaging tools assessing atheromatous plaque inflammation and stress analysis. Development of MRI and PET tools for delineating microscopic brain tumour infiltration in man.
  • Michel Goedert Dr Michel Goedert
    Alzheimer's disease and Parkinson's disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in related disorders, including progressive supranuclear palsy, dementia with Le...
  • John Griffiths Professor John Griffiths
    My work involves the use and development of Magnetic Resonance methods for understanding the biology of cancer and the determination of tumour-associated MR parameters for diagnosis, prognosis and monitoring of therapy.
  • Mark Gurnell Dr Mark Gurnell
    Current programmes of research: 1. endocrine basis of financial decision-making 2. genetic and acquired disorders of the hypothalamic-pituitary-thyroid axis 3. novel approaches to sparing hypothalamic-pituitary function in patients with sellar/par...
  • Joe Herbert Professor Joe Herbert
    I am interested in the role of the brain in adaptive responses, with particular reference to the reciprocal interaction between hormones and the brain. My experimental work is focussed on the way that neural factors, such as serotonin and glucocor...
  • Emily Holmes Professor Emily Holmes
    In the Emotional Disorders and Mental Imagery programme we investigate three areas: Psychological trauma Depressed mood Bipolar disorder
  • Michael Hornberger Dr Michael Hornberger
    I am a translational neuroscientist who works in the interface between cognitive and clinical neuroscience. My research focus is on decision making and memory in the human brain. To investigate these processes I develop and employ experimental cog...
  • Peter Hutchinson Professor Peter Hutchinson
    I am a NIHR Research Professor at the Department of Clinical Neurosciences, University of Cambridge and Honorary Consultant Neurosurgeon at Addenbrooke's Hospital, Cambridge. I have a general neurosurgical practice with a subspecialist interest in...
  • Peter Jones Professor Peter Jones
    The Cambridge “epiCentre” group works at the interface between population-based research, neuroscience and clinical psychiatry in order to understand the causes, mechanisms and treatments for psychosis (particularly schizophrenia) dementia, depres...
  • Dr Phil Jones
    We are investigating how normal stem cells transform into cancer cells in a range of sytems, both by studying stem and progenitor cell fate and also by investigating the role of a specific cell fate regulators. Our focus has been on Hes6, which r...
  • Ragnhildur Karadottir Dr Ragnhildur Thora Karadottir
    My lab’s interests are neurotransmitter signalling to oligodendrocytes and their progenitor cells, in both health and disease. Oligodendrocytes produce myelin (in the CNS), which speeds the propagation of the action potential. When the myelin s...
  • Dr Mark Kotter
    My group is interested in the biology of adult CNS stem and precursor cells in the context of disease. A particular focus lies on mechanisms of CNS remyelination, a stem/precursor cell-mediated process in which new myelin sheaths are restored to d...
  • Andras Lakatos Dr Andras Lakatos
    Andras is interested in the adaptive changes in glia-neuron interactions following remote axonal insults, such as axonal degeneration, injury and demyelination. The particular focus is how endogenous cortical/gray matter astrocytes and stem cells ...
  • Michael Lombardo Dr Michael Lombardo
    I am interested in understanding the mechanisms occurring in early development that are behind atypical brain development in autism and other neurodevelopmental disorders.
  • Tom Manly Dr Tom Manly
    Our research relates to understanding impairment and rehabilitation in attentional and executive function. Our work with stroke patients mainly focuses on spatial neglect and its relationship to executive/frontal impairment. Our work with patients...
  • Professor Hugh Markus
    I use molecular genetic and neuroimaging (MRI and Transcranial Doppler) techniques to investigate the pathogenesis of, and develop treatments for, cerebrovascular disease. A particular interest is in cerebral small vessel disease, a major cause of...
  • Keith Martin Professor Keith Martin
    The main goal of our group is to understand better the mechanisms of retinal ganglion cell (RGC) death in glaucoma, the leading cause of irreversible blindness worldwide. We aim to develop methods to protect RGC thus slowing the progression of gla...
  • Matthew Mason Dr Matthew Mason
    I investigate the function and evolution of the middle ear apparatus in vertebrates. Comparative anatomy is backed up with more recent techniques, such as micro-CT and laser interferometry, in order to visualise the middle ear structures and exami...
  • David Menon Professor David Menon
    The research program of the University Division of Anaesthesia has aimed to understand regional cerebral pathophysiology to advance the care of critically ill patients after brain injury, from initial ictus, through recovery from coma and rehabili...
  • Su Metcalfe Dr Su Metcalfe
    The application of nanotechnology to healthcare - nano-medicine - is now recognised worldwide as a new era in clinical medicine. Currently untreatable illnesses including neurodegenerative diseases (NDD) present key future targets for nano-therape...
  • Brian Moore Professor Brian Moore
    Mechanisms of normal hearing and hearing impairments; relationship of auditory abilities to speech perception; design of signal processing hearing aids for sensorineural hearing loss; fitting of hearing aids to suit the individual; electrical stim...
  • Ulrich Müller Dr Ulrich Müller
    My major research interest is the neurotransmitter modulation of cognitive and emotional processes, with a focus on the role of dopamine and noradrenaline in frontostriatal functions. I use fMRI, radioligand imaging with PET, pharmacological chall...
  • Pradeep Nathan Pradeep Nathan
    I am a clinical pharmacologist with research interests in the neuropharmacology and neural substrates of cognition and emotion and psychiatric and neurological endophenotypes. I use cognitive, functional and molecular neuroimaging techniques (i.e....
  • John T O'Brien Professor John T O'Brien
    My research interests in dementia include the role of biomarkers, especially MRI, SPECT and PET imaging, in the differential and early diagnosis of dementia, including identifying those ‘at risk’ of future cognitive decline and developing markers ...
  • Jesus Perez Dr Jesus Perez
    My research activity is mainly focused on early detection and intervention in psychosis and the history of psychiatry. I am particularly interested in the epidemiological apects of young people at high-risk of developing psychosis and with first-e...
  • John Pickard Professor John Pickard
    Advancing the care of patients with acute brain injury (trauma, haemorrhage and hydrocephalus) from initial ictus, neurointensive care, recovery from coma and rehabilitation to final outcome through the study of pathophysiology (multimodality beds...
  • Stephen Price Mr Stephen Price
    My group uses advanced multimodal MR and PET imaging to understand the heterogeneity of gliomas (high and low grade) in individual patients. We know that gliomas are among the most heterogeneous tumours but still do not have a method of detecting ...
  • Ruma Raha-Chowdhury Dr Ruma Raha-Chowdhury
    My main interest is in brain iron homeostasis, its role in normal ageing, neuronal inflammation and neurodegenerative diseases. Iron is an essential nutrient for almost all living organisms but in excess is toxic. There is evidence that iron homeo...
  • Lucy Raymond Dr Lucy Raymond
    The group aims to understand the molecular mechanisms underlying intellectual disability in humans. Our main focus is on families with X linked disease. In collaboration with The Wellcome Trust Sanger Institute, we are using a new approach to dise...
  • Rhys Roberts Dr Rhys Roberts
    Our group is interested in peripheral nerve diseases, particularly the inherited peripheral neuropathies, Charcot-Marie-Tooth disease (CMT). We have focused on the demyelinating forms of CMT, where defects in intracellular membrane trafficking p...
  • David  Rubinsztein Professor David Rubinsztein
    The pathogenesis of diseases caused by codon reiteration mutations (like Huntington’s disease and oculopharangeal muscular dystrophy). Description of research: We are studying the pathogenesis of diseases caused by codon reiteration mutations, l...
  • Umar  Sadat Dr Umar Sadat
    1. Magnetic resonance imaging of atherosclerotic plaques 2. Applied biomechanics of atherosclerotic plaques and other cardiovascular pathologies 3. Contrast-induced-nephropathy 4. Ischaemic Pre-conditioning in patients undergoing open and endovas...
  • Barbara Sahakian Professor Barbara Sahakian FMedSci
    My research is aimed at understanding the neural basis of cognitive, emotional and behavioural dysfunction in order to develop more effective pharmacological and psychological treatments. The focus of my lab is on early detection, differential dia...
  • Stephen Sawcer Professor Stephen Sawcer
    My group researches multiple sclerosis. We use genetic analysis to identify relevant variants and then attempt to understand the immunological and neurobiological consequences of these using expression studies and functional assays. As well as con...
  • Michael Spencer Dr Michael Spencer
    I am interested in the scientific investigation of psychiatric disorders, particularly through the integration of clinical research methods together with brain imaging. I led a team of researchers at the Department of Psychiatry, Cambridge, that ...
  • Professor Robert Tasker
    1. Multicenter clinical studies: In the USA I am a co-investigator and Executive Committee member for the recently funded NIH ‘Multiple Medical Therapies for Pediatric Traumatic Brain Injury – A Comparative Effectiveness Approach’ that will recrui...
  • Elizabeth Warburton Dr Elizabeth Warburton
    Research interests are as follows 1. Molecular imaging of atheroma - particularly carotid plaque imaging using PET/CT and MRI techniques. Both Clinical and microPET imaging. Proof of principle trials of novel atheroma drugs with imaging biomarker...
  • Colin Watts Dr Colin Watts
    Lab-based research is focused on the genomics of glioblastoma (GBM) and in the role of glial progenitors in their evolution and development. We are also interested in developing patient-specific models of GBM to evaluate intra-tumour variability i...
  • Paul Wilkinson Dr Paul Wilkinson
    Paul Wilkinson is University Lecturer and Honorary Consultant in Child and Adolescent Psychiatry at the University of Cambridge. His main research interests are the epidemiology and treatment of self-harm and depression. He investigates biologi...
  • Ian Wilkinson Dr Ian Wilkinson
    My research is clinically orientated and centres on the physiology and pharmacology of the cardiovascular system, and particularly the large arteries and endothelial function. As a clinical pharmacologist, I combine detailed physiological measure...
  • Guy Williams Dr Guy Williams
    Our group’s research interests lie broadly in nuclear magnetic resonance (NMR). This phenomenon allows data to be collected noninvasively on both the structure and function of the human brain. We research novel acquisition methods to provide contr...
  • John Xuereb Dr John Xuereb
    The neuropathological basis of dementia with a special interest in clinicopathological correlation of Frontotemporal Syndromes.
  • Dr Shahid Zaman
    The main theme of our research is to understand the role of amyloid and mitochondrial dysfunction in the genesis of cognitive impairment and dementia in people with Down's syndrome.