Clinical & Veterinary
Clinical and veterinary researchers are naturally focused around Clinical School and the School of Veterinary Science. The University recently established a new Department of Clinical Neurosciences to include the former University units of Neurology and Neurosurgery, the Brain Repair Centre and the Wolfson Brain Imaging Centre. Research in this areas has a strong emphasis on clinical application in conditions such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, multiple sclerosis, stroke, brain injury, autism, schizophrenia and depression. There are clear links between clinical and veterinary science, as well as fundamental science research conducted within the School of Biology.
Principal investigators
Dr Julio Acosta-Cabronero
In developing novel magnetic resonance imaging (MRI) methods of acquisition and analysis to elucidate the mechanisms underlying neurodegeneration in very early dementia.
Dr Franklin Aigbirhio
Research in the development and application of molecular imaging probes, in particular for the in vivo imaging technique of positron emission tomography. Objectives are to design, develop and apply imaging probes that are specific and selective to...
Dr Richard Ansorge
My current interests include hardware and software development for various medical imaging modalities, especially PET and MRI. This work is done in close collaboration with the Wolfson Brain Imaging Centre. One particular current project is the d...
Dr Topun Austin
Brain injury in the newborn is a major cause of death and lifelong neurodisability placing an enormous burden on patients, their families and wider society. My research interests are in the development of systems to identify vulnerable infants at...
Dr Roger Barker
I work on: Clinical aspects of Parkinson's and Huntington's disease including the study of disease heterogeneity using cognitive testing, functional imaging and genetic biomarkers. Examining the value of different biomarkers to assess disease onse...
Professor Jean-Claude Baron
My research focuses on the pathophysiology of ischaemic stroke and the mechanisms underlying subsequent deterioration or recovery, including neuronal damage, tissue inflammation and long-term plasticity processes. In terms of methodology, my appro...
Professor German Berrios
I am interested in the study of psychiatric symptoms (e.g. hallucinations, delusions, obsessions) appearing in the context of neurological disease. Since the 19th century, the view that 'mental symptoms' seen in the context of neurological diseas...
Professor Carol Brayne
My research programme is based around longitudinal population based studies of people aged 65 and above, running since 1985. They include collections of blood, and are linked to the Cambridge Brain Bank. Opportunities exist for translation from la...
Professor Kevin Brindle
We have developed non-invasive magnetic resonance imaging (MRI) techniques that enable us to track labelled cells that have been implanted in the CNS. This work has been conducted in collaboration with Robin Franklin. In addition we are developi...
Dr Raymond Bujdoso
Prion diseases such as scrapie of sheep and goats, BSE of cattle and CJD of humans are transmissible neurodegenerative diseases. The research of our prion group is concerned with providing knowledge to try and answer some of the important question...
Professor Ed Bullmore
I am interested in understanding human brain network organization from neuroimaging data in health and disease. My recent methodological work has focused on graph theory to measure aspects of brain network topology. I am also interested in bette...
Dr Philip Buttery
We work on the role of rho family GTPases and their regulators in the plasticity of CNS synapses, as related to brain disease and recovery from brain injury. We are currently focussing on a regulator of the GTPase Rac1 which is upregulated with n...
Professor Roger Carpenter
I work on the brain mechanisms of human decision. The most common decision we make - two or three times every second - is what to look at next, and the measurement of the time taken to choose to look at a visual target - the saccadic latency - ha...
Dr Adrian Carpenter
Our group develops new techniques for the acquisition and analysis of PET and MR images to improve our understanding of the pathophysiology of disease. We also develop novel instrumentation, for example we are an internationally leading centre d...
Dr Luke Clark
My research is directed at the broad interface between psychological disorders and cognitive neuroscience, with a particular focus on the brain mechanisms underlying gambling decisions. Gambling is a popular recreational activity that can also bec...
Dr Jonathan Coles
As a clinician specialising within Neurointensive care my research interests are focused on describing the pathophysiology of head injury and optimising patient outcome. Using the combined facilities of the Wolfson Brain Imaging and Neurosciences ...
Revd Dr Alasdair Coles
We study people with immunological illnesses of the brain, especially multiple sclerosis. We combine clinical and basic laboratory work. Our most important work to date has been on alemtuzumab (Campath-1H), a humanised monoclonal antibody made or...
Dr Tony Coll
My current research continues to focus upon the roles of the hypothalamus in the control of energy balance. Our current understanding of the central control of appetite has relied heavily upon mouse models and I continue to utilise the power of b...
Professor William Colledge
My research group is interested in the neuroendocrine regulation of mammalian fertility using transgenic mice as a model system. Puberty and the regulation of mammalian fertility is controlled by hormonal signalling within the hypothalamus. My re...
Professor Alastair Compston
My research interests focus on clinical and experimental demyelinating disease with an emphasis on multiple sclerosis - the commonest potentially disabling disease of young adults. The research group has a broad set of interests: we work on the a...
Dr Damian Crowther
We are dedicated to understanding the molecular pathogenesis of neurodegenerative diseases using the fruit fly, Drosophila melanogaster, as our primary tool. Our creation of a fly model of Alzheimer's disease by expressing the amyloid beta peptid...
Dr Marek Czosnyka
Brain Physics is a very young branch of clinical neuroscience, certainly not defined in any encyclopedia. It summarizes physical interactions between volumes, flows and pressures in brain. Measurement, data processing and analysis, forecasting and...
Professor Christopher Dobson
Our group is investigating the molecular origins of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s Disease, that are characterised neuropathologically by the presence of amyloid fibrils. The aim of our research is to understand ...
Dr Robert Dudas
I have carried out research projects on cognitive impairment in the context of progressive-degenerative dementias and affective symptomatology. My current research focuses on the neurobiology of emotional dysregulation and self-harm in the affect...
Dr Karen Ersche
My research focuses on the neuropsychological correlates and neurochemical processes underlying addictive behaviour and the translation of this knowledge into therapeutic interventions. This work involves a combination of approaches including neur...
Dr Sadaf Farooqi
Using a candidate gene approach in patients with severe, early onset obesity recruited to the Genetics Of Obesity Study (GOOS), we have identified patients with mutations in genes encoding leptin, the leptin receptor and targets of leptin action ...
Dr Emilio Fernandez-Egea
My research interests are mostly the biological and clinical aspects of chronic schizophrenia. I’m the Clozapine Clinic Lead and the Good Outcome Schizophrenia Clinic lead for the local MH Trust (Cambridgeshire and Peterborough NHS Foundation Trus...
Professor Robin Franklin
The Franklin lab is interested in the mechanisms of CNS regeneration with a particular focus on remyelination, an adult stem/precursor cell-mediated process in which new myelin sheaths are restored to demyelinated axons. Using developmental-, tran...
Professor Jonathan Gillard
Development of novel Magnetic Resonance imaging tools assessing atheromatous plaque inflammation and stress analysis. Development of MRI and PET tools for delineating microscopic brain tumour infiltration in man.
Dr Michel Goedert
Alzheimer's disease and Parkinson's disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in related disorders, including progressive supranuclear palsy, dementia with Le...
Professor John Griffiths
My work involves the use and development of Magnetic Resonance methods for understanding the biology of cancer and the determination of tumour-associated MR parameters for diagnosis, prognosis and monitoring of therapy.
Professor Joe Herbert
I am interested in the role of the brain in adaptive responses, with particular reference to the reciprocal interaction between hormones and the brain. My experimental work is focussed on the way that neural factors, such as serotonin and glucocor...
Mr Peter Hutchinson
My research areas include acute brain injury (head injury, subarachnoid haemorrhage), decompressive craniectomy in head injury and stroke, multimodality monitoring (intracranial pressure, brain tissue oxygen, intracerebral microdialysis), brain im...
Dr Phil Jones
We are investigating how normal stem cells transform into cancer cells in a range of sytems, both by studying stem and progenitor cell fate and also by investigating the role of a specific cell fate regulators. Our focus has been on Hes6, which r...
Professor Peter Jones
The Cambridge “epiCentre” group works at the interface between population-based research, neuroscience and clinical psychiatry in order to understand the causes, mechanisms and treatments for psychosis (particularly schizophrenia) dementia, depres...
Dr Ragnhildur Thora Karadottir
My lab’s interests are neurotransmitter signalling to oligodendrocytes and their progenitor cells, in both health and disease. Oligodendrocytes produce myelin (in the CNS), which speeds the propagation of the action potential. When the myelin s...- Dr Mark Kotter
My group is interested in the biology of adult CNS stem and precursor cells in the context of disease. A particular focus lies on mechanisms of CNS remyelination, a stem/precursor cell-mediated process in which new myelin sheaths are restored to d... 
Dr Andras Lakatos
Andras is interested in the adaptive changes in glia-neuron interactions following remote axonal insults, such as axotomy and demyelination. The particular focus is how endogenous cortical/gray matter astrocytes and stem cells responding to such c...
Dr Belinda Lennox
My interest is in the biological basis of psychosis. I have used fMRI to capture the neural activation associated with auditory hallucinations in schizophrenia, and associated abnormalities in auditory processing. I have undertaken studies to...
Dr Michael Lombardo
My research deals with the neural systems of social cognition/behavior and autism spectrum conditions.
Dr Tom Manly
Our research relates to understanding impairment and rehabilitation in attentional and executive function. Our work with stroke patients mainly focuses on spatial neglect and its relationship to executive/frontal impairment. Our work with patients...
Professor Keith Martin
The main goal of our group is to understand better the mechanisms of retinal ganglion cell (RGC) death in glaucoma, the leading cause of irreversible blindness worldwide. We aim to develop methods to protect RGC thus slowing the progression of gla...
Dr Matthew Mason
I investigate the function and evolution of the middle ear apparatus in vertebrates. Comparative anatomy is backed up with more recent techniques, such as micro-CT and laser interferometry, in order to visualise the middle ear structures and exami...
Dr Tarik Massoud
My current interests are in experimental molecular neuroimaging of reporter gene expression, as applied to imaging protein-protein interactions and signal transduction in brain gliomas and neural stem cells, within living subjects.
Professor David Menon
The research program of the University Division of Anaesthesia has aimed to understand regional cerebral pathophysiology to advance the care of critically ill patients after brain injury, from initial ictus, through recovery from coma and rehabili...
Dr Su Metcalfe
The application of nanotechnology to healthcare - nano-medicine - is now recognised worldwide as a new era in clinical medicine. Currently untreatable illnesses including neurodegenerative diseases (NDD) present key future targets for nano-therape...
Professor Brian Moore
Mechanisms of normal hearing and hearing impairments; relationship of auditory abilities to speech perception; design of signal processing hearing aids for sensorineural hearing loss; fitting of hearing aids to suit the individual; electrical stim...
Dr Ulrich Müller
My major research interest is the neurotransmitter modulation of cognitive and emotional processes, with a focus on the role of dopamine and noradrenaline in frontostriatal functions. I use fMRI, radioligand imaging with PET, pharmacological chall...
Pradeep Nathan
I am a clinical pharmacologist with research interests in the neuropharmacology and neural substrates of cognition and emotion and psychiatric and neurological endophenotypes. I use cognitive, functional and molecular neuroimaging techniques (i.e....
Dr Peter Nestor
To relate the neuropsychological and behavioural profiles of degenerative dementias, such as Alzheimer's disease and frontotemporal dementia, to regional brain damage through neuroimaging (MRI and PET) and histopathological analysis. A particular ...
Professor John T O'Brien
My research interests in dementia include the role of biomarkers, especially MRI, SPECT and PET imaging, in the differential and early diagnosis of dementia, including identifying those ‘at risk’ of future cognitive decline and developing markers ...
Professor Adrian Owen
In January 2011, my research team and I moved to the University of Western Ontario, Canada, where I have taken up the Canada Excellence Research Chair (CERC) in Cognitive Neuroscience and Imaging. Although I continue to maintain strong collaborati...
Dr Jesus Perez
My research activity is mainly focused on early detection and intervention in psychosis and the history of psychiatry. I am particularly interested in the epidemiological apects of young people at high-risk of developing psychosis and with first-e...
Professor John Pickard
Advancing the care of patients with acute brain injury (trauma, haemorrhage and hydrocephalus) from initial ictus, neurointensive care, recovery from coma and rehabilitation to final outcome through the study of pathophysiology (multimodality beds...
Mr Stephen Price
My group uses advanced multimodal MR and PET imaging to understand the heterogeneity of gliomas (high and low grade) in individual patients. We know that gliomas are among the most heterogeneous tumours but still do not have a method of detecting ...
Dr Ruma Raha-Chowdhury
I have a passion for Iron. My main interest is investigate role of iron proteins in brain iron homeostasis, neuronal inflammation and neurodegenerative diseases. Recently I found a family of inhibitory Guidance molecules regulate by iron and have ...
Dr Lucy Raymond
The group aims to understand the molecular mechanisms underlying intellectual disability in humans. Our main focus is on families with X linked disease. In collaboration with The Wellcome Trust Sanger Institute, we are using a new approach to dise...
Dr Rhys Roberts
Our group is interested in peripheral nerve diseases, particularly the inherited peripheral neuropathies, Charcot-Marie-Tooth disease (CMT). We have focused on the demyelinating forms of CMT, where defects in intracellular membrane trafficking p...
Professor David Rubinsztein
The pathogenesis of diseases caused by codon reiteration mutations (like Huntington’s disease and oculopharangeal muscular dystrophy). Description of research: We are studying the pathogenesis of diseases caused by codon reiteration mutations, l...
Dr Umar Sadat
1. Magnetic resonance imaging of atherosclerotic plaques 2. Applied biomechanics of atherosclerotic plaques and other cardiovascular pathologies 3. Contrast-induced-nephropathy 4. Ischaemic Pre-conditioning in patients undergoing open and endovas...
Professor Barbara Sahakian
My research is aimed at understanding the neural basis of cognitive, emotional and behavioural dysfunction in order to develop more effective pharmacological and psychological treatments. The focus of my lab is on early detection, differential dia...
Dr Michael Spencer
I am interested in the scientific investigation of psychiatric disorders, particularly through the integration of clinical research methods together with brain imaging. I led a team of researchers at the Department of Psychiatry, Cambridge, that ...
Jillian Sullivan
My PhD study investigates the relationship between neural/physical growth trajectories and cognitive/developmental trajectories in infants and toddlers who are at risk for autism, children with autism, children with tuberous sclerosis, and those w...- Dr Robert Tasker
Over 10,000 children are admitted to a Paediatric Intensive Care Unit (PICU) in the UK each year and, of these, 1500 have acute brain injury. In our recent studies in cohorts of children from the Addenbrooke’s Hospital PICU we have examined the e... 
Dr Elizabeth Warburton
Research interests are as follows 1. Molecular imaging of atheroma - particularly carotid plaque imaging using PET and MRI techniques. Both Clinical and microPET imaging. Proof of principle trials of novel atheroma drugs with imaging biomarkers...
Dr Colin Watts
Lab-based research is focused on the genomics of glioblastoma (GBM) and in the role of glial progenitors in their evolution and development. We are also interested in developing patient-specific models of GBM to evaluate intra-tumour variability i...
Dr Daniel Wheeler
Dr. Wheeler's main clinical interest is Pain Medicine, and since his appointment to the Lectureship in Anaesthesia in the Department of Medicine, he is building collaborations to explore the potential novel interventions for chronic painful condit...
Dr Paul Wilkinson
My main research interest is the intermediate biology and cognitions of adolescent depression, in particular how such intermediate variables mediate associations between genotype, environment and disorder. The main intermediate variable I study i...
Dr Ian Wilkinson
My research is clinically orientated and centres on the physiology and pharmacology of the cardiovascular system, and particularly the large arteries and endothelial function. As a clinical pharmacologist, I combine detailed physiological measure...
Dr Guy Williams
Our group’s research interests lie broadly in nuclear magnetic resonance (NMR). This phenomenon allows data to be collected noninvasively on both the structure and function of the human brain. We research novel acquisition methods to provide contr...- Dr David Williamson
Development of novel PET ligands for use in preclinical studies to image neurodegenerative processes e.g. Stroke & Dementia 
Dr John Xuereb
The neuropathological basis of dementia with a special interest in clinicopathological correlation of Frontotemporal Syndromes.- Dr Shahid Zaman
The main theme of our research is to understand the role of amyloid and mitochondrial dysfunction in the genesis of cognitive impairment and dementia in people with Down's syndrome.
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