Bibliographic entry:

Rodríguez-Moreno A, Paulsen O (2008) “Spike timing-dependent long-term depression requires presynaptic NMDA receptors.” Nat Neurosci 11(7):744-5

Abstract:

NMDA receptors are necessary for both synaptic potentiation and depression, but the precise location of these receptors has not been established. By loading MK-801 into pre- or postsynaptic neurons during paired recordings of synaptically connected layer 4 and layer 2/3 neurons in mouse barrel cortex, we found that synaptic potentiation requires postsynaptic, but not presynaptic, NMDA receptors, whereas synaptic depression requires presynaptic, but not postsynaptic, NMDA receptors.

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