Rodríguez-Moreno A, Paulsen O (2008) “Spike timing-dependent long-term depression requires presynaptic NMDA receptors.” Nat Neurosci 11(7):744-5
NMDA receptors are necessary for both synaptic potentiation and depression, but the precise location of these receptors has not been established. By loading MK-801 into pre- or postsynaptic neurons during paired recordings of synaptically connected layer 4 and layer 2/3 neurons in mouse barrel cortex, we found that synaptic potentiation requires postsynaptic, but not presynaptic, NMDA receptors, whereas synaptic depression requires presynaptic, but not postsynaptic, NMDA receptors.
|Online links:||Available online from Nature Publishing Group|
|Publication type:||Journal Article|
|Publication status:||In print, Electronically published|
|Publication date:||2008 Jul|
|Electronic publication date:||2008 May 30|
|Record status:||PubMed - indexed for MEDLINE|