Czosnyka M, Smielewski P, Timofeev I, Lavinio A, Guazzo E, Hutchinson P, Pickard JD (2007) “Intracranial pressure: more than a number.” Neurosurg Focus 22(5):E10
Many doctors involved in the critical care of head-injured patients understand intracranial pressure (ICP) as a number, characterizing the state of the brain pressure-volume relationships. However, the dynamics of ICP, its waveform, and secondarily derived indices portray useful information about brain homeostasis. There is circumstantial evidence that this information can be used to modify and optimize patients' treatment. Secondary variables, such as pulse amplitude and the magnitude of slow waves, index of compensatory reserve, and pressure-reactivity index (PRx), look promising in clinical practice. The optimal cerebral perfusion pressure (CPP) derived using the PRx is a new concept that may help to avoid excessive use of vasopressors in CPP-oriented therapy. However, the use of secondary ICP indices remains to be confirmed in clinical trials.
|Online links:||This article is not recorded as available online within PubMed.|
|Publication type:||Journal Article|
|Publication status:||Electronically published|
|Publication date:||2007 May 15|
|Electronic publication date:||2007 May 15|
|Record status:||PubMed - indexed for MEDLINE|