Müller U, Ullsperger M, Hammerstein E, Sachweh S, Becker T (2005) “Directed forgetting in schizophrenia: prefrontal memory and inhibition deficits.” Eur Arch Psychiatry Clin Neurosci 255(4):251-7
Schizophrenia is associated with cognitive deficits in the domains of working memory, strategic memory and other executive functions. In the current study we used a computerised and item-cued variant of the directed forgetting (DF) task to assess inhibitory processes in verbal memory. Twenty-five patients with schizophrenia and a group of matched controls were tested. Recognition memory was better for to-be-remembered (TBR) than for to-be-forgotten (TBF) words in both patients and controls. As compared to healthy controls the patients with schizophrenia showed overall memory deficits and difficulties to inhibit memories as indicated by a significant group by cue interaction and a smaller DF effect. The DF effect was associated with disease duration but not with symptom severity. Memory-related inhibition problems are difficult to assess in patients with schizophrenia and might be related to fronto-temporal disconnection.
|Online links:||Available online from Springer|
|Publication type:||Journal Article|
|Publication status:||In print, Electronically published|
|Publication date:||2005 Aug|
|Electronic publication date:||2004 Nov 22|
|Record status:||PubMed - indexed for MEDLINE|