Russell TA, Rubia K, Bullmore ET, Soni W, Suckling J, Brammer MJ, Simmons A, Williams SC, Sharma T (2000) “Exploring the social brain in schizophrenia: left prefrontal underactivation during mental state attribution.” Am J Psychiatry 157(12):2040-2
Evidence suggests that patients with schizophrenia have a deficit in "theory of mind," i.e., interpretation of the mental state of others. The authors used functional magnetic resonance imaging (MRI) to investigate the hypothesis that patients with schizophrenia have a dysfunction in brain regions responsible for mental state attribution.
Mean brain activation in five male patients with schizophrenia was compared to that in seven comparison subjects during performance of a task involving attribution of mental state.
During performance of the mental state attribution task, the patients made more errors and showed less blood-oxygen-level-dependent signal in the left inferior frontal gyrus.
To the authors' knowledge, this is the first functional MRI study to show a deficit in the left prefrontal cortex in schizophrenia during a socioemotional task.
|Online links:||Available online from Silverchair Information Systems|
|Publication type:||Journal Article|
|Publication status:||In print|
|Publication date:||2000 Dec|
|Record status:||PubMed - indexed for MEDLINE|