This article is in the news archive.
Breaking the mould: Untangling the jelly-like properties of diseased proteins
Image Credit: Steven Depola
Credit: Steven Depolo
Scientists at the University of Cambridge have identified a new property of essential proteins which, when it malfunctions, can cause the build up, or ‘aggregation’, of misshaped proteins and lead to serious diseases.
A common characteristic of neurodegenerative diseases – such as Alzheimer’s, Parkinson’s and Huntington’s disease – is the build-up of ‘misfolded’ proteins, which cause irreversible damage to the brain. For example, Alzheimer’s disease sees the build-up of beta-amyloid ‘plaques’ and tau ‘tangles’.
Like jelly on a plate
The behaviour of FUS can be likened to that of a jelly, explains Professor Peter St George Hyslop from the Cambridge Institute for Medical Research.
Adapted from University of Cambridge News
Posted on 17/12/2015
Go to the news index page.