Dr Young T. Hong

University position

Senior Research Associate

Dr Young T. Hong is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Wolfson Brain Imaging Centre

Email

yth20@wbic.cam.ac.uk

Research Themes

Systems and Computational Neuroscience

Clinical and Veterinary Neuroscience

Interests

My main research area is developing mathematical models and numerical techniques in analysis of positron emission tomography (PET) data. Most of the PET images are obtained for acute head injury, psychiatry and neurology clinical research.

Research Focus

Keywords

PET

mathematical model

Clinical conditions

Addiction

Alzheimer's disease

Cancers

Cognitive impairment

Dementia

Stroke

Traumatic brain injury

Equipment

Computational modelling

Magnetic resonance imaging (MRI)

Positron Emission Tomography (PET)

Collaborators

Cambridge

Jonathan Coles

Tim Fryer

Associated News Items


    Key publications

    Baron JC, Farid K, Dolan E, Turc G, Marrapu ST, O'Brien E, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Hong YT (2014), “Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage.” J Cereb Blood Flow Metab Details

    Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK (2013), “Amyloid Imaging With Carbon 11-Labeled Pittsburgh Compound B for Traumatic Brain Injury.” JAMA Neurol Details

    Geeraerts T, Coles JP, Aigbirhio FI, Pickard JD, Menon DK, Fryer TD, Hong YT (2011), “Validation of reference tissue modelling for [(11)C]flumazenil positron emission tomography following head injury.” Ann Nucl Med Details

    Hong YT, Beech JS, Smith R, Baron JC, Fryer TD (2011), “Parametric mapping of [18F]fluoromisonidazole positron emission tomography using basis functions.” J Cereb Blood Flow Metab 31(2):648-57 Details

    Hong YT, Fryer TD (2010), “Kinetic modelling using basis functions derived from two-tissue compartmental models with a plasma input function: general principle and application to [18F]fluorodeoxyglucose positron emission tomography.” Neuroimage 51(1):164-72 Details

    Dalley JW, Fryer TD, Brichard L, Robinson ES, Theobald DE, Lääne K, Peña Y, Murphy ER, Shah Y, Probst K, Abakumova I, Aigbirhio FI, Richards HK, Hong Y, Baron JC, Everitt BJ, Robbins TW (2007), “Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.” Science 315(5816):1267-70 Details

    Publications

    2014

    Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC (2014), “Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.” J Neurosci 34(22):7663-76 Details

    2013

    Caprioli D, Hong YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Adrian Carpenter T, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer TD, Dalley JW (2013), “Baseline-dependent effects of cocaine pre-exposure on impulsivity and D(2/3) receptor availability in the rat striatum: Possible relevance to the attention-deficit hyperactivity syndrome.” Neuropsychopharmacology Details

    Carrera E, Jones PS, Morris RS, Alawneh J, Hong YT, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2013), “Is neural activation within the rescued penumbra impeded by selective neuronal loss?” Brain Details

    Del Campo N, Fryer TD, Hong YT, Smith R, Brichard L, Acosta-Cabronero J, Chamberlain SR, Tait R, Izquierdo D, Regenthal R, Dowson J, Suckling J, Baron JC, Aigbirhio FI, Robbins TW, Sahakian BJ, Müller U (2013), “A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.” Brain 136(Pt 11):3252-70 Details

    Ejaz S, Williamson DJ, Ahmed T, Sitnikov S, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Baron JC (2013), “Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.” Neurobiol Dis 51:120-32 Details

    Patrick J. Riss, Laurent Brichard, Valentina Ferrari, David J. Williamson, Tim D. Fryer, Young T. Hong, Jean-Claude Baron and Franklin I. Aigbirhio (2013), “Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of τ-pathology” Med. Chem. Commun. 4: 852-855

    Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI (2013), “Synthesis and Evaluation of 18F-FE-PEO in Rodents: An 18F-Labeled Full Agonist for Opioid Receptor Imaging.” J Nucl Med Details

    2012

    Pengas G, Williams GB, Acosta-Cabronero J, Ash TW, Hong YT, Izquierdo-Garcia D, Fryer TD, Hodges JR, Nestor PJ (2012), “The relationship of topographical memory performance to regional neurodegeneration in Alzheimer's disease.” Front Aging Neurosci 4:17 Details

    2011

    del Campo N, Tait RJ, Acosta-Cabronero J, Hong YT, Izquierdo-Garcia D, Smith R, Aigbirhio FI, Sahakian BJ, Müller U, Robbins TW, Fryer TD (2011), “Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.” Neuroimage 55(1):101-12 Details

    Landt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using Positron Emission Tomography and Carbon 11-Labeled Pittsburgh Compound B to Image Brain Fibrillar {beta}-Amyloid in Adults With Down Syndrome: Safety, Acceptability, and Feasibility.” Arch Neurol Details

    Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011), “Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.” J Cereb Blood Flow Metab 31(12):2334-42 Details

    2010

    Mion M, Patterson K, Acosta-Cabronero J, Pengas G, Izquierdo-Garcia D, Hong YT, Fryer TD, Williams GB, Hodges JR, Nestor PJ (2010), “What the left and right anterior fusiform gyri tell us about semantic memory.” Brain 133(11):3256-68 Details

    2009

    Clatworthy PL, Lewis SJ, Brichard L, Hong YT, Izquierdo D, Clark L, Cools R, Aigbirhio FI, Baron JC, Fryer TD, Robbins TW (2009), “Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.” J Neurosci 29(15):4690-6 Details

    Dalley JW, Fryer TD, Aigbirhio FI, Brichard L, Richards HK, Hong YT, Baron JC, Everitt BJ, Robbins TW (2009), “Modelling human drug abuse and addiction with dedicated small animal positron emission tomography.” Neuropharmacology 56 Suppl 1:9-17 Details

    2007

    Takasawa M, Beech JS, Fryer TD, Hong YT, Hughes JL, Igase K, Jones PS, Smith R, Aigbirhio FI, Menon DK, Clark JC, Baron JC (2007), “Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study.” J Cereb Blood Flow Metab 27(4):679-89 Details

    2004

    McGuinness M, Hong YT, Galletly D, Larsen P (2004), “Arnold tongues in human cardiorespiratory systems” Chaos 14(1):1-6