Department

Research Theme Neurons, Circuits and Networks

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Dr Yuan Huang

University Position

Research Associate

Interests

I am interested in using mathematical and mechanical tools to describe the biological systems. Better understanding of diseases can be achieved by further analysing the structural and functional imaging data. We hope our work will improve the diagnostic and prognostic values of current imaging modalities, and ultimately aid the risk stratification and clinical management.

Key Publications

Publications

Association of Collagen, Elastin, Glycosaminoglycans, and Macrophages With Tissue Ultimate Material Strength and Stretch in Human Thoracic Aortic Aneurysms: A Uniaxial Tension Study.

DOI: http://doi.org/10.1115/1.4054060
Journal: J Biomech Eng
E-pub date: 1 Oct 2022
Authors: A Tokgoz, S Wang, P Sastry, C Sun, NL Figg, Y Huang, MR Bennett, S Sinha, JH Gillard, MPF Sutcliffe, Z Teng

Study on the association of wall shear stress and vessel structural stress with atherosclerosis: An experimental animal study.

DOI: http://doi.org/10.1016/j.atherosclerosis.2021.01.017
Journal: Atherosclerosis
E-pub date: 1 Mar 2021
Authors: Z Teng, S Wang, A Tokgoz, V Taviani, J Bird, U Sadat, Y Huang, AJ Patterson, N Figg, MJ Graves, JH Gillard

Assessing robustness of carotid artery CT angiography radiomics in the identification of culprit lesions in cerebrovascular events.

DOI: http://doi.org/10.1038/s41598-021-82760-w
Journal: Sci Rep
E-pub date: 10 Feb 2021
Authors: EPV Le, L Rundo, JM Tarkin, NR Evans, MM Chowdhury, PA Coughlin, H Pavey, C Wall, F Zaccagna, FA Gallagher, Y Huang, R Sriranjan, A Le, JR Weir-McCall, M Roberts, FJ Gilbert, EA Warburton, C-B Schönlieb, E Sala, JHF Rudd

Biomechanical insight of the stent-induced thrombosis following flow-diverting strategy in the management of complicated aortic aneurysms.

DOI: http://doi.org/10.23736/S0392-9590.20.04447-8
Journal: Int Angiol
E-pub date: 1 Feb 2021
Authors: Y Zhang, Y Huang, Z Teng, J Cui, Q Lu, Z Jing

A Bayesian Updating Scheme for Pandemics: Estimating the Infection Dynamics of COVID-19

DOI: http://doi.org/10.1109/MCI.2020.3019874
Journal: IEEE Computational Intelligence Magazine
E-pub date: 1 Nov 2020
Authors: S Wang, X Yang, L Li, P Nadler, R Arcucci, Y Huang, Z Teng, Y Guo

Greater aortic inflammation and calcification in abdominal aortic aneurysmal disease than atherosclerosis: a prospective matched cohort study.

DOI: http://doi.org/10.1136/openhrt-2019-001141
Journal: Open Heart
E-pub date: 1 Aug 2020
Authors: NV Joshi, M Elkhawad, RO Forsythe, OMB McBride, NK Rajani, JM Tarkin, MM Chowdhury, E Donoghue, JMJ Robson, JR Boyle, TD Fryer, Y Huang, Z Teng, MR Dweck, AA Tawakol, JH Gillard, PA Coughlin, IB Wilkinson, DE Newby, JHF Rudd

Heterogeneity of Plaque Structural Stress Is Increased in Plaques Leading to MACE: Insights From the PROSPECT Study.

DOI: http://doi.org/10.1016/j.jcmg.2019.05.024
Journal: JACC Cardiovasc Imaging
E-pub date: 1 May 2020
Authors: C Costopoulos, A Maehara, Y Huang, AJ Brown, JH Gillard, Z Teng, GW Stone, MR Bennett

The role of porosity and 3D cross-stent configuration of multiple overlapping uncovered stents in the management of complex aortic aneurysms – insights from haemodynamics

DOI: http://doi.org/10.1016/j.medntd.2019.100020
Journal: Medicine in Novel Technology and Devices
E-pub date: 1 Dec 2019
Authors: S Wang, Y Zhang, J Feng, Y Huang, P Hui, JH Gillard, Q Lu, Z Teng

Bayesian Inference-Based Estimation of Normal Aortic, Aneurysmal and Atherosclerotic Tissue Mechanical Properties: From Material Testing, Modeling and Histology.

DOI: http://doi.org/10.1109/TBME.2018.2886681
Journal: IEEE Trans Biomed Eng
E-pub date: 31 Aug 2019
Authors: S Wang, A Tokgoz, Y Huang, Y Zhang, J Feng, P Sastry, C Sun, N Figg, Q Lu, MPF Sutcliffe, Z Teng, JH Gillard

Impact of combined plaque structural stress and wall shear stress on coronary plaque progression, regression, and changes in composition.

DOI: http://doi.org/10.1093/eurheartj/ehz132
Journal: Eur Heart J
E-pub date: 7 May 2019
Authors: C Costopoulos, LH Timmins, Y Huang, OY Hung, DS Molony, AJ Brown, EL Davis, Z Teng, JH Gillard, H Samady, MR Bennett

Neural network fusion: a novel CT-MR Aortic Aneurysm image segmentation method.

DOI: http://doi.org/10.1117/12.2293371
Journal: Proc SPIE Int Soc Opt Eng
E-pub date: 2 Mar 2018
Authors: D Wang, R Zhang, J Zhu, Z Teng, Y Huang, F Spiga, M Hong-Fei Du, JH Gillard, Q Lu, P Liò

Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress.

DOI: http://doi.org/10.1016/j.jcmg.2017.04.017
Journal: JACC Cardiovasc Imaging
E-pub date: 1 Dec 2017
Authors: C Costopoulos, Y Huang, AJ Brown, PA Calvert, SP Hoole, NEJ West, JH Gillard, Z Teng, MR Bennett

Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment: A patient-specific parameter study.

DOI: http://doi.org/10.1016/j.jbiomech.2017.06.048
Journal: J Biomech
E-pub date: 26 Jul 2017
Authors: S Wang, Y Zhang, J Feng, Y Huang, A Tokgoz, U Sadat, JH Gillard, Q Lu, Z Teng

High Structural Stress and Presence of Intraluminal Thrombus Predict Abdominal Aortic Aneurysm 18F-FDG Uptake: Insights From Biomechanics.

DOI: http://doi.org/10.1161/CIRCIMAGING.116.004656
Journal: Circ Cardiovasc Imaging
E-pub date: 1 Nov 2016
Authors: Y Huang, Z Teng, M Elkhawad, JM Tarkin, N Joshi, JR Boyle, JR Buscombe, TD Fryer, Y Zhang, AY Park, IB Wilkinson, DE Newby, JH Gillard, JHF Rudd

TCT-598 Plaque rupture in coronary atherosclerosis is associated with increased plaque structural stress.

DOI: http://doi.org/10.1016/j.jacc.2016.09.737
Journal: J Am Coll Cardiol
E-pub date: 1 Nov 2016
Authors: C Costopoulos, Y Huang, A Brown, P Calvert, S Hoole, N West, J Gillard, Z Teng, M Bennett

Plaque Structural Stress Estimations Improve Prediction of Future Major Adverse Cardiovascular Events After Intracoronary Imaging.

DOI: http://doi.org/10.1161/CIRCIMAGING.115.004172
Journal: Circ Cardiovasc Imaging
E-pub date: 1 Jun 2016
Authors: AJ Brown, Z Teng, PA Calvert, NK Rajani, O Hennessy, N Nerlekar, DR Obaid, C Costopoulos, Y Huang, SP Hoole, M Goddard, NEJ West, JH Gillard, MR Bennett

A uni-extension study on the ultimate material strength and extreme extensibility of atherosclerotic tissue in human carotid plaques.

DOI: http://doi.org/10.1016/j.jbiomech.2015.09.037
Journal: J Biomech
E-pub date: 5 Nov 2015
Authors: Z Teng, J Feng, Y Zhang, MPF Sutcliffe, Y Huang, AJ Brown, Z Jing, Q Lu, JH Gillard

Layer- and Direction-Specific Material Properties, Extreme Extensibility and Ultimate Material Strength of Human Abdominal Aorta and Aneurysm: A Uniaxial Extension Study.

DOI: http://doi.org/10.1007/s10439-015-1323-6
Journal: Ann Biomed Eng
E-pub date: 1 Nov 2015
Authors: Z Teng, J Feng, Y Zhang, Y Huang, MPF Sutcliffe, AJ Brown, Z Jing, JH Gillard, Q Lu

Management of complicated aortic aneurysms using multiple overlapping uncovered stents: mid-term outcome from a cohort study.

DOI: http://doi.org/10.1097/MD.0000000000000209
Journal: Medicine (Baltimore)
E-pub date: 1 Dec 2014
Authors: Y Zhang, Z Teng, Q Lu, Z Zhao, J Bao, X Feng, R Feng, Z Chen, Y Huang, U Sadat, JH Gillard, Z Jing

Material properties of components in human carotid atherosclerotic plaques: a uniaxial extension study.

DOI: http://doi.org/10.1016/j.actbio.2014.09.001
Journal: Acta Biomater
E-pub date: 1 Dec 2014
Authors: Z Teng, Y Zhang, Y Huang, J Feng, J Yuan, Q Lu, MPF Sutcliffe, AJ Brown, Z Jing, JH Gillard

IN VIVO CORONARY PLAQUE STRUCTURAL STRESS IS INFLUENCED BY BOTH PLAQUE COMPOSITION AND CLASSIFICATION

DOI: http://doi.org/10.1016/S0735-1097(14)61759-9
Journal: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
E-pub date: 1 Aug 2014
Authors: AJ Brown, Z Teng, P Calvert, Y Huang, DR Obaid, S Hoole, N West, JH Gillard, M Bennett

Coronary plaque structural stress is associated with plaque composition and subtype and higher in acute coronary syndrome: the BEACON I (Biomechanical Evaluation of Atheromatous Coronary Arteries) study.

DOI: http://doi.org/10.1161/CIRCIMAGING.113.001526
Journal: Circ Cardiovasc Imaging
E-pub date: 1 May 2014
Authors: Z Teng, AJ Brown, PA Calvert, RA Parker, DR Obaid, Y Huang, SP Hoole, NEJ West, JH Gillard, MR Bennett

The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses.

DOI: http://doi.org/10.1016/j.jbiomech.2014.01.030
Journal: J Biomech
E-pub date: 11 Apr 2014
Authors: Y Huang, Z Teng, U Sadat, MJ Graves, MR Bennett, JH Gillard

In vivo MRI-based simulation of fatigue process: a possible trigger for human carotid atherosclerotic plaque rupture.

DOI: http://doi.org/10.1186/1475-925X-12-36
Journal: Biomed Eng Online
E-pub date: 23 Apr 2013
Authors: Y Huang, Z Teng, U Sadat, J He, MJ Graves, JH Gillard

Microcalcification acts as a stress and stretch amplifier in the coronary atherosclerotic plaque affecting its vulnerability – An ivus-based finite element study

DOI: http://doi.org/10.1115/SBC2012-80430
Journal: ASME 2012 Summer Bioengineering Conference, SBC 2012
E-pub date: 1 Dec 2012
Authors: Y Huang, W Wang, Z Teng, DR Obaid, J He, PA Calvert, MR Bennett, JH Gillard

In vivo MRI-based 3D mechanical stress-strain profiles of carotid plaques with juxtaluminal plaque haemorrhage: an exploratory study for the mechanism of subsequent cerebrovascular events.

DOI: http://doi.org/10.1016/j.ejvs.2011.05.009
Journal: Eur J Vasc Endovasc Surg
E-pub date: 1 Oct 2011
Authors: Z Teng, U Sadat, Y Huang, VE Young, MJ Graves, J Lu, JH Gillard

Non-uniform shrinkage for obtaining computational start shape for in-vivo MRI-based plaque vulnerability assessment.

DOI: http://doi.org/10.1016/j.jbiomech.2011.06.014
Journal: J Biomech
E-pub date: 11 Aug 2011
Authors: Y Huang, Z Teng, U Sadat, S Hilborne, VE Young, MJ Graves, JH Gillard