Dr Wei-Li Kuan
University position
Research Associate
Departments
Department of Clinical Neurosciences
Institutes
Cambridge Centre for Brain Repair
Research Themes
Interests
My primary research interest lies in the study of novel interactions between neurotransmitters in the basal ganglia in the context of locomotor and mood disorders. Currently I am working on whether the serotonergic system has a modulatory function on locomotor behaviours in the dopamine-deprived striatum.
Research Focus
KeywordsParkinson's disease dopaminergic system serotonergic system levodopa-induced dyskinesia basal ganglia |
Clinical conditionsAnxiety disorders Depressive disorders Movement disorders Parkinson's disease |
Equipment
Behavioural analysis
Immunohistochemistry
Collaborators
CambridgeJohn Sinclair | InternationalHiroyuki Umegaki Web: http://umegaki@med.nagoya-u.ac.jp |
Key publications
Kuan et al (2008), “The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram” Psychopharmacology 197 (2):279-93
Kuan et al (2007), “The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesias” Neurobiol Dis 25(3):594-608
Kuan et al (2006), “Increased capacity for axonal outgrowth using xenogenic tissue in vitro and in a rodent model of Parkinson's disease” Xenotransplantation 13(3):233-47
Research and Collaboration
News, events and seminars
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