Interests

My primary area of research is the potential role of oligodendrocyte precursor cells as a stem cell. To answer this I use in vitro and in vivo techniques. I also use extensive lesioning experience to examine whether integrated OPC populations can be altered or stimulated to change their normal fate. My other research is involved in examining the role of transplanted OPCs in a neonatal hypoxia/ischemia animal model. This is important because in the human form of the disease many of the problems are a result of specific white matter damage that occurs in the neonate

Research Focus

Keywords

OPC

animal transplantation

neurodegenerative disease

stem cells

Clinical conditions

Childhood disorders

Multiple sclerosis

Equipment

Behavioural analysis

Cell culture

Fluorescence microscopy

Immunohistochemistry

Microscopy

Protein purification

Collaborators

Cambridge

James Fawcett

Maria Spillantini

United Kingdom

Donald Peebles Web: http://www.instituteforwomenshealth.ucl.ac.uk/Academi...

Gena Raivich Web: http://www.instituteforwomenshealth.ucl.ac.uk/Academi...

Key publications

Webber DJ, Compston A, Chandran S (in submission), “Unmanipulated oligodendrocyte precursor cells retian exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus” Eur J Neuro

Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S (2007), “Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells” Brain 130(Pt 5):1263-75 Details

Webber DJ (2007), “Adult neural precursor cells and the dysmyelinated spinal cord” J Neurosci 27(25):6605-6 Details