Dr Daniel Webber

University position
Research Associate
Departments
Department of Clinical Neurosciences
Institutes
Cambridge Centre for Brain Repair
Home page
http://www.brc.cam.ac.uk/chandra...
Research Themes
Interests
My primary area of research is the potential role of oligodendrocyte precursor cells as a stem cell. To answer this I use in vitro and in vivo techniques. I also use extensive lesioning experience to examine whether integrated OPC populations can be altered or stimulated to change their normal fate. My other research is involved in examining the role of transplanted OPCs in a neonatal hypoxia/ischemia animal model. This is important because in the human form of the disease many of the problems are a result of specific white matter damage that occurs in the neonate
Research Focus
KeywordsOPC animal transplantation neurodegenerative disease stem cells |
Clinical conditionsChildhood disorders Multiple sclerosis |
Equipment
Behavioural analysis
Cell culture
Fluorescence microscopy
Immunohistochemistry
Microscopy
Protein purification
Collaborators
Cambridge | United KingdomDonald Peebles Web: http://www.instituteforwomenshealth.ucl.ac.uk/Academi... Gena Raivich Web: http://www.instituteforwomenshealth.ucl.ac.uk/Academi... |
Key publications
Webber DJ, Compston A, Chandran S (in submission), “Unmanipulated oligodendrocyte precursor cells retian exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus” Eur J Neuro
Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S (2007), “Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells” Brain 130(Pt 5):1263-75 Details
Webber DJ (2007), “Adult neural precursor cells and the dysmyelinated spinal cord” J Neurosci 27(25):6605-6 Details

