Dr Valerie Voon

Valerie Voon

University position

Wellcome Trust Fellow

Dr Valerie Voon is pleased to consider applications from prospective PhD students.

Departments

Department of Psychiatry

Institutes

Behavioural and Clinical Neuroscience Institute

Email

vv247@cam.ac.uk

Research Theme

Cognitive and Behavioural Neuroscience

Interests

Why do we repeat behaviours that we know are bad for us? I am an Honorary Consultant Neuropsychiatrist and Wellcome Trust Fellow with the Department of Psychiatry. The Voon lab focuses on mechanisms underlying compulsive disorders such as substance and behavioural addictions and obsessive compulsive disorder in the general population and in neurological disorders such as Parkinson's disease. I have a side interest in the pathophysiology of conversion disorder. My research uses a combination of pharmacological manipulation, cognitive paradigms and functional and anatomical MRI in clinical and healthy populations.

Research Focus

Keywords

None specified

Clinical conditions

Addiction

Impulse control disorders

Movement disorders

Obsessive compulsive disorder

Parkinson's disease

Equipment

No equipment indicated

Collaborators

Cambridge

Ed Bullmore

Naomi Feinberg

Trevor Robbins

Barbara Sahakian

International

William Hutchison

Valterri Kaasinen

Mircea Polosan

Associated News Items


    Key publications

    Banca P, Vestergaard MD, Rankov V, Baek K, Mitchell S, Lapa T, Castelo-Branco M, Voon V (2014), “Evidence Accumulation in Obsessive-Compulsive Disorder: the Role of Uncertainty and Monetary Reward on Perceptual Decision-Making Thresholds.” Neuropsychopharmacology Details

    Voon V, Derbyshire K, Rück C, Irvine MA, Worbe Y, Enander J, Schreiber LR, Gillan C, Fineberg NA, Sahakian BJ, Robbins TW, Harrison NA, Wood J, Daw ND, Dayan P, Grant JE, Bullmore ET (2014), “Disorders of compulsivity: a common bias towards learning habits.” Mol Psychiatry Details

    Voon V, Irvine MA, Derbyshire K, Worbe Y, Lange I, Abbott S, Morein-Zamir S, Dudley R, Caprioli D, Harrison NA, Wood J, Dalley JW, Bullmore ET, Grant JE, Robbins TW (2013), “Measuring "Waiting" Impulsivity in Substance Addictions and Binge Eating Disorder in a Novel Analogue of Rodent Serial Reaction Time Task.” Biol Psychiatry Details

    Voon V, Sohr M, Lang AE, Potenza MN, Siderowf AD, Whetteckey J, Weintraub D, Wunderlich GR, Stacy M (2011), “Impulse control disorders in Parkinson disease: a multicenter case--control study.” Ann Neurol 69(6):986-96 Details

    Voon V, Pessiglione M, Brezing C, Gallea C, Fernandez HH, Dolan RJ, Hallett M (2010), “Mechanisms underlying dopamine-mediated reward bias in compulsive behaviors.” Neuron 65(1):135-42 Details

    Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM, Kennedy SH (2005), “Deep brain stimulation for treatment-resistant depression.” Neuron 45(5):651-60 Details

    Publications

    2015

    Banca P, Lange I, Worbe Y, Howell NA, Irvine M, Harrison NA, Moutoussis M, Voon V (2015), “Reflection impulsivity in binge drinking: behavioural and volumetric correlates.” Addict Biol Details

    Banca P, Voon V, Vestergaard MD, Philipiak G, Almeida I, Pocinho F, Relvas J, Castelo-Branco M (2015), “Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder.” Brain Details

    Joutsa J, Voon V, Johansson J, Niemelä S, Bergman J, Kaasinen V (2015), “Dopaminergic function and intertemporal choice.” Transl Psychiatry 5:e491 Details

    in press

    Meoni S, Zurowski M, Lozano AM, Hodaie M, Poon YY, Fallis M, Voon V, Moro E (in press), “Long-term neuropsychiatric outcomes after pallidal stimulation in primary and secondary dystonia” Neurology

    2015

    Worbe Y, Palminteri S, Savulich G, Daw ND, Fernandez-Egea E, Robbins TW, Voon V (2015), “Valence-dependent influence of serotonin depletion on model-based choice strategy.” Mol Psychiatry Details

    2014

    Cooper EA, Garlick J, Featherstone E, Voon V, Singer T, Critchley HD, Harrison NA (2014), “You turn me cold: evidence for temperature contagion.” PLoS One 9(12):e116126 Details

    Fineberg NA, Chamberlain SR, Goudriaan AE, Stein DJ, Vanderschuren LJ, Gillan CM, Shekar S, Gorwood PA, Voon V, Morein-Zamir S, Denys D, Sahakian BJ, Moeller FG, Robbins TW, Potenza MN (2014), “New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity.” CNS Spectr 19(1):69-89 Details

    Harrison NA, Cercignani M, Voon V, Critchley HD (2014), “Effects of Inflammation on Hippocampus and Substantia Nigra Responses to Novelty in Healthy Human Participants.” Neuropsychopharmacology Details

    Harrison NA, Cooper E, Dowell NG, Keramida G, Voon V, Critchley HD, Cercignani M (2014), “Quantitative Magnetization Transfer Imaging as a Biomarker for Effects of Systemic Inflammation on the Brain.” Biol Psychiatry Details

    Harrison NA, Doeller CF, Voon V, Burgess N, Critchley HD (2014), “Peripheral Inflammation Acutely Impairs Human Spatial Memory via Actions on Medial Temporal Lobe Glucose Metabolism.” Biol Psychiatry Details

    Mechelmans DJ, Irvine M, Banca P, Porter L, Mitchell S, Mole TB, Lapa TR, Harrison NA, Potenza MN, Voon V (2014), “Enhanced Attentional Bias towards Sexually Explicit Cues in Individuals with and without Compulsive Sexual Behaviours.” PLoS One 9(8):e105476 Details

    Mole TB, Irvine MA, Worbe Y, Collins P, Mitchell SP, Bolton S, Harrison NA, Robbins TW, Voon V (2014), “Impulsivity in disorders of food and drug misuse.” Psychol Med :1-12 Details

    Napier TC, Corvol JC, Grace AA, Roitman JD, Rowe J, Voon V, Strafella AP (2014), “Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease.” Mov Disord Details

    Voon V (2014), “Functional neurological disorders: Imaging.” Neurophysiol Clin 44(4):339-342 Details

    Voon V (2014), “Models of Impulsivity with a Focus on Waiting Impulsivity: Translational Potential for Neuropsychiatric Disorders.” Curr Addict Rep 1(4):281-288 Details

    Voon V, Mole TB, Banca P, Porter L, Morris L, Mitchell S, Lapa TR, Karr J, Harrison NA, Potenza MN, Irvine M (2014), “Neural Correlates of Sexual Cue Reactivity in Individuals with and without Compulsive Sexual Behaviours.” PLoS One 9(7):e102419 Details

    Voon V, Morris LS, Irvine MA, Ruck C, Worbe Y, Derbyshire K, Rankov V, Schreiber LR, Odlaug BL, Harrison NA, Wood J, Robbins TW, Bullmore ET, Grant JE (2014), “Risk Taking in Disorders of Natural and Drug Rewards: Neural Correlates and Effects of Probability, Valence and Magnitude.” Neuropsychopharmacology Details

    Worbe Y, Savulich G, Voon V, Fernandez-Egea E, Robbins TW (2014), “Serotonin Depletion Induces 'Waiting Impulsivity' on the Human Four Choice Serial Reaction Time Task: Cross-Species Translational Significance.” Neuropsychopharmacology Details

    2013

    Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2013), “Gamma Aminobutyric Acidergic and Neuronal Structural Markers in the Nucleus Accumbens Core Underlie Trait-like Impulsive Behavior.” Biol Psychiatry Details

    Clark-Elford R, Nathan PJ, Auyeung B, Voon V, Sule A, Müller U, Dudas R, Sahakian BJ, Phan KL, Baron-Cohen S (2013), “The effects of oxytocin on social reward learning in humans.” Int J Neuropsychopharmacol :1-11 Details

    Gillan CM, Morein-Zamir S, Urcelay GP, Sule A, Voon V, Apergis-Schoute AM, Fineberg NA, Sahakian BJ, Robbins TW (2013), “Enhanced Avoidance Habits in Obsessive-Compulsive Disorder.” Biol Psychiatry Details

    Harrison NA, Cooper E, Voon V, Miles K, Critchley HD (2013), “Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?” Brain Behav Immun 31:189-96 Details

    Howell NA, Worbe Y, Lange I, Tait R, Irvine M, Banca P, Harrison NA, Bullmore ET, Hutchison WD, Voon V (2013), “Increased Ventral Striatal Volume in College-Aged Binge Drinkers.” PLoS One 8(9):e74164 Details

    Insel TR, Voon V, Nye JS, Brown VJ, Altevogt BM, Bullmore ET, Goodwin GM, Howard RJ, Kupfer DJ, Malloch G, Marston HM, Nutt DJ, Robbins TW, Stahl SM, Tricklebank MD, Williams JH, Sahakian BJ (2013), “Innovative solutions to novel drug development in mental health.” Neurosci Biobehav Rev Details

    Irvine MA, Worbe Y, Bolton S, Harrison NA, Bullmore ET, Voon V (2013), “Impaired decisional impulsivity in pathological videogamers.” PLoS One 8(10):e75914 Details

    Kranick SM, Moore JW, Yusuf N, Martinez VT, Lafaver K, Edwards MJ, Mehta AR, Collins P, Harrison NA, Haggard P, Hallett M, Voon V (2013), “Action-effect binding is decreased in motor conversion disorder: Implications for sense of agency.” Mov Disord 28(8):1110-6 Details

    Kundu P, Brenowitz ND, Voon V, Worbe Y, Vértes PE, Inati SJ, Saad ZS, Bandettini PA, Bullmore ET (2013), “Integrated strategy for improving functional connectivity mapping using multiecho fMRI.” Proc Natl Acad Sci U S A Details

    Mestre TA, Strafella AP, Thomsen T, Voon V, Miyasaki J (2013), “Diagnosis and treatment of impulse control disorders in patients with movement disorders.” Ther Adv Neurol Disord 6(3):175-88 Details

    Voon V, Ekanayake V, Wiggs E, Kranick S, Ameli R, Harrison NA, Hallett M (2013), “Response inhibition in motor conversion disorder.” Mov Disord 28(5):612-8 Details

    Voon V, Howell NA, Krack P (2013), “Psychiatric considerations in deep brain stimulation for Parkinson's disease.” Handb Clin Neurol 116C:147-154 Details

    Voon V, Rizos A, Chakravartty R, Mulholland N, Robinson S, Howell NA, Harrison N, Vivian G, Ray Chaudhuri K (2013), “Impulse control disorders in Parkinson's disease: decreased striatal dopamine transporter levels.” J Neurol Neurosurg Psychiatry Details

    Worbe Y, Irvine M, Lange I, Kundu P, Howell NA, Harrison NA, Bullmore ET, Robbins TW, Voon V (2013), “Neuronal Correlates of Risk-Seeking Attitudes to Anticipated Losses in Binge Drinkers.” Biol Psychiatry Details

    2012

    Carson AJ, Brown R, David AS, Duncan R, Edwards MJ, Goldstein LH, Grunewald R, Howlett S, Kanaan R, Mellers J, Nicholson TR, Reuber M, Schrag AE, Stone J, Voon V, UK-FNS (2012), “Functional (conversion) neurological symptoms: research since the millennium.” J Neurol Neurosurg Psychiatry 83(8):842-50 Details

    Joutsa J, Johansson J, Niemelä S, Ollikainen A, Hirvonen MM, Piepponen P, Arponen E, Alho H, Voon V, Rinne JO, Hietala J, Kaasinen V (2012), “Mesolimbic dopamine release is linked to symptom severity in pathological gambling.” Neuroimage 60(4):1992-9 Details

    Joutsa J, Martikainen K, Vahlberg T, Voon V, Kaasinen V (2012), “Impulse control disorders and depression in Finnish patients with Parkinson's disease.” Parkinsonism Relat Disord 18(2):155-60 Details

    2011

    Kranick S, Ekanayake V, Martinez V, Ameli R, Hallett M, Voon V (2011), “Psychopathology and psychogenic movement disorders.” Mov Disord 26(10):1844-50 Details

    Lang AE, Voon V (2011), “Psychogenic movement disorders: past developments, current status, and future directions.” Mov Disord 26(6):1175-86 Details

    Meissner WG, Frasier M, Gasser T, Goetz CG, Lozano A, Piccini P, Obeso JA, Rascol O, Schapira A, Voon V, Weiner DM, Tison F, Bezard E (2011), “Priorities in Parkinson's disease research.” Nat Rev Drug Discov 10(5):377-93 Details

    Voon V, Brezing C, Gallea C, Hallett M (2011), “Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder.” Mov Disord 26(13):2396-403 Details

    Voon V, Dalley JW (2011), “Parkinson disease: impulsive choice-Parkinson disease and dopaminergic therapy.” Nat Rev Neurol 7(10):541-2 Details

    Voon V, Gao J, Brezing C, Symmonds M, Ekanayake V, Fernandez H, Dolan RJ, Hallett M (2011), “Dopamine agonists and risk: impulse control disorders in Parkinson's disease.” Brain 134(Pt 5):1438-46 Details

    Voon V, Mehta AR, Hallett M (2011), “Impulse control disorders in Parkinson's disease: recent advances.” Curr Opin Neurol 24(4):324-30 Details

    Voon V, Schoerling A, Wenzel S, Ekanayake V, Reiff J, Trenkwalder C, Sixel-Döring F (2011), “Frequency of impulse control behaviours associated with dopaminergic therapy in restless legs syndrome.” BMC Neurol 11:117 Details

    2010

    Voon V, Brezing C, Gallea C, Ameli R, Roelofs K, LaFrance WC Jr, Hallett M (2010), “Emotional stimuli and motor conversion disorder.” Brain 133(Pt 5):1526-36 Details

    Voon V, Butler TR, Ekanayake V, Gallea C, Ameli R, Murphy DL, Hallett M (2010), “Psychiatric symptoms associated with focal hand dystonia.” Mov Disord Details

    Voon V, Gallea C, Hattori N, Bruno M, Ekanayake V, Hallett M (2010), “The involuntary nature of conversion disorder.” Neurology 74(3):223-8 Details

    Voon V, Reynolds B, Brezing C, Gallea C, Skaljic M, Ekanayake V, Fernandez H, Potenza MN, Dolan RJ, Hallett M (2010), “Impulsive choice and response in dopamine agonist-related impulse control behaviors.” Psychopharmacology (Berl) 207(4):645-59 Details

    Weintraub D, Koester J, Potenza MN, Siderowf AD, Stacy M, Voon V, Whetteckey J, Wunderlich GR, Lang AE (2010), “Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients.” Arch Neurol 67(5):589-95 Details

    Weintraub D, Sohr M, Potenza MN, Siderowf AD, Stacy M, Voon V, Whetteckey J, Wunderlich GR, Lang AE (2010), “Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional study.” Ann Neurol 68(6):963-8 Details

    2009

    Benbadis SR, LaFrance WC Jr, Papandonatos GD, Korabathina K, Lin K, Kraemer HC, NES Treatment Workshop (2009), “Interrater reliability of EEG-video monitoring.” Neurology 73(11):843-6 Details

    Espay AJ, Goldenhar LM, Voon V, Schrag A, Burton N, Lang AE (2009), “Opinions and clinical practices related to diagnosing and managing patients with psychogenic movement disorders: An international survey of movement disorder society members.” Mov Disord 24(9):1366-74 Details

    Voon V, Fernagut PO, Wickens J, Baunez C, Rodriguez M, Pavon N, Juncos JL, Obeso JA, Bezard E (2009), “Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders.” Lancet Neurol 8(12):1140-9 Details

    Voon V, Krack P, Lang AE, Lozano AM, Dujardin K, Schüpbach M, Thobois S, Tamma F, Herzog J, Samanta J, Kubu C, Rossignol H, Poon YY, Saint-Cyr JA, Ardouin C, Moro E (2009), “Parkinson's disease, DBS and suicide: a role for serotonin?” Brain

    Weintraub D, Hoops S, Shea JA, Lyons KE, Pahwa R, Driver-Dunckley ED, Adler CH, Potenza MN, Miyasaki J, Siderowf AD, Duda JE, Hurtig HI, Colcher A, Horn SS, Stern MB, Voon V (2009), “Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease.” Mov Disord 24(10):1461-7 Details

    2008

    Voon V, Krack P, Lang AE, Lozano AM, Dujardin K, Schüpbach M, D'Ambrosia J, Thobois S, Tamma F, Herzog J, Speelman JD, Samanta J, Kubu C, Rossignol H, Poon YY, Saint-Cyr JA, Ardouin C, Moro E (2008), “A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease.” Brain 131(Pt 10):2720-8 Details

    2007

    Miyasaki JM, Al Hassan K, Lang AE, Voon V (2007), “Punding prevalence in Parkinson's disease.” Mov Disord 22(8):1179-81 Details

    Potenza MN, Voon V, Weintraub D (2007), “Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease.” Nat Clin Pract Neurol 3(12):664-72 Details

    Ravina B, Marder K, Fernandez HH, Friedman JH, McDonald W, Murphy D, Aarsland D, Babcock D, Cummings J, Endicott J, Factor S, Galpern W, Lees A, Marsh L, Stacy M, Gwinn-Hardy K, Voon V, Goetz C (2007), “Diagnostic criteria for psychosis in Parkinson's disease: report of an NINDS, NIMH work group.” Mov Disord 22(8):1061-8 Details

    Voon V, Fox S, Butler TR, Lang AE (2007), “Antidepressants and psychosis in Parkinson disease: a case series.” Int J Geriatr Psychiatry 22(6):601-4 Details

    Voon V, Fox SH (2007), “Medication-related impulse control and repetitive behaviors in Parkinson disease.” Arch Neurol 64(8):1089-96 Details

    Voon V, Lang AE, Hallett M (2007), “Diagnosing psychogenic movement disorders-which criteria should be used in clinical practice?” Nat Clin Pract Neurol 3(3):134-5 Details

    Voon V, Potenza MN, Thomsen T (2007), “Medication-related impulse control and repetitive behaviors in Parkinson's disease.” Curr Opin Neurol 20(4):484-92 Details

    Voon V, Thomsen T, Miyasaki JM, de Souza M, Shafro A, Fox SH, Duff-Canning S, Lang AE, Zurowski M (2007), “Factors associated with dopaminergic drug-related pathological gambling in Parkinson disease.” Arch Neurol 64(2):212-6 Details

    2006

    Ardouin C, Voon V, Worbe Y, Abouazar N, Czernecki V, Hosseini H, Pelissolo A, Moro E, Lhommée E, Lang AE, Agid Y, Benabid AL, Pollak P, Mallet L, Krack P (2006), “Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation.” Mov Disord 21(11):1941-6 Details

    Deuschl G, Herzog J, Kleiner-Fisman G, Kubu C, Lozano AM, Lyons KE, Rodriguez-Oroz MC, Tamma F, Tröster AI, Vitek JL, Volkmann J, Voon V (2006), “Deep brain stimulation: postoperative issues.” Mov Disord 21 Suppl 14:S219-37 Details

    Fox SH, Visanji NP, Johnston TH, Gomez-Ramirez J, Voon V, Brotchie JM (2006), “Dopamine receptor agonists and levodopa and inducing psychosis-like behavior in the MPTP primate model of Parkinson disease.” Arch Neurol 63(9):1343-4 Details

    Lang AE, Houeto JL, Krack P, Kubu C, Lyons KE, Moro E, Ondo W, Pahwa R, Poewe W, Tröster AI, Uitti R, Voon V (2006), “Deep brain stimulation: preoperative issues.” Mov Disord 21 Suppl 14:S171-96 Details

    Miyasaki JM, Shannon K, Voon V, Ravina B, Kleiner-Fisman G, Anderson K, Shulman LM, Gronseth G, Weiner WJ, Quality Standards Subcommittee of the American Academy of Neurology (2006), “Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.” Neurology 66(7):996-1002 Details

    Visanji NP, Gomez-Ramirez J, Johnston TH, Pires D, Voon V, Brotchie JM, Fox SH (2006), “Pharmacological characterization of psychosis-like behavior in the MPTP-lesioned nonhuman primate model of Parkinson's disease.” Mov Disord 21(11):1879-91 Details

    Voon V, Hassan K, Zurowski M, de Souza M, Thomsen T, Fox S, Lang AE, Miyasaki J (2006), “Prevalence of repetitive and reward-seeking behaviors in Parkinson disease.” Neurology 67(7):1254-7 Details

    Voon V, Hassan K, Zurowski M, Duff-Canning S, de Souza M, Fox S, Lang AE, Miyasaki J (2006), “Prospective prevalence of pathologic gambling and medication association in Parkinson disease.” Neurology 66(11):1750-2 Details

    Voon V, Kubu C, Krack P, Houeto JL, Tröster AI (2006), “Deep brain stimulation: neuropsychological and neuropsychiatric issues.” Mov Disord 21 Suppl 14:S305-27 Details

    2005

    Samuel M, Voon V (2005), “Beyond the holy grail of motor symptoms: deep brain stimulation for Parkinson's disease.” J Neurol Neurosurg Psychiatry 76(6):759-60 Details

    Voon V, Lang AE (2005), “Antidepressant treatment outcomes of psychogenic movement disorder.” J Clin Psychiatry 66(12):1529-34 Details

    Voon V, Moro E, Saint-Cyr JA, Lozano AM, Lang AE (2005), “Psychiatric symptoms following surgery for Parkinson's disease with an emphasis on subthalamic stimulation.” Adv Neurol 96:130-47 Details

    Voon V, Saint-Cyr J, Lozano AM, Moro E, Poon YY, Lang AE (2005), “Psychiatric symptoms in patients with Parkinson disease presenting for deep brain stimulation surgery.” J Neurosurg 103(2):246-51 Details

    2004

    Voon V (2004), “Repetition, repetition, and repetition: compulsive and punding behaviors in Parkinson's disease.” Mov Disord 19(4):367-70 Details

    Voon V, Lang AE (2004), “Antidepressants in the treatment of psychosis with comorbid depression in Parkinson disease.” Clin Neuropharmacol 27(2):90-2 Details