Dr Valerie Voon

Valerie Voon

University position

Wellcome Trust Fellow

Dr Valerie Voon is pleased to consider applications from prospective PhD students.

Departments

Department of Psychiatry

Institutes

Behavioural and Clinical Neuroscience Institute

Email

vv247@cam.ac.uk

Research Theme

Cognitive and Behavioural Neuroscience

Interests

Why do we repeat behaviours that we know are bad for us? I am an Honorary Consultant Neuropsychiatrist and Wellcome Trust Fellow with the Department of Psychiatry. I head the Compulsive Behaviours research group and focus on mechanisms underlying compulsive disorders such as substance and behavioural addictions and obsessive compulsive disorder in the general population and in neurological disorders such as Parkinson's disease. I have a side interest in the pathophysiology of conversion disorder. My research uses a combination of pharmacological manipulation, cognitive paradigms and functional and anatomical MRI in clinical and healthy populations.

Research Focus

Keywords

None specified

Clinical conditions

Addiction

Impulse control disorders

Movement disorders

Obsessive compulsive disorder

Parkinson's disease

Equipment

No equipment indicated

Collaborators

Cambridge

Ed Bullmore

Naomi Feinberg

Trevor Robbins

Barbara Sahakian

International

William Hutchison

Valterri Kaasinen

Mircea Polosan

Key publications

Voon V, Derbyshire K, Rück C, Irvine MA, Worbe Y, Enander J, Schreiber LR, Gillan C, Fineberg NA, Sahakian BJ, Robbins TW, Harrison NA, Wood J, Daw ND, Dayan P, Grant JE, Bullmore ET (2014), “Disorders of compulsivity: a common bias towards learning habits.” Mol Psychiatry Details

Voon V, Irvine MA, Derbyshire K, Worbe Y, Lange I, Abbott S, Morein-Zamir S, Dudley R, Caprioli D, Harrison NA, Wood J, Dalley JW, Bullmore ET, Grant JE, Robbins TW (2013), “Measuring "Waiting" Impulsivity in Substance Addictions and Binge Eating Disorder in a Novel Analogue of Rodent Serial Reaction Time Task.” Biol Psychiatry Details

Voon V, Sohr M, Lang AE, Potenza MN, Siderowf AD, Whetteckey J, Weintraub D, Wunderlich GR, Stacy M (2011), “Impulse control disorders in Parkinson disease: a multicenter case--control study.” Ann Neurol 69(6):986-96 Details

Voon V, Pessiglione M, Brezing C, Gallea C, Fernandez HH, Dolan RJ, Hallett M (2010), “Mechanisms underlying dopamine-mediated reward bias in compulsive behaviors.” Neuron 65(1):135-42 Details

Voon V, Krack P, Lang AE, Lozano AM, Dujardin K, Schüpbach M, D'Ambrosia J, Thobois S, Tamma F, Herzog J, Speelman JD, Samanta J, Kubu C, Rossignol H, Poon YY, Saint-Cyr JA, Ardouin C, Moro E (2008), “A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease.” Brain 131(Pt 10):2720-8 Details

Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM, Kennedy SH (2005), “Deep brain stimulation for treatment-resistant depression.” Neuron 45(5):651-60 Details

Publications

2014

Fineberg NA, Chamberlain SR, Goudriaan AE, Stein DJ, Vanderschuren LJ, Gillan CM, Shekar S, Gorwood PA, Voon V, Morein-Zamir S, Denys D, Sahakian BJ, Moeller FG, Robbins TW, Potenza MN (2014), “New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity.” CNS Spectr 19(1):69-89 Details

in press

Harrison NA, Cercignani M, Voon V, Critchley H (in press), “Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants” Neuropsychopharmacology

2014

Harrison NA, Doeller CF, Voon V, Burgess N, Critchley HD (2014), “Peripheral Inflammation Acutely Impairs Human Spatial Memory via Actions on Medial Temporal Lobe Glucose Metabolism.” Biol Psychiatry Details

Mechelmans DJ, Irvine M, Banca P, Porter L, Mitchell S, Mole TB, Lapa TR, Harrison NA, Potenza MN, Voon V (2014), “Enhanced Attentional Bias towards Sexually Explicit Cues in Individuals with and without Compulsive Sexual Behaviours.” PLoS One 9(8):e105476 Details

Mole TB, Irvine MA, Worbe Y, Collins P, Mitchell SP, Bolton S, Harrison NA, Robbins TW, Voon V (2014), “Impulsivity in disorders of food and drug misuse.” Psychol Med :1-12 Details

in press

Voon V (in press), “Functional neurological disorders: imaging” Neurophysiologie Clinique / Clinical Neurophysiology

2014

Voon V, Mole TB, Banca P, Porter L, Morris L, Mitchell S, Lapa TR, Karr J, Harrison NA, Potenza MN, Irvine M (2014), “Neural Correlates of Sexual Cue Reactivity in Individuals with and without Compulsive Sexual Behaviours.” PLoS One 9(7):e102419 Details

Worbe Y, Savulich G, Voon V, Fernandez-Egea E, Robbins TW (2014), “Serotonin Depletion Induces 'Waiting Impulsivity' on the Human Four Choice Serial Reaction Time Task: Cross-Species Translational Significance.” Neuropsychopharmacology Details

2013

Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2013), “Gamma Aminobutyric Acidergic and Neuronal Structural Markers in the Nucleus Accumbens Core Underlie Trait-like Impulsive Behavior.” Biol Psychiatry Details

Clark-Elford R, Nathan PJ, Auyeung B, Voon V, Sule A, Müller U, Dudas R, Sahakian BJ, Phan KL, Baron-Cohen S (2013), “The effects of oxytocin on social reward learning in humans.” Int J Neuropsychopharmacol :1-11 Details

Gillan CM, Morein-Zamir S, Urcelay GP, Sule A, Voon V, Apergis-Schoute AM, Fineberg NA, Sahakian BJ, Robbins TW (2013), “Enhanced Avoidance Habits in Obsessive-Compulsive Disorder.” Biol Psychiatry Details

Harrison NA, Cooper E, Voon V, Miles K, Critchley HD (2013), “Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?” Brain Behav Immun 31:189-96 Details

Howell NA, Worbe Y, Lange I, Tait R, Irvine M, Banca P, Harrison NA, Bullmore ET, Hutchison WD, Voon V (2013), “Increased Ventral Striatal Volume in College-Aged Binge Drinkers.” PLoS One 8(9):e74164 Details

Insel TR, Voon V, Nye JS, Brown VJ, Altevogt BM, Bullmore ET, Goodwin GM, Howard RJ, Kupfer DJ, Malloch G, Marston HM, Nutt DJ, Robbins TW, Stahl SM, Tricklebank MD, Williams JH, Sahakian BJ (2013), “Innovative solutions to novel drug development in mental health.” Neurosci Biobehav Rev Details

Irvine MA, Worbe Y, Bolton S, Harrison NA, Bullmore ET, Voon V (2013), “Impaired decisional impulsivity in pathological videogamers.” PLoS One 8(10):e75914 Details

Kranick SM, Moore JW, Yusuf N, Martinez VT, Lafaver K, Edwards MJ, Mehta AR, Collins P, Harrison NA, Haggard P, Hallett M, Voon V (2013), “Action-effect binding is decreased in motor conversion disorder: Implications for sense of agency.” Mov Disord 28(8):1110-6 Details

Kundu P, Brenowitz ND, Voon V, Worbe Y, Vértes PE, Inati SJ, Saad ZS, Bandettini PA, Bullmore ET (2013), “Integrated strategy for improving functional connectivity mapping using multiecho fMRI.” Proc Natl Acad Sci U S A Details

Mestre TA, Strafella AP, Thomsen T, Voon V, Miyasaki J (2013), “Diagnosis and treatment of impulse control disorders in patients with movement disorders.” Ther Adv Neurol Disord 6(3):175-88 Details

Voon V, Ekanayake V, Wiggs E, Kranick S, Ameli R, Harrison NA, Hallett M (2013), “Response inhibition in motor conversion disorder.” Mov Disord 28(5):612-8 Details

Voon V, Howell NA, Krack P (2013), “Psychiatric considerations in deep brain stimulation for Parkinson's disease.” Handb Clin Neurol 116C:147-154 Details

Voon V, Rizos A, Chakravartty R, Mulholland N, Robinson S, Howell NA, Harrison N, Vivian G, Ray Chaudhuri K (2013), “Impulse control disorders in Parkinson's disease: decreased striatal dopamine transporter levels.” J Neurol Neurosurg Psychiatry Details

Worbe Y, Irvine M, Lange I, Kundu P, Howell NA, Harrison NA, Bullmore ET, Robbins TW, Voon V (2013), “Neuronal Correlates of Risk-Seeking Attitudes to Anticipated Losses in Binge Drinkers.” Biol Psychiatry Details

2012

Carson AJ, Brown R, David AS, Duncan R, Edwards MJ, Goldstein LH, Grunewald R, Howlett S, Kanaan R, Mellers J, Nicholson TR, Reuber M, Schrag AE, Stone J, Voon V, UK-FNS (2012), “Functional (conversion) neurological symptoms: research since the millennium.” J Neurol Neurosurg Psychiatry 83(8):842-50 Details

Joutsa J, Johansson J, Niemelä S, Ollikainen A, Hirvonen MM, Piepponen P, Arponen E, Alho H, Voon V, Rinne JO, Hietala J, Kaasinen V (2012), “Mesolimbic dopamine release is linked to symptom severity in pathological gambling.” Neuroimage 60(4):1992-9 Details

Joutsa J, Martikainen K, Vahlberg T, Voon V, Kaasinen V (2012), “Impulse control disorders and depression in Finnish patients with Parkinson's disease.” Parkinsonism Relat Disord 18(2):155-60 Details

2011

Kranick S, Ekanayake V, Martinez V, Ameli R, Hallett M, Voon V (2011), “Psychopathology and psychogenic movement disorders.” Mov Disord 26(10):1844-50 Details

Lang AE, Voon V (2011), “Psychogenic movement disorders: past developments, current status, and future directions.” Mov Disord 26(6):1175-86 Details

Meissner WG, Frasier M, Gasser T, Goetz CG, Lozano A, Piccini P, Obeso JA, Rascol O, Schapira A, Voon V, Weiner DM, Tison F, Bezard E (2011), “Priorities in Parkinson's disease research.” Nat Rev Drug Discov 10(5):377-93 Details

Voon V, Brezing C, Gallea C, Hallett M (2011), “Aberrant supplementary motor complex and limbic activity during motor preparation in motor conversion disorder.” Mov Disord 26(13):2396-403 Details

Voon V, Dalley JW (2011), “Parkinson disease: impulsive choice-Parkinson disease and dopaminergic therapy.” Nat Rev Neurol 7(10):541-2 Details

Voon V, Gao J, Brezing C, Symmonds M, Ekanayake V, Fernandez H, Dolan RJ, Hallett M (2011), “Dopamine agonists and risk: impulse control disorders in Parkinson's disease.” Brain 134(Pt 5):1438-46 Details

Voon V, Mehta AR, Hallett M (2011), “Impulse control disorders in Parkinson's disease: recent advances.” Curr Opin Neurol 24(4):324-30 Details

Voon V, Schoerling A, Wenzel S, Ekanayake V, Reiff J, Trenkwalder C, Sixel-Döring F (2011), “Frequency of impulse control behaviours associated with dopaminergic therapy in restless legs syndrome.” BMC Neurol 11:117 Details

2010

Voon V, Brezing C, Gallea C, Ameli R, Roelofs K, LaFrance WC Jr, Hallett M (2010), “Emotional stimuli and motor conversion disorder.” Brain 133(Pt 5):1526-36 Details

Voon V, Butler TR, Ekanayake V, Gallea C, Ameli R, Murphy DL, Hallett M (2010), “Psychiatric symptoms associated with focal hand dystonia.” Mov Disord Details

Voon V, Gallea C, Hattori N, Bruno M, Ekanayake V, Hallett M (2010), “The involuntary nature of conversion disorder.” Neurology 74(3):223-8 Details

Voon V, Reynolds B, Brezing C, Gallea C, Skaljic M, Ekanayake V, Fernandez H, Potenza MN, Dolan RJ, Hallett M (2010), “Impulsive choice and response in dopamine agonist-related impulse control behaviors.” Psychopharmacology (Berl) 207(4):645-59 Details

Weintraub D, Koester J, Potenza MN, Siderowf AD, Stacy M, Voon V, Whetteckey J, Wunderlich GR, Lang AE (2010), “Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients.” Arch Neurol 67(5):589-95 Details

Weintraub D, Sohr M, Potenza MN, Siderowf AD, Stacy M, Voon V, Whetteckey J, Wunderlich GR, Lang AE (2010), “Amantadine use associated with impulse control disorders in Parkinson disease in cross-sectional study.” Ann Neurol 68(6):963-8 Details

2009

Benbadis SR, LaFrance WC Jr, Papandonatos GD, Korabathina K, Lin K, Kraemer HC, NES Treatment Workshop (2009), “Interrater reliability of EEG-video monitoring.” Neurology 73(11):843-6 Details

Espay AJ, Goldenhar LM, Voon V, Schrag A, Burton N, Lang AE (2009), “Opinions and clinical practices related to diagnosing and managing patients with psychogenic movement disorders: An international survey of movement disorder society members.” Mov Disord 24(9):1366-74 Details

Voon V, Fernagut PO, Wickens J, Baunez C, Rodriguez M, Pavon N, Juncos JL, Obeso JA, Bezard E (2009), “Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders.” Lancet Neurol 8(12):1140-9 Details

Voon V, Krack P, Lang AE, Lozano AM, Dujardin K, Schüpbach M, Thobois S, Tamma F, Herzog J, Samanta J, Kubu C, Rossignol H, Poon YY, Saint-Cyr JA, Ardouin C, Moro E (2009), “Parkinson's disease, DBS and suicide: a role for serotonin?” Brain

Weintraub D, Hoops S, Shea JA, Lyons KE, Pahwa R, Driver-Dunckley ED, Adler CH, Potenza MN, Miyasaki J, Siderowf AD, Duda JE, Hurtig HI, Colcher A, Horn SS, Stern MB, Voon V (2009), “Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease.” Mov Disord 24(10):1461-7 Details

2007

Miyasaki JM, Al Hassan K, Lang AE, Voon V (2007), “Punding prevalence in Parkinson's disease.” Mov Disord 22(8):1179-81 Details

Potenza MN, Voon V, Weintraub D (2007), “Drug Insight: impulse control disorders and dopamine therapies in Parkinson's disease.” Nat Clin Pract Neurol 3(12):664-72 Details

Ravina B, Marder K, Fernandez HH, Friedman JH, McDonald W, Murphy D, Aarsland D, Babcock D, Cummings J, Endicott J, Factor S, Galpern W, Lees A, Marsh L, Stacy M, Gwinn-Hardy K, Voon V, Goetz C (2007), “Diagnostic criteria for psychosis in Parkinson's disease: report of an NINDS, NIMH work group.” Mov Disord 22(8):1061-8 Details

Voon V, Fox S, Butler TR, Lang AE (2007), “Antidepressants and psychosis in Parkinson disease: a case series.” Int J Geriatr Psychiatry 22(6):601-4 Details

Voon V, Fox SH (2007), “Medication-related impulse control and repetitive behaviors in Parkinson disease.” Arch Neurol 64(8):1089-96 Details

Voon V, Lang AE, Hallett M (2007), “Diagnosing psychogenic movement disorders-which criteria should be used in clinical practice?” Nat Clin Pract Neurol 3(3):134-5 Details

Voon V, Potenza MN, Thomsen T (2007), “Medication-related impulse control and repetitive behaviors in Parkinson's disease.” Curr Opin Neurol 20(4):484-92 Details

Voon V, Thomsen T, Miyasaki JM, de Souza M, Shafro A, Fox SH, Duff-Canning S, Lang AE, Zurowski M (2007), “Factors associated with dopaminergic drug-related pathological gambling in Parkinson disease.” Arch Neurol 64(2):212-6 Details

2006

Ardouin C, Voon V, Worbe Y, Abouazar N, Czernecki V, Hosseini H, Pelissolo A, Moro E, Lhommée E, Lang AE, Agid Y, Benabid AL, Pollak P, Mallet L, Krack P (2006), “Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation.” Mov Disord 21(11):1941-6 Details

Deuschl G, Herzog J, Kleiner-Fisman G, Kubu C, Lozano AM, Lyons KE, Rodriguez-Oroz MC, Tamma F, Tröster AI, Vitek JL, Volkmann J, Voon V (2006), “Deep brain stimulation: postoperative issues.” Mov Disord 21 Suppl 14:S219-37 Details

Fox SH, Visanji NP, Johnston TH, Gomez-Ramirez J, Voon V, Brotchie JM (2006), “Dopamine receptor agonists and levodopa and inducing psychosis-like behavior in the MPTP primate model of Parkinson disease.” Arch Neurol 63(9):1343-4 Details

Lang AE, Houeto JL, Krack P, Kubu C, Lyons KE, Moro E, Ondo W, Pahwa R, Poewe W, Tröster AI, Uitti R, Voon V (2006), “Deep brain stimulation: preoperative issues.” Mov Disord 21 Suppl 14:S171-96 Details

Miyasaki JM, Shannon K, Voon V, Ravina B, Kleiner-Fisman G, Anderson K, Shulman LM, Gronseth G, Weiner WJ, Quality Standards Subcommittee of the American Academy of Neurology (2006), “Practice Parameter: evaluation and treatment of depression, psychosis, and dementia in Parkinson disease (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.” Neurology 66(7):996-1002 Details

Visanji NP, Gomez-Ramirez J, Johnston TH, Pires D, Voon V, Brotchie JM, Fox SH (2006), “Pharmacological characterization of psychosis-like behavior in the MPTP-lesioned nonhuman primate model of Parkinson's disease.” Mov Disord 21(11):1879-91 Details

Voon V, Hassan K, Zurowski M, de Souza M, Thomsen T, Fox S, Lang AE, Miyasaki J (2006), “Prevalence of repetitive and reward-seeking behaviors in Parkinson disease.” Neurology 67(7):1254-7 Details

Voon V, Hassan K, Zurowski M, Duff-Canning S, de Souza M, Fox S, Lang AE, Miyasaki J (2006), “Prospective prevalence of pathologic gambling and medication association in Parkinson disease.” Neurology 66(11):1750-2 Details

Voon V, Kubu C, Krack P, Houeto JL, Tröster AI (2006), “Deep brain stimulation: neuropsychological and neuropsychiatric issues.” Mov Disord 21 Suppl 14:S305-27 Details

2005

Samuel M, Voon V (2005), “Beyond the holy grail of motor symptoms: deep brain stimulation for Parkinson's disease.” J Neurol Neurosurg Psychiatry 76(6):759-60 Details

Voon V, Lang AE (2005), “Antidepressant treatment outcomes of psychogenic movement disorder.” J Clin Psychiatry 66(12):1529-34 Details

Voon V, Moro E, Saint-Cyr JA, Lozano AM, Lang AE (2005), “Psychiatric symptoms following surgery for Parkinson's disease with an emphasis on subthalamic stimulation.” Adv Neurol 96:130-47 Details

Voon V, Saint-Cyr J, Lozano AM, Moro E, Poon YY, Lang AE (2005), “Psychiatric symptoms in patients with Parkinson disease presenting for deep brain stimulation surgery.” J Neurosurg 103(2):246-51 Details

2004

Voon V (2004), “Repetition, repetition, and repetition: compulsive and punding behaviors in Parkinson's disease.” Mov Disord 19(4):367-70 Details

Voon V, Lang AE (2004), “Antidepressants in the treatment of psychosis with comorbid depression in Parkinson disease.” Clin Neuropharmacol 27(2):90-2 Details