Professor V. Peter Collins

V. Peter Collins

University position

Professor

Departments

Department of Pathology

Institutes

Addenbrooke's Hospital Department of Histopathology and Cytology

Email

vpc20@cam.ac.uk

Home page

http://www.path.cam.ac.uk/pages/c... (personal home page)

Research Theme

Cellular and Molecular Neuroscience

Interests

The group is focusing on human brain tumours. The studies aim at documenting the genetic abnormalities involved in the development of these tumours and how these affect cell function. We wish to identify prognostic markers, therapy response markers and to identify targets for innovative molecular therapies. Methodologies include microarray Comparative Genomic Hybridization (array–CGH), mutation and methylation analysis of the genome. The transcriptosome of brain tumours is presently being documented. The genes found to be abberant are then analysed in a cell biological framework. In all cases the data can be correlated with clinical findings. Currently a number of potential tumour suppressor genes and potential oncogenes in regions consistently amplified or rearranged are being investigated.

Research Focus

Keywords

brain tumours

oncogenes

tumour suppressor genes

somatic mutations

Clinical conditions

Cancers

Genetic disorders

Equipment

Cell culture

Confocal microscopy

Cross-sectional and cohort studies

Fluorescence microscopy

Immunohistochemistry

Microscopy

Molecular genetic techniques

Protein purification

Randomised control trials

Recombinant protein expression

Collaborators

Cambridge

Colin Watts

Associated News Items


    Publications

    2014

    Collins VP (2014), “Pathology of Gliomas and Developments in Molecular Testing.” Clin Oncol (R Coll Radiol) Details

    Kool M, Jones DT, Jäger N, Northcott PA, Pugh TJ, Hovestadt V, Piro RM, Esparza LA, Markant SL, Remke M, Milde T, Bourdeaut F, Ryzhova M, Sturm D, Pfaff E, Stark S, Hutter S, Seker-Cin H, Johann P, Bender S, Schmidt C, Rausch T, Shih D, Reimand J, Sieber L, Wittmann A, Linke L, Witt H, Weber UD, Zapatka M, König R, Beroukhim R, Bergthold G, van Sluis P, Volckmann R, Koster J, Versteeg R, Schmidt S, Wolf S, Lawerenz C, Bartholomae CC, von Kalle C, Unterberg A, Herold-Mende C, Hofer S, Kulozik AE, von Deimling A, Scheurlen W, Felsberg J, Reifenberger G, Hasselblatt M, Crawford JR, Grant GA, Jabado N, Perry A, Cowdrey C, Croul S, Zadeh G, Korbel JO, Doz F, Delattre O, Bader GD, McCabe MG, Collins VP, Kieran MW, Cho YJ, Pomeroy SL, Witt O, Brors B, Taylor MD, Schüller U, Korshunov A, Eils R, Wechsler-Reya RJ, Lichter P, Pfister SM, ICGC PedBrain Tumor Project (2014), “Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.” Cancer Cell 25(3):393-405 Details

    2013

    Arita H, Narita Y, Fukushima S, Tateishi K, Matsushita Y, Yoshida A, Miyakita Y, Ohno M, Collins VP, Kawahara N, Shibui S, Ichimura K (2013), “Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss.” Acta Neuropathol 126(2):267-76 Details

    Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M, Zapatka M, Northcott PA, Sturm D, Wang W, Radlwimmer B, Højfeldt JW, Truffaux N, Castel D, Schubert S, Ryzhova M, Seker-Cin H, Gronych J, Johann PD, Stark S, Meyer J, Milde T, Schuhmann M, Ebinger M, Monoranu CM, Ponnuswami A, Chen S, Jones C, Witt O, Collins VP, von Deimling A, Jabado N, Puget S, Grill J, Helin K, Korshunov A, Lichter P, Monje M, Plass C, Cho YJ, Pfister SM (2013), “Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.” Cancer Cell 24(5):660-72 Details

    Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM, International Cancer Genome Consortium PedBrain Tumor Project (2013), “Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.” Nat Genet 45(8):927-32 Details

    Lambert SR, Witt H, Hovestadt V, Zucknick M, Kool M, Pearson DM, Korshunov A, Ryzhova M, Ichimura K, Jabado N, Fontebasso AM, Lichter P, Pfister SM, Collins VP, Jones DT (2013), “Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma.” Acta Neuropathol 126(2):291-301 Details

    Leprivier G, Remke M, Rotblat B, Dubuc A, Mateo AR, Kool M, Agnihotri S, El-Naggar A, Yu B, Somasekharan SP, Faubert B, Bridon G, Tognon CE, Mathers J, Thomas R, Li A, Barokas A, Kwok B, Bowden M, Smith S, Wu X, Korshunov A, Hielscher T, Northcott PA, Galpin JD, Ahern CA, Wang Y, McCabe MG, Collins VP, Jones RG, Pollak M, Delattre O, Gleave ME, Jan E, Pfister SM, Proud CG, Derry WB, Taylor MD, Sorensen PH (2013), “The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.” Cell 153(5):1064-79 Details

    Sahm F, Bissel J, Koelsche C, Schweizer L, Capper D, Reuss D, Böhmer K, Lass U, Göck T, Kalis K, Meyer J, Habel A, Brehmer S, Mittelbronn M, Jones DT, Schittenhelm J, Urbschat S, Ketter R, Heim S, Mawrin C, Hainfellner JA, Berghoff AS, Preusser M, Becker A, Herold-Mende C, Unterberg A, Hartmann C, Kickingereder P, Collins VP, Pfister SM, von Deimling A (2013), “AKT1E17K mutations cluster with meningothelial and transitional meningiomas and can be detected by SFRP1 immunohistochemistry.” Acta Neuropathol 126(5):757-62 Details