Dr Ugo Mayor

Ugo Mayor

University position

Senior Research Associate

Departments

Department of Genetics

Home page

http://www.gen.cam.ac.uk

Research Themes

Cellular and Molecular Neuroscience

Developmental Neuroscience

Interests

For several years my research was focused on protein dynamics and structure. Currently, I am isolating substrates of the ubiquitin proteosome system in flies. For this purpose, I have developed a tissue-specific approach for isolating and identifying all ubiquitinated proteins in the Drosophila nervous system. I am also using this technique to try to identify the link between polyglutamine diseases and ubiquitination, using Drosophila as a model system.

My research is being funded by a Royal Society Dorothy Hodgkin Fellowship.

Research Focus

Keywords

drosophila

ubiquitin

neuron

biotinylation

extracts

Clinical conditions

Huntington's disease

Equipment

Protein purification

Collaborators

Cambridge

Andrea Brand

Cath Lindon

International

Junmin Peng Web: http://www.genetics.emory.edu/FACULTY...

Key publications

Mayor U, Guydosh NR, Johnson CM, Grossmann JG, Sato S, Jas GS, Freund SM, Alonso DO, Daggett V, Fersht AR (2003), “The complete folding pathway of a protein from nanoseconds to microseconds” Nature 421:863-867