Dr Ulrich Müller

Ulrich Müller

University position

Lecturer

Dr Ulrich Müller is pleased to consider applications from prospective PhD students.

Departments

Department of Psychology

Institutes

Behavioural and Clinical Neuroscience Institute

Email

um207@cam.ac.uk

Research Themes

Cognitive and Behavioural Neuroscience

Clinical and Veterinary Neuroscience

Interests

My major research interest is the neurotransmitter modulation of cognitive and emotional processes, with a focus on the role of dopamine and noradrenaline in frontostriatal functions. I use fMRI, radioligand imaging with PET, pharmacological challenges and genetic testing for neurotransmitter polymorphisms in combination with working memory and other prefrontal tasks in healthy volunteers and patients with attention deficit hyperactivity disorder (ADHD), schizophrenia and other neuropsychiatric diseases. The aim of this research is to develop pharmacological and behavioural strategies to improve cognitive functions in patients with ADHD and schizophrenia.

I am a honorary consultant psychiatrist with Cambridgeshire and Peterborough NHS Foundation Trust and director of the Adult ADHD Research Clinic.

Research Focus

Keywords

dopamine

working memory

ADHD

noradrenaline

prefrontal

Clinical conditions

Attention deficit hyperactivity disorder

Cognitive impairment

Schizophrenia

Equipment

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

Cambridge

Ed Bullmore

Sam Chamberlain

Luke Clark

Chris Dodds

Peter Jones

Trevor Robbins

Barbara Sahakian

United Kingdom

Jonathan Roiser Web: http://www.ion.ucl.ac.uk/

International

Roshan Cools Web: http://www.roshancools.com/

Hesse Swen Web: http://www.uni-leipzig.de/english...

Key publications

Seixas M, Weiss M, Müller U (2012), “Systematic review of national and international guidelines on attention-deficit hyperactivity disorder.” J Psychopharmacol 26(6):753-65 Details

Dodds CM, Müller U, Clark L, van Loon A, Cools R, Robbins TW (2008), “Methylphenidate has differential effects on blood oxygenation level-dependent signal related to cognitive subprocesses of reversal learning.” J Neurosci 28(23):5976-82 PDF Details

Barnett JH, Jones PB, Robbins TW, Müller U (2007), “Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls.” Mol Psychiatry 12(5):502-9 Details

Chamberlain SR, Müller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006), “Neurochemical modulation of response inhibition and probabilistic learning in humans.” Science 311(5762):861-3 PDF Details

Müller U, Steffenhagen N, Regenthal R, Bublak P (2004), “Effects of modafinil on working memory processes in humans.” Psychopharmacology (Berl) 177(1-2):161-9 Details

Publications

2013

Adamou M, Arif M, Asherson P, Aw TC, Bolea B, Coghill D, Guðjónsson G, Halmøy A, Hodgkins P, Müller U, Pitts M, Trakoli A, Williams N, Young S (2013), “Occupational issues of adults with ADHD.” BMC Psychiatry 13(1):59 Details

Crockett MJ, Apergis-Schoute A, Herrmann B, Lieberman M, Müller U, Robbins TW, Clark L (2013), “Serotonin Modulates Striatal Responses to Fairness and Retaliation in Humans.” J Neurosci 33(8):3505-3513 Details

Kuhlmei A, Walther B, Becker T, Müller U, Nikolaus T (2013), “Actigraphic daytime activity is reduced in patients with cognitive impairment and apathy.” Eur Psychiatry 28(2):94-7 Details

Müller U, Rowe JB, Rittman T, Lewis C, Robbins TW, Sahakian BJ (2013), “Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers.” Neuropharmacology 64(1):490-5 Details

2012

Bolea B, Adamou M, Arif M, Asherson P, Gudjonsson G, Müller U, Nutt Dj, Pitts M, Thome J, Young S (2012), “ADHD matures: time for practitioners to do the same?” J Psychopharmacol 26(6):766-70 PDF Details

Caisley H, Müller U (2012), “Adherence to medication in adults with attention deficit hyperactivity disorder and pro re nata dosing of psychostimulants: A systematic review.” Eur Psychiatry 27(5):343-9 Details

Coogan AN, Dobrean A, Donev RM, Mateescu L, Müller U, Thome J, Voinescu BI (2012), “Adult attention deficit hyperactivity disorder: translating research into practice.” Atten Defic Hyperact Disord PDF Details

Del Campo N, Müller U, Sahakian BJ (2012), “Neural and behavioral endophenotypes in ADHD.” Curr Top Behav Neurosci 11:65-91 Details

Ersche KD, Cumming P, Craig KJ, Müller U, Fineberg NA, Bullmore ET, Robbins TW (2012), “Amisulpride-induced acute akathisia in OCD: an example of dysfunctional dopamine-serotonin interactions?” J Psychopharmacol 26(6):887-90 Details

Ersche KD, Turton AJ, Chamberlain SR, Müller U, Bullmore ET, Robbins TW (2012), “Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence.” Am J Psychiatry 169(9):926-36 Details

Magon U, Müller U (2012), “ADHD with comorbid substance use disorder: review of treatment” Advances in Psychiatric Treatment 18: 436-446

Müller U, Asherson P (2012), “Addressing common misconceptions about attention deficit hyperactivity disorder in adults” Neuropsychiatry 2: 185-188 PDF

Zaman R, Arif M, Vaze A, Müller U (2012), “Setting up adult ADHD services in the United Kingdom” Cutting Egde Psychiatry in Practice 2: 170-175 PDF

2011

Blanchard MM, Chamberlain SR, Roiser J, Robbins TW, Müller U (2011), “Effects of two dopamine-modulating genes ( DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers.” Psychol Med 41(3):611-8 Details

Chamberlain SR, Robbins TW, Winder-Rhodes S, Müller U, Sahakian BJ, Blackwell AD, Barnett JH (2011), “Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological battery.” Biol Psychiatry 69(12):1192-203 Details

Costa A, Riedel M, Müller U, Möller HJ, Ettinger U (2011), “Relationship between SLC6A3 genotype and striatal dopamine transporter availability: A meta-analysis of human single photon emission computed tomography studies.” Synapse Details

Del Campo N, Tait RJ, Acosta-Cabronero J, Hong YT, Izquierdo-Garcia D, Smith R, Aigbirhio FI, Sahakian BJ, Müller U, Robbins TW, Fryer TD (2011), “Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.” Neuroimage 55(1):101-12 Details

Ersche KD, Roiser JP, Abbott S, Craig KJ, Müller U, Suckling J, Ooi C, Shabbir SS, Clark L, Sahakian BJ, Fineberg NA, Merlo-Pich EV, Robbins TW, Bullmore ET (2011), “Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist.” Biol Psychiatry 70(8):754-62 Details

Finke K, Schwarzkopf W, Müller U, Frodl T, Müller HJ, Schneider WX, Engel RR, Riedel M, Möller HJ, Hennig-Fast K (2011), “Disentangling the adult attention-deficit hyperactivity disorder endophenotype: Parametric measurement of attention.” J Abnorm Psychol 120(4):890-901 Details

Valenzuela M, Bartrés-Faz D, Beg F, Fornito A, Merlo-Pich E, Müller U, Ongür D, Toga AW, Yücel M (2011), “Neuroimaging as endpoints in clinical trials: Are we there yet? Perspective from the first Provence workshop.” Mol Psychiatry 16(11):1064-6 Details

Young SJ, Adamou M, Bolea B, Gudjonsson G, Muller U, Pitts M, Thome J, Asherson P (2011), “The identification and management of ADHD offenders within the criminal justice system: a consensus statement from the UK Adult ADHD Network and criminal justice agencies.” BMC Psychiatry 11(1):32 Details

2010

Asherson P, Adamou M, Bolea B, Muller U, Morua SD, Pitts M, Thome J, Young S (2010), “Is ADHD a valid diagnosis in adults? Yes.” BMJ 340:c549 Details

Chamberlain SR, Grant JE, Costa A, Müller U, Sahakian BJ (2010), “Effects of acute modafinil on cognition in trichotillomania.” Psychopharmacology (Berl) 212(4):597-601 Details

Ersche KD, Bullmore ET, Craig KJ, Shabbir SS, Abbott S, Müller U, Ooi C, Suckling J, Barnes A, Sahakian BJ, Merlo-Pich EV, Robbins TW (2010), “Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence.” Arch Gen Psychiatry 67(6):632-44 Details

Finke K, Dodds CM, Bublak P, Regenthal R, Baumann F, Manly T, Müller U (2010), “Effects of modafinil and methylphenidate on visual attention capacity: a TVA-based study.” Psychopharmacology (Berl) 210(3):317-29 Details

Lynall ME, Bassett DS, Kerwin R, McKenna PJ, Kitzbichler M, Muller U, Bullmore E (2010), “Functional connectivity and brain networks in schizophrenia.” J Neurosci 30(28):9477-87 PDF Details

Morein-Zamir S, Craig KJ, Ersche KD, Abbott S, Muller U, Fineberg NA, Bullmore ET, Sahakian BJ, Robbins TW (2010), “Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation.” Psychopharmacology (Berl) 212(3):357-67 Details

Roesch-Ely D, Pfueller U, Mundt C, Müller U, Weisbrod M (2010), “[Treatment of cognitive deficits in schizophrenia. Part 2: Pharmacological strategies]” Nervenarzt 81(5):564-76 Details

Winder-Rhodes SE, Chamberlain SR, Idris MI, Robbins TW, Sahakian BJ, Müller U (2010), “Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers.” J Psychopharmacol 24(11):1649-57 Details

2009

Chamberlain SR, Hampshire A, Müller U, Rubia K, Del Campo N, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ (2009), “Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study.” Biol Psychiatry 65(7):550-5 Details

Dodds C, Müller U, Manly T (2009), “Effects of psychostimulants on alertness and spatial bias in healthy participants.” J Cogn Neurosci 21(3):529-37 Details

Dodds CM, Clark L, Dove A, Regenthal R, Baumann F, Bullmore E, Robbins TW, Müller U (2009), “The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory.” Psychopharmacology (Berl) 207(1):35-45 PDF Details

Müller U, Roesch-Ely D (2009), “Can we treat cognitive impairment in schizophrenia?” In: Gallhofer B, Eberhard J (eds.) Controversies in Cognition: From Laboratory and Testing to Better Functioning. Lundbeck, Copenhagen, pp 47-59

Ullsperger M, Müller U (2009), “Pharmakologische Interventionen in der Klinischen Neuropsychologie” In: Sturm H, Herrmann M, Münte T (eds) Lehrbuch der Klinischen Neuropsychologie: Grundlagen, Methoden, Diagnostik, Therapie. 2. Auflage. Spektrum Akademischer Verlag, Heidelberg, pp 843-858

2008

Chamberlain SR, Menzies LA, Fineberg NA, Del Campo N, Suckling J, Craig K, Müller U, Robbins TW, Bullmore ET, Sahakian BJ (2008), “Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study.” Br J Psychiatry 193(3):216-21 Details

Müller U (2008), “Pharmacological treatment” In: Cappa SF, Abutalebi J, Démonet J-F, Fletcher P, Garrard P (eds.) Cognitive Neurology: A Clinical Textbook. Oxford University Press, Oxford, pp 475-498

Müller U, Becker T (2008), “Kognition und Rehabilitation” In: Kircher TT, Gauggel S (eds.) Neuropsychologie der Schizophrenie. Springer, Heidelberg, pp 613-623

2007

Chamberlain SR, Del Campo N, Dowson J, Müller U, Clark L, Robbins TW, Sahakian BJ (2007), “Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder.” Biol Psychiatry 62(9):977-84 Details

Chamberlain SR, Müller U, Cleary S, Robbins TW, Sahakian BJ (2007), “Atomoxetine increases salivary cortisol in healthy volunteers.” J Psychopharmacol 21(5):545-9 Details

Chamberlain SR, Müller U, Deakin JB, Corlett PR, Dowson J, Cardinal RN, Aitken MR, Robbins TW, Sahakian BJ (2007), “Lack of deleterious effects of buspirone on cognition in healthy male volunteers.” J Psychopharmacol 21(2):210-5 Details

Roiser JP, Müller U, Clark L, Sahakian BJ (2007), “The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention.” Int J Neuropsychopharmacol 10(4):449-61 Details

2006

Chamberlain SR, Müller U, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Noradrenergic modulation of working memory and emotional memory in humans.” Psychopharmacology (Berl) 188(4):397-407 Details

Chamberlain SR, Müller U, Robbins TW, Sahakian BJ (2006), “Neuropharmacological modulation of cognition.” Curr Opin Neurol 19(6):607-12 Details

Müller U, Czymmek J, Thöne-Otto A, Von Cramon DY (2006), “Reduced daytime activity in patients with acquired brain damage and apathy: a study with ambulatory actigraphy.” Brain Inj 20(2):157-60 Details

Müller U, Fletcher PC, Steinberg H (2006), “The origin of pharmacopsychology: Emil Kraepelin's experiments in Leipzig, Dorpat and Heidelberg (1882-1892).” Psychopharmacology (Berl) 184(2):131-8 Details

Stengler-Wenzke K, Müller U, Barthel H, Angermeyer MC, Sabri O, Hesse S (2006), “Serotonin transporter imaging with [123I]beta-CIT SPECT before and after one year of citalopram treatment of obsessive-compulsive disorder.” Neuropsychobiology 53(1):40-5 Details

2005

Hesse S, Müller U, Lincke T, Barthel H, Villmann T, Angermeyer MC, Sabri O, Stengler-Wenzke K (2005), “Serotonin and dopamine transporter imaging in patients with obsessive-compulsive disorder.” Psychiatry Res 140(1):63-72 Details

Müller U (2005), “Somatische Behandlungsverfahren mit rehabilitativem Charakter” In: Frieboes RM, Zaudig M, Nosper M (eds) Rehabilitation bei psychischen Störungen. Elsevier/Urban & Fischer, München, pp 110-134

Müller U, Clark L, Lam ML, Moore RM, Murphy CL, Richmond NK, Sandhu RS, Wilkins IA, Menon DK, Sahakian BJ, Robbins TW (2005), “Lack of effects of guanfacine on executive and memory functions in healthy male volunteers.” Psychopharmacology (Berl) 182(2):205-13 Details

Müller U, Mottweiler E, Bublak P (2005), “Noradrenergic blockade and numeric working memory in humans.” J Psychopharmacol 19(1):21-8 Details

Müller U, Suckling J, Zelaya F, Honey G, Faessel H, Williams SC, Routledge C, Brown J, Robbins TW, Bullmore ET (2005), “Plasma level-dependent effects of methylphenidate on task-related functional magnetic resonance imaging signal changes.” Psychopharmacology (Berl) 180(4):624-33 Details

Müller U, Ullsperger M, Hammerstein E, Sachweh S, Becker T (2005), “Directed forgetting in schizophrenia: prefrontal memory and inhibition deficits.” Eur Arch Psychiatry Clin Neurosci 255(4):251-7 Details

Müller U, Werheid K, Hammerstein E, Jungmann S, Becker T (2005), “Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychotics.” Eur Psychiatry 20(1):70-3 Details

Steinberg H, Müller U (2005), “Emil Kraepelin 1882/83 in Leipzig und seine frühen pharmakopsychologischen Arbeiten im Lichte der aktuellen Forschung” In: Angermeyer M, Steinberg H (eds) 200 Jahre Psychiatrie an der Universität Leipzig: Personen und Konzepte. Springer, Heidelberg, pp 121-154

2004

Hensel A, Ibach B, Muller U, Kruggel F, Kiefer M, Gertz HJ (2004), “Does the pattern of atrophy of the Corpus callosum differ between patients with frontotemporal dementia and patients with Alzheimer's disease?” Dement Geriatr Cogn Disord 18(1):44-9 Details

Hesse S, Barthel H, Schwarz J, Sabri O, Müller U (2004), “Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders.” Neurosci Biobehav Rev 28(6):547-63 Details

Stengler-Wenzke K, Müller U, Angermeyer MC, Sabri O, Hesse S (2004), “Reduced serotonin transporter-availability in obsessive-compulsive disorder (OCD).” Eur Arch Psychiatry Clin Neurosci 254(4):252-5 Details

2003

Hesse S, Barthel H, Murai T, Müller U, Müller D, Seese A, Kluge R, Sabri O (2003), “Is correction for age necessary in neuroimaging studies of the central serotonin transporter?” Eur J Nucl Med Mol Imaging 30(3):427-30 Details

Müller U, Wolf H, Kiefer M, Gertz HJ (2003), “[A systematic comparison of national and international dementia guidelines]” Fortschr Neurol Psychiatr 71(6):285-95 Details

Murai T, Barthel H, Berrouschot J, Sorger D, von Cramon DY, Müller U (2003), “Neuroimaging of serotonin transporters in post-stroke pathological crying.” Psychiatry Res 123(3):207-11 Details

Stengler-Wenzke K, Müller U, Matthes-von-Cramon G (2003), “[Compulsive-obsessive disorder after severe head trauma: diagnosis and treatment]” Psychiatr Prax 30(1):37-9 Details

2002

Bublak P, Müller U, Grön G, Reuter M, von Cramon DY (2002), “Manipulation of working memory information is impaired in Parkinson's disease and related to working memory capacity.” Neuropsychology 16(4):577-90 Details

Müller U, Reuter M, Hermann W, Gertz HJ (2002), “[Levodopa dependency in Parkinson's disease: case report and review]” Nervenarzt 73(9):887-91 Details

Schubert T, Volkmann J, Müller U, Sturm V, Voges J, Freund HJ, Von Cramon DY (2002), “Effects of pallidal deep brain stimulation and levodopa treatment on reaction-time performance in Parkinson's disease.” Exp Brain Res 144(1):8-16 Details

Stengler-Wenzke K, Müller U (2002), “Fluoxetine for OCD after brain injury.” Am J Psychiatry 159(5):872 Details

Werheid K, Hoppe C, Thöne A, Müller U, Müngersdorf M, von Cramon DY (2002), “The Adaptive Digit Ordering Test: clinical application, reliability, and validity of a verbal working memory test.” Arch Clin Neuropsychol 17(6):547-65 Details

2001

Murai T, Müller U, Werheid K, Sorger D, Reuter M, Becker T, von Cramon DY, Barthel H (2001), “In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson's disease.” J Neuropsychiatry Clin Neurosci 13(2):222-8 Details

Schneider S, Müller U (2001), “[Synaesthesia - towards a cognitive neuroscience of coloured hearing]” Fortschr Neurol Psychiatr 69(11):532-8 Details

2000

Barthel H, Müller U, Wächter T, Slomka P, Dannenberg C, Murai T, Kahn T, Georgi P (2000), “[Multimodal SPECT and MRT imaging data analysis for an improvement in the diagnosis of idiopathic Parkinson's syndrome]” Radiologe 40(10):863-9 Details

Hoppe CD, Müller UD, Werheid KD, Thöne AD, von Cramon YD (2000), “Digit Ordering Test: clinical, psychometric, and experimental evaluation of a verbal working memory test.” Clin Neuropsychol 14(1):38-55 Details

Müller U, Wächter T, Barthel H, Reuter M, von Cramon DY (2000), “Striatal [123I]beta-CIT SPECT and prefrontal cognitive functions in Parkinson's disease.” J Neural Transm 107(3):303-19 Details

Ullsperger M, Mecklinger A, Müller U (2000), “An electrophysiological test of directed forgetting: the role of retrieval inhibition.” J Cogn Neurosci 12(6):924-40 Details

1999

Frieboes RM, Müller U, Murck H, von Cramon DY, Holsboer F, Steiger A (1999), “Nocturnal hormone secretion and the sleep EEG in patients several months after traumatic brain injury.” J Neuropsychiatry Clin Neurosci 11(3):354-60 Details

Müller U (1999), “Pharmakologie” In: Frommelt P, Grötzbach H (eds) Neuro-Rehabilitation: Grundlagen, Praxis, Dokumentation. Blackwell, Berlin, pp 541-551

Müller U, Murai T, Bauer-Wittmund T, von Cramon DY (1999), “Paroxetine versus citalopram treatment of pathological crying after brain injury.” Brain Inj 13(10):805-11 Details

1998

Becker T, Müller U (1998), “Relevance of brain imaging studies for social psychiatry.” Epidemiol Psichiatr Soc 7(2):89-93 Details

Müller U, von Cramon DY, Pollmann S (1998), “D1- versus D2-receptor modulation of visuospatial working memory in humans.” J Neurosci 18(7):2720-8 PDF Details

von Cramon DY, Müller U (1998), “The septal region and memory.” Adv Tech Stand Neurosurg 24:3-40 Details

1996

Müller U, Frieboes R, von Cramon DY (1996), “Diagnose und Therapie emotionaler Instabilität nach Hirninfarkt” In: Möller HJ, Müller-Spahn F, Kurtz G (eds) Aktuelle Perspektiven der Biologischen Psychiatrie. Springer, Wien, pp 112-116

1994

Müller U, von Cramon DY (1994), “The therapeutic potential of bromocriptine in neuropsychological rehabilitation of patients with acquired brain damage.” Prog Neuropsychopharmacol Biol Psychiatry 18(7):1103-20 Details

1992

Weller M, Müller U, Kornhuber J (1992), “Paranoid psychosis, epidermoid tumor, and epilepsy: "symptomatic" psychosis or coincidence?” J Clin Psychiatry 53(7):257-8 Details

1989

Lesch KP, Müller U, Rupprecht R, Kruse K, Schulte HM (1989), “Endocrine responses to growth hormone-releasing hormone, thyrotropin-releasing hormone and corticotropin-releasing hormone in depression.” Acta Psychiatr Scand 79(6):597-602 Details

Rupprecht R, Lesch KP, Müller U, Beck G, Beckmann H, Schulte HM (1989), “Blunted adrenocorticotropin but normal beta-endorphin release after human corticotropin-releasing hormone administration in depression.” J Clin Endocrinol Metab 69(3):600-3 Details