Dr Thomas Jahn
Dr Thomas Jahn is pleased to consider applications from prospective PhD students.
The hallmark of numerous neurodegenerative disorders is the accumulation of microscopic protein deposits such as the amyloid plaques in Alzheimer's Disease and the Lewy Bodies of Parkinson's Disease. My research is focused on understanding the relationship between the protein sequence, its aggregation characteristics and the subsequent disease pathogenesis. I am currently focusing on alpha-synuclein, whose assembly is implicated in the etiology of Parkinson's Disease, and explore its aggregation behavior computationally, in in vitro experiments as well as in a simple model organism, the fruit fly. A particular aim will be to understand the extent to which intrinsic and cellular factors drive protein aggregation and to pinpoint specific routes that can be taken to predict and prevent this phenomenon.
Recombinant protein expression
Jahn et al. (2009), “The common architecture of cross-beta amyloid.” J. Mol. Biol. 395, 717-727
Jahn et al. (2008), “A common β-sheet architecture underlies in vitro and in vivo β2-microglobulin amyloid fibrils. ” J. Biol. Chem. 283, 17279-86
Jahn et. al (2006), “Amyloid formation under physiological conditions proceeds via a native-like folding intermediate” Nature Struct Mol Biol 13:195-201
Jahn & Radford (2005), “The Yin and Yang of protein folding” FEBS J 272:5962-5970 Details