Dr Timothy Rittman BMBS BMedSci PgCertMedEd MRCP(London)

Interests

I work with patients suffering from Progressive Supranuclear Palsy (PSP) and Corticobasal Degeneration (CBD) in collaboration with James Rowe. These are two rare types of dementia with similarities to Parkinson's disease and Alzheimer's disease. My main interest is functional brain connectivity (how bits of the brain talk to each other), in particular the application of graph theory and independent component analysis. I use fMRI and MEG data for this purpose and I develop computer models of disease processes to help understand how they might affect brain networks. I am interested in what we can learn about PSP and CBD from network connectivity, in particular bridging the gap between pathological changes and cognitive changes of disease.

I also perform saccadometry (measuring a certain type of fast eye movement) in PSP, CBD and Parkinson's disease with a focus on inhibitory pathways.

I hold a Medical Research Council Clinical Research Training Fellowship.

Research Focus

Keywords

computational neuroscience

MRI

PSP

CBD

connectivity

Clinical conditions

Cognitive impairment

Corticobasal Degeneration

Dementia

Movement disorders

Parkinson's disease

Progressive supranuclear palsy

Equipment

Computational modelling

Electrophysiological recording techniques

Magenetoencephalography

Magnetic resonance imaging (MRI)

Saccadometry

Collaborators

Cambridge

Ellemarije Altena

Laura Hughes

Cristina Nombela-Otero

Charlotte Rae

James Rowe

Noham Wolpe

Associated News Items


Publications

2014

Alexander SK, Rittman T, Xuereb JH, Bak TH, Hodges JR, Rowe JB (2014), “Validation of the new consensus criteria for the diagnosis of corticobasal degeneration.” J Neurol Neurosurg Psychiatry 85(8):925-9 Details

Nombela C, Rittman T, Robbins TW, Rowe JB (2014), “Multiple modes of impulsivity in Parkinson's disease.” PLoS One 9(1):e85747 Details

Wolpe N, Moore JW, Rae CL, Rittman T, Altena E, Haggard P, Rowe JB (2014), “The medial frontal-prefrontal network for altered awareness and control of action in corticobasal syndrome.” Brain 137(Pt 1):208-20 Details

Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014), “Improving Response Inhibition in Parkinson's Disease with Atomoxetine.” Biol Psychiatry Details

Ye Z, Altena E, Nombela C, Housden CR, Maxwell H, Rittman T, Huddleston C, Rae CL, Regenthal R, Sahakian BJ, Barker RA, Robbins TW, Rowe JB (2014), “Selective serotonin reuptake inhibition modulates response inhibition in Parkinson's disease.” Brain 137(Pt 4):1145-55 Details

2013

Rittman T, Ghosh BC, McColgan P, Breen DP, Evans J, Williams-Gray CH, Barker RA, Rowe JB (2013), “The Addenbrooke's Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders.” J Neurol Neurosurg Psychiatry Details

2012

Iorio F, Rittman T, Ge H, Menden M, Saez-Rodriguez J (2012), “Transcriptional data: a new gateway to drug repositioning?” Drug Discov Today Details

Müller U, Rowe JB, Rittman T, Lewis C, Robbins TW, Sahakian BJ (2012), “Effects of modafinil on non-verbal cognition, task enjoyment and creative thinking in healthy volunteers.” Neuropharmacology Details

Rittman T, Corns R, Kumar A, Bhangoo R, Ashkan K (2012), “Is referral to the neuro-oncology MDT safe?” Br J Neurosurg 26(3):321-4 Details

Rittman T, Rowe, JB (2012), “What's New in Progressive Supranuclear Palsy?” ACNR 11(6): 8-10

2011

Schwarz ST, Rittman T, Gontu V, Morgan PS, Bajaj N, Auer DP (2011), “T1-Weighted MRI shows stage-dependent substantia nigra signal loss in Parkinson's disease.” Mov Disord Details

2010

Rio A, Ellis C, Shaw C, Willey E, Ampong MA, Wijesekera L, Rittman T, Nigel Leigh P, Sidhu PS, Al-Chalabi A (2010), “Nutritional factors associated with survival following enteral tube feeding in patients with motor neurone disease.” J Hum Nutr Diet 23(4):408-15 Details

2005

Grainge MJ, Seth R, Coupland C, Guo L, Rittman T, Vryenhoef P, Johnson J, Jenkins D, Neal KR (2005), “Human papillomavirus infection in women who develop high-grade cervical intraepithelial neoplasia or cervical cancer: a case-control study in the UK.” Br J Cancer 92(9):1794-9 Details