Dr Topun Austin

Topun Austin

University position

Consultant Neonatologist

Dr Topun Austin is pleased to consider applications from prospective PhD students.

Departments

Department of Paediatrics

Email

topun.austin@addenbrookes.nhs.uk

Home page

http://neolabresearch.com

Research Themes

Clinical and Veterinary Neuroscience

Developmental Neuroscience

Interests

Brain injury in the newborn is a major cause of death and lifelong neurodisability placing an enormous burden on patients, their families and wider society.

I lead the Evelyn Perinatal Imaging Centre (EPIC), based at the Rosie Hospital, Cambridge. The centre has a dedicated infant functional brain imaging unit and also houses a 1.5T MRI scanner for mothers and babies. The research interests of the group are in the development of monitoring and imaging technologies to identify vulnerable infants at an early stage.

neoLAB is a formal collaborative group between EPIC and Biomedical Optics Laboratory at UCL. The group has been involved in developing an integrated optical-EEG system to study neurovascular coupling as well as a unique fast optical tomography system for 3D imaging of regional blood flow and oxygenation.

Other active collaborations are with the Department of Neurosurgery, Autism Research Centre and Brazelton Centre in Cambridge.

Integrated optical-EEG cap on infant (left) and optical-EEG study on NICU
Integrated optical-EEG cap on infant (left) and optical-EEG study on NICU
Click image to view full-size

Research Focus

Keywords

Perintal Brain Injury

NIRS

Optical Imaging

Clinical conditions

Neonatal brain injury

Equipment

Electroencephalography (EEG)

Magnetic resonance imaging (MRI)

Optical Imaging

Collaborators

Cambridge

Simon Baron-Cohen

Marek Czosnyka

Pickard John

Peter Smielewski

John Suckling

United Kingdom

Robert Cooper Web: https://www.ucl.ac.uk/medphys...

Adam Gibson Web: https://www.ucl.ac.uk/medphys...

Jem Hebden Web: https://www.ucl.ac.uk/medphys...

Mark Johnson Web: http://www.cbcd.bbk.ac.uk/babylab

Sarah Lloyd-Fox Web: http://www.cbcd.bbk.ac.uk/babylab

International

Gorm Greisen Web: http://www.rigshospitalet.dk/menu/AF...

Associated News Items


Publications

2015

Austin T (2015), “Measurement of cerebral oxygenation in preterm infants: is it useful?” Dev Med Child Neurol 57(5):404-5 Details

da Costa CS, Czosnyka M, Smielewski P, Mitra S, Stevenson GN, Austin T (2015), “Monitoring of Cerebrovascular Reactivity for Determination of Optimal Blood Pressure in Preterm Infants.” J Pediatr 167(1):86-91 Details

Hyttel-Sorensen S, Pellicer A, Alderliesten T, Austin T, van Bel F, Benders M, Claris O, Dempsey E, Franz AR, Fumagalli M, Gluud C, Grevstad B, Hagmann C, Lemmers P, van Oeveren W, Pichler G, Plomgaard AM, Riera J, Sanchez L, Winkel P, Wolf M, Greisen G (2015), “Cerebral near infrared spectroscopy oximetry in extremely preterm infants: phase II randomised clinical trial.” BMJ 350:g7635 Details

2014

Mitra S, Czosnyka M, Smielewski P, O'Reilly H, Brady K, Austin T (2014), “Heart rate passivity of cerebral tissue oxygenation is associated with predictors of poor outcome in preterm infants.” Acta Paediatr Details

Singh H, Cooper RJ, Wai Lee C, Dempsey L, Edwards A, Brigadoi S, Airantzis D, Everdell N, Michell A, Holder D, Hebden JC, Austin T (2014), “Mapping cortical haemodynamics during neonatal seizures using diffuse optical tomography: a case study.” Neuroimage Clin 5:256-65 Details

2013

Austin T, Shanmugalingam S, Clarke P (2013), “To cool or not to cool? Hypothermia treatment outside trial criteria.” Arch Dis Child Fetal Neonatal Ed 98(5):F451-3 Details

Chaudhary R, Farrer K, Broster S, McRitchie L, Austin T (2013), “Active Versus Passive Cooling During Neonatal Transport.” Pediatrics Details

Dassios T, Austin T (2013), “Respiratory function parameters in ventilated newborn infants undergoing whole body hypothermia.” Acta Paediatr Details

Hyttel-Sorensen S, Austin T, van Bel F, Benders M, Claris O, Dempsey E, Fumagalli M, Greisen G, Grevstad B, Hagmann C, Hellström-Westas L, Lemmers P, Lindschou J, Naulaers G, van Oeveren W, Pellicer A, Pichler G, Roll C, Skoog M, Winkel P, Wolf M, Gluud C (2013), “A phase II randomized clinical trial on cerebral near-infrared spectroscopy plus a treatment guideline versus treatment as usual for extremely preterm infants during the first three days of life (SafeBoosC): study protocol for a randomized controlled trial.” Trials 14:120 Details

Hyttel-Sørensen S, Austin T, van Bel F, Benders M, Claris O, Dempsey EM, Fumagalli M, Gluud C, Hagmann C, Hellström-Westas L, Lemmers P, Naulaers G, van Oeveren W, Pellicer A, Pichler G, Roll C, Støy LS, Wolf M, Greisen G (2013), “Clinical use of cerebral oximetry in extremely preterm infants is feasible.” Dan Med J 60(1):A4533 Details

Pellicer A, Greisen G, Benders M, Claris O, Dempsey E, Fumagalli M, Gluud C, Hagmann C, Hellström-Westas L, Hyttel-Sorensen S, Lemmers P, Naulaers G, Pichler G, Roll C, van Bel F, van Oeveren W, Skoog M, Wolf M, Austin T (2013), “The SafeBoosC Phase II Randomised Clinical Trial: A Treatment Guideline for Targeted Near-Infrared-Derived Cerebral Tissue Oxygenation versus Standard Treatment in Extremely Preterm Infants.” Neonatology 104(3):171-178 Details

2012

Arthurs OJ, Edwards A, Austin T, Graves MJ, Lomas DJ (2012), “The challenges of neonatal magnetic resonance imaging.” Pediatr Radiol 42(10):1183-94 Details

2011

Austin T, O'Reilly H (2011), “Advances in imaging the neonatal brain.” Expert Opin Med Diagn 5(2):95-107 Details

Cooper RJ, Hebden JC, O'Reilly H, Mitra S, Michell AW, Everdell NL, Gibson AP, Austin T (2011), “Transient haemodynamic events in neurologically compromised infants: a simultaneous EEG and diffuse optical imaging study.” Neuroimage 55(4):1610-6 Details

Dyson C, Austin T, Lees C (2011), “Could routine cardiotocography reduce long term cognitive impairment?” BMJ 342:d3120 Details

Squier W, Austin T, Anslow P, Weller RO (2011), “Infant subcortical cystic leucomalacia: a distinct pathological entity resulting from impaired fluid handling.” Early Hum Dev 87(6):421-6 Details

2008

Pichler G, Wolf M, Roll C, Weindling MA, Greisen G, Wardle SP, Zaramella P, Naulaers G, Pellicer A, Austin T, Bartocci M, Urlesberger B (2008), “Recommendations to increase the validity and comparability of peripheral measurements by near infrared spectroscopy in neonates. 'Round table', section of haematology, oxygen transport and microcirculation, 48th annual meeting of ESPR, Prague 2007.” Neonatology 94(4):320-2 Details

Wong FY, Leung TS, Austin T, Wilkinson M, Meek JH, Wyatt JS, Walker AM (2008), “Impaired autoregulation in preterm infants identified by using spatially resolved spectroscopy.” Pediatrics 121(3):e604-11 Details

2007

Austin T (2007), “Optical imaging of the neonatal brain.” Arch Dis Child Fetal Neonatal Ed 92(4):F238-41 Details

Hebden JC, Austin T (2007), “Optical tomography of the neonatal brain.” Eur Radiol 17(11):2926-33 Details

2006

Austin T, Gibson AP, Branco G, Yusof RM, Arridge SR, Meek JH, Wyatt JS, Delpy DT, Hebden JC (2006), “Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain.” Neuroimage 31(4):1426-33 Details

Gibson AP, Austin T, Everdell NL, Schweiger M, Arridge SR, Meek JH, Wyatt JS, Delpy DT, Hebden JC (2006), “Three-dimensional whole-head optical tomography of passive motor evoked responses in the neonate.” Neuroimage 30(2):521-8 Details

2005

Elwell CE, Henty JR, Leung TS, Austin T, Meek JH, Delpy DT, Wyatt JS (2005), “Measurement of CMRO2 in neonates undergoing intensive care using near infrared spectroscopy.” Adv Exp Med Biol 566:263-8 Details

2004

Hebden JC, Gibson A, Austin T, Yusof RM, Everdell N, Delpy DT, Arridge SR, Meek JH, Wyatt JS (2004), “Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography.” Phys Med Biol 49(7):1117-30 Details

Ibe OE, Austin T, Sullivan K, Fabanwo O, Disu E, Costello AM (2004), “A comparison of kangaroo mother care and conventional incubator care for thermal regulation of infants < 2000 g in Nigeria using continuous ambulatory temperature monitoring.” Ann Trop Paediatr 24(3):245-51 Details

2002

Hebden JC, Gibson A, Yusof RM, Everdell N, Hillman EM, Delpy DT, Arridge SR, Austin T, Meek JH, Wyatt JS (2002), “Three-dimensional optical tomography of the premature infant brain.” Phys Med Biol 47(23):4155-66 Details

1997

Austin T, Bridges N, Markiewicz M, Abrahamson E (1997), “Severe neonatal polycythaemia after third stage of labour underwater.” Lancet 350(9089):1445 Details