Dr Tahl Holtzman
University position
Research Associate
Departments
Institutes
Behavioural and Clinical Neuroscience Institute
Research Themes
Interests
My research is concerned with how neural circuits process information and use it as a basis for learning and behavioural control.
My current work focuses on the role of fronto-striatal circuits in governing impulsive decision making and in the control of attention and behaviour.
Methodologically, I address these questions in awake, freely moving animals using innovative wireless multi-site electrophysiological recording techniques in order to correlate neural activity signatures with behavioural features. In parallel, I work closely with microelectronic technologists to develop and implement next-generation neuro-technologies incorporating a variety of functions alongside multi-site electrophysiology ranging from real-time neurochemical sensing, microfluidic drug delivery and multi-site optogenetic stimulation.
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Research Focus
Keywordsimpulsivity electrophysiology information processing networks optogenetics |
Clinical conditionsAddiction |
Equipment
Behavioural analysis
Electrophysiological recording techniques
Collaborators
CambridgeGert van Dijk | InternationalPablo Blasquez Web: http://vor.wustl.edu/ Olivier Frey Web: http://www.bsse.ethz.ch/bel/peo... Henrik Jorntell Web: http://www.lunduniversity.lu.se/o.o.i.s... Patrick Ruther Web: http://www.imtek.de/materia... |
Key publications
Fan D, Rich D, Holtzman T, Ruther P, Dalley JW, Lopez A, Rossi MA, Barter JW, Salas-Meza D, Herwik S, Holzhammer T, Morizio J, Yin HH (2011), “A wireless multi-channel recording system for freely behaving mice and rats.” PLoS One 6(7):e22033 Details
Holtzman T, Sivam V, Zhao T, Frey O, Dow van der Wal P, Derooj NF, Dalley JW, Edgley SA (2011), “Multiple extra-synaptic spillover mechanisms regulate prolonged activity in cerebellar Golgi cell - granule cell loops.” J Physiol Details
Frey O, Holtzman T, McNamara RM, Theobald DE, van der Wal PD, de Rooij NF, Dalley JW, Koudelka-Hep M (2010), “Enzyme-based choline and L-glutamate biosensor electrodes on silicon microprobe arrays.” Biosens Bioelectron 26(2):477-84 Details
Mostofi A, Holtzman T, Grout AS, Yeo CH, Edgley SA (2010), “Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex.” J Neurosci 30(26):8920-34 Details
Publications
2012
Spieth S, Schumacher A, Holtzman T, Rich PD, Theobald DE, Dalley JW, Nouna R, Messner S, Zengerle R (2012), “An intra-cerebral drug delivery system for freely moving animals.” Biomed Microdevices 14(5):799-809 Details
2011
Frey O, Holtzman T, McNamara RM, Theobald DEH, van der Wal PD, de Rooij NF, Dalley JW & Kouldelka-Hep M. (2011), “Simultaneous neurochemical stimulation and recording using an assembly of biosensor silicon microprobes and SU-8 microinjectors. ” Sensors & Actuators B: Chemical. 2011 154(2): 96-105
Ruther P, Holzhammer T, Herwik S, Rich PD, Dalley JW, Paul O, Holtzman T (2011), “Compact wireless neural recording system for small animals using silicon-based probe arrays.” Conf Proc IEEE Eng Med Biol Soc 2011:2284-7 Details
2009
Holtzman T, Cerminara NL, Edgley SA, Apps R (2009), “Characterization in vivo of bilaterally branching pontocerebellar mossy fibre to Golgi cell inputs in the rat cerebellum.” Eur J Neurosci 29(2):328-39 Details
2006
Holtzman T, Mostofi A, Phuah CL, Edgley SA (2006), “Cerebellar Golgi cells in the rat receive multimodal convergent peripheral inputs via the lateral funiculus of the spinal cord.” J Physiol 577(Pt 1):69-80 Details
Holtzman T, Rajapaksa T, Mostofi A, Edgley SA (2006), “Different responses of rat cerebellar Purkinje cells and Golgi cells evoked by widespread convergent sensory inputs.” J Physiol 574(Pt 2):491-507 Details
Research and Collaboration
News, events and seminars
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