Dr Thomas Cope MA MClinRes MRCP

Interests

I am a Clinical Research Fellow and Specialist Registrar in Neurology, working in the University Neurology Unit with Professor James Rowe.

My research has two overarching aims:

1) to employ systems neuroscience as a translational bridge between the molecular biology of dementia and targeted clinical trials.

2) to define perceptual mechanisms, neural codes and brain substrates, and how they go wrong in patients with neurological pathology.

I am particularly interested in how brain mechanisms for prediction, language and learning become abnormal in patients with the aphasic forms of frontotemporal dementia. These are ideal demonstrator conditions, because of their stereotyped patterns of neurodegeneration, the psychophysical precision of language as a probe, and the fragility of human language networks to synaptic disruption.

My research uses a variety of techniques, including auditory psychophysics and functional imaging with magnetoencephalography and ultra-high field (7T) MRI.

Research Focus

Keywords

Dementia

Aphasia

Psychophysics

Magnetoencephalography

MRI

Clinical conditions

Alzheimer's disease

Anomia

Aphasia

Cognitive impairment

Dementia

Language disorders

Musical Hallucination

Progressive supranuclear palsy

Equipment

Behavioural analysis

Computational modelling

Electroencephalography (EEG)

Magnetic resonance imaging (MRI)

Magnetoencephalography (MEG)

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

Cambridge

David Baguley

Matt Davis

Karalyn Patterson

James Rowe

United Kingdom

Tim Griffiths Web: http://www.fil.ion.ucl.ac.uk/~tgriff/

Chris Petkov Web: http://www.ncl.ac.uk/ion/sta...

Associated News Items


Key publications

Cope TE, Borchert R, Rittman TD, Jones PS, Vatansever D, Allinson KSJ, Passamonti L, Vazquez Rodriguez P, Bevan Jones WR, O’Brien JT, Rowe JB. (2018), “Tau Burden and the Functional Connectome in Alzheimer's Disease and Progressive Supranuclear Palsy” Brain https://doi.org/10.1093/brain/awx347

Cope TE, Sohoglu E, Sedley W, Patterson K, Jones PS, Wiggins J, Dawson C, Grube M, Carlyon RP, Griffiths TD, Davis M, Rowe JB. (2017), “Evidence for causal top-down frontal contributions to predictive processes in speech perception” Nature Communications 2154 http://dx.doi.org/10.1038/s41467-017-01958-7

Publications

2017

Bevan Jones WR, Cope TE, Jones PS, Passamonti L, Hong YT, Fryer TD, Arnold R, Allinson KSJ, Coles J, Aigbirhio F, Patterson K, O’Brien JT, Rowe JB. (2017), “[18F]AV1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.” Journal of Neurology, Neurosurgery & Psychiatry (JNNP) http://dx.doi.org/10.1136/jnnp-2017-316402

Cope TE, Wilson B (joint first authors), Robson H, Drinkall R, Dean L, Grube M, Jones PS, Patterson K, Griffiths TD, Rowe JB, Petkov CI. (2017), “Artificial grammar learning in vascular and progressive non-fluent aphasias.” Neuropsychologia 104:201-213

Kumar S, Tansley-Hancock O, Sedley W, Winston JS, Callaghan MF, Allen M, Cope TE, Gander PE, Bamiou DE, Griffiths TD (2017), “The brain basis for misophonia” Current Biology 27(4):527-533

Passamonti L, Vázquez Rodríguez P, Hong YT, Allinson KSJ, Williamson D, Borchert RJ, Sami S, Cope TE, Bevan-Jones WR, Jones PS, Arnold R, Surendranathan A, Mak E, Su L, Fryer TD, Aigbirhio F, O’Brien JT, Rowe JB. (2017), “[18F]AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy” Brain 140(3):781-791

2016

Bekuis A, Cope TE, Grube M (2016), “The Beat to Read: A Cross-lingual Link between Rhythmic Regularity Perception and Reading Skill.” Frontiers in Human Neuroscience 10: 425

Bevan-Jones WR, Cope TE (joint first authors), Passamonti L, Fryer TD, Hong YT, Aigbirhio F, Kril JJ, Forrest SL, Allinson K, Coles JP, Jones PS, Spillantini MG, Hodges JR, O’Brien JT, Rowe JB (2016), “[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation” Annals of Clinical and Translational Neurology 3: 940-947

Cope TE, Breen DP, Chawda S, Cifelli A (2016), “Anti-collapsin response mediator protein 5 encephalitis masquerading as a low-grade brain tumour” Practical Neurology 16(5):376-380

2015

Cope TE, Baguley DM, Griffiths TD (2015), “The functional anatomy of central auditory processing” Practical Neurology 15(4):302:308

2014

Cope TE, Grube M, Mandal A, Cooper FE, Brechany U, Burn DJ, Griffiths TD (2014), “Subthalamic deep brain stimulation in Parkinson׳s disease has no significant effect on perceptual timing in the hundreds of milliseconds range.” Neuropsychologia 57:29-37 Details

Cope TE, Grube M, Singh B, Burn DJ, Griffiths TD (2014), “The basal ganglia in perceptual timing: Timing performance in Multiple System Atrophy and Huntington's disease.” Neuropsychologia 52:73-81 Details

2013

Cope TE, Cope W, Beaumont DM (2013), “A case of necrotising fasciitis caused by Serratia marsescens: extreme age as functional immunosuppression?” Age Ageing 42(2):266-8 Details

Cope TE, Samaraweera AP, Burn DJ (2013), “Thyrotoxic periodic paralysis: correct hypokalemia with caution.” J Emerg Med 45(3):338-40 Details

2012

Alcántara JI, Cope TE, Cope W, Weisblatt EJ (2012), “Auditory temporal-envelope processing in high-functioning children with Autism Spectrum Disorder.” Neuropsychologia 50(7):1235-51 Details

Cope TE, Grube M, Griffiths TD (2012), “Temporal predictions based on a gradual change in tempo.” J Acoust Soc Am 131(5):4013-22 Details

2011

Cope TE, Baguley DM, Moore BC (2011), “Tinnitus loudness in quiet and noise after resection of vestibular schwannoma.” Otol Neurotol 32(3):488-96 Details

Cope TE, McFarland R, Schaefer A (2011), “Rapid-onset, linezolid-induced lactic acidosis in MELAS.” Mitochondrion 11(6):992-3 Details

2009

Cope TE, Baguley DM (2009), “Is musical hallucination an otological phenomenon? a review of the literature.” Clin Otolaryngol 34(5):423-30 Details

2008

Cope TE (2008), “Clinical hypnosis for the alleviation of tinnitus.” Int Tinnitus J 14(2):135-8 Details

2006

Moore BC, Glasberg BR, Low KE, Cope T, Cope W (2006), “Effects of level and frequency on the audibility of partials in inharmonic complex tones.” J Acoust Soc Am 120(2):934-44 Details