Dr Tim Fryer

Tim Fryer

University position

Assistant Director of Research

Dr Tim Fryer is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Wolfson Brain Imaging Centre

Email

tdf21@wbic.cam.ac.uk

Home page

http://www.wbic.cam.ac.uk

Research Theme

Cellular and Molecular Neuroscience

Interests

My research concentrates on positron emission tomography (PET) methodology, with particular emphasis on the quantitative accuracy of the physiological parameters derived from the data.

Current research themes are:

parametric mapping using basis functions

spatio-temporal image reconstruction for kinetic analysis

direct parameter estimation

wavelet-based kinetic analysis

4D motion compensated image reconstruction

MRI-based motion correction for PET/MRI scanners

image optimisation using automated observers

automated region-of-interest definition

attenuation correction for PET/MRI scanners.

Simulation of PET data acquisition using SimG4
Simulation of PET data acquisition using SimG4 (Barret et al, Phys Med Biol 2005)
Click image to view full-size

Research Focus

Keywords

PET

kinetic modeling

image reconstruction

data corrections

automated image assessment

Clinical conditions

Addiction

Attention deficit hyperactivity disorder

Cancers

Cerebrovascular disorders

Dementia

Stroke

Traumatic brain injury

Equipment

Computational modelling

Positron Emission Tomography (PET)

Collaborators

Cambridge

Jonathan Coles

Jeff Dalley

Tim Eisen

Fiona Gilbert

Martin Graves

Tony Holland

Young Hong

Duncan Jodrell

Giovanna Mallucci

Roie Manavaki

David Menon

Trevor Robbins

Angela Roberts

James Rudd

Elizabeth Warburton

Shahid Zaman

United Kingdom

Nikos Dikaios Web: http://cmic.cs.ucl.ac.uk

Jonathan Friedland Web: http://www1.imperial.ac.uk/medicine

International

Jean-Claude Baron Web: https://cpn.paris5.inserm.fr/equipes...

Peter Nestor Web: http://www.dzne.de

Patrick Riss Web: http://www.mn.uio.no/kjemi

Dimitris Visvikis Web: http://latim.univ-brest.fr

Associated News Items


    Key publications

    Dikaios N, Fryer TD (2012), “Registration-weighted motion correction for PET.” Med Phys 39(3):1253-64 Details

    Dikaios N, Izquierdo-Garcia D, Graves MJ, Mani V, Fayad ZA, Fryer TD (2012), “MRI-based motion correction of thoracic PET: initial comparison of acquisition protocols and correction strategies suitable for simultaneous PET/MRI systems.” Eur Radiol 22(2):439-46 Details

    del Campo N, Tait RJ, Acosta-Cabronero J, Hong YT, Izquierdo-Garcia D, Smith R, Aigbirhio FI, Sahakian BJ, Müller U, Robbins TW, Fryer TD (2011), “Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.” Neuroimage 55(1):101-12 Details

    Dikaios N, Fryer TD (2011), “Acceleration of motion-compensated PET reconstruction: ordered subsets-gates EM algorithms and a priori reference gate information.” Phys Med Biol 56(6):1695-1715 Details

    Dikaios N, Fryer TD (2011), “Improved motion-compensated image reconstruction for PET using sensitivity correction per respiratory gate and an approximate tube-of-response backprojector.” Med Phys 38(9):4958-70 Details

    Hong YT, Beech JS, Smith R, Baron JC, Fryer TD (2011), “Parametric mapping of [(18)F]fluoromisonidazole positron emission tomography using basis functions.” J Cereb Blood Flow Metab 31(2):648-57 Details

    Malone IB, Ansorge RE, Williams GB, Nestor PJ, Carpenter TA, Fryer TD (2011), “Attenuation Correction Methods Suitable for Brain Imaging with a PET/MRI Scanner: A Comparison of Tissue Atlas and Template Attenuation Map Approaches.” J Nucl Med 52(7):1142-9 Details

    Hong YT, Fryer TD (2010), “Kinetic modelling using basis functions derived from two-tissue compartmental models with a plasma input function: general principle and application to [18F]fluorodeoxyglucose positron emission tomography.” Neuroimage 51(1):164-72 Details

    Publications

    2015

    Annus T, Wilson LR, Hong YT, Acosta-Cabronero J, Fryer TD, Cardenas-Blanco A, Smith R, Boros I, Coles JP, Aigbirhio FI, Menon DK, Zaman SH, Nestor PJ, Holland AJ (2015), “The pattern of amyloid accumulation in the brains of adults with Down syndrome” Alzheimers Dement

    Caprioli D, Jupp B, Hong YT, Sawiak SJ, Ferrari V, Wharton L, Williamson DJ, McNabb C, Berry D, Aigbirhio FI, Robbins TW, Fryer TD, Dalley JW (2015), “Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum.” J Neurosci 35(9):3747-55 Details

    Charidimou A, Hong YT, Jäger HR, Fox Z, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Werring DJ, Baron JC (2015), “White Matter Perivascular Spaces on Magnetic Resonance Imaging: Marker of Cerebrovascular Amyloid Burden?” Stroke Details

    Farid K, Hong YT, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Baron JC (2015), “Early-Phase 11C-PiB PET in Amyloid Angiopathy-Related Symptomatic Cerebral Hemorrhage: Potential Diagnostic Value?” PLoS One 10(10):e0139926

    Li L, Shao X, Cole EL, Ohnmacht SA, Ferrari V, Hong YT, Williamson DJ, Fryer TD, Quesada CA, Sherman P, Riss PJ, Scott PJ, Aigbirhio FI (2015), “Synthesis and Initial in Vivo Studies with [(11)C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3” ACS Med Chem Lett 6(5):548-52

    2014

    Alawneh JA, Moustafa RR, Marrapu ST, Jensen-Kondering U, Morris RS, Jones PS, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2014), “Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study.” Eur J Nucl Med Mol Imaging 41(4):736-44 Details

    Baron JC, Farid K, Dolan E, Turc G, Marrapu ST, O'Brien E, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Hong YT (2014), “Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage.” J Cereb Blood Flow Metab 34(5):753-8 Details

    Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC (2014), “Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.” J Neurosci 34(22):7663-76 Details

    Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK (2014), “Amyloid imaging with carbon 11-labeled pittsburgh compound B for traumatic brain injury.” JAMA Neurol 71(1):23-31 Details

    2013

    Caprioli D, Fryer TD, Sawiak SJ, Aigbirhio FI, Dalley JW (2013), “Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls.” Curr Opin Neurobiol 23(4):597-606 Details

    Caprioli D, Hong YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Adrian Carpenter T, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer TD, Dalley JW (2013), “Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome.” Neuropsychopharmacology 38(8):1460-71 Details

    Carrera E, Jones PS, Morris RS, Alawneh J, Hong YT, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2013), “Is neural activation within the rescued penumbra impeded by selective neuronal loss?” Brain 136(Pt 6):1816-29 Details

    del Campo N, Fryer TD, Hong YT, Smith R, Brichard L, Acosta-Cabronero J, Chamberlain SR, Tait R, Izquierdo D, Regenthal R, Dowson J, Suckling J, Baron JC, Aigbirhio FI, Robbins TW, Sahakian BJ, Müller U (2013), “A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.” Brain 136(Pt 11):3252-70 Details

    Ejaz S, Williamson DJ, Ahmed T, Sitnikov S, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Baron JC (2013), “Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.” Neurobiol Dis 51:120-32 Details

    Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI (2013), “Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging.” J Nucl Med 54(2):299-305 Details

    Williamson DJ, Ejaz S, Sitnikov S, Fryer TD, Sawiak SJ, Burke P, Baron JC, Aigbirhio FI (2013), “A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke.” Nucl Med Biol 40(3):338-44 Details

    2012

    Hughes JL, Jones PS, Beech JS, Wang D, Menon DK, Aigbirhio FI, Fryer TD, Baron JC (2012), “A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation.” Neuroimage 59(3):2007-16 Details

    Johnström P, Fryer TD, Bird JL, Richards HK, Davenport AP (2012), “Dynamic in vivo imaging of receptors in small animals using positron emission tomography.” Methods Mol Biol 897:221-37 Details

    Pengas G, Williams GB, Acosta-Cabronero J, Ash TW, Hong YT, Izquierdo-Garcia D, Fryer TD, Hodges JR, Nestor PJ (2012), “The relationship of topographical memory performance to regional neurodegeneration in Alzheimer's disease.” Front Aging Neurosci 4:17 Details

    Virdee K, Cumming P, Caprioli D, Jupp B, Rominger A, Aigbirhio FI, Fryer TD, Riss PJ, Dalley JW (2012), “Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders.” Neurosci Biobehav Rev 36(4):1188-216 Details

    2011

    Acosta-Cabronero J, Patterson K, Fryer TD, Hodges JR, Pengas G, Williams GB, Nestor PJ (2011), “Atrophy, hypometabolism and white matter abnormalities in semantic dementia tell a coherent story.” Brain 134(Pt 7):2025-35 Details

    Carrera E, Jones PS, Alawneh JA, Klærke Mikkelsen I, Cho TH, Siemonsen S, Guadagno JV, Mouridsen K, Ribe L, Hjort N, Fryer TD, Carpenter TA, Aigbirhio FI, Fiehler J, Nighoghossian N, Warburton EA, Ostergaard L, Baron JC (2011), “Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?” Stroke 42(6):1602-7 Details

    Carrera E, Jones PS, Iglesias S, Guadagno JV, Warburton EA, Fryer TD, Aigbirhio FI, Baron JC (2011), “The vascular mean transit time: a surrogate for the penumbra flow threshold?” J Cereb Blood Flow Metab 31(4):1027-35 Details

    Geeraerts T, Coles JP, Aigbirhio FI, Pickard JD, Menon DK, Fryer TD, Hong YT (2011), “Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.” Ann Nucl Med 25(6):396-405 Details

    Landt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.” Arch Neurol 68(7):890-6 Details

    Moustafa RR, Momjian-Mayor I, Jones PS, Morbelli S, Day DJ, Aigbirhio FI, Fryer TD, Warburton EA, Baron JC (2011), “Microembolism versus hemodynamic impairment in rosary-like deep watershed infarcts: a combined positron emission tomography and transcranial Doppler study.” Stroke 42(11):3138-43 Details

    Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011), “Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.” J Cereb Blood Flow Metab 31(12):2334-42 Details

    Takasawa M, Beech JS, Fryer TD, Jones PS, Ahmed T, Smith R, Aigbirhio FI, Baron JC (2011), “Single-subject statistical mapping of acute brain hypoxia in the rat following middle cerebral artery occlusion: a microPET study.” Exp Neurol 229(2):251-8 Details

    2010

    Atack JR, Wong DF, Fryer TD, Ryan C, Sanabria S, Zhou Y, Dannals RF, Eng WS, Gibson RE, Burns HD, Vega JM, Vessy L, Scott-Stevens P, Beech JS, Baron JC, Sohal B, Schrag ML, Aigbirhio FI, McKernan RM, Hargreaves RJ (2010), “Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in rats, primates, and humans.” J Pharmacol Exp Ther 332(1):17-25 Details

    Davies JR, Izquierdo-Garcia D, Rudd JH, Figg N, Richards HK, Bird JL, Aigbirhio FI, Davenport AP, Weissberg PL, Fryer TD, Warburton EA (2010), “FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.” Int J Cardiovasc Imaging 26(1):41-8 Details

    Hawkes RC, Fryer TD, Siegel S, Ansorge RE, Carpenter TA (2010), “Preliminary evaluation of a combined microPET-MR system.” Technol Cancer Res Treat 9(1):53-60 Details

    Johnström P, Fryer TD, Richards HK, Maguire JJ, Clark JC, Pickard JD, Davenport AP (2010), “Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver.” Br J Pharmacol 159(4):812-9 Details

    Mion M, Patterson K, Acosta-Cabronero J, Pengas G, Izquierdo-Garcia D, Hong YT, Fryer TD, Williams GB, Hodges JR, Nestor PJ (2010), “What the left and right anterior fusiform gyri tell us about semantic memory.” Brain 133(11):3256-68 Details

    Moustafa RR, Izquierdo-Garcia D, Fryer TD, Graves MJ, Rudd JH, Gillard JH, Weissberg PL, Baron JC, Warburton EA (2010), “Carotid plaque inflammation is associated with cerebral microembolism in patients with recent transient ischemic attack or stroke: a pilot study.” Circ Cardiovasc Imaging 3(5):536-41 Details

    Moustafa RR, Izquierdo-Garcia D, Jones PS, Graves MJ, Fryer TD, Gillard JH, Warburton EA, Baron JC (2010), “Watershed infarcts in transient ischemic attack/minor stroke with > or = 50% carotid stenosis: hemodynamic or embolic?” Stroke 41(7):1410-6 Details

    2009

    Clatworthy PL, Lewis SJ, Brichard L, Hong YT, Izquierdo D, Clark L, Cools R, Aigbirhio FI, Baron JC, Fryer TD, Robbins TW (2009), “Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.” J Neurosci 29(15):4690-6 Details

    Dalley JW, Fryer TD, Aigbirhio FI, Brichard L, Richards HK, Hong YT, Baron JC, Everitt BJ, Robbins TW (2009), “Modelling human drug abuse and addiction with dedicated small animal positron emission tomography.” Neuropharmacology 56 Suppl 1:9-17 Details

    Donswijk ML, Jones PS, Guadagno JV, Carpenter TA, Moustafa RR, Fryer TD, Aigbirhio FI, Warburton EA, Baron JC (2009), “T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke.” Cerebrovasc Dis 28(3):306-13 Details

    Hutchinson PJ, O'Connell MT, Seal A, Nortje J, Timofeev I, Al-Rawi PG, Coles JP, Fryer TD, Menon DK, Pickard JD, Carpenter KL (2009), “A combined microdialysis and FDG-PET study of glucose metabolism in head injury.” Acta Neurochir (Wien) 151(1):51-61; discussion 61 Details

    Izquierdo-Garcia D, Davies JR, Graves MJ, Rudd JH, Gillard JH, Weissberg PL, Fryer TD, Warburton EA (2009), “Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: reproducibility, partial volume correction, and correlation between methods.” Stroke 40(1):86-93 Details

    Kipps CM, Hodges JR, Fryer TD, Nestor PJ (2009), “Combined magnetic resonance imaging and positron emission tomography brain imaging in behavioural variant frontotemporal degeneration: refining the clinical phenotype.” Brain 132(Pt 9):2566-78 Details

    Price SJ, Fryer TD, Cleij MC, Dean AF, Joseph J, Salvador R, Wang DD, Hutchinson PJ, Clark JC, Burnet NG, Pickard JD, Aigbirhio FI, Gillard JH (2009), “Imaging regional variation of cellular proliferation in gliomas using 3'-deoxy-3'-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study.” Clin Radiol 64(1):52-63 Details

    2008

    Abate MG, Trivedi M, Fryer TD, Smielewski P, Chatfield DA, Williams GB, Aigbirhio F, Carpenter TA, Pickard JD, Menon DK, Coles JP (2008), “Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity.” Neurocrit Care 9(3):319-25 Details

    Guadagno JV, Jones PS, Aigbirhio FI, Wang D, Fryer TD, Day DJ, Antoun N, Nimmo-Smith I, Warburton EA, Baron JC (2008), “Selective neuronal loss in rescued penumbra relates to initial hypoperfusion.” Brain 131(Pt 10):2666-78 Details

    Nortje J, Coles JP, Timofeev I, Fryer TD, Aigbirhio FI, Smielewski P, Outtrim JG, Chatfield DA, Pickard JD, Hutchinson PJ, Gupta AK, Menon DK (2008), “Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.” Crit Care Med 36(1):273-81 Details

    Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, Gillard JH, Williams GB, Aigbirhio FI, Warburton EA, Østergaard L, Baron JC (2008), “How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET.” Stroke 39(3):870-7 Details

    2007

    Atack JR, Scott-Stevens P, Beech JS, Fryer TD, Hughes JL, Cleij MC, Baron JC, Clark JC, Hargreaves RJ, Aigbirhio FI (2007), “Comparison of lorazepam [7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one] occupancy of rat brain gamma-aminobutyric acid(A) receptors measured using in vivo [3H]flumazenil (8-fluoro 5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester) binding and [11C]flumazenil micro-positron emission tomography.” J Pharmacol Exp Ther 320(3):1030-7 Details

    Coles JP, Fryer TD, Coleman MR, Smielewski P, Gupta AK, Minhas PS, Aigbirhio F, Chatfield DA, Williams GB, Boniface S, Carpenter TA, Clark JC, Pickard JD, Menon DK (2007), “Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.” Crit Care Med 35(2):568-78 Details

    Dalley JW, Fryer TD, Brichard L, Robinson ES, Theobald DE, Lääne K, Peña Y, Murphy ER, Shah Y, Probst K, Abakumova I, Aigbirhio FI, Richards HK, Hong Y, Baron JC, Everitt BJ, Robbins TW (2007), “Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.” Science 315(5816):1267-70 Details

    Kipps CM, Nestor PJ, Fryer TD, Hodges JR (2007), “Behavioural variant frontotemporal dementia: not all it seems?” Neurocase 13(4):237-47 Details

    Nestor PJ, Balan K, Cheow HK, Fryer TD, Knibb JA, Xuereb JH, Hodges JR (2007), “Nuclear imaging can predict pathologic diagnosis in progressive nonfluent aphasia.” Neurology 68(3):238-9 Details

    Probst KC, Izquierdo D, Bird JL, Brichard L, Franck D, Davies JR, Fryer TD, Richards HK, Clark JC, Davenport AP, Weissberg PL, Warburton EA (2007), “Strategy for improved [(11)C]DAA1106 radiosynthesis and in vivo peripheral benzodiazepine receptor imaging using microPET, evaluation of [(11)C]DAA1106.” Nucl Med Biol 34(4):439-46 Details

    Takasawa M, Beech JS, Fryer TD, Hong YT, Hughes JL, Igase K, Jones PS, Smith R, Aigbirhio FI, Menon DK, Clark JC, Baron JC (2007), “Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study.” J Cereb Blood Flow Metab 27(4):679-89 Details

    2006

    Coles JP, Fryer TD, Bradley PG, Nortje J, Smielewski P, Rice K, Clark JC, Pickard JD, Menon DK (2006), “Intersubject variability and reproducibility of 15O PET studies.” J Cereb Blood Flow Metab 26(1):48-57 Details

    Ersche KD, Fletcher PC, Roiser JP, Fryer TD, London M, Robbins TW, Sahakian BJ (2006), “Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers.” Psychopharmacology (Berl) 188(3):364-73 Details

    Guadagno JV, Jones PS, Fryer TD, Barret O, Aigbirhio FI, Carpenter TA, Price CJ, Gillard JH, Warburton EA, Baron JC (2006), “Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain.” Stroke 37(7):1741-8 Details

    Guadagno JV, Warburton EA, Jones PS, Day DJ, Aigbirhio FI, Fryer TD, Harding S, Price CJ, Green HA, Barret O, Gillard JH, Baron JC (2006), “How affected is oxygen metabolism in DWI lesions?: A combined acute stroke PET-MR study.” Neurology 67(5):824-9 Details

    Johnström P, Rudd JH, Richards HK, Fryer TD, Clark JC, Weissberg PL, Pickard JD, Davenport AP (2006), “Imaging endothelin ET(B) receptors using [18F]-BQ3020: in vitro characterization and positron emission tomography (microPET).” Exp Biol Med (Maywood) 231(6):736-40 Details

    Lucas AJ, Hawkes RC, Ansorge RE, Williams GB, Nutt RE, Clark JC, Fryer TD, Carpenter TA (2006), “Development of a combined microPET-MR system.” Technol Cancer Res Treat 5(4):337-41 Details

    Nestor PJ, Fryer TD, Hodges JR (2006), “Declarative memory impairments in Alzheimer's disease and semantic dementia.” Neuroimage 30(3):1010-20 Details

    Price CJ, Wang D, Menon DK, Guadagno JV, Cleij M, Fryer T, Aigbirhio F, Baron JC, Warburton EA (2006), “Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.” Stroke 37(7):1749-53 Details

    2005

    Barret O, Carpenter TA, Clark JC, Ansorge RE, Fryer TD (2005), “Monte Carlo simulation and scatter correction of the GE advance PET scanner with SimSET and Geant4.” Phys Med Biol 50(20):4823-40 Details

    Coleman MR, Menon DK, Fryer TD, Pickard JD (2005), “Neurometabolic coupling in the vegetative and minimally conscious states: preliminary findings.” J Neurol Neurosurg Psychiatry 76(3):432-4 Details

    Crossley M, Shiel A, Wilson B, Coleman MR, Gelling L, Fryer T, Boniface S, Pickard J (2005), “Monitoring emergence from coma following severe brain injury in an octogenarian using behavioural indicators, electrophysiological measures and metabolic studies: a demonstration of the potential for good recovery in older adults.” Brain Inj 19(9):729-37 Details

    Cunningham AS, Salvador R, Coles JP, Chatfield DA, Bradley PG, Johnston AJ, Steiner LA, Fryer TD, Aigbirhio FI, Smielewski P, Williams GB, Carpenter TA, Gillard JH, Pickard JD, Menon DK (2005), “Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury.” Brain 128(Pt 8):1931-42 Details

    Davies JR, Rudd JF, Fryer TD, Weissberg PL (2005), “Targeting the vulnerable plaque: the evolving role of nuclear imaging.” J Nucl Cardiol 12(2):234-46 Details

    Davies JR, Rudd JH, Fryer TD, Graves MJ, Clark JC, Kirkpatrick PJ, Gillard JH, Warburton EA, Weissberg PL (2005), “Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging.” Stroke 36(12):2642-7 Details

    Guadagno JV, Warburton EA, Jones PS, Fryer TD, Day DJ, Gillard JH, Carpenter TA, Aigbirhio FI, Price CJ, Baron JC (2005), “The diffusion-weighted lesion in acute stroke: heterogeneous patterns of flow/metabolism uncoupling as assessed by quantitative positron emission tomography.” Cerebrovasc Dis 19(4):239-46 Details

    Johnston AJ, Steiner LA, Coles JP, Chatfield DA, Fryer TD, Smielewski P, Hutchinson PJ, O'Connell MT, Al-Rawi PG, Aigbirihio FI, Clark JC, Pickard JD, Gupta AK, Menon DK (2005), “Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury.” Crit Care Med 33(1):189-95; discussion 255-7 Details

    Johnström P, Fryer TD, Richards HK, Barret O, Davenport AP (2005), “Dynamic in vivo imaging of receptors in small animals using positron emission tomography.” Methods Mol Biol 306:217-32 Details

    Johnström P, Fryer TD, Richards HK, Harris NG, Barret O, Clark JC, Pickard JD, Davenport AP (2005), “Positron emission tomography using 18F-labelled endothelin-1 reveals prevention of binding to cardiac receptors owing to tissue-specific clearance by ET B receptors in vivo.” Br J Pharmacol 144(1):115-22 Details

    O'Connell MT, Seal A, Nortje J, Al-Rawi PG, Coles JP, Fryer TD, Menon DK, Pickard JD, Hutchinson PJ (2005), “Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study.” Acta Neurochir Suppl 95:165-8 Details

    Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK (2005), “Imaging of cerebral blood flow and metabolism in brain injury in the ICU.” Acta Neurochir Suppl 95:459-64 Details

    2004

    Coles JP, Fryer TD, Smielewski P, Chatfield DA, Steiner LA, Johnston AJ, Downey SP, Williams GB, Aigbirhio F, Hutchinson PJ, Rice K, Carpenter TA, Clark JC, Pickard JD, Menon DK (2004), “Incidence and mechanisms of cerebral ischemia in early clinical head injury.” J Cereb Blood Flow Metab 24(2):202-11 Details

    Coles JP, Fryer TD, Smielewski P, Rice K, Clark JC, Pickard JD, Menon DK (2004), “Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology.” J Cereb Blood Flow Metab 24(2):191-201 Details

    Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smieleweski P, Chatfield DA, Aigbirhio F, Williams GB, Boniface S, Rice K, Clark JC, Pickard JD, Menon DK (2004), “Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?” Brain 127(Pt 11):2479-90 Details

    Guadagno JV, Warburton EA, Aigbirhio FI, Smielewski P, Fryer TD, Harding S, Price CJ, Gillard JH, Carpenter TA, Baron JC (2004), “Does the acute diffusion-weighted imaging lesion represent penumbra as well as core? A combined quantitative PET/MRI voxel-based study.” J Cereb Blood Flow Metab 24(11):1249-54 Details

    Johnström P, Fryer TD, Richards HK, Barret O, Clark JC, Ohlstein EH, Pickard JD, Davenport AP (2004), “In vivo imaging of cardiovascular endothelin receptors using the novel radiolabelled antagonist [18F]-SB209670 and positron emission tomography (microPET).” J Cardiovasc Pharmacol 44 Suppl 1:S34-8 Details

    Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD (2004), “Diffusion limited oxygen delivery following head injury.” Crit Care Med 32(6):1384-90 Details

    Owler BK, Momjian S, Czosnyka Z, Czosnyka M, Péna A, Harris NG, Smielewski P, Fryer T, Donovan T, Coles J, Carpenter A, Pickard JD (2004), “Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values.” J Cereb Blood Flow Metab 24(1):17-23 Details

    Owler BK, Pena A, Momjian S, Czosnyka Z, Czosnyka M, Harris NG, Smielewski P, Fryer T, Donvan T, Carpenter A, Pickard JD (2004), “Changes in cerebral blood flow during cerebrospinal fluid pressure manipulation in patients with normal pressure hydrocephalus: a methodological study.” J Cereb Blood Flow Metab 24(5):579-87 Details

    Price CJ, Menon DK, Peters AM, Ballinger JR, Barber RW, Balan KK, Lynch A, Xuereb JH, Fryer T, Guadagno JV, Warburton EA (2004), “Cerebral neutrophil recruitment, histology, and outcome in acute ischemic stroke: an imaging-based study.” Stroke 35(7):1659-64 Details

    2003

    Donovan T, Fryer TD, Peña A, Watts C, Carpenter TA, Pickard JD (2003), “Stereotactic MR imaging for planning neural transplantation: a reliable technique at 3 Tesla?” Br J Neurosurg 17(5):443-9 Details

    Nestor PJ, Caine D, Fryer TD, Clarke J, Hodges JR (2003), “The topography of metabolic deficits in posterior cortical atrophy (the visual variant of Alzheimer's disease) with FDG-PET.” J Neurol Neurosurg Psychiatry 74(11):1521-9 Details

    Nestor PJ, Fryer TD, Ikeda M, Hodges JR (2003), “Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease).” Eur J Neurosci 18(9):2663-7 Details

    Nestor PJ, Fryer TD, Smielewski P, Hodges JR (2003), “Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment.” Ann Neurol 54(3):343-51 Details

    Nestor PJ, Graham NL, Fryer TD, Williams GB, Patterson K, Hodges JR (2003), “Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula.” Brain 126(Pt 11):2406-18 Details

    Steiner LA, Coles JP, Czosnyka M, Minhas PS, Fryer TD, Aigbirhio FI, Clark JC, Smielewski P, Chatfield DA, Donovan T, Pickard JD, Menon DK (2003), “Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury.” J Neurol Neurosurg Psychiatry 74(6):765-70 Details

    Steiner LA, Coles JP, Johnston AJ, Chatfield DA, Smielewski P, Fryer TD, Aigbirhio FI, Clark JC, Pickard JD, Menon DK, Czosnyka M (2003), “Assessment of cerebrovascular autoregulation in head-injured patients: a validation study.” Stroke 34(10):2404-9 Details

    Steiner LA, Coles JP, Johnston AJ, Czosnyka M, Fryer TD, Smielewski P, Chatfield DA, Salvador R, Aigbirhio FI, Clark JC, Menon DK, Pickard JD (2003), “Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure.” J Cereb Blood Flow Metab 23(11):1371-7 Details

    Watts C, Donovan T, Gillard JH, Antoun NM, Burnstein R, Menon DK, Carpenter TA, Fryer T, Thomas DG, Pickard JD (2003), “Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease.” Cell Transplant 12(7):697-704 Details

    2002

    Coles JP, Minhas PS, Fryer TD, Smielewski P, Aigbirihio F, Donovan T, Downey SP, Williams G, Chatfield D, Matthews JC, Gupta AK, Carpenter TA, Clark JC, Pickard JD, Menon DK (2002), “Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates.” Crit Care Med 30(9):1950-9 Details

    Gupta AK, Hutchinson PJ, Fryer T, Al-Rawi PG, Parry DA, Minhas PS, Kett-White R, Kirkpatrick PJ, Mathews JC, Downey S, Aigbirhio F, Clark J, Pickard JD, Menon DK (2002), “Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method.” J Neurosurg 96(2):263-8 Details

    Hutchinson PJ, Gupta AK, Fryer TF, Al-Rawi PG, Chatfield DA, Coles JP, O'Connell MT, Kett-White R, Minhas PS, Aigbirhio FI, Clark JC, Kirkpatrick PJ, Menon DK, Pickard JD (2002), “Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.” J Cereb Blood Flow Metab 22(6):735-45 Details

    Johnström P, Harris NG, Fryer TD, Barret O, Clark JC, Pickard JD, Davenport AP (2002), “(18)F-Endothelin-1, a positron emission tomography (PET) radioligand for the endothelin receptor system: radiosynthesis and in vivo imaging using microPET.” Clin Sci (Lond) 103 Suppl 48:4S-8S Details

    Peña A, Owler BK, Fryer TD, Minhas P, Czosnyka M, Crawford PJ, Pickard JD (2002), “A case study of hemispatial neglect using finite element analysis and positron emission tomography.” J Neuroimaging 12(4):360-7 Details

    Rudd JH, Warburton EA, Fryer TD, Jones HA, Clark JC, Antoun N, Johnström P, Davenport AP, Kirkpatrick PJ, Arch BN, Pickard JD, Weissberg PL (2002), “Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography.” Circulation 105(23):2708-11 Details

    Smielewski P, Coles JP, Fryer TD, Minhas PS, Menon DK, Pickard JD (2002), “Integrated image analysis solutions for PET datasets in damaged brain.” J Clin Monit Comput 17(7-8):427-40 Details

    2000

    Fleming JS, Goatman KA, Julyan PJ, Boivin CM, Wilson MJ, Barber RW, Bird NJ, Fryer TD (2000), “A comparison of performance of three gamma camera systems for positron emission tomography.” Nucl Med Commun 21(12):1095-102 Details

    Pickard JD, Kirkpatrick PJ, Melsen T, Andreasen RB, Gelling L, Fryer T, Matthews J, Minhas P, Hutchinson PJ, Menon D, Downey SP, Kendall I, Clark J, Carpenter TA, Williams E, Persson L (2000), “Potential role of NovoSeven in the prevention of rebleeding following aneurysmal subarachnoid haemorrhage.” Blood Coagul Fibrinolysis 11 Suppl 1:S117-20 Details