Dr Taufiq Rahman

Taufiq Rahman

University position

Royal Society University Research Fellow

Dr Taufiq Rahman is pleased to consider applications from prospective PhD students.

Departments

Department of Pharmacology

Email

mtur2@cam.ac.uk

Home page

http://www.phar.cam.ac.uk/researc...

Research Themes

Cellular and Molecular Neuroscience

Systems and Computational Neuroscience

Interests

My research interests broadly lie in two categories - structure-function studies of intracellular calcium channels and rational design and development of selective modulators of signalling proteins including ion channels

Research Focus

Keywords

calcium signalling

in silico screening

rational drug design

single channel recording

Clinical conditions

No direct clinical relevance

Equipment

Computational modelling

Electrophysiological recording techniques

Fluorescence microscopy

Collaborators

Cambridge

Laura Itzhaki

Ewan Smith

Colin Taylor

Martin Welch

United Kingdom

Sandip Patel Web: http://www.ucl.ac.uk/cdb/res...

Associated News Items


    Publications

    2014

    Ohene-Agyei T, Mowla R, Rahman T, Venter H (2014), “Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump.” Microbiologyopen 3(6):885-96 Details

    Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S (2014), “Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.” Sci Signal 7(352):ra109 Details

    Rahman T, Smith ES (2014), “In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing ion channel 3.” Biochem Biophys Res Commun 450(1):384-9 Details

    Taylor CW, Tovey SC, Rossi AM, Lopez Sanjurjo CI, Prole DL, Rahman T (2014), “Structural organization of signalling to and from IP3 receptors.” Biochem Soc Trans 42(1):63-70 Details

    2013

    Churamani D, Hooper R, Rahman T, Brailoiu E, Patel S (2013), “The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.” Biochem J Details

    Li C, Enomoto M, Rossi AM, Seo MD, Rahman T, Stathopulos PB, Taylor CW, Ikura M, Ames JB (2013), “CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.” Proc Natl Acad Sci U S A 110(21):8507-12 Details

    Saleem H, Tovey SC, Rahman T, Riley AM, Potter BV, Taylor CW (2013), “Stimulation of Inositol 1,4,5-Trisphosphate (IP(3)) Receptor Subtypes by Analogues of IP(3).” PLoS One 8(1):e54877 Details

    Sun Y, Rossi AM, Rahman T, Taylor CW (2013), “Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif.” Biochem J 449(1):39-49 Details

    2012

    Rahman T (2012), “Dynamic clustering of IP3 receptors by IP3.” Biochem Soc Trans 40(2):325-30 Details

    Rossi AM, Tovey SC, Rahman T, Prole DL, Taylor CW (2012), “Analysis of IP3 receptors in and out of cells.” Biochim Biophys Acta 1820(8):1214-27 Details

    2011

    Musa MA, Cooperwood JS, Khan MO, Rahman T (2011), “In-vitro antiproliferative activity of benzopyranone derivatives in comparison with standard chemotherapeutic drugs.” Arch Pharm (Weinheim) 344(2):102-10 Details

    Patel S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E (2011), “The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.” Cell Calcium 50(2):157-67 Details

    2010

    Brailoiu E, Rahman T, Churamani D, Prole DL, Brailoiu GC, Hooper R, Taylor CW, Patel S (2010), “An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.” J Biol Chem 285(49):38511-6 Details

    Ding Z, Rossi AM, Riley AM, Rahman T, Potter BV, Taylor CW (2010), “Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand.” Mol Pharmacol 77(6):995-1004 Details

    Rahman T, Rahmatullah M (2010), “Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.” Bioorg Med Chem Lett 20(2):537-40 Details

    Rahman T, Taylor CW (2010), “Nuclear patch-clamp recording from inositol 1,4,5-trisphosphate receptors.” Methods Cell Biol 99:199-224 Details

    Tovey SC, Dedos SG, Rahman T, Taylor EJ, Pantazaka E, Taylor CW (2010), “Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase.” J Biol Chem 285(17):12979-89 Details

    2009

    Rahman T, Taylor CW (2009), “Dynamic regulation of IP3 receptor clustering and activity by IP3.” Channels (Austin) 3(4):226-32 Details

    Rossi AM, Riley AM, Tovey SC, Rahman T, Dellis O, Taylor EJ, Veresov VG, Potter BV, Taylor CW (2009), “Synthetic partial agonists reveal key steps in IP3 receptor activation.” Nat Chem Biol 5(9):631-9 Details

    Taufiq-Ur-Rahman, Skupin A, Falcke M, Taylor CW (2009), “Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.” Nature 458(7238):655-9 Details

    Taylor CW, Prole DL, Rahman T (2009), “Ca(2+) channels on the move.” Biochemistry 48(51):12062-80 Details

    Taylor CW, Rahman T, Tovey SC, Dedos SG, Taylor EJ, Velamakanni S (2009), “IP3 receptors: some lessons from DT40 cells.” Immunol Rev 231(1):23-44 Details

    Taylor CW, Taufiq-Ur-Rahman, Pantazaka E (2009), “Targeting and clustering of IP3 receptors: key determinants of spatially organized Ca2+ signals.” Chaos 19(3):037102 Details

    2006

    Dellis O, Dedos SG, Tovey SC, Taufiq-Ur-Rahman, Dubel SJ, Taylor CW (2006), “Ca2+ entry through plasma membrane IP3 receptors.” Science 313(5784):229-33 Details