Dr Adrian Carpenter

Adrian Carpenter

University position

Reader

Dr Adrian Carpenter is pleased to consider applications from prospective PhD students.

Departments

Department of Clinical Neurosciences

Institutes

Wolfson Brain Imaging Centre

Email

tac12@wbic.cam.ac.uk

Home page

http://www.pet-mr.com

Research Theme

Clinical and Veterinary Neuroscience

Interests

Our group develops new techniques for the acquisition and analysis of PET and MR images to improve our understanding of the pathophysiology of disease. We also develop novel instrumentation, for example we are an internationally leading centre developing hybrid PET/MR scanners.

Research Focus

Keywords

MRI

DTI

PET/MR

fMRI

Clinical conditions

Huntington's disease

Hydrocephalus

Parkinson's disease

Stroke

Traumatic brain injury

Equipment

Magnetic resonance imaging (MRI)

Collaborators

Cambridge

Richard Ansorge

Jeff Daley

Jenny Morton

Guy Williams

International

Alberto del Guerra Web: http://virmap.unipi.it/cgi-bin...

Key publications

Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2013), “A fast protocol for infarct quantification in mice.” J Magn Reson Imaging Details

Sawiak SJ, Wood NI, Carpenter TA, Morton AJ (2012), “Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy.” PLoS One 7(12):e53361 Details

Sleigh A, Stears A, Thackray K, Watson L, Gambineri A, Nag S, Campi VI, Schoenmakers N, Brage S, Carpenter TA, Murgatroyd PR, O'Rahilly S, Kemp GJ, Savage DB (2012), “Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy.” J Clin Endocrinol Metab 97(3):E438-42 Details

Hawkes RC, Fryer TD, Siegel S, Ansorge RE, Carpenter TA (2010), “Preliminary evaluation of a combined microPET-MR system.” Technol Cancer Res Treat 9(1):53-60 Details

Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry.” Neurobiol Dis 33(1):20-7 Details

Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease.” Neurobiol Dis 33(1):12-9 Details

Publications

2014

Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Trajectory correction for free-breathing radial cine MRI.” Magn Reson Imaging 32(7):961-4 Details

Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Functional assessment of the mouse heart by MRI with a 1-min acquisition.” NMR Biomed 27(6):733-7 Details

Buonincontri G, Wood NI, Puttick SG, Ward AO, Carpenter TA, Sawiak SJ, Morton AJ (2014), “Right ventricular dysfunction in the R6/2 transgenic mouse model of Huntington's disease is unmasked by dobutamine.” J Huntingtons Dis 3(1):25-32 Details

Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2014), “Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior.” Biol Psychiatry 75(2):115-23 Details

2013

Alawneh JA, Moustafa RR, Marrapu ST, Jensen-Kondering U, Morris RS, Jones PS, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2013), “Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study.” Eur J Nucl Med Mol Imaging Details

Buonincontri G, Methner C, Carpenter TA, Hawkes RC, Sawiak SJ, Krieg T (2013), “MRI and PET in mouse models of myocardial infarction.” J Vis Exp (82):e50806 Details

Buonincontri G, Sawiak SJ, Methner C, Krieg T, Hawkes RC, Carpenter TA (2013), “PET/MRI in the infarcted mouse heart with the Cambridge split magnet.” Nucl Instrum Methods Phys Res A 702 Details

Carpenter KL, Jalloh I, Gallagher CN, Grice P, Howe DJ, Mason A, Timofeev I, Helmy A, Murphy MP, Menon DK, Kirkpatrick PJ, Carpenter TA, Sutherland GR, Pickard JD, Hutchinson PJ (2013), “13C-labelled microdialysis studies of cerebral metabolism in TBI patients.” Eur J Pharm Sci Details

Carrera E, Jones PS, Morris RS, Alawneh J, Hong YT, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2013), “Is neural activation within the rescued penumbra impeded by selective neuronal loss?” Brain 136(Pt 6):1816-29 Details

Phillips AC, Sleigh A, McAllister CJ, Brage S, Carpenter TA, Kemp GJ, Holland AJ (2013), “Defective mitochondrial function in vivo in skeletal muscle in adults with Down's syndrome: a 31P-MRS study.” PLoS One 8(12):e84031 Details

Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2013), “Voxel-based morphometry with templates and validation in a mouse model of Huntington's disease.” Magn Reson Imaging 31(9):1522-31 Details

2012

Adapa RM, Axell RG, Mangat JS, Carpenter TA, Absalom AR (2012), “Safety and performance of TCI pumps in a magnetic resonance imaging environment.” Anaesthesia 67(1):33-9 Details

Wood NI, Sawiak SJ, Buonincontri G, Niu Y, Kane AD, Carpenter TA, Giussani DA, Morton AJ (2012), “Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease.” J Huntingtons Dis 1(1) Details

2011

Carrera E, Jones PS, Alawneh JA, Klærke Mikkelsen I, Cho TH, Siemonsen S, Guadagno JV, Mouridsen K, Ribe L, Hjort N, Fryer TD, Carpenter TA, Aigbirhio FI, Fiehler J, Nighoghossian N, Warburton EA, Ostergaard L, Baron JC (2011), “Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?” Stroke 42(6):1602-7 Details

Kasahara M, Menon DK, Salmond CH, Outtrim JG, Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2011), “Traumatic brain injury alters the functional brain network mediating working memory.” Brain Inj 25(12):1170-87 Details

Malone IB, Ansorge RE, Williams GB, Nestor PJ, Carpenter TA, Fryer TD (2011), “Attenuation correction methods suitable for brain imaging with a PET/MRI scanner: a comparison of tissue atlas and template attenuation map approaches.” J Nucl Med 52(7):1142-9 Details

Newcombe V, Chatfield D, Outtrim J, Vowler S, Manktelow A, Cross J, Scoffings D, Coleman M, Hutchinson P, Coles J, Carpenter TA, Pickard J, Williams G, Menon D (2011), “Mapping traumatic axonal injury using diffusion tensor imaging: correlations with functional outcome.” PLoS One 6(5):e19214 Details

Sleigh A, Raymond-Barker P, Thackray K, Porter D, Hatunic M, Vottero A, Burren C, Mitchell C, McIntyre M, Brage S, Carpenter TA, Murgatroyd PR, Brindle KM, Kemp GJ, O'Rahilly S, Semple RK, Savage DB (2011), “Mitochondrial dysfunction in patients with primary congenital insulin resistance.” J Clin Invest 121(6):2457-61 Details

2010

Calautti C, Jones PS, Guincestre JY, Naccarato M, Sharma N, Day DJ, Carpenter TA, Warburton EA, Baron JC (2010), “The neural substrates of impaired finger tapping regularity after stroke.” Neuroimage 50(1):1-6 Details

Dickson JD, Ash TW, Williams GB, Harding SG, Carpenter TA, Menon DK, Ansorge RE (2010), “Quantitative BOLD: the effect of diffusion.” J Magn Reson Imaging 32(4):953-61 Details

Kasahara M, Menon DK, Salmond CH, Outtrim JG, Taylor Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2010), “Altered functional connectivity in the motor network after traumatic brain injury.” Neurology 75(2):168-76 Details

Newcombe VF, Williams GB, Scoffings D, Cross J, Carpenter TA, Pickard JD, Menon DK (2010), “Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications.” J Neurol Neurosurg Psychiatry 81(5):552-61 Details

2009

Donswijk ML, Jones PS, Guadagno JV, Carpenter TA, Moustafa RR, Fryer TD, Aigbirhio FI, Warburton EA, Baron JC (2009), “T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke.” Cerebrovasc Dis 28(3):306-13 Details

Salgin B, Sleigh AJ, Williams RM, Jackson SJ, Bluck LJ, Murgatroyd PR, Humphreys SM, Harding S, Carpenter TA, Dunger DB (2009), “Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects.” Clin Sci (Lond) 117(3):111-8 Details

Semple RK, Sleigh A, Murgatroyd PR, Adams CA, Bluck L, Jackson S, Vottero A, Kanabar D, Charlton-Menys V, Durrington P, Soos MA, Carpenter TA, Lomas DJ, Cochran EK, Gorden P, O'Rahilly S, Savage DB (2009), “Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.” J Clin Invest 119(2):315-22 Details

Sharma N, Simmons LH, Jones PS, Day DJ, Carpenter TA, Pomeroy VM, Warburton EA, Baron JC (2009), “Motor imagery after subcortical stroke: a functional magnetic resonance imaging study.” Stroke 40(4):1315-24 Details

2008

Correia MM, Carpenter TA, Williams GB (2008), “Looking for the optimal DTI acquisition scheme given a maximum scan time: are more b-values a waste of time?” Magn Reson Imaging Details

Hosey TP, Harding SG, Carpenter TA, Ansorge RE, Williams GB (2008), “Application of a probabilistic double-fibre structure model to diffusion-weighted MR images of the human brain.” Magn Reson Imaging 26(2):236-45 Details

Stevick JW, Harding SG, Paquet U, Ansorge RE, Carpenter TA, Williams GB (2008), “Gaussian process modeling for image distortion correction in echo planar imaging.” Magn Reson Med 59(3):598-606 Details

2006

Lucas AJ, Hawkes RC, Ansorge RE, Williams GB, Nutt RE, Clark JC, Fryer TD, Carpenter TA (2006), “Development of a combined microPET-MR system.” Technol Cancer Res Treat 5(4):337-41 Details