Dr Ben Sutcliffe

Interests

In the Drosophila olfactory system around 1300 olfactory receptor neurons transmit sensory information to the antennal lobe where neurons of the same class converge on distinct glomeruli. Projection neuron dendrites innervate these glomeruli in a glomerular specific manner and send their axonal projections to the higher brain centres of the mushroom body and the lateral horn. In the mushroom body the projection neurons converge on the Kenyon cells with roughly a 10:1 ratio. In the lateral horn the projections neurons converge on a yet unknown number of cells. The lateral horn is thought to be anatomically subdivided into distinct region, one for processing of pheromone information and another for processing of food odour information. My aim is to use the chemical labelling techniques recently developed in our lab to map the neurons of the lateral horn, classifying them based on neuroblast lineage and assigning neurotransmitter profiles.

Research Focus

Keywords

circuits

drosophila

olfaction

genetics

neuron

Clinical conditions

No direct clinical relevance

Equipment

Calcium imaging

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Microscopy

Protein purification

Collaborators

Cambridge

Matthias Landgraf

Darren Logan

United Kingdom

Iain Robinson Web: http://www.plymouth.ac.uk/staff/i...

Associated News Items


    Publications

    2013

    Diaper DC, Adachi Y, Sutcliffe B, Humphrey DM, Elliott CJ, Stepto A, Ludlow ZN, Vanden Broeck L, Callaerts P, Dermaut B, Al-Chalabi A, Shaw CE, Robinson IM, Hirth F (2013), “Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes.” Hum Mol Genet 22(8):1539-57 Details

    Sutcliffe B, Forero MG, Zhu B, Robinson IM, Hidalgo A (2013), “Neuron-Type Specific Functions of DNT1, DNT2 and Spz at the Drosophila Neuromuscular Junction.” PLoS One 8(10):e75902 Details

    2011

    Hidalgo A, Kato K, Sutcliffe B, McIlroy G, Bishop S, Alahmed S (2011), “Trophic neuron-glia interactions and cell number adjustments in the fruit fly.” Glia 59(9):1296-303 Details

    2008

    Zhu B, Pennack JA, McQuilton P, Forero MG, Mizuguchi K, Sutcliffe B, Gu CJ, Fenton JC, Hidalgo A (2008), “Drosophila neurotrophins reveal a common mechanism for nervous system formation.” PLoS Biol 6(11):e284 Details