Dr Simon Stott
I am interested in the development, maintenance and functioning of subsets of midbrain dopamine neurons, with a particular interest in Parkinson's disease.
My current lab work involves two lines of research:
The first is investigating the possible role the glycoprotein CD24 has in the selective cell death observed in Parkinson’s disease. The goal of this work is to identify novel therapeutic targets for Parkinson’s disease.
The second line of research is examining gene expression in dopamine neurons in the human midbrain as part of an EU-wide consortium (DDPDgenes). This work is determining if developmentally expressed genes have any function in Parkinson’s disease.
I also help out in the clinic, conducting cognitive assessments on people with Parkinson's disease.
Laser capture microdissection
Recombinant protein expression
Associated News Items
La Manno G, Gyllborg D, Codeluppi S, Nishimura K, Salto C, Zeisel A, Borm LE, Stott SRW, Toledo EM, Villaescusa JC, Lönnerberg P, Ryge J, Barker RA, Arenas E, Linnarsson S (in press), “Molecular Diversity of Midbrain Development in Mouse, Human and Stem Cells ” Cell
Miller SR, Perera SN, Benito C, Stott SR, Baker CV (2016), “Evidence for a Notch1-mediated transition during olfactory ensheathing cell development” Journal of Anatomy, 229(3):369-83
Neuroprotective effect of TREM-2 in ageing and Alzheimer’s disease model (in press), “Raha AA, Henderson JW, Stott SRW, Vuono R, Foscarin S, Friedland RP, Zaman SH, Raha-Chowdhury R” Journal of Alzheimer's Disease
Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lönnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L, Arenas E (in press), “A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease ” EMBO
Raha-Chowdhury R, Raha AA, Forostyak S, Zhao JW, Stott SR, Bomford A (2015), “Expression and cellular localization of hepcidin mRNA and protein in normal rat brain.” BMC Neurosci 16(1):24 Details
Roybon L, Mastracci TL, Li J, Stott SR, Leiter AB, Sussel L, Brundin P, Li JY (2015), “The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.” PLoS One 10(6):e0128035 Details
Schwab LC, Garas SN, Drouin-Ouellet J, Mason SL, Stott SR, Barker RA (2015), “Dopamine and Huntington's disease.” Expert Rev Neurother 15(4):445-58 Details
Stott SR (2015), “The wrong James Parkinson.” Pract Neurol Details
Stott SR, Barker RA (2014), “Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson's disease.” Eur J Neurosci 39(6):1042-56 Details
Ali F, Stott SR, Barker RA (2013), “Stem cells and the treatment of Parkinson's disease.” Exp Neurol Details
Stott SR, Metzakopian E, Lin W, Kaestner KH, Hen R, Ang SL (2013), “Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.” J Neurosci 33(18):8022-34 Details
Kornum BR, Stott SR, Mattsson B, Wisman L, Ettrup A, Hermening S, Knudsen GM, Kirik D (2010), “Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain.” Exp Neurol 222(1):70-85 Details
Hebsgaard JB, Nelander J, Sabelström H, Jönsson ME, Stott S, Parmar M (2009), “Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics.” Glia 57(15):1648-58 Details
Liuba K, Pronk CJ, Stott SR, Jacobsen SE (2009), “Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors.” Blood 113(19):4790-8 Details
Roybon L, Hjalt T, Stott S, Guillemot F, Li JY, Brundin P (2009), “Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis.” PLoS One 4(3):e4779 Details
Nygren JM, Liuba K, Breitbach M, Stott S, Thorén L, Roell W, Geisen C, Sasse P, Kirik D, Björklund A, Nerlov C, Fleischmann BK, Jovinge S, Jacobsen SE (2008), “Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.” Nat Cell Biol 10(5):584-92 Details
Barraud P, Stott S, Møllgård K, Parmar M, Björklund A (2007), “In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133.” J Neurosci Res 85(2):250-9 Details
Stott SR, Kirik D (2006), “Targeted in utero delivery of a retroviral vector for gene transfer in the rodent brain.” Eur J Neurosci 24(7):1897-906 Details
Krishnamurthi R, Stott S, Maingay M, Faull RL, McCarthy D, Gluckman P, Guan J (2004), “N-terminal tripeptide of IGF-1 improves functional deficits after 6-OHDA lesion in rats.” Neuroreport 15(10):1601-4 Details