Dr Sabine Rühle

Interests

By combining behavioural, genetic, electrophysiological and optical techniques, I aim to investigate how sensory inputs and motivational states are integrated to produce behavioural outputs.

Research Focus

Keywords

defensive behaviour

synaptic integration

motivation

hypothalamus

Clinical conditions

No direct clinical relevance

Equipment

Behavioural analysis

Calcium imaging

Confocal microscopy

Electrophysiological recording techniques

Fluorescence microscopy

Immunohistochemistry

Optogenetics

Viral vectors

Collaborators

No collaborators listed

Associated News Items


    Key publications

    Rosa JM*, Ruehle S*, Ding H, Lagnado L. *Co-first author (2016), “Crossover-inhibition generates sustained visual responses in the inner retina” Neuron 90(2):308-19

    Soria-Gómez E, Bellocchio L, Reguero L, Lepousez G, Martin C, Bendahmane M, Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B, Guzmán M, Gurden H, Ferreira G, Lledo PM, Grandes P, Marsicano G (2014), “The endocannabinoid system controls food intake via olfactory processes.” Nat Neurosci 17(3):407-15 Details

    Ruehle S, Remmers F, Romo-Parra H, Massa F, Wickert M, Wörtge S, Häring M, Kaiser N, Marsicano G, Pape HC, Lutz B (2013), “Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions.” J Neurosci 33(25):10264-77 Details

    Publications

    2016

    Gutiérrez-Rodríguez A, Puente N, Elezgarai I, Ruehle S, Lutz B, Reguero L, Gerrikagoitia I, Marsicano G, Grandes P (2016), “Anatomical characterization of the cannabinoid CB1 receptor in cell type-specific mutant mouse rescue models” J Comp Neurol Jun 23. doi: 10.1002/cne.24066

    2014

    Kohl J, Ng J, Cachero S, Ciabatti E, Dolan MJ, Sutcliffe B, Tozer A, Ruehle S, Krueger D, Frechter S, Branco T, Tripodi M, Jefferis GS. (2014), “Ultrafast tissue staining with chemical tags” Proc Natl Acad Sci U S A 111(36):E3805-14

    2013

    Steindel F, Lerner R, Häring M, Ruehle S, Marsicano G, Lutz B, Monory K (2013), “Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus.” J Neurochem 124(6):795-807 Details

    2012

    Ruehle S, Rey AA, Remmers F, Lutz B (2012), “The endocannabinoid system in anxiety, fear memory and habituation.” J Psychopharmacol 26(1):23-39 Details

    2011

    Mersmann N, Tkachev D, Jelinek R, Röth PT, Möbius W, Ruhwedel T, Rühle S, Weber-Fahr W, Sartorius A, Klugmann M (2011), “Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.” PLoS One 6(5):e20336 Details