Dr Sybil Stacpoole

University position

Clinical Fellow in Neurology

Departments

Department of Clinical Neurosciences

Institutes

Division of Anaesthesia

Email

srls2@cam.ac.uk

Home page

http://www.brc.cam.ac.uk

Research Themes

Clinical and Veterinary Neuroscience

Developmental Neuroscience

Interests

I am currently a neurology registrar, having completed a PhD working with neural precursor cells derived from human embryonic stem cells. I studied the pathways involved in directing neural precursor cells into oligodendrocytes, and investigated some of the biuological properties of human OPCs and oligodendrocytes in vitro. I have also developed an interest in the role of low, physiological oxygen levels in cell culture.

Research Focus

Keywords

human embryonic stem cells

oligodendrocytes

neural precursors

multiple sclerosis

hypoxia

Clinical conditions

Motor Neurone Disease

Multiple sclerosis

Parkinson's disease

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Microscopy

Collaborators

No collaborators listed

Associated News Items


    Publications

    2013

    Stacpoole SR, Spitzer S, Bilican B, Compston A, Karadottir R, Chandran S, Franklin RJ (2013), “High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology.” Stem Cell Reports 1(5):437-50 Details

    Stacpoole SR, Webber DJ, Bilican B, Compston A, Chandran S, Franklin RJ (2013), “Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation.” Stem Cells Transl Med 2(6):464-72 Details

    2011

    Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S (2011), “Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.” Nat Protoc 6(8):1229-40 Details

    Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S (2011), “Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation.” Cell Death Differ 18(6):1016-23 Details