Dr Samuel Chamberlain MD PhD
University position
Senior Visiting Clinical Research Fellow
Departments
Home page
http://www.srchamb.com (personal home page)
Research Themes
Interests
My research focuses on the neurochemical and neural substrates of cognition, and psychiatric endophenotypes.
Click image to view full-size
Research Focus
KeywordsOCD trichotillomania impulsivity compulsivity pharmacology |
Clinical conditionsAnxiety disorders Attention deficit hyperactivity disorder Bipolar disorder Cognitive impairment Compulsive skin-picking Obsessive compulsive disorder Post-traumatic stress disorder Stress Tourette's syndrome Trichotillomania (compulsive hair-pulling) |
Equipment
Behavioural analysis
Magnetic resonance imaging (MRI)
Neuropsychological testing
Collaborators
CambridgeNaomi Fineberg Adam Hampshire Sophie Winder-Rhodes | United KingdomAndrew Blackwell Web: http://www.camcog.com/ InternationalJon Grant Eric Hollander Brian Odlaug Stefano Pallanti Dan Stein |
Key publications
Chamberlain SR, Fineberg NA, Menzies LA, Blackwell AD, Bullmore ET, Robbins TW, Sahakian BJ (2007), “Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder” Am J Psychiatry 164(2):335-8 Details
Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania” Am J Psychiatry 163(7):1282-4 Details
Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006), “Neurochemical modulation of response inhibition and probabilistic learning in humans” Science 311(5762):861-3 Details
Publications
2009
Boulougouris V, Chamberlain SR, Robbins TW (2009), “Cross-species models of OCD spectrum disorders.” Psychiatry Res Details
Chamberlain SR, Hampshire A, Müller U, Rubia K, Del Campo N, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ (2009), “Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study.” Biol Psychiatry 65(7):550-5 Details
Chamberlain SR, Menzies L (2009), “Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential.” Expert Rev Neurother 9(8):1133-46 Details
Chamberlain SR, Odlaug BL, Boulougouris V, Fineberg NA, Grant JE (2009), “Trichotillomania: neurobiology and treatment.” Neurosci Biobehav Rev 33(6):831-42 Details
Clark L, Chamberlain SR, Sahakian BJ (2009), “Neurocognitive mechanisms in depression: implications for treatment.” Annu Rev Neurosci 32:57-74 Details
Pallanti S, Castellini G, Chamberlain SR, Quercioli L, Zaccara G, Fineberg NA (2009), “Cognitive event-related potentials differentiate schizophrenia with obsessive-compulsive disorder (schizo-OCD) from OCD and schizophrenia without OC symptoms.” Psychiatry Res Details
Winder-Rhodes S, Chamberlain S, Idris M, Robbins T, Sahakian B, Müller U (2009), “Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers.” J Psychopharmacol Details
2008
Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N, Aitken M, Craig K, Owen AM, Bullmore ET, Robbins TW, Sahakian BJ (2008), “Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.” Science 321(5887):421-2 Details
Chamberlain SR, Menzies LA, Fineberg NA, Del Campo N, Suckling J, Craig K, Müller U, Robbins TW, Bullmore ET, Sahakian BJ (2008), “Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study.” Br J Psychiatry 193(3):216-21 Details
Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET (2008), “Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited.” Neurosci Biobehav Rev 32(3):525-49 Details
Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, Sahakian BJ, Robbins TW, Bullmore ET (2008), “White Matter Abnormalities in Patients With Obsessive-Compulsive Disorder and Their First-Degree Relatives.” Am J Psychiatry Details
2007
Chamberlain SR, Del Campo N, Dowson J, Müller U, Clark L, Robbins TW, Sahakian BJ (2007), “Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder.” Biol Psychiatry 62(9):977-84 Details
Chamberlain SR, Fineberg NA, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2007), “A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania.” Neuropsychologia 45(4):654-62 Details
Chamberlain SR, Menzies L, Sahakian BJ, Fineberg NA (2007), “Lifting the veil on trichotillomania.” Am J Psychiatry 164(4):568-74 Details
Chamberlain SR, Müller U, Cleary S, Robbins TW, Sahakian BJ (2007), “Atomoxetine increases salivary cortisol in healthy volunteers.” J Psychopharmacol 21(5):545-9 Details
Chamberlain SR, Müller U, Deakin JB, Corlett PR, Dowson J, Cardinal RN, Aitken MR, Robbins TW, Sahakian BJ (2007), “Lack of deleterious effects of buspirone on cognition in healthy male volunteers.” J Psychopharmacol 21(2):210-5 Details
Chamberlain SR, Robbins TW, Sahakian BJ (2007), “The neurobiology of attention-deficit/hyperactivity disorder.” Biol Psychiatry 61(12):1317-9 Details
Chamberlain SR, Sahakian BJ (2007), “The neuropsychiatry of impulsivity.” Curr Opin Psychiatry 20(3):255-61 Details
Fineberg NA, Sharma P, Sivakumaran T, Sahakian B, Chamberlain SR (2007), “Does obsessive-compulsive personality disorder belong within the obsessive-compulsive spectrum?” CNS Spectr 12(6):467-82 Details
Menzies L, Achard S, Chamberlain SR, Fineberg N, Chen CH, del Campo N, Sahakian BJ, Robbins TW, Bullmore E (2007), “Neurocognitive endophenotypes of obsessive-compulsive disorder.” Brain 130(Pt 12):3223-36 Details
2006
Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2006), “Strategy implementation in obsessive-compulsive disorder and trichotillomania.” Psychol Med 36(1):91-7 Details
Chamberlain SR, Müller U, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Noradrenergic modulation of working memory and emotional memory in humans.” Psychopharmacology (Berl) 188(4):397-407 Details
Chamberlain SR, Müller U, Robbins TW, Sahakian BJ (2006), “Neuropharmacological modulation of cognition.” Curr Opin Neurol 19(6):607-12 Details
Chamberlain SR, Sahakian BJ (2006), “The neuropsychology of mood disorders.” Curr Psychiatry Rep 8(6):458-63 Details
Stein DJ, Chamberlain SR, Fineberg N (2006), “An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditions.” CNS Spectr 11(11):824-7 Details
2005
Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2005), “The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers.” Neurosci Biobehav Rev 29(3):399-419 Details
2004
Chamberlain SR, Sahakian BJ (2004), “Cognition in mania and depression: psychological models and clinical implications.” Curr Psychiatry Rep 6(6):451-8 Details