Dr Samuel Chamberlain MD PhD

Samuel Chamberlain

University position

Senior Visiting Clinical Research Fellow

Departments

Department of Psychiatry

Email

srchamb@gmail.com

Home page

http://www.srchamb.com (personal home page)

Research Themes

Cognitive and Behavioural Neuroscience

Clinical and Veterinary Neuroscience

Interests

My research focuses on the neurochemical and neural substrates of cognition, and psychiatric endophenotypes.

Brain activation during reversal of responses. Patients with OCD and their unaffected relatives showed under-active brain regions during reversal compared to people with no family history of the condition.
Brain activation during reversal of responses. Patients with OCD and their unaffected relatives showed under-active brain regions during reversal compared to people with no family history of the condition.
Click image to view full-size

Research Focus

Keywords

OCD

trichotillomania

impulsivity

compulsivity

pharmacology

Clinical conditions

Anxiety disorders

Attention deficit hyperactivity disorder

Bipolar disorder

Cognitive impairment

Compulsive skin-picking

Obsessive compulsive disorder

Post-traumatic stress disorder

Stress

Tourette's syndrome

Trichotillomania (compulsive hair-pulling)

Equipment

Behavioural analysis

Magnetic resonance imaging (MRI)

Neuropsychological testing

Collaborators

Cambridge

Ed Bullmore

Luke Clark

Kevin Craig

Naomi Fineberg

Adam Hampshire

Lara Menzies

Ulrich Muller

Adrian Owen

Trevor Robbins

Barbara Sahakian

Sophie Winder-Rhodes

United Kingdom

Andrew Blackwell Web: http://www.camcog.com/

International

Jon Grant

Eric Hollander

Brian Odlaug

Stefano Pallanti

Dan Stein

Key publications

Chamberlain SR, Fineberg NA, Menzies LA, Blackwell AD, Bullmore ET, Robbins TW, Sahakian BJ (2007), “Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder” Am J Psychiatry 164(2):335-8 Details

Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania” Am J Psychiatry 163(7):1282-4 Details

Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006), “Neurochemical modulation of response inhibition and probabilistic learning in humans” Science 311(5762):861-3 Details

Publications

2009

Boulougouris V, Chamberlain SR, Robbins TW (2009), “Cross-species models of OCD spectrum disorders.” Psychiatry Res Details

Chamberlain SR, Hampshire A, Müller U, Rubia K, Del Campo N, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ (2009), “Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study.” Biol Psychiatry 65(7):550-5 Details

Chamberlain SR, Menzies L (2009), “Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential.” Expert Rev Neurother 9(8):1133-46 Details

Chamberlain SR, Odlaug BL, Boulougouris V, Fineberg NA, Grant JE (2009), “Trichotillomania: neurobiology and treatment.” Neurosci Biobehav Rev 33(6):831-42 Details

Clark L, Chamberlain SR, Sahakian BJ (2009), “Neurocognitive mechanisms in depression: implications for treatment.” Annu Rev Neurosci 32:57-74 Details

Pallanti S, Castellini G, Chamberlain SR, Quercioli L, Zaccara G, Fineberg NA (2009), “Cognitive event-related potentials differentiate schizophrenia with obsessive-compulsive disorder (schizo-OCD) from OCD and schizophrenia without OC symptoms.” Psychiatry Res Details

Winder-Rhodes S, Chamberlain S, Idris M, Robbins T, Sahakian B, Müller U (2009), “Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers.” J Psychopharmacol Details

2008

Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N, Aitken M, Craig K, Owen AM, Bullmore ET, Robbins TW, Sahakian BJ (2008), “Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.” Science 321(5887):421-2 Details

Chamberlain SR, Menzies LA, Fineberg NA, Del Campo N, Suckling J, Craig K, Müller U, Robbins TW, Bullmore ET, Sahakian BJ (2008), “Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study.” Br J Psychiatry 193(3):216-21 Details

Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET (2008), “Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited.” Neurosci Biobehav Rev 32(3):525-49 Details

Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, Sahakian BJ, Robbins TW, Bullmore ET (2008), “White Matter Abnormalities in Patients With Obsessive-Compulsive Disorder and Their First-Degree Relatives.” Am J Psychiatry Details

2007

Chamberlain SR, Del Campo N, Dowson J, Müller U, Clark L, Robbins TW, Sahakian BJ (2007), “Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder.” Biol Psychiatry 62(9):977-84 Details

Chamberlain SR, Fineberg NA, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2007), “A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania.” Neuropsychologia 45(4):654-62 Details

Chamberlain SR, Menzies L, Sahakian BJ, Fineberg NA (2007), “Lifting the veil on trichotillomania.” Am J Psychiatry 164(4):568-74 Details

Chamberlain SR, Müller U, Cleary S, Robbins TW, Sahakian BJ (2007), “Atomoxetine increases salivary cortisol in healthy volunteers.” J Psychopharmacol 21(5):545-9 Details

Chamberlain SR, Müller U, Deakin JB, Corlett PR, Dowson J, Cardinal RN, Aitken MR, Robbins TW, Sahakian BJ (2007), “Lack of deleterious effects of buspirone on cognition in healthy male volunteers.” J Psychopharmacol 21(2):210-5 Details

Chamberlain SR, Robbins TW, Sahakian BJ (2007), “The neurobiology of attention-deficit/hyperactivity disorder.” Biol Psychiatry 61(12):1317-9 Details

Chamberlain SR, Sahakian BJ (2007), “The neuropsychiatry of impulsivity.” Curr Opin Psychiatry 20(3):255-61 Details

Fineberg NA, Sharma P, Sivakumaran T, Sahakian B, Chamberlain SR (2007), “Does obsessive-compulsive personality disorder belong within the obsessive-compulsive spectrum?” CNS Spectr 12(6):467-82 Details

Menzies L, Achard S, Chamberlain SR, Fineberg N, Chen CH, del Campo N, Sahakian BJ, Robbins TW, Bullmore E (2007), “Neurocognitive endophenotypes of obsessive-compulsive disorder.” Brain 130(Pt 12):3223-36 Details

2006

Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2006), “Strategy implementation in obsessive-compulsive disorder and trichotillomania.” Psychol Med 36(1):91-7 Details

Chamberlain SR, Müller U, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Noradrenergic modulation of working memory and emotional memory in humans.” Psychopharmacology (Berl) 188(4):397-407 Details

Chamberlain SR, Müller U, Robbins TW, Sahakian BJ (2006), “Neuropharmacological modulation of cognition.” Curr Opin Neurol 19(6):607-12 Details

Chamberlain SR, Sahakian BJ (2006), “The neuropsychology of mood disorders.” Curr Psychiatry Rep 8(6):458-63 Details

Stein DJ, Chamberlain SR, Fineberg N (2006), “An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditions.” CNS Spectr 11(11):824-7 Details

2005

Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2005), “The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers.” Neurosci Biobehav Rev 29(3):399-419 Details

2004

Chamberlain SR, Sahakian BJ (2004), “Cognition in mania and depression: psychological models and clinical implications.” Curr Psychiatry Rep 6(6):451-8 Details