Dr Samuel Chamberlain MB/BChir PhD MRCPsych University positionWellcome Trust Fellow, Honorary Consultant Psychiatrist DepartmentsHome pagehttp://www.srchamb.com (personal home page) Research ThemesInterestsNeurobiology and treatment of impulsive, compulsive, and behaviourally-addictive disorders. I use a variety of techniques, including cognitive assessment, brain imaging, and pharmacological challenges, to explore the brain underpinnings of these conditions and the mechanisms through which treatments affect cognition, and improve symptoms.  Brain activation during reversal of responses. Patients with OCD and their unaffected relatives showed under-active brain regions during reversal compared to people with no family history of the condition. Click image to view full-size Research Focus
EquipmentBehavioural analysis Magnetic resonance imaging (MRI) Neuropsychological testing Collaborators
Associated News ItemsKey publications* NOTE: THIS PUBLICATION LIST IS NOT UPDATED. PLEASE SEE MY PERSONAL HOME SITE FOR LATEST LIST. THANK YOU. (2016), “--” -- Grant JE, Odlaug B, Chamberlain SR (in press), “Why can't I stop? Reclaiming Your Life from a Behavioral Addiction” Book Grant JE, Chamberlain SR, Odlaug B (2014), “Clinical Guide to Obsessive Compulsive and Related Disorders” Book (Oxford University Press) Chamberlain SR, Fineberg NA, Menzies LA, Blackwell AD, Bullmore ET, Robbins TW, Sahakian BJ (2007), “Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder” Am J Psychiatry 164(2):335-8 Details Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania” Am J Psychiatry 163(7):1282-4 Details Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2006), “Neurochemical modulation of response inhibition and probabilistic learning in humans” Science 311(5762):861-3 Details Publications2015Chamberlain SR, Derbyshire KL, Leppink E, Grant JE (2015), “Obesity and dissociable forms of impulsivity in young adults.” CNS Spectr :1-8 Details Chamberlain SR, Fineberg NA (2015), “Fractionating impulsivity: Commentary on "choice impulsivity" and "rapid-response impulsivity" articles by Hamilton and colleagues.” Personal Disord 6(2):201-3 Details Grant JE, Chamberlain SR (2015), “Gambling disorder and its relationship with substance use disorders: Implications for nosological revisions and treatment.” Am J Addict 24(2):126-31 Details Grant JE, Leppink EW, Redden SA, Odlaug BL, Chamberlain SR (2015), “COMT genotype, gambling activity, and cognition.” J Psychiatr Res 68:371-376 Details Grant JE, Odlaug BL, Chamberlain SR (2015), “Reduced cortical thickness in gambling disorder: a morphometric MRI study.” Eur Arch Psychiatry Clin Neurosci Details Odlaug BL, Hampshire A, Chamberlain SR, Grant JE (2015), “Abnormal brain activation in excoriation (skin-picking) disorder: evidence from an executive planning fMRI study.” Br J Psychiatry Details Odlaug BL, Lust K, Wimmelmann CL, Chamberlain SR, Mortensen EL, Derbyshire K, Christenson G, Grant JE (2015), “Prevalence and correlates of being overweight or obese in college.” Psychiatry Res Details 2014Chamberlain SR, Derbyshire K, Leppink E, Grant JE (2014), “Impact of ADHD symptoms on clinical and cognitive aspects of problem gambling.” Compr Psychiatry Details Derbyshire KL, Chamberlain SR, Odlaug BL, Schreiber LR, Grant JE (2014), “Neurocognitive functioning in compulsive buying disorder.” Ann Clin Psychiatry 26(1):57-63 Details Fineberg NA, Chamberlain SR, Goudriaan AE, Stein DJ, Vanderschuren LJ, Gillan CM, Shekar S, Gorwood PA, Voon V, Morein-Zamir S, Denys D, Sahakian BJ, Moeller FG, Robbins TW, Potenza MN (2014), “New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity.” CNS Spectr 19(1):69-89 Details Grant JE, Chamberlain SR (2014), “Impulsive action and impulsive choice across substance and behavioral addictions: Cause or consequence?” Addict Behav Details Grant JE, Derbyshire K, Leppink E, Chamberlain SR (2014), “One-year follow-up of subsyndromal gambling disorder in non-treatment-seeking young adults.” Ann Clin Psychiatry 26(3):199-205 Details Grant JE, Derbyshire K, Leppink E, Chamberlain SR (2014), “Suicidality in Non-Treatment Seeking Young Adults with Subsyndromal Gambling Disorder.” Psychiatr Q Details Grant JE, Derbyshire K, Leppink E, Chamberlain SR (2014), “Obesity and gambling: neurocognitive and clinical associations.” Acta Psychiatr Scand Details Ioannidis K, Chamberlain SR, Müller U (2014), “Ostracising caffeine from the pharmacological arsenal for attention-deficit hyperactivity disorder - was this a correct decision? A literature review.” J Psychopharmacol Details Leppink E, Derbyshire K, Chamberlain SR, Grant JE (2014), “A preliminary comparison of cannabis use in subsyndromal gamblers: select neurocognitive and behavioral differences based on use.” J Addict Med 8(6):443-9 Details Morein-Zamir S, Papmeyer M, Pertusa A, Chamberlain SR, Fineberg NA, Sahakian BJ, Mataix-Cols D, Robbins TW (2014), “The profile of executive function in OCD hoarders and hoarding disorder.” Psychiatry Res 215(3):659-67 Details Odlaug BL, Chamberlain SR, Derbyshire KL, Leppink EW, Grant JE (2014), “Impaired response inhibition and excess cortical thickness as candidate endophenotypes for trichotillomania.” J Psychiatr Res Details Ziauddeen H, Chamberlain SR, Nathan PJ, Koch A, Maltby K, Bush M, Tao WX, Napolitano A, Skeggs AL, Brooke AC, Cheke L, Clayton NS, Sadaf Farooqi I, O'Rahilly S, Waterworth D, Song K, Hosking L, Richards DB, Fletcher PC, Bullmore ET (2014), “Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.” Mol Psychiatry 19(12):1341 2013Camilla d'Angelo LS, Eagle DM, Grant JE, Fineberg NA, Robbins TW, Chamberlain SR (2013), “Animal models of obsessive-compulsive spectrum disorders.” CNS Spectr :1-22 Details Chamberlain SR (2013), “Modafinil, inhibitory control, and alcoholism.” Biol Psychiatry 73(3):207-8 Details Chamberlain SR, Odlaug BL, Schreiber LR, Grant JE (2013), “Clinical and neurocognitive markers of suicidality in young adults.” J Psychiatr Res 47(5):586-91 Details Chamberlain SR, Robbins TW (2013), “Noradrenergic modulation of cognition: Therapeutic implications.” J Psychopharmacol Details del Campo N, Fryer TD, Hong YT, Smith R, Brichard L, Acosta-Cabronero J, Chamberlain SR, Tait R, Izquierdo D, Regenthal R, Dowson J, Suckling J, Baron JC, Aigbirhio FI, Robbins TW, Sahakian BJ, Müller U (2013), “A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.” Brain 136(Pt 11):3252-70 Details Grant JE, Chamberlain SR (2013), “Gambling disorder and its relationship with substance use disorders: Implications for nosological revisions and treatment.” Am J Addict Details Grant JE, Odlaug BL, Chamberlain SR, Hampshire A, Schreiber LR, Kim SW (2013), “A proof of concept study of tolcapone for pathological gambling: Relationships with COMT genotype and brain activation.” Eur Neuropsychopharmacol Details Grant JE, Odlaug BL, Chamberlain SR, Potenza MN, Schreiber LR, Donahue CB, Kim SW (2013), “A randomized, placebo-controlled trial of N-acetylcysteine plus imaginal desensitization for nicotine-dependent pathological gamblers.” J Clin Psychiatry Details Grant JE, Odlaug BL, Schreiber LR, Chamberlain SR, Won Kim S (2013), “Memantine reduces stealing behavior and impulsivity in kleptomania: a pilot study.” Int Clin Psychopharmacol 28(2):106-11 Details Odlaug BL, Chamberlain SR, Schreiber LR, Grant JE (2013), “Where on the Impulsive-Obsessive Compulsive Spectrum Does Hair Pulling Disorder Belong?” Int J Psychiatry Clin Pract Details Rothbart R, Amos T, Siegfried N, Ipser JC, Fineberg N, Chamberlain SR, Stein DJ (2013), “Pharmacotherapy for trichotillomania.” Cochrane Database Syst Rev 11:CD007662 Details 2012Cambridge VC, Ziauddeen H, Nathan PJ, Subramaniam N, Dodds C, Chamberlain SR, Koch A, Maltby K, Skeggs AL, Napolitano A, Sadaf Farooqi I, Bullmore ET, Fletcher PC (2012), “Neural and Behavioral Effects of a Novel Mu Opioid Receptor Antagonist in Binge-Eating Obese People.” Biol Psychiatry Details Chamberlain SR, Mogg K, Bradley BP, Koch A, Dodds CM, Tao WX, Maltby K, Sarai B, Napolitano A, Richards DB, Bullmore ET, Nathan PJ (2012), “Effects of mu opioid receptor antagonism on cognition in obese binge-eating individuals.” Psychopharmacology (Berl) Details Chamberlain SR, Odlaug BL, Schreiber LR, Grant JE (2012), “Association between tobacco smoking and cognitive functioning in young adults.” Am J Addict 21 Suppl 1:S14-9 Details Ersche KD, Turton AJ, Chamberlain SR, Müller U, Bullmore ET, Robbins TW (2012), “Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependence.” Am J Psychiatry 169(9):926-36 Details Grant JE, Chamberlain SR, Schreiber L, Odlaug BL (2012), “Neuropsychological deficits associated with cannabis use in young adults.” Drug Alcohol Depend 121(1-2):159-62 Details Grant JE, Chamberlain SR, Schreiber LR, Odlaug BL (2012), “Gender-related clinical and neurocognitive differences in individuals seeking treatment for pathological gambling.” J Psychiatr Res 46(9):1206-11 Details Grant JE, Chamberlain SR, Schreiber LR, Odlaug BL (2012), “Neurocognitive deficits associated with shoplifting in young adults.” Compr Psychiatry Details Grant JE, Odlaug BL, Chamberlain SR, Keuthen NJ, Lochner C, Stein DJ (2012), “Skin picking disorder.” Am J Psychiatry 169(11):1143-9 Details Grant JE, Odlaug BL, Chamberlain SR, Schreiber LR (2012), “Neurocognitive dysfunction in strategic and non-strategic gamblers.” Prog Neuropsychopharmacol Biol Psychiatry 38(2):336-40 Details Grant JE, Odlaug BL, Hampshire A, Schreiber LR, Chamberlain SR (2012), “White Matter Abnormalities in Skin Picking Disorder: A Diffusion Tensor Imaging Study.” Neuropsychopharmacology Details Lochner C, Fouché JP, du Plessis S, Spottiswoode B, Seedat S, Fineberg N, Chamberlain SR, Stein DJ (2012), “Evidence for fractional anisotropy and mean diffusivity white matter abnormalities in the internal capsule and cingulum in patients with obsessive-compulsive disorder.” J Psychiatry Neurosci 37(3):193-9 Details Lochner C, Simmons C, Kidd M, Chamberlain SR, Fineberg NA, van Honk J, Ipser J, Stein DJ (2012), “Differential effects of escitalopram challenge on disgust processing in obsessive-compulsive disorder.” Behav Brain Res 226(1):274-80 Details Odlaug BL, Chamberlain SR, Harvanko AM, Grant JE (2012), “Age at onset in trichotillomania:clinical variables and neurocognitive performance.” Prim Care Companion CNS Disord 14(4) Details Ziauddeen H, Chamberlain SR, Nathan PJ, Koch A, Maltby K, Bush M, Tao WX, Napolitano A, Skeggs AL, Brooke AC, Cheke L, Clayton NS, Sadaf Farooqi I, O'Rahilly S, Waterworth D, Song K, Hosking L, Richards DB, Fletcher PC, Bullmore ET (2012), “Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.” Mol Psychiatry Details 2011Blanchard MM, Chamberlain SR, Roiser J, Robbins TW, Müller U (2011), “Effects of two dopamine-modulating genes (DAT1 9/10 and COMT Val/Met) on n-back working memory performance in healthy volunteers.” Psychol Med 41(3):611-8 Details Chamberlain SR, Blackwell AD, Nathan PJ, Hammond G, Robbins TW, Hodges JR, Michael A, Semple JM, Bullmore ET, Sahakian BJ (2011), “Differential Cognitive Deterioration in Dementia: A Two Year Longitudinal Study.” J Alzheimers Dis Details Del Campo N, Chamberlain SR, Sahakian BJ, Robbins TW (2011), “The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder.” Biol Psychiatry 69(12):e145-57 Details Fineberg N, Chamberlain S, Hollander E, Boulougouris V, Robbins T (2011), “TRANSLATIONAL APPROACHES TO OBSESSIVE-COMPULSIVE DISORDER: FROM ANIMAL MODELS TO CLINICAL TREATMENT.” Br J Pharmacol Details Grant JE, Chamberlain SR, Schreiber LR, Odlaug BL, Kim SW (2011), “Selective decision-making deficits in at-risk gamblers.” Psychiatry Res 189(1):115-20 Details Grant JE, Odlaug BL, Chamberlain SR (2011), “Neurocognitive response to deep brain stimulation for obsessive-compulsive disorder: a case report.” Am J Psychiatry 168(12):1338-9 Details Grant JE, Odlaug BL, Chamberlain SR (2011), “A cognitive comparison of pathological skin picking and trichotillomania.” J Psychiatr Res 45(12):1634-8 Details Grant JE, Odlaug BL, Chamberlain SR, Kim SW (2011), “Dronabinol, a cannabinoid agonist, reduces hair pulling in trichotillomania: a pilot study.” Psychopharmacology (Berl) Details Odlaug BL, Chamberlain SR, Kim SW, Schreiber LR, Grant JE (2011), “A neurocognitive comparison of cognitive flexibility and response inhibition in gamblers with varying degrees of clinical severity.” Psychol Med :1-9 Details 2010Chamberlain SR, Grant JE, Costa A, Müller U, Sahakian BJ (2010), “Effects of acute modafinil on cognition in trichotillomania.” Psychopharmacology (Berl) 212(4):597-601 Details Chamberlain SR, Hampshire A, Menzies LA, Garyfallidis E, Grant JE, Odlaug BL, Craig K, Fineberg N, Sahakian BJ (2010), “Reduced brain white matter integrity in trichotillomania: a diffusion tensor imaging study.” Arch Gen Psychiatry 67(9):965-71 Details Chamberlain SR, Robbins TW, Winder-Rhodes S, Müller U, Sahakian BJ, Blackwell AD, Barnett JH (2010), “Translational Approaches to Frontostriatal Dysfunction in Attention-Deficit/Hyperactivity Disorder Using a Computerized Neuropsychological Battery.” Biol Psychiatry Details Dittrich WH, Johansen T, Padhi AK, Smith IE, Chamberlain SR, Fineberg NA (2010), “Clinical and neurocognitive changes with modafinil in obsessive-compulsive disorder: a case report.” Psychopharmacology (Berl) 212(3):449-51 Details Fineberg NA, Potenza MN, Chamberlain SR, Berlin HA, Menzies L, Bechara A, Sahakian BJ, Robbins TW, Bullmore ET, Hollander E (2010), “Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative review.” Neuropsychopharmacology 35(3):591-604 Details Grant JE, Chamberlain SR, Odlaug BL, Potenza MN, Kim SW (2010), “Memantine shows promise in reducing gambling severity and cognitive inflexibility in pathological gambling: a pilot study.” Psychopharmacology (Berl) Details Grant JE, Odlaug BL, Chamberlain SR, Kim SW (2010), “A Double-Blind, Placebo-Controlled Trial of Lamotrigine for Pathological Skin Picking: Treatment Efficacy and Neurocognitive Predictors of Response.” J Clin Psychopharmacol Details Hampshire A, Chamberlain SR, Monti MM, Duncan J, Owen AM (2010), “The role of the right inferior frontal gyrus: inhibition and attentional control.” Neuroimage 50(3):1313-9 Details Odlaug BL, Chamberlain SR, Grant JE (2010), “Motor inhibition and cognitive flexibility in pathologic skin picking.” Prog Neuropsychopharmacol Biol Psychiatry 34(1):208-11 Details 2009Boulougouris V, Chamberlain SR, Robbins TW (2009), “Cross-species models of OCD spectrum disorders.” Psychiatry Res Details Chamberlain SR, Hampshire A, Müller U, Rubia K, Del Campo N, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ (2009), “Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study.” Biol Psychiatry 65(7):550-5 Details Chamberlain SR, Menzies L (2009), “Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potential.” Expert Rev Neurother 9(8):1133-46 Details Chamberlain SR, Odlaug BL, Boulougouris V, Fineberg NA, Grant JE (2009), “Trichotillomania: neurobiology and treatment.” Neurosci Biobehav Rev 33(6):831-42 Details Clark L, Chamberlain SR, Sahakian BJ (2009), “Neurocognitive mechanisms in depression: implications for treatment.” Annu Rev Neurosci 32:57-74 Details Pallanti S, Castellini G, Chamberlain SR, Quercioli L, Zaccara G, Fineberg NA (2009), “Cognitive event-related potentials differentiate schizophrenia with obsessive-compulsive disorder (schizo-OCD) from OCD and schizophrenia without OC symptoms.” Psychiatry Res Details Winder-Rhodes S, Chamberlain S, Idris M, Robbins T, Sahakian B, Müller U (2009), “Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers.” J Psychopharmacol Details 2008Chamberlain SR, Menzies L, Hampshire A, Suckling J, Fineberg NA, del Campo N, Aitken M, Craig K, Owen AM, Bullmore ET, Robbins TW, Sahakian BJ (2008), “Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives.” Science 321(5887):421-2 Details Chamberlain SR, Menzies LA, Fineberg NA, Del Campo N, Suckling J, Craig K, Müller U, Robbins TW, Bullmore ET, Sahakian BJ (2008), “Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study.” Br J Psychiatry 193(3):216-21 Details Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET (2008), “Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited.” Neurosci Biobehav Rev 32(3):525-49 Details Menzies L, Williams GB, Chamberlain SR, Ooi C, Fineberg N, Suckling J, Sahakian BJ, Robbins TW, Bullmore ET (2008), “White Matter Abnormalities in Patients With Obsessive-Compulsive Disorder and Their First-Degree Relatives.” Am J Psychiatry Details 2007Chamberlain SR, Del Campo N, Dowson J, Müller U, Clark L, Robbins TW, Sahakian BJ (2007), “Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder.” Biol Psychiatry 62(9):977-84 Details Chamberlain SR, Fineberg NA, Blackwell AD, Clark L, Robbins TW, Sahakian BJ (2007), “A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania.” Neuropsychologia 45(4):654-62 Details Chamberlain SR, Menzies L, Sahakian BJ, Fineberg NA (2007), “Lifting the veil on trichotillomania.” Am J Psychiatry 164(4):568-74 Details Chamberlain SR, Müller U, Cleary S, Robbins TW, Sahakian BJ (2007), “Atomoxetine increases salivary cortisol in healthy volunteers.” J Psychopharmacol 21(5):545-9 Details Chamberlain SR, Müller U, Deakin JB, Corlett PR, Dowson J, Cardinal RN, Aitken MR, Robbins TW, Sahakian BJ (2007), “Lack of deleterious effects of buspirone on cognition in healthy male volunteers.” J Psychopharmacol 21(2):210-5 Details Chamberlain SR, Robbins TW, Sahakian BJ (2007), “The neurobiology of attention-deficit/hyperactivity disorder.” Biol Psychiatry 61(12):1317-9 Details Chamberlain SR, Sahakian BJ (2007), “The neuropsychiatry of impulsivity.” Curr Opin Psychiatry 20(3):255-61 Details Fineberg NA, Sharma P, Sivakumaran T, Sahakian B, Chamberlain SR (2007), “Does obsessive-compulsive personality disorder belong within the obsessive-compulsive spectrum?” CNS Spectr 12(6):467-82 Details Menzies L, Achard S, Chamberlain SR, Fineberg N, Chen CH, del Campo N, Sahakian BJ, Robbins TW, Bullmore E (2007), “Neurocognitive endophenotypes of obsessive-compulsive disorder.” Brain 130(Pt 12):3223-36 Details 2006Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2006), “Strategy implementation in obsessive-compulsive disorder and trichotillomania.” Psychol Med 36(1):91-7 Details Chamberlain SR, Müller U, Blackwell AD, Robbins TW, Sahakian BJ (2006), “Noradrenergic modulation of working memory and emotional memory in humans.” Psychopharmacology (Berl) 188(4):397-407 Details Chamberlain SR, Müller U, Robbins TW, Sahakian BJ (2006), “Neuropharmacological modulation of cognition.” Curr Opin Neurol 19(6):607-12 Details Chamberlain SR, Sahakian BJ (2006), “The neuropsychology of mood disorders.” Curr Psychiatry Rep 8(6):458-63 Details Stein DJ, Chamberlain SR, Fineberg N (2006), “An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditions.” CNS Spectr 11(11):824-7 Details 2005Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ (2005), “The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers.” Neurosci Biobehav Rev 29(3):399-419 Details 2004Chamberlain SR, Sahakian BJ (2004), “Cognition in mania and depression: psychological models and clinical implications.” Curr Psychiatry Rep 6(6):451-8 Details |