Dr Richard Eva
Investigating Integrin trafficking in neurons.
Integrins are adhesion receptors expressed throughout the body. I am invovled with projects aimed at increasing axon regeneration after injury via the viral introduction of integrins. My job is to try to make integrins available at the growth cones of regenerating axons. In order to achieve this I am first trying to understand how integrins are trafficked into axons and at the growth cone.
spinal cord injury, axon regeneration
neuronal cell biology, biochemistry, live cell imaging
Venkateswarlu Kanamarlapudi Web: http://www.swan.ac.uk/
Jim Norman Web: http://www.beatson.gla.ac.uk/Regulat...
Eva R, Bouyoucef-Cherchalli D, Patel K, Cullen PJ, Banting G (2012), “IP3 3-kinase opposes NGF driven neurite outgrowth.” PLoS One 7(2):e32386 Details
Eva R, Crisp S, Marland JR, Norman JC, Kanamarlapudi V, Ffrench-Constant C, Fawcett JW (2012), “ARF6 Directs Axon Transport and Traffic of Integrins and Regulates Axon Growth in Adult DRG Neurons.” J Neurosci 32(30):10352-10364 Details
Eva R, Dassie E, Caswell PT, Dick G, ffrench-Constant C, Norman JC, Fawcett JW (2010), “Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.” J Neurosci 30(35):11654-69 Details