Dr Richard Eva

University position

Research Associate

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Research Theme

Cellular and Molecular Neuroscience

The Cambridge Neuroscience Community

Interests

Investigating Integrin trafficking in neurons.

Integrins are adhesion receptors expressed throughout the body. I am invovled with projects aimed at increasing axon regeneration after injury via the viral introduction of integrins. My job is to try to make integrins available at the growth cones of regenerating axons. In order to achieve this I am first trying to understand how integrins are trafficked into axons and at the growth cone.

Growth Cone of an adult DRG axon expressing Rab Coupling protein GFP and labelled for beta1 integrin
Click image to view full-size

Research Focus

Keywords

Neuron

Axon growth

Traffic

Integrin

cell biology

Clinical conditions

spinal cord injury, axon regeneration

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Microscopy

neuronal cell biology, biochemistry, live cell imaging

Collaborators

United Kingdom

Venkateswarlu Kanamarlapudi Web: http://www.swan.ac.uk/

Jim Norman Web: http://www.beatson.gla.ac.uk/Regulat...

Publications

2012

Eva R, Bouyoucef-Cherchalli D, Patel K, Cullen PJ, Banting G (2012), “IP3 3-kinase opposes NGF driven neurite outgrowth.” PLoS One 7(2):e32386 Details

Eva R, Crisp S, Marland JR, Norman JC, Kanamarlapudi V, Ffrench-Constant C, Fawcett JW (2012), “ARF6 Directs Axon Transport and Traffic of Integrins and Regulates Axon Growth in Adult DRG Neurons.” J Neurosci 32(30):10352-10364 Details

2010

Eva R, Dassie E, Caswell PT, Dick G, ffrench-Constant C, Norman JC, Fawcett JW (2010), “Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.” J Neurosci 30(35):11654-69 Details

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