Dr Shigekazu Oda

Interests

My long-term goal is to discover a general principle of information process in a neural circuit. The main subject is that 'how biological system behave as a system?' To answer this question, I am using a simple model organism, C. elegans by using highly quantitative methods, information coding analysis and genetic tools. I am analysing a neural circuit both locally and globally.

I have been studying the molecular and neural dynamics in C. elegans by using and developing in vivo imaging techniques. And I discovered neuronal dynamics in learning & memory, information coding of MAPK-ERK and signal transduction of cGMP.

Now I am working on molecular mechanism underlying aggregation behaviour of C. elegans. And I am also working on modulation of frequency coding properties by neuroglobin in a neural circuit.

Research Focus

Keywords

neural encoding

quantitative biology

signal transduction

systems neuroscience

C. elegans

Clinical conditions

No direct clinical relevance

Equipment

Behavioural analysis

Calcium imaging

Computational modelling

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

in vivo imaging (Calcium, ERK-MAPK, release of synaptic vesicles and cGMP), MATLAB, IgorPro, microfluidic device

Microscopy

Collaborators

Cambridge

Changchun Chen

Mario de Bono

International

Einav Gross

Sayaka Hori

Shohei Mitani

Yu Toyoshima

Associated News Items


    Key publications

    Couto A, Oda S, Nikolaev VO, Soltesz Z, de Bono M (2013), “In vivo genetic dissection of O2-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor.” Proc Natl Acad Sci U S A Details

    Tomida* T, Oda* S, Takekawa M, Iino Y, Saito H (*Co-first authors) (2012), “The temporal pattern of stimulation determines the extent and duration of MAPK activation in a Caenorhabditis elegans sensory neuron.” Sci Signal 5(246):ra76

    Oda S, Tomioka M, Iino Y (2011), “Neuronal plasticity regulated by the insulin-like signaling pathway underlies salt chemotaxis learning in Caenorhabditis elegans.” J Neurophysiol 106(1):301-8 Details

    Publications

    2014

    Gross E, Soltesz Z, Oda S, Zelmanovich V, Abergel Z, de Bono M (2014), “GLOBIN-5-Dependent O2 Responses Are Regulated by PDL-1/PrBP That Targets Prenylated Soluble Guanylate Cyclases to Dendritic Endings.” J Neurosci 34(50):16726-38 Details

    2012

    Yoshida K, Hirotsu T, Tagawa T, Oda S, Wakabayashi T, Iino Y, Ishihara T (2012), “Odour concentration-dependent olfactory preference change in C. elegans.” Nat Commun 3:739 Details

    2011

    Iwata R, Oda S, Kunitomo H, Iino Y (2011), “Roles for class IIA phosphatidylinositol transfer protein in neurotransmission and behavioral plasticity at the sensory neuron synapses of Caenorhabditis elegans.” Proc Natl Acad Sci U S A 108(18):7589-94 Details