Sarah Isherwood

Sarah Isherwood

University position

PhD student
Supervised by Dr. Jeff Dalley

Departments

Department of Psychology

Research Theme

Cognitive and Behavioural Neuroscience

Interests

My research focuses on the neural and neuropsychopharmacological basis of impulsivity in rodent models. Specifically, I am interested in the role of glutamate in the expression of impulsive behaviour and how modulation of glutamatergic signalling, via metabotropic glutamate receptors (mGluR), may mediate this behaviour at the cortical or sub-cortical level. I am also interested in investigating the differential modulation of impulsive behaviour in high and low impulsive phenotypes.

Using behavioural assays, phenotypic screening and systemic and local drug administration I am exploring, mechanistically, whether targeting mGluRs may offer potential therapeutic utility in modulating impulsive behaviour in humans.

Research Focus

Keywords

Impulsivity

Glutmate

Metabotropic Glutamate Receptors

Cortico-striatal systems

Addiction

Clinical conditions

Addiction

Attention deficit hyperactivity disorder

Bipolar disorder

Cognitive impairment

Obsessive compulsive disorder

Schizophrenia

Equipment

Behavioural analysis

Collaborators

No collaborators listed

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