My research focuses on the neural and neuropsychopharmacological basis of impulsivity in rodent models. Specifically, I am interested in the role of glutamate in the expression of impulsive behaviour and how modulation of glutamatergic signalling, via metabotropic glutamate receptors (mGluR), may mediate this behaviour at the cortical or sub-cortical level. I am also interested in investigating the differential modulation of impulsive behaviour in high and low impulsive phenotypes.
Using behavioural assays, phenotypic screening and systemic and local drug administration I am exploring, mechanistically, whether targeting mGluRs may offer potential therapeutic utility in modulating impulsive behaviour in humans.
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