Dr Stephen Sawiak

Interests

I am a physicist working with MRI.

My primary research interest has been in morphometry, with structural imaging, diffusion tensor imaging and spectroscopy. I am particularly focussed on preclinical applications.

Map of cortical thickness of a rat brain derived from MRI images
Map of cortical thickness of a rat brain derived from MRI images
Click image to view full-size

Research Focus

Keywords

MRI

mouse

imaging

brain

atlas

Clinical conditions

Addiction

Cardiac disease

Genetic disorders

Huntington's disease

Equipment

Magnetic resonance imaging (MRI)

Positron Emission Tomography (PET)

Collaborators

Cambridge

Richard Ansorge

Adrian Carpenter

Jeffrey Dalley

Jennifer Morton

Angela Roberts

Associated News Items


Key publications

Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry.” Neurobiol Dis 33(1):20-7 Details

Publications

2014

Buonincontri G, Hu CH, Sawiak S, Krieg T (2014), “P516Diastolic dysfunction in diabetic mice revealed by MRI.” Cardiovasc Res 103 Suppl 1:S94-5

Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Functional assessment of the mouse heart by MRI with a 1-min acquisition.” NMR Biomed Details

Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Trajectory correction for free-breathing radial cine MRI.” Magn Reson Imaging Details

Buonincontri G, Wood NI, Puttick SG, Ward AO, Carpenter TA, Sawiak SJ, Morton AJ (2014), “Right ventricular dysfunction in the R6/2 transgenic mouse model of Huntington's disease is unmasked by dobutamine.” J Huntingtons Dis 3(1):25-32 Details

Chouchani ET, Methner C, Buonincontri G, Hu CH, Logan A, Sawiak SJ, Murphy MP, Krieg T (2014), “Complex I deficiency due to selective loss of ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.” PLoS One 9(4):e94157 Details

Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC (2014), “Orbitofrontal Dopamine Depletion Upregulates Caudate Dopamine and Alters Behavior via Changes in Reinforcement Sensitivity.” J Neurosci 34(22):7663-76 Details

Hayes DJ, Jupp B, Sawiak SJ, Merlo E, Caprioli D, Dalley JW (2014), “Brain γ-aminobutyric acid: a neglected role in impulsivity.” Eur J Neurosci Details

Izquierdo-Garcia D, Sawiak SJ, Knesaurek K, Narula J, Fuster V, Machac J, Fayad ZA (2014), “Comparison of MR-based attenuation correction and CT-based attenuation correction of whole-body PET/MR imaging.” Eur J Nucl Med Mol Imaging Details

Methner C, Chouchani ET, Buonincontri G, Pell VR, Sawiak SJ, Murphy MP, Krieg T (2014), “Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.” Eur J Heart Fail Details

Morton AJ, Rudiger SR, Wood NI, Sawiak SJ, Brown GC, McLaughlan CJ, Kuchel TR, Snell RG, Faull RL, Bawden CS (2014), “Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment.” Hum Mol Genet Details

Sawiak SJ, Picq JL, Dhenain M (2014), “Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate.” Front Aging Neurosci 6:82 Details

2013

Buonincontri G, Methner C, Carpenter TA, Hawkes RC, Sawiak SJ, Krieg T (2013), “MRI and PET in mouse models of myocardial infarction.” J Vis Exp (82):e50806 Details

Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2013), “A fast protocol for infarct quantification in mice.” J Magn Reson Imaging Details

Buonincontri G, Sawiak SJ, Methner C, Krieg T, Hawkes RC, Carpenter TA (2013), “PET/MRI in the infarcted mouse heart with the Cambridge split magnet.” Nucl Instrum Methods Phys Res A 702 Details

Caprioli D, Fryer TD, Sawiak SJ, Aigbirhio FI, Dalley JW (2013), “Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls.” Curr Opin Neurobiol 23(4):597-606 Details

Caprioli D, Hong YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Adrian Carpenter T, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer TD, Dalley JW (2013), “Baseline-dependent effects of cocaine pre-exposure on impulsivity and D(2/3) receptor availability in the rat striatum: Possible relevance to the attention-deficit hyperactivity syndrome.” Neuropsychopharmacology Details

Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2013), “Gamma Aminobutyric Acidergic and Neuronal Structural Markers in the Nucleus Accumbens Core Underlie Trait-like Impulsive Behavior.” Biol Psychiatry Details

Ejaz S, Williamson DJ, Ahmed T, Sitnikov S, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Baron JC (2013), “Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.” Neurobiol Dis 51:120-32 Details

Methner C, Buonincontri G, Hu CH, Vujic A, Kretschmer A, Sawiak S, Carpenter A, Stasch JP, Krieg T (2013), “Riociguat reduces infarct size and post-infarct heart failure in mouse hearts: insights from MRI/PET imaging.” PLoS One 8(12):e83910 Details

Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2013), “Voxel-based morphometry with templates and validation in a mouse model of Huntington's disease.” Magn Reson Imaging 31(9):1522-31 Details

Williamson DJ, Ejaz S, Sitnikov S, Fryer TD, Sawiak SJ, Burke P, Baron JC, Aigbirhio FI (2013), “A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke.” Nucl Med Biol 40(3):338-44 Details

2012

Kielar C, Sawiak SJ, Navarro Negredo P, Tse DH, Morton AJ (2012), “Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse.” PLoS One 7(2):e32636 Details

Sawiak SJ, Wood NI, Carpenter TA, Morton AJ (2012), “Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy.” PLoS One 7(12):e53361 Details

Wood NI, Sawiak SJ, Buonincontri G, Niu Y, Kane AD, Carpenter TA, Giussani DA, Morton AJ (2012), “Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease.” J Huntingtons Dis 1(1) Details

2011

Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011), “Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.” J Cereb Blood Flow Metab 31(12):2334-42 Details

2009

Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease.” Neurobiol Dis 33(1):12-9 Details