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  • Cancer
  • Research Focus

    Keywords

  • Surgery
  • Glioblastoma
  • Cognitive Impairment
  • Tumour Invasion
  • Neurorehabilitation
  • Clinical Conditions

  • Brain cancer
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)
  • Neuropsychological testing
  • Cross-sectional and cohort studies
  • Science Culture

  • Mentorship
  • Public Engagement
  • Teaching
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    Professor Stephen Price

    (he/him/his)
    University Position
    Professor
    Professor Stephen Price is pleased to consider applications from prospective PhD students.

    Interests

    Glioblastomas are the most aggressive, malignant primary tumour of the brain. They are also, unfortunately, the commonest. We have not seen any new treatments in over a decade. My group is particularly interested in focal therapies, surgery and radiotherapy. As a surgeon, we walk a tightrope between not taking enough tumour so it progresses rapidly or taking too much and damaging the normal brain. My research group focuses on identifying individualised treatment volumes to maximise tumour resection without impacting quality of life. Our research has four themes: 1. Develop imaging tools to map the extent of glioblastomas 2. Understand the impact of surgery on cognitive function and develop rehabilitation strategies to overcome neurocognitive deficits. 3. Imaging intra- and inter-tumoural heterogeneity 4. Develop machine learning tools to phenotype patients better We believe that if we can understand tumour heterogeneity, we can individualise therapy for patients.

    Bringing advanced imaging into the operating theatre

    This is an example of incorporating advanced imaging into our surgical image-guidance system. We have outlined the contrast enhancing tumour (in green) and the [C-11]-methionine PET in orange (as the likely target to be resected with 5-ALA fluorescence). The blue is the DTI anisotropic component (q) that identifies likely residual tumour. The PRaM-GBM study has shown that this can identify where tumours will progress with sensitivities around 80% with specificity of 95%. This is now a target for biopsy (to provide biological validation) before starting an early stage surgical trial to resect these regions.

    Collaborators

    Cambridge
  • Chao Li
  • Key Publications

    Structural connectome quantifies tumour invasion and predicts survival in glioblastoma patients.

    DOI: http://doi.org/10.1093/brain/awac360
    Journal: Brain
    E-pub date: 19 Apr 2023
    Authors: Y Wei, C Li, Z Cui, RC Mayrand, J Zou, ALKC Wong, R Sinha, T Matys, C-B Schönlieb, SJ Price

    Multi-modal learning for predicting the genotype of glioma

    DOI: http://doi.org/10.48550/arxiv.2203.10852
    Journal:
    E-pub date: 21 Mar 2022
    Authors: Y Wei, X Chen, L Zhu, L Zhang, C-B Schönlieb, SJ Price, C Li

    Multi-scale segmentation in GBM treatment using diffusion tensor imaging.

    DOI: http://doi.org/10.1016/j.compbiomed.2020.103815
    Journal: Comput Biol Med
    E-pub date: 31 Aug 2020
    Authors: R Rahmat, K Saednia, MR Haji Hosseini Khani, M Rahmati, R Jena, SJ Price

    Glioblastoma surgery related emotion recognition deficits are associated with right cerebral hemisphere tract changes.

    DOI: http://doi.org/10.1093/braincomms/fcaa169
    Journal: Brain Commun
    E-pub date: 1 Aug 2020
    Authors: R Sinha, ABC Dijkshoorn, C Li, T Manly, SJ Price

    A systematic review of cognitive function in patients with glioblastoma undergoing surgery.

    DOI: http://doi.org/10.1093/nop/npz018
    Journal: Neurooncol Pract
    E-pub date: 1 Mar 2020
    Authors: R Sinha, JM Stephenson, SJ Price

    Identifying Multiple Invasive Intratumor Habitats in Glioblastoma Using Multi-Parametric Magnetic Resonance Imaging and Copula Transform

    DOI: http://doi.org/10.1016/j.ijrobp.2019.06.544
    Journal: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
    E-pub date: 1 Aug 2019
    Authors: C Li, S Wang, C Sun, CB Schonlieb, S Price

    Neuroimaging classification of progression patterns in glioblastoma: a systematic review.

    DOI: http://doi.org/10.1007/s11060-018-2843-3
    Journal: J Neurooncol
    E-pub date: 31 Aug 2018
    Authors: RJ Piper, KK Senthil, J-L Yan, SJ Price

    Multiparametric MR Imaging of Diffusion and Perfusion in Contrast-enhancing and Nonenhancing Components in Patients with Glioblastoma.

    DOI: http://doi.org/10.1148/radiol.2017160150
    Journal: Radiology
    E-pub date: 1 Jul 2017
    Authors: NR Boonzaier, TJ Larkin, T Matys, A van der Hoorn, J-L Yan, SJ Price

    Global effects of focal brain tumours on functional complexity and network robustness

    DOI: http://doi.org/10.1101/142844
    Journal:
    E-pub date: 29 May 2017
    Authors: MG Hart, R Romero-Garcia, SJ Price, J Suckling

    Extent of resection of peritumoral diffusion tensor imaging-detected abnormality as a predictor of survival in adult glioblastoma patients.

    DOI: http://doi.org/10.3171/2016.1.JNS152153
    Journal: J Neurosurg
    E-pub date: 1 Jan 2017
    Authors: J-L Yan, A van der Hoorn, TJ Larkin, NR Boonzaier, T Matys, SJ Price

    Validation of a semi-automatic co-registration of MRI scans in patients with brain tumors during treatment follow-up.

    DOI: http://doi.org/10.1002/nbm.3538
    Journal: NMR Biomed
    E-pub date: 1 Jul 2016
    Authors: A van der Hoorn, J-L Yan, TJ Larkin, NR Boonzaier, T Matys, SJ Price

    Multimodal MRI can identify perfusion and metabolic changes in the invasive margin of glioblastomas.

    DOI: http://doi.org/10.1002/jmri.24996
    Journal: J Magn Reson Imaging
    E-pub date: 1 Feb 2016
    Authors: SJ Price, AMH Young, WJ Scotton, J Ching, LA Mohsen, NR Boonzaier, VC Lupson, JR Griffiths, MA McLean, TJ Larkin

    Diffusion tensor invasive phenotypes can predict progression-free survival in glioblastomas.

    DOI: http://doi.org/10.3109/02688697.2013.771136
    Journal: Br J Neurosurg
    E-pub date: 31 Aug 2013
    Authors: LA Mohsen, V Shi, R Jena, JH Gillard, SJ Price

    Predicting patterns of glioma recurrence using diffusion tensor imaging.

    DOI: http://doi.org/10.1007/s00330-006-0561-2
    Journal: Eur Radiol
    E-pub date: 1 Jul 2007
    Authors: SJ Price, R Jena, NG Burnet, TA Carpenter, JD Pickard, JH Gillard

    Tissue signature characterisation of diffusion tensor abnormalities in cerebral gliomas.

    DOI: http://doi.org/10.1007/s00330-004-2381-6
    Journal: Eur Radiol
    E-pub date: 1 Oct 2004
    Authors: SJ Price, A Peña, NG Burnet, R Jena, HAL Green, TA Carpenter, JD Pickard, JH Gillard

    Diffusion tensor imaging of brain tumours at 3T: a potential tool for assessing white matter tract invasion?

    DOI: http://doi.org/10.1016/s0009-9260(03)00115-6
    Journal: Clin Radiol
    E-pub date: 1 Jun 2003
    Authors: SJ Price, NG Burnet, T Donovan, HAL Green, A Peña, NM Antoun, JD Pickard, TA Carpenter, JH Gillard

    Publications

    Refining the Intraoperative Identification of Suspected High-Grade Glioma Using a Surgical Fluorescence Biomarker: GALA BIDD Study Report.

    DOI: http://doi.org/10.3390/jpm13030514
    Journal: J Pers Med
    E-pub date: 13 Mar 2023
    Authors: C Watts, A Dayimu, T Matys, K Ashkan, S Price, MD Jenkinson, G Doughton, C Mather, G Young, W Qian, KM Kurian

    High gamma activity distinguishes frontal cognitive control regions from adjacent cortical networks.

    DOI: http://doi.org/10.1016/j.cortex.2022.12.007
    Journal: Cortex
    E-pub date: 1 Feb 2023
    Authors: M Assem, MG Hart, P Coelho, R Romero-Garcia, A McDonald, E Woodberry, RC Morris, SJ Price, J Suckling, T Santarius, J Duncan, Y Erez

    A Prospective Study of Longitudinal Risks of Cognitive Deficit for People Undergoing Glioblastoma Surgery Using a Tablet Computer Cognition Testing Battery: Towards Personalized Understanding of Risks to Cognitive Function.

    DOI: http://doi.org/10.3390/jpm13020278
    Journal: J Pers Med
    E-pub date: 31 Jan 2023
    Authors: R Sinha, R Masina, C Morales, K Burton, Y Wan, A Joannides, RJ Mair, RC Morris, T Santarius, T Manly, SJ Price

    Assessment of neuropsychological function in brain tumor treatment: a comparison of traditional neuropsychological assessment with app-based cognitive screening.

    DOI: http://doi.org/10.1007/s00701-022-05162-5
    Journal: Acta Neurochir (Wien)
    E-pub date: 31 Aug 2022
    Authors: R Romero-Garcia, M Owen, A McDonald, E Woodberry, M Assem, P Coelho, RC Morris, SJ Price, T Santarius, J Suckling, T Manly, Y Erez, MG Hart

    Tumour-infiltrated cortex participates in large-scale cognitive circuits

    DOI: http://doi.org/10.1101/2022.12.19.22283690
    Journal:
    E-pub date: 1 Aug 2022
    Authors: A Mandal, M Assem, R Romero-Garcia, P Coelho, A McDonald, E Woodberry, R Morris, S Price, J Duncan, T Santarius, J Suckling, M Hart, Y Erez

    Utility of 5-ALA for resection of CNS tumours other than high-grade gliomas: a protocol for a systematic review.

    DOI: http://doi.org/10.1136/bmjopen-2021-056059
    Journal: BMJ Open
    E-pub date: 22 Jul 2022
    Authors: G Solomou, A-A Gharooni, W Patel, CS Gillespie, M Gough, A Venkatesh, MTC Poon, V Wykes, SJ Price, MD Jenkinson, C Watts, P Plaha

    Mutual Contrastive Low-rank Learning to Disentangle Whole Slide Image Representations for Glioma Grading

    DOI: http://doi.org/10.48550/arxiv.2203.04013
    Journal:
    E-pub date: 8 Mar 2022
    Authors: L Zhang, Y Wei, Y Fu, S Price, C-B Schönlieb, C Li

    Memory recovery in relation to default mode network impairment and neurite density during brain tumor treatment.

    DOI: http://doi.org/10.3171/2021.1.JNS203959
    Journal: J Neurosurg
    E-pub date: 1 Feb 2022
    Authors: R Romero-Garcia, J Suckling, M Owen, M Assem, R Sinha, P Coelho, E Woodberry, SJ Price, A Burke, T Santarius, Y Erez, MG Hart

    Collaborative learning of images and geometrics for predicting isocitrate dehydrogenase status of glioma

    DOI: http://doi.org/10.48550/arxiv.2201.05530
    Journal:
    E-pub date: 14 Jan 2022
    Authors: Y Wei, C Li, X Chen, C-B Schönlieb, SJ Price

    BOLD Coupling between Lesioned and Healthy Brain Is Associated with Glioma Patients’ Recovery.

    DOI: http://doi.org/10.3390/cancers13195008
    Journal: Cancers (Basel)
    E-pub date: 6 Oct 2021
    Authors: R Romero-Garcia, MG Hart, RAI Bethlehem, A Mandal, M Assem, B Crespo-Facorro, JM Gorriz, GAA Burke, SJ Price, T Santarius, Y Erez, J Suckling

    Structural connectome quantifies tumor invasion and predicts survival in glioblastoma patients

    DOI: http://doi.org/10.1101/2021.03.09.434656
    Journal:
    E-pub date: 1 Aug 2021
    Authors: Y Wei, C Li, Z Cui, R Mayrand, J Zou, ALKC Wong, R Sinha, T Matys, C-B Schönlieb, SJ Price

    An Evaluation of the Tolerability and Feasibility of Combining 5-Amino-Levulinic Acid (5-ALA) with BCNU Wafers in the Surgical Management of Primary Glioblastoma.

    DOI: http://doi.org/10.3390/cancers13133241
    Journal: Cancers (Basel)
    E-pub date: 29 Jun 2021
    Authors: C Watts, K Ashkan, MD Jenkinson, SJ Price, T Santarius, T Matys, TT Zhang, A Finch, P Collins, K Allinson, SJ Jefferies, DJ Scoffings, A Zisakis, M Phillips, K Wanek, P Smith, L Clifton-Hadley, N Counsell

    Expectation-Maximization Regularized Deep Learning for Weakly Supervised Tumor Segmentation for Glioblastoma

    DOI: http://doi.org/10.48550/arxiv.2101.08757
    Journal:
    E-pub date: 21 Jan 2021
    Authors: C Li, W Huang, X Chen, Y Wei, SJ Price, C-B Schönlieb

    Intraoperative mapping of executive function using electrocorticography for patients with low-grade gliomas

    DOI: http://doi.org/10.31219/osf.io/gy84r
    Journal:
    E-pub date: 27 Aug 2020
    Authors: Y Erez, M Assem, P Coelho, R Romero-Garcia, M Owen, A McDonald, E Woodberry, RC Morris, SJ Price, J Suckling, J Duncan, M Hart, T Santarius

    Assessment of neuropsychological function in brain tumour treatment: A comparison of traditional neuropsychological assessment with app-based cognitive screening

    DOI: http://doi.org/10.1101/2020.06.03.20119255
    Journal:
    E-pub date: 1 Aug 2020
    Authors: R Romero-Garcia, M Owen, A McDonald, E Woodberry, M Assem, P Coelho, R Morris, S Price, T Santarius, J Suckling, T Manly, Y Erez, M Hart

    Practical Application of Networks in Neurosurgery: Combined 3-Dimensional Printing, Neuronavigation, and Preoperative Surgical Planning.

    DOI: http://doi.org/10.1016/j.wneu.2020.01.085
    Journal: World Neurosurg
    E-pub date: 1 May 2020
    Authors: R Romero-Garcia, Y Erez, G Oliver, M Owen, S Merali, A Poologaindran, RC Morris, SJ Price, T Santarius, J Suckling, MG Hart

    Practical Application of Networks in Neurosurgery: Combined 3D Printing, Neuronavigation, and Pre-Operative Surgical Planning

    DOI: http://doi.org/10.31219/osf.io/cmg7u
    Journal:
    E-pub date: 15 Nov 2019
    Authors: R Romero-Garcia, Y Erez, G Oliver, M Owen, S Merali, A Poologaindran, RC Morris, S Price, T Santarius, J Suckling, M Hart

    Disruptive and protective outcomes to memory and attention when treating diffuse glioma

    DOI: http://doi.org/10.1101/19008581
    Journal:
    E-pub date: 8 Oct 2019
    Authors: R Romero-Garcia, J Suckling, M Owen, M Assem, R Sinha, P Coelho, E Woodberry, S Price, AGA Burke, T Santarius, Y Erez, M Hart

    Non-invasive assessment of glioma microstructure using VERDICT MRI: correlation with histology.

    DOI: http://doi.org/10.1007/s00330-019-6011-8
    Journal: Eur Radiol
    E-pub date: 1 Oct 2019
    Authors: F Zaccagna, F Riemer, AN Priest, MA McLean, K Allinson, JT Grist, C Dragos, T Matys, JH Gillard, C Watts, SJ Price, MJ Graves, FA Gallagher

    Defining unmet clinical need across the pathway of brain tumor care: a patient and carer perspective.

    DOI: http://doi.org/10.2147/CMAR.S175886
    Journal: Cancer Manag Res
    E-pub date: 1 Aug 2019
    Authors: W Sage, R Fernández-Méndez, A Crofton, MJ Gifford, A Bannykh, C Chrysaphinis, E Tingley, H Bulbeck, M Brahmbhatt, JD Pickard, FM Walter, A Brodbelt, SJ Price, AJ Joannides

    A map of transcriptional heterogeneity and regulatory variation in human microglia

    DOI: http://doi.org/10.1101/2019.12.20.874099
    Journal:
    E-pub date: 1 Aug 2019
    Authors: AMH Young, N Kumasaka, F Calvert, T Hammond, A Knights, N Panousis, J Schwartzentruber, J Liu, K Kundu, M Segel, N Murphy, C McMurran, H Bulstrode, J Correia, K Budohoski, A Joannides, M Guilfoyle, R Trivedi, R Kirollos, R Morris, M Garnett, H Fernandes, I Timofeev, I Jalloh, K Holland, R Mannion, R Mair, C Watts, S Price, P Kirkpatrick, T Santarius, N Soranzo, B Stevens, P Hutchinson, RJM Franklin, D Gaffney

    Global Effects of Focal Brain Tumors on Functional Complexity and Network Robustness: A Prospective Cohort Study.

    DOI: http://doi.org/10.1093/neuros/nyy378
    Journal: Neurosurgery
    E-pub date: 1 Jun 2019
    Authors: MG Hart, R Romero-Garcia, SJ Price, J Suckling

    Missed opportunities for diagnosing brain tumours in primary care: a qualitative study of patient experiences.

    DOI: http://doi.org/10.3399/bjgp19X701861
    Journal: Br J Gen Pract
    E-pub date: 1 Apr 2019
    Authors: FM Walter, C Penfold, A Joannides, S Saji, M Johnson, C Watts, A Brodbelt, MD Jenkinson, SJ Price, W Hamilton, SE Scott

    Brain tumor research in the United Kingdom: current perspective and future challenges. A strategy document from the NCRI Brain Tumor CSG.

    DOI: http://doi.org/10.1093/nop/npx022
    Journal: Neurooncol Pract
    E-pub date: 1 Mar 2018
    Authors: KM Kurian, MD Jenkinson, PM Brennan, R Grant, S Jefferies, AG Rooney, H Bulbeck, SC Erridge, S Mills, C McBain, MG McCabe, SJ Price, S Marino, E Moyes, W Qian, A Waldman, B Vaqas, D Keatley, P Burchill, C Watts

    Local alkylating chemotherapy applied immediately after 5-ALA guided resection of glioblastoma does not provide additional benefit.

    DOI: http://doi.org/10.1007/s11060-017-2649-8
    Journal: J Neurooncol
    E-pub date: 1 Jan 2018
    Authors: W Sage, M Guilfoyle, C Luney, A Young, R Sinha, D Sgubin, JH McAbee, R Ma, S Jefferies, R Jena, F Harris, K Allinson, T Matys, W Qian, T Santarius, S Price, C Watts

    Diagnostic Accuracy of Neuroimaging to Delineate Diffuse Gliomas within the Brain: A Meta-Analysis.

    DOI: http://doi.org/10.3174/ajnr.A5368
    Journal: AJNR Am J Neuroradiol
    E-pub date: 1 Oct 2017
    Authors: N Verburg, FWA Hoefnagels, F Barkhof, R Boellaard, S Goldman, J Guo, JJ Heimans, OS Hoekstra, R Jain, M Kinoshita, PJW Pouwels, SJ Price, JC Reijneveld, A Stadlbauer, WP Vandertop, P Wesseling, AH Zwinderman, PC De Witt Hamer

    Functional connectivity networks for preoperative brain mapping in neurosurgery.

    DOI: http://doi.org/10.3171/2016.6.JNS1662
    Journal: J Neurosurg
    E-pub date: 1 Jun 2017
    Authors: MG Hart, SJ Price, J Suckling

    Connectome analysis for pre-operative brain mapping in neurosurgery.

    DOI: http://doi.org/10.1080/02688697.2016.1208809
    Journal: Br J Neurosurg
    E-pub date: 1 Oct 2016
    Authors: MG Hart, SJ Price, J Suckling

    Posttreatment Apparent Diffusion Coefficient Changes in the Periresectional Area in Patients with Glioblastoma.

    DOI: http://doi.org/10.1016/j.wneu.2016.04.129
    Journal: World Neurosurg
    E-pub date: 31 Aug 2016
    Authors: A van der Hoorn, J-L Yan, TJ Larkin, NR Boonzaier, T Matys, SJ Price

    Graph theory analysis of complex brain networks: new concepts in brain mapping applied to neurosurgery.

    DOI: http://doi.org/10.3171/2015.4.JNS142683
    Journal: J Neurosurg
    E-pub date: 1 Jun 2016
    Authors: MG Hart, RJF Ypma, R Romero-Garcia, SJ Price, J Suckling

    The Multimodal Brain Tumor Image Segmentation Benchmark (BRATS).

    DOI: http://doi.org/10.1109/TMI.2014.2377694
    Journal: IEEE Trans Med Imaging
    E-pub date: 1 Oct 2015
    Authors: BH Menze, A Jakab, S Bauer, J Kalpathy-Cramer, K Farahani, J Kirby, Y Burren, N Porz, J Slotboom, R Wiest, L Lanczi, E Gerstner, M-A Weber, T Arbel, BB Avants, N Ayache, P Buendia, DL Collins, N Cordier, JJ Corso, A Criminisi, T Das, H Delingette, Ç Demiralp, CR Durst, M Dojat, S Doyle, J Festa, F Forbes, E Geremia, B Glocker, P Golland, X Guo, A Hamamci, KM Iftekharuddin, R Jena, NM John, E Konukoglu, D Lashkari, JA Mariz, R Meier, S Pereira, D Precup, SJ Price, TR Raviv, SMS Reza, M Ryan, D Sarikaya, L Schwartz, H-C Shin, J Shotton, CA Silva, N Sousa, NK Subbanna, G Szekely, TJ Taylor, OM Thomas, NJ Tustison, G Unal, F Vasseur, M Wintermark, DH Ye, L Zhao, B Zhao, D Zikic, M Prastawa, M Reyes, K Van Leemput

    Development of an Integrated Subspecialist Multidisciplinary Neuro-oncology Service.

    DOI: http://doi.org/10.1136/bmjquality.u201857.w981
    Journal: BMJ Qual Improv Rep
    E-pub date: 1 Aug 2013
    Authors: SJ Price, M Guilfoyle, S J Jefferies, F Harris, I Oberg, N G Burnet, T Santarius, C Watts

    Classification Forests for Semantic Segmentation of Brain Lesions in Multi-channel MRI

    DOI: http://doi.org/10.1007/978-1-4471-4929-3_17
    Journal:
    E-pub date: 1 Aug 2013
    Authors: E Geremia, D Zikic, O Clatz, BH Menze, B Glocker, E Konukoglu, J Shotton, OM Thomas, SJ Price, T Das, R Jena, N Ayache, A Criminisi

    Decision forests for tissue-specific segmentation of high-grade gliomas in multi-channel MR.

    DOI: http://doi.org/10.1007/978-3-642-33454-2_46
    Journal: Med Image Comput Comput Assist Interv
    E-pub date: 1 Aug 2012
    Authors: D Zikic, B Glocker, E Konukoglu, A Criminisi, C Demiralp, J Shotton, OM Thomas, T Das, R Jena, SJ Price

    Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study.

    DOI: http://doi.org/10.3174/ajnr.A2312
    Journal: AJNR Am J Neuroradiol
    E-pub date: 1 Mar 2011
    Authors: SJ Price, HAL Green, AF Dean, J Joseph, PJ Hutchinson, JH Gillard

    Imaging regional variation of cellular proliferation in gliomas using 3′-deoxy-3′-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study.

    DOI: http://doi.org/10.1016/j.crad.2008.01.016
    Journal: Clin Radiol
    E-pub date: 1 Jan 2009
    Authors: SJ Price, TD Fryer, MC Cleij, AF Dean, J Joseph, R Salvador, DD Wang, PJ Hutchinson, JC Clark, NG Burnet, JD Pickard, FI Aigbirhio, JH Gillard

    Detecting glioma invasion of the corpus callosum using diffusion tensor imaging.

    DOI: http://doi.org/10.1080/02688690400005255
    Journal: Br J Neurosurg
    E-pub date: 31 Aug 2004
    Authors: SJ Price, A Peña, NG Burnet, JD Pickard, JH Gillard