Dr Sian Alexander DPhil MRCP

Sian Alexander

University position

Neurology Specialist Registrar


Department of Clinical Neurosciences

Research Theme

Clinical and Veterinary Neuroscience


I am a full time Neurology Specialist Registrar in the East of England. In addition to training in general neurology, I have a particular interest in the mechanisms of cognitive disturbance - memory, language and behaviour.

I investigated the aetiology of acquired memory deficits in autoimmune limbic encephalitis during my D Phil. I subsequently researched cellular mechanisms of neurodegeneration and clinical aspects of cognitive disorders, as part of the academic clinical training pathway. I am now continuing my clinical training in Neurology.

Primary culture of GAD65-GFP hippocampal neurons
GFP neurona
Click image to view full-size

Research Focus


None specified

Clinical conditions

Alzheimer's disease

Autoimmune diseases

Cognitive impairment


Progressive supranuclear palsy


No equipment indicated


No collaborators listed

Associated News Items



    Alexander SK, Brown JM, Graham A, Nestor PJ (2014), “CADASIL presenting with a behavioural variant frontotemporal dementia phenotype.” J Clin Neurosci 21(1):165-7 Details

    in press

    Alexander SK, Holland AJ (in press), “Down Syndrome as a Model for Investigating Alzheimer’s Disease” ACNR


    Alexander SK, Rittman T, Xuereb JH, Bak TH, Hodges JR, Rowe JB (2014), “Validation of the new consensus criteria for the diagnosis of corticobasal degeneration.” J Neurol Neurosurg Psychiatry 85(8):925-9 Details


    Chang T, Alexopoulos H, McMenamin M, Carvajal-González A, Alexander SK, Deacon R, Erdelyi F, Gabor S, Lang B, Blaes F, Brown P, Vincent A (2013), “Neuronal surface and glutamic acid decarboxylase autoantibodies in Nonparaneoplastic stiff person syndrome.” JAMA Neurol 70(9):1140-9 Details


    Alam M, Alexander SK, Asbey M, Higgins JN, Kirkpatrick PJ (2012), “Mirror-image temporal arteriovenous malformations presenting with left cervical internal carotid aneurysm.” Br J Neurosurg 26(6):921-2 Details

    Alexander SK, Acosta-Cabronero J, Pengas G, Diaz-de-Grenu L, Nestor PJ (2012), “Beyond the hippocampus: memory impairment in AD might also relate to restrosplenial damage” J Neurol Neurosurg Psychiatry 83:Suppl 2 15doi:10.1136/jnnp-2012-304200a.58

    Irani SR, Alexander S, Vincent A (2012), “Case 34-2011: a man with memory loss and partial seizures.” N Engl J Med 366(8):768-9; author reply 769 Details


    Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L, Peles E, Buckley C, Lang B, Vincent A (2010), “Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia.” Brain 133(9):2734-48 Details


    Watson R, Jepson JE, Bermudez I, Alexander S, Hart Y, McKnight K, Roubertie A, Fecto F, Valmier J, Sattelle DB, Beeson D, Vincent A, Lang B (2005), “Alpha7-acetylcholine receptor antibodies in two patients with Rasmussen encephalitis.” Neurology 65(11):1802-4 Details