Dr Shahid Zaman
University position
Affiliated Lecturer
Departments
Institutes
Cambridge Intellectual Disabilty Research Group and Wolfson Brain Imaging Centre
Home page
Research Themes
Interests
The main theme of our research is to understand the role of amyloid and mitochondrial dysfunction in the genesis of cognitive impairment and dementia in people with Down's syndrome.
Research Focus
KeywordsDown's syndrom Alzheimer's disease cognitive impairment amyloid mitochondria |
Clinical conditionsAlzheimer's disease Cognitive impairment Down's syndrome Learning disabilities |
Equipment
Cell culture
Confocal microscopy
Enzyme assays
Immunohistochemistry
Magnetic resonance imaging (MRI)
Microscopy
Neuropsychological testing
Positron Emission Tomography (PET)
Collaborators
CambridgeRob Smith Antonella Spinazzola John Walker |
Publications
2012
S H Zaman (2012), “'The impact of studies of memory mechanisms for psychiatry'” Chapter in, 'The Memory Mechanism' Edited by KP Giese published by World Scientific Publishing pp 397-430
2011
d'Abrera JC, Holland AJ, Landt J, Stocks-Gee G, Zaman SH (2011), “A neuroimaging proof of principle study of Down's syndrome and dementia: ethical and methodological challenges in intrusive research.” J Intellect Disabil Res Details
Landt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.” Arch Neurol 68(7):890-6 Details
2010
Malinow R, Hayashi Y, Maletic-Savatic M, Zaman SH, Poncer JC, Shi SH, Esteban JA, Osten P, Seidenman K (2010), “Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection.” Cold Spring Harb Protoc 2010(4):pdb.prot5406 Details
2007
Craig MC, Zaman SH, Daly EM, Cutter WJ, Robertson DM, Hallahan B, Toal F, Reed S, Ambikapathy A, Brammer M, Murphy CM, Murphy DG (2007), “Women with autistic-spectrum disorder: magnetic resonance imaging study of brain anatomy.” Br J Psychiatry 191:224-8 Details
2004
Terashima A, Cotton L, Dev KK, Meyer G, Zaman S, Duprat F, Henley JM, Collingridge GL, Isaac JT (2004), “Regulation of synaptic strength and AMPA receptor subunit composition by PICK1.” J Neurosci 24(23):5381-90 Details
2002
Daw MI, Bortolotto ZA, Saulle E, Zaman S, Collingridge GL, Isaac JT (2002), “Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression.” Nat Neurosci 5(9):835-6 Details
Greenfield LJ Jr, Zaman SH, Sutherland ML, Lummis SC, Niemeyer MI, Barnard EA, Macdonald RL (2002), “Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement.” Neuropharmacology 42(4):502-21 Details
2000
Zaman SH, Parent A, Laskey A, Lee MK, Borchelt DR, Sisodia SS, Malinow R (2000), “Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine.” Neurobiol Dis 7(1):54-63 Details
1999
Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R (1999), “Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.” Science 284(5421):1811-6 Details
1993
Barnard EA, Sutherland M, Zaman S, Matsumoto M, Nayeem N, Green T, Darlison MG, Bateson AN (1993), “Multiplicity, structure, and function in GABAA receptors.” Ann N Y Acad Sci 707:116-25 Details
1992
Zaman SH, Harvey RJ, Barnard EA, Darlison MG (1992), “Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAA receptor.” FEBS Lett 307(3):351-4 Details
Zaman SH, Shingai R, Harvey RJ, Darlison MG, Barnard EA (1992), “Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.” Eur J Pharmacol 225(4):321-30 Details
1991
Harvey RJ, Vreugdenhil E, Zaman SH, Bhandal NS, Usherwood PN, Barnard EA, Darlison MG (1991), “Sequence of a functional invertebrate GABAA receptor subunit which can form a chimeric receptor with a vertebrate alpha subunit.” EMBO J 10(11):3239-45 Details
1990
Zaman SH (1990), “Endogenous steroids and pathogenesis of hepatic encephalopathy.” Lancet 336(8714):573-4 Details


