Dr Shel Hwa Yeo

Shel Hwa Yeo

University position

Research Associate

Departments

Department of Physiology, Development and Neuroscience

Research Theme

Cellular and Molecular Neuroscience

Interests

My research interest is the kisspeptin neuronal network in the adult mouse brain. Kisspeptin neuropeptides are the potent stimulators of the gonadotrophin-releasing hormone (GnRH) neurons that govern the reproductive functions in mammals. My current research aims to map out the afferent inputs onto kisspeptin neurons in the adult female mouse brain. I am also interested in the changes of these neuronal circuits under different physiological conditions such as ovulations, lactation and aging. By using viral transneuronal tracing combined with Cre/loxP recombination technology, I want to map out the synaptic inputs to kisspeptin neurons. The main techniques involved in my research are stereotaxic injection, immunohistochemistry, confocal microscopy and hormonal manipulations.

Hypothalamic neurosecretory gonadotrophin-releasing hormone (GnRH) neuron that projects into brain regions outside the blood-brain barrier.
Hypothalamic neurosecretory gonadotrophin-releasing hormone (GnRH) neuron that projects into brain regions outside the blood-brain barrier.
Click image to view full-size

Research Focus

Keywords

kisspeptin

reproduction

neuroanatomical tracing

HPG axis

afferent

Clinical conditions

Hormonal disorders

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Stereotaxic surgery

Viral transneuronal tracing

Collaborators

International

Lynn Enquist Web: http://molbio.princeton.edu/labs/en...

Associated News Items


    Key publications

    Yeo SH (2013), “Neuronal circuits in the hypothalamus controlling gonadotrophin-releasing hormone release: the neuroanatomical projections of kisspeptin neurons.” Exp Physiol 98(11):1544-9 Details

    Yeo SH, Herbison AE (2011), “Projections of arcuate nucleus and rostral periventricular kisspeptin neurons in the adult female mouse brain.” Endocrinology 152(6):2387-99 Details

    Publications

    2014

    Yeo SH, Herbison AE (2014), “Estrogen-Negative Feedback and Estrous Cyclicity Are Critically Dependent Upon Estrogen Receptor-α Expression in the Arcuate Nucleus of Adult Female Mice.” Endocrinology 155(8):2986-95 Details

    2013

    Franceschini I, Yeo SH, Beltramo M, Desroziers E, Okamura H, Herbison AE, Caraty A (2013), “Immunohistochemical evidence for the presence of various kisspeptin isoforms in the mammalian brain.” J Neuroendocrinol 25(9):839-51 Details

    Mei H, Doran J, Kyle V, Yeo SH, Colledge WH (2013), “Does Kisspeptin Signaling have a Role in the Testes?” Front Endocrinol (Lausanne) 4:198 Details

    2011

    Png E, Samivelu GK, Yeo SH, Chew J, Chaurasia SS, Tong L (2011), “Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human corneal epithelial cells.” J Cell Physiol 226(3):693-9 Details

    Porteous R, Petersen SL, Yeo SH, Bhattarai JP, Ciofi P, de Tassigny XD, Colledge WH, Caraty A, Herbison AE (2011), “Kisspeptin neurons co-express met-enkephalin and galanin in the rostral periventricular region of the female mouse hypothalamus.” J Comp Neurol 519(17):3456-69 Details