Professor Seth Grant FRSE

Seth Grant

University position

Visiting Professor

Departments

Department of Psychology

Institutes

Edinburgh University

Email

seth.grant@ed.ac.uk

Home page

http://www.genes2cognition.org/

Research Themes

Cellular and Molecular Neuroscience

Cognitive and Behavioural Neuroscience

Interests

The Genes to Cognition programme (G2C) established a framework for studying genes, brain and behaviour in order to link basic molecular research from genomes and experimental genetic organisms with human clinical studies of cognition. The G2C framework was developed around the current understanding of the molecular basis of learning & memory.

The G2C programme collects and integrates data in the areas of psychiatry, human and mouse psychology, cellular neurophysiology and cell biology, proteomics and biochemistry, molecular biology, human and mouse genetics and genomics.

Research Focus

Keywords

learning

proteomics

genetics

plasticity

neural circuit

Clinical conditions

Alzheimer's disease

Autism

Bipolar disorder

Cognitive impairment

Dementia

Learning disabilities

Schizophrenia

Stroke

Equipment

No equipment indicated

Collaborators

Cambridge

Tim Bussey

Stephen Eglen

Gos Micklem

Trevor Robbins

Lisa Saksida

Nigel Unwin

Key publications

Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD, Grant SG (2008), “Evolutionary expansion and anatomical specialization of synapse proteome complexity.” Nat Neurosci 11(7):799-806 Details

Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000), “Proteomic analysis of NMDA receptor-adhesion protein signaling complexes” Nature Neuroscience 3:661-9

Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH, O'Dell TJ, Grant SG (1998), “Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.” Nature 396(6710):433-9 Details

Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER (1992), “Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.” Science 258(5090):1903-10 Details

Publications

2014

Daut RA, Busch EF, Ihne J, Fisher D, Mishina M, Grant SG, Camp M, Holmes A (2014), “Tolerance to ethanol intoxication after chronic ethanol: role of GluN2A and PSD-95.” Addict Biol Details

Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC (2014), “De novo mutations in schizophrenia implicate synaptic networks.” Nature 506(7487):179-84 Details

Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kähler A, Duncan L, Stahl E, Genovese G, Fernández E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, DePristo M, Grant SG, Haggarty SJ, Gabriel S, Scolnick EM, Lander ES, Hultman CM, Sullivan PF, McCarroll SA, Sklar P (2014), “A polygenic burden of rare disruptive mutations in schizophrenia.” Nature 506(7487):185-90 Details

Zhang J, Saur T, Duke AN, Grant SG, Platt DM, Rowlett JK, Isacson O, Yao WD (2014), “Motor Impairments, Striatal Degeneration, and Altered Dopamine-Glutamate Interplay in Mice Lacking PSD-95.” J Neurogenet Details

2013

De Rubeis S, Pasciuto E, Li KW, Fernández E, Di Marino D, Buzzi A, Ostroff LE, Klann E, Zwartkruis FJ, Komiyama NH, Grant SG, Poujol C, Choquet D, Achsel T, Posthuma D, Smit AB, Bagni C (2013), “CYFIP1 coordinates mRNA translation and cytoskeleton remodeling to ensure proper dendritic spine formation.” Neuron 79(6):1169-82 Details

Debrouse L, Hurd B, Kiselycznyk C, Plitt A, Todaro A, Mishina M, Grant SG, Camp M, Gunduz-Cinar O, Holmes A (2013), “Probing the modulation of acute ethanol intoxication by pharmacological manipulation of the NMDAR glycine co-agonist site.” Alcohol Clin Exp Res 37(2):223-33 Details

Grant SG (2013), “SnapShot: Organizational principles of the postsynaptic proteome.” Neuron 80(2):534.e1 Details

Milner LC, Shirley RL, Kozell LB, Walter NA, Kruse LC, Komiyama NH, Grant SG, Buck KJ (2013), “Novel MPDZ/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption.” Addict Biol Details

Nithianantharajah J, Grant SG (2013), “Cognitive components in mice and humans: combining genetics and touchscreens for medical translation.” Neurobiol Learn Mem 105:13-9 Details

Nithianantharajah J, Komiyama NH, McKechanie A, Johnstone M, Blackwood DH, St Clair D, Emes RD, van de Lagemaat LN, Saksida LM, Bussey TJ, Grant SG (2013), “Synaptic scaffold evolution generated components of vertebrate cognitive complexity.” Nat Neurosci 16(1):16-24 Details

Ryan TJ, Kopanitsa MV, Indersmitten T, Nithianantharajah J, Afinowi NO, Pettit C, Stanford LE, Sprengel R, Saksida LM, Bussey TJ, O'Dell TJ, Grant SG, Komiyama NH (2013), “Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior.” Nat Neurosci 16(1):25-32 Details

von Eichborn J, Dunkel M, Gohlke BO, Preissner SC, Hoffmann MF, Bauer JM, Armstrong JD, Schaefer MH, Andrade-Navarro MA, Le Novere N, Croning MD, Grant SG, van Nierop P, Smit AB, Preissner R (2013), “SynSysNet: integration of experimental data on synaptic protein-protein interactions with drug-target relations.” Nucleic Acids Res 41(Database issue):D834-40 Details

2012

Bayés A, Collins MO, Croning MD, van de Lagemaat LN, Choudhary JS, Grant SG (2012), “Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins.” PLoS One 7(10):e46683 Details

Buck KJ, Milner LC, Denmark DL, Grant SG, Kozell LB (2012), “Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models.” Alcohol Res 34(3):367-74 Details

Coba MP, Komiyama NH, Nithianantharajah J, Kopanitsa MV, Indersmitten T, Skene NG, Tuck EJ, Fricker DG, Elsegood KA, Stanford LE, Afinowi NO, Saksida LM, Bussey TJ, O'Dell TJ, Grant SG (2012), “TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function.” J Neurosci 32(40):13987-99 Details

Emes RD, Grant SG (2012), “Evolution of synapse complexity and diversity.” Annu Rev Neurosci 35:111-31 Details

Grant SG (2012), “Synaptopathies: diseases of the synaptome.” Curr Opin Neurobiol 22(3):522-9 Details

Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, van de Lagemaat LN, Smith KA, Ebbert A, Riley ZL, Abajian C, Beckmann CF, Bernard A, Bertagnolli D, Boe AF, Cartagena PM, Chakravarty MM, Chapin M, Chong J, Dalley RA, Daly BD, Dang C, Datta S, Dee N, Dolbeare TA, Faber V, Feng D, Fowler DR, Goldy J, Gregor BW, Haradon Z, Haynor DR, Hohmann JG, Horvath S, Howard RE, Jeromin A, Jochim JM, Kinnunen M, Lau C, Lazarz ET, Lee C, Lemon TA, Li L, Li Y, Morris JA, Overly CC, Parker PD, Parry SE, Reding M, Royall JJ, Schulkin J, Sequeira PA, Slaughterbeck CR, Smith SC, Sodt AJ, Sunkin SM, Swanson BE, Vawter MP, Williams D, Wohnoutka P, Zielke HR, Geschwind DH, Hof PR, Smith SM, Koch C, Grant SG, Jones AR (2012), “An anatomically comprehensive atlas of the adult human brain transcriptome.” Nature 489(7416):391-9 Details

Manakov SA, Morton A, Enright AJ, Grant SG (2012), “A Neuronal Transcriptome Response Involving Stress Pathways is Buffered by Neuronal microRNAs.” Front Neurosci 6:156 Details

Martel MA, Ryan TJ, Bell KF, Fowler JH, McMahon A, Al-Mubarak B, Komiyama NH, Horsburgh K, Kind PC, Grant SG, Wyllie DJ, Hardingham GE (2012), “The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.” Neuron 74(3):543-56 Details

2011

Àlex Bayés, Louie N. van de Lagemaat, Mark O. Collins, Mike D.R. Croning, Ian R. Whittle, Jyoti S. Choudhary & Seth G.N. Grant (2011), “Characterisation of the proteome diseases and evolution of the human postsynaptic density” Nature Neuroscience 14(1):19-2. PMID:21170055. doi: 10.1038/nn.2719.

Bayés A, van de Lagemaat LN, Collins MO, Croning MD, Whittle IR, Choudhary JS, Grant SG (2011), “Characterization of the proteome, diseases and evolution of the human postsynaptic density.” Nat Neurosci 14(1):19-21 Details

Camp MC, Feyder M, Ihne J, Palachick B, Hurd B, Karlsson RM, Noronha B, Chen YC, Coba MP, Grant SG, Holmes A (2011), “A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference.” Addict Biol 16(3):428-39 Details

Emes RD, Grant SG (2011), “The human postsynaptic density shares conserved elements with proteomes of unicellular eukaryotes and prokaryotes.” Front Neurosci 5:44 Details

Frank RA, McRae AF, Pocklington AJ, van de Lagemaat LN, Navarro P, Croning MD, Komiyama NH, Bradley SJ, Challiss RA, Armstrong JD, Finn RD, Malloy MP, MacLean AW, Harris SE, Starr JM, Bhaskar SS, Howard EK, Hunt SE, Coffey AJ, Ranganath V, Deloukas P, Rogers J, Muir WJ, Deary IJ, Blackwood DH, Visscher PM, Grant SG (2011), “Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder.” PLoS One 6(4):e19011 Details

George Kirov, Andrew J Pocklington, Peter Holmans, Dobril Ivanov, Masashi Ikeda, Douglas Ruderfer, Jennifer Moran, Kimberly Chambert, Luydmila Georgieva, Detelina Grozeva, Marija Fjodorova1, Rebecca Wollerton1, Ivan Nikolov, Louie N van de Lagemaat, Alex Bayes, Esperanza Fernandez, Noboru H. Komiyama, Mark O Collins, Jyoti Choudhary, Seth GN Grant, Shaun Purcell, Pamela Sklar, Michael C O’Donovan, Michael J Owen (2011), “De novo CNV analysis identifies specific abnormalities of synaptic function as primary pathogenic events in schizophrenia” Mol Psychiatry 1-12

MacLaren EJ, Charlesworth P, Coba MP, Grant SG (2011), “Knockdown of mental disorder susceptibility genes disrupts neuronal network physiology in vitro.” Mol Cell Neurosci 47(2):93-9 Details

Moody TD, Watabe AM, Indersmitten T, Komiyama NH, Grant SG, O'Dell TJ (2011), “Beta-adrenergic receptor activation rescues theta frequency stimulation-induced LTP deficits in mice expressing C-terminally truncated NMDA receptor GluN2A subunits.” Learn Mem 18(2):118-27 Details

Seth Grant and Alex Bayes (2011), “Postsynaptic Proteins Play a Major Role in Neurological and Psychiatric Disease” ACNR ISSN 1473-9348 July/August 2011 11(3) 13-14

Van Campenhout CA, Eitelhuber A, Gloeckner CJ, Giallonardo P, Gegg M, Oller H, Grant SG, Krappmann D, Ueffing, M. Licker H (2011), “Dlg traffing and apical tight junction formation is regulated by nedd 4 and nedd4-2 e3 ubiquitin ligases” Dev Cell. Sept 13,21(3):479-91

2010

Arbuckle MI, Komiyama NH, Delaney A, Coba M, Garry EM, Rosie R, Allchorne AJ, Forsyth LH, Bence M, Carlisle HJ, O'Dell TJ, Mitchell R, Fleetwood-Walker SM, Grant SG (2010), “The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment.” EMBO Rep 11(6):473-8 Details

Croning MD, Fricker DG, Komiyama NH, Grant SG (2010), “Automated design of genomic Southern blot probes.” BMC Genomics 11:74 Details

Delint-Ramirez I, Fernández E, Bayés A, Kicsi E, Komiyama NH, Grant SG (2010), “In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.” J Neurosci 30(24):8162-70 Details

Feyder M, Karlsson RM, Mathur P, Lyman M, Bock R, Momenan R, Munasinghe J, Scattoni ML, Ihne J, Camp M, Graybeal C, Strathdee D, Begg A, Alvarez VA, Kirsch P, Rietschel M, Cichon S, Walter H, Meyer-Lindenberg A, Grant SG, Holmes A (2010), “Association of Mouse Dlg4 (PSD-95) Gene Deletion and Human DLG4 Gene Variation With Phenotypes Relevant to Autism Spectrum Disorders and Williams' Syndrome.” Am J Psychiatry Details

Grant SG (2010), “Targeted TAP tags, phosphoproteomes and the biology of thought.” Expert Rev Proteomics 7(2):169-71 Details

Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, Schwarz JR, Holzbaur EL, Kneussel M (2010), “Neuroligin 1 is dynamically exchanged at postsynaptic sites.” J Neurosci 30(38):12733-44 Details

Tam GW, van de Lagemaat LN, Redon R, Strathdee KE, Croning MD, Malloy MP, Muir WJ, Pickard BS, Deary IJ, Blackwood DH, Carter NP, Grant SG (2010), “Confirmed rare copy number variants implicate novel genes in schizophrenia.” Biochem Soc Trans 38(2):445-51 Details

van de Lagemaat LN, Grant SG (2010), “Genome variation and complexity in the autism spectrum.” Neuron 67(1):8-10 Details

2009

Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, Roth BL (2009), “PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.” J Neurosci 29(22):7124-36 Details

Bayés A, Grant SG (2009), “Neuroproteomics: understanding the molecular organization and complexity of the brain.” Nat Rev Neurosci 10(9):635-46 Details

Coba MP, Pocklington AJ, Collins MO, Kopanitsa MV, Uren RT, Swamy S, Croning MD, Choudhary JS, Grant SG (2009), “Neurotransmitters drive combinatorial multistate postsynaptic density networks.” Sci Signal 2(68):ra19 Details

Croning MD, Marshall MC, McLaren P, Armstrong JD, Grant SG (2009), “G2Cdb: the Genes to Cognition database.” Nucleic Acids Res 37(Database issue):D846-51 Details

Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MD, Zografos L, Armstrong JD, Choudhary JS, Grant SG (2009), “Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.” Mol Syst Biol 5:269 Details

Manakov SA, Grant SG, Enright AJ (2009), “Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation.” BMC Genomics 10:419 Details

Ryan TJ, Grant SG (2009), “The origin and evolution of synapses.” Nat Rev Neurosci Details

Tam GW, Redon R, Carter NP, Grant SG (2009), “The role of DNA copy number variation in schizophrenia.” Biol Psychiatry 66(11):1005-12 Details

2008

Carlisle HJ, Fink AE, Grant SG, O'Dell TJ (2008), “Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.” J Physiol 586(Pt 24):5885-900 Details

Coba MP, Valor LM, Kopanitsa MV, Afinowi NO, Grant SG (2008), “Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus.” J Biol Chem 283(49):34101-7 Details

Collins MO, Yu L, Campuzano I, Grant SG, Choudhary JS (2008), “Phosphoproteomic analysis of the mouse brain cytosol reveals a predominance of protein phosphorylation in regions of intrinsic sequence disorder.” Mol Cell Proteomics 7(7):1331-48 Details

2007

Cuthbert PC, Stanford LE, Coba MP, Ainge JA, Fink AE, Opazo P, Delgado JY, Komiyama NH, O'Dell TJ, Grant SG (2007), “Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.” J Neurosci 27(10):2673-82 Details

Delgado JY, Coba M, Anderson CN, Thompson KR, Gray EE, Heusner CL, Martin KC, Grant SG, O'Dell TJ (2007), “NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840.” J Neurosci 27(48):13210-21 Details

Grant SG (2007), “Toward a molecular catalogue of synapses.” Brain Res Rev 55(2):445-9 Details

Laumonnier F, Cuthbert PC, Grant SG (2007), “The role of neuronal complexes in human X-linked brain diseases.” Am J Hum Genet 80(2):205-20 Details

Valor LM, Charlesworth P, Humphreys L, Anderson CN, Grant SG (2007), “Network activity-independent coordinated gene expression program for synapse assembly.” Proc Natl Acad Sci U S A 104(11):4658-63 Details

Valor LM, Grant SG (2007), “Clustered gene expression changes flank targeted gene loci in knockout mice.” PLoS One 2(12):e1303 Details

Zalfa F, Eleuteri B, Dickson KS, Mercaldo V, De Rubeis S, di Penta A, Tabolacci E, Chiurazzi P, Neri G, Grant SG, Bagni C (2007), “A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability.” Nat Neurosci 10(5):578-87 Details

2006

Anderson CN, Grant SG (2006), “High throughput protein expression screening in the nervous system--needs and limitations.” J Physiol 575(Pt 2):367-72 Details

Armstrong JD, Pocklington AJ, Cumiskey MA, Grant SG (2006), “Reconstructing protein complexes: from proteomics to systems biology.” Proteomics 6(17):4724-31 Details

Barnett MW, Watson RF, Vitalis T, Porter K, Komiyama NH, Stoney PN, Gillingwater TH, Grant SG, Kind PC (2006), “Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice.” J Neurosci 26(5):1355-65 Details

Collins MO, Husi H, Yu L, Brandon JM, Anderson CN, Blackstock WP, Choudhary JS, Grant SG (2006), “Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome.” J Neurochem 97 Suppl 1:16-23 Details

Kopanitsa MV, Afinowi NO, Grant SG (2006), “Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays.” BMC Neurosci 7:61 Details

Pocklington AJ, Cumiskey M, Armstrong JD, Grant SG (2006), “The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour.” Mol Syst Biol 2:2006.0023 Details

Strathdee D, Ibbotson H, Grant SG (2006), “Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent.” PLoS One 1:e4 Details

2005

Bence M, Arbuckle MI, Dickson KS, Grant SG (2005), “Analyses of murine postsynaptic density-95 identify novel isoforms and potential translational control elements.” Brain Res Mol Brain Res 133(1):143-52 Details

Collins MO, Yu L, Coba MP, Husi H, Campuzano I, Blackstock WP, Choudhary JS, Grant SG (2005), “Proteomic analysis of in vivo phosphorylated synaptic proteins.” J Biol Chem 280(7):5972-82 Details

Collins MO, Yu L, Husi H, Blackstock WP, Choudhary JS, Grant SG (2005), “Robust enrichment of phosphorylated species in complex mixtures by sequential protein and peptide metal-affinity chromatography and analysis by tandem mass spectrometry.” Sci STKE 2005(298):pl6 Details

Grant SG (2005), “AMPA receptor trafficking and GluR1.” Science 310(5746):234-5; author reply 234-5 Details

Grant SG, Marshall MC, Page KL, Cumiskey MA, Armstrong JD (2005), “Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases.” Hum Mol Genet 14 Spec No. 2:R225-34 Details

Porter K, Komiyama NH, Vitalis T, Kind PC, Grant SG (2005), “Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development.” Eur J Neurosci 21(2):351-62 Details

Toresson H, Grant SG (2005), “Dynamic distribution of endoplasmic reticulum in hippocampal neuron dendritic spines.” Eur J Neurosci 22(7):1793-8 Details

2004

Choudhary J, Grant SG (2004), “Proteomics in postgenomic neuroscience: the end of the beginning.” Nat Neurosci 7(5):440-5 Details

Hermjakob H, Montecchi-Palazzi L, Bader G, Wojcik J, Salwinski L, Ceol A, Moore S, Orchard S, Sarkans U, von Mering C, Roechert B, Poux S, Jung E, Mersch H, Kersey P, Lappe M, Li Y, Zeng R, Rana D, Nikolski M, Husi H, Brun C, Shanker K, Grant SG, Sander C, Bork P, Zhu W, Pandey A, Brazma A, Jacq B, Vidal M, Sherman D, Legrain P, Cesareni G, Xenarios I, Eisenberg D, Steipe B, Hogue C, Apweiler R (2004), “The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data.” Nat Biotechnol 22(2):177-83 Details

McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D, Chambon P, Grant SG, Frame MC (2004), “Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.” Genes Dev 18(24):2998-3003 Details

Yao WD, Gainetdinov RR, Arbuckle MI, Sotnikova TD, Cyr M, Beaulieu JM, Torres GE, Grant SG, Caron MG (2004), “Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity.” Neuron 41(4):625-38 Details