Professor Seth Grant
University position
Principal Investigator
Institutes
Genes to Cognition and Wellcome Trust Sanger Institute
Home page
http://www.genes2cognition.org/
Research Themes
Interests
The Genes to Cognition programme (G2C) established a framework for studying genes, brain and behaviour in order to link basic molecular research from genomes and experimental genetic organisms with human clinical studies of cognition. The G2C framework was developed around the current understanding of the molecular basis of learning & memory.
The G2C programme collects and integrates data in the areas of psychiatry, human and mouse psychology, cellular neurophysiology and cell biology, proteomics and biochemistry, molecular biology, human and mouse genetics and genomics.
Research Focus
Keywordslearning proteomics genetics plasticity neural circuit |
Clinical conditionsAlzheimer's disease Autism Bipolar disorder Cognitive impairment Dementia Learning disabilities Schizophrenia Stroke |
Equipment
No equipment indicated
Collaborators
Cambridge |
Key publications
Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD, Grant SG (2008), “Evolutionary expansion and anatomical specialization of synapse proteome complexity.” Nat Neurosci 11(7):799-806 Details
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000), “Proteomic analysis of NMDA receptor-adhesion protein signaling complexes” Nature Neuroscience 3:661-9
Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH, O'Dell TJ, Grant SG (1998), “Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.” Nature 396(6710):433-9 Details
Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER (1992), “Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.” Science 258(5090):1903-10 Details
Publications
2009
Bayés A, Grant SG (2009), “Neuroproteomics: understanding the molecular organization and complexity of the brain.” Nat Rev Neurosci 10(9):635-46 Details
Coba MP, Pocklington AJ, Collins MO, Kopanitsa MV, Uren RT, Swamy S, Croning MD, Choudhary JS, Grant SG (2009), “Neurotransmitters drive combinatorial multistate postsynaptic density networks.” Sci Signal 2(68):ra19 Details
Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MD, Zografos L, Armstrong JD, Choudhary JS, Grant SG (2009), “Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.” Mol Syst Biol 5:269 Details
Ryan TJ, Grant SG (2009), “The origin and evolution of synapses.” Nat Rev Neurosci Details
2008
Carlisle HJ, Fink AE, Grant SG, O'Dell TJ (2008), “Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.” J Physiol 586(Pt 24):5885-900 Details
2007
Cuthbert PC, Stanford LE, Coba MP, Ainge JA, Fink AE, Opazo P, Delgado JY, Komiyama NH, O'Dell TJ, Grant SG (2007), “Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.” J Neurosci 27(10):2673-82 Details
Zalfa F, Eleuteri B, Dickson KS, Mercaldo V, De Rubeis S, di Penta A, Tabolacci E, Chiurazzi P, Neri G, Grant SG, Bagni C (2007), “A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability.” Nat Neurosci 10(5):578-87 Details
2006
Pocklington AJ, Cumiskey M, Armstrong JD, Grant SG (2006), “The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour.” Mol Syst Biol 2:2006.0023 Details