Professor Seth Grant FRSE

Seth Grant

University position

Visiting Professor


Department of Psychology


Edinburgh University


Home page

Research Themes

Cellular and Molecular Neuroscience

Cognitive and Behavioural Neuroscience


The Genes to Cognition programme (G2C) established a framework for studying genes, brain and behaviour in order to link basic molecular research from genomes and experimental genetic organisms with human clinical studies of cognition. The G2C framework was developed around the current understanding of the molecular basis of learning & memory.

The G2C programme collects and integrates data in the areas of psychiatry, human and mouse psychology, cellular neurophysiology and cell biology, proteomics and biochemistry, molecular biology, human and mouse genetics and genomics.

Research Focus






neural circuit

Clinical conditions

Alzheimer's disease


Bipolar disorder

Cognitive impairment


Learning disabilities




No equipment indicated



Tim Bussey

Stephen Eglen

Gos Micklem

Trevor Robbins

Lisa Saksida

Nigel Unwin

Key publications

Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD, Grant SG (2008), “Evolutionary expansion and anatomical specialization of synapse proteome complexity.” Nat Neurosci 11(7):799-806 Details

Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000), “Proteomic analysis of NMDA receptor-adhesion protein signaling complexes” Nature Neuroscience 3:661-9

Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH, O'Dell TJ, Grant SG (1998), “Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.” Nature 396(6710):433-9 Details

Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER (1992), “Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.” Science 258(5090):1903-10 Details



Àlex Bayés, Louie N. van de Lagemaat, Mark O. Collins, Mike D.R. Croning, Ian R. Whittle, Jyoti S. Choudhary & Seth G.N. Grant (2011), “Characterisation of the proteome diseases and evolution of the human postsynaptic density” Nature Neuroscience 14(1):19-2. PMID:21170055. doi: 10.1038/nn.2719.

George Kirov, Andrew J Pocklington, Peter Holmans, Dobril Ivanov, Masashi Ikeda, Douglas Ruderfer, Jennifer Moran, Kimberly Chambert, Luydmila Georgieva, Detelina Grozeva, Marija Fjodorova1, Rebecca Wollerton1, Ivan Nikolov, Louie N van de Lagemaat, Alex Bayes, Esperanza Fernandez, Noboru H. Komiyama, Mark O Collins, Jyoti Choudhary, Seth GN Grant, Shaun Purcell, Pamela Sklar, Michael C O’Donovan, Michael J Owen (2011), “De novo CNV analysis identifies specific abnormalities of synaptic function as primary pathogenic events in schizophrenia” Mol Psychiatry 1-12

Seth Grant and Alex Bayes (2011), “Postsynaptic Proteins Play a Major Role in Neurological and Psychiatric Disease” ACNR ISSN 1473-9348 July/August 2011 11(3) 13-14

Van Campenhout CA, Eitelhuber A, Gloeckner CJ, Giallonardo P, Gegg M, Oller H, Grant SG, Krappmann D, Ueffing, M. Licker H (2011), “Dlg traffing and apical tight junction formation is regulated by nedd 4 and nedd4-2 e3 ubiquitin ligases” Dev Cell. Sept 13,21(3):479-91


Arbuckle MI, Komiyama NH, Delaney A, Coba M, Garry EM, Rosie R, Allchorne AJ, Forsyth LH, Bence M, Carlisle HJ, O'Dell TJ, Mitchell R, Fleetwood-Walker SM, Grant SG (2010), “The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment.” EMBO Rep 11(6):473-8 Details

Croning MD, Fricker DG, Komiyama NH, Grant SG (2010), “Automated design of genomic Southern blot probes.” BMC Genomics 11:74 Details

Delint-Ramirez I, Fernández E, Bayés A, Kicsi E, Komiyama NH, Grant SG (2010), “In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93.” J Neurosci 30(24):8162-70 Details

Feyder M, Karlsson RM, Mathur P, Lyman M, Bock R, Momenan R, Munasinghe J, Scattoni ML, Ihne J, Camp M, Graybeal C, Strathdee D, Begg A, Alvarez VA, Kirsch P, Rietschel M, Cichon S, Walter H, Meyer-Lindenberg A, Grant SG, Holmes A (2010), “Association of Mouse Dlg4 (PSD-95) Gene Deletion and Human DLG4 Gene Variation With Phenotypes Relevant to Autism Spectrum Disorders and Williams' Syndrome.” Am J Psychiatry Details

Grant SG (2010), “Targeted TAP tags, phosphoproteomes and the biology of thought.” Expert Rev Proteomics 7(2):169-71 Details

Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, Schwarz JR, Holzbaur EL, Kneussel M (2010), “Neuroligin 1 is dynamically exchanged at postsynaptic sites.” J Neurosci 30(38):12733-44 Details

Tam GW, van de Lagemaat LN, Redon R, Strathdee KE, Croning MD, Malloy MP, Muir WJ, Pickard BS, Deary IJ, Blackwood DH, Carter NP, Grant SG (2010), “Confirmed rare copy number variants implicate novel genes in schizophrenia.” Biochem Soc Trans 38(2):445-51 Details

van de Lagemaat LN, Grant SG (2010), “Genome variation and complexity in the autism spectrum.” Neuron 67(1):8-10 Details


Abbas AI, Yadav PN, Yao WD, Arbuckle MI, Grant SG, Caron MG, Roth BL (2009), “PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.” J Neurosci 29(22):7124-36 Details

Bayés A, Grant SG (2009), “Neuroproteomics: understanding the molecular organization and complexity of the brain.” Nat Rev Neurosci 10(9):635-46 Details

Coba MP, Pocklington AJ, Collins MO, Kopanitsa MV, Uren RT, Swamy S, Croning MD, Choudhary JS, Grant SG (2009), “Neurotransmitters drive combinatorial multistate postsynaptic density networks.” Sci Signal 2(68):ra19 Details

Croning MD, Marshall MC, McLaren P, Armstrong JD, Grant SG (2009), “G2Cdb: the Genes to Cognition database.” Nucleic Acids Res 37(Database issue):D846-51 Details

Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MD, Zografos L, Armstrong JD, Choudhary JS, Grant SG (2009), “Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.” Mol Syst Biol 5:269 Details

Manakov SA, Grant SG, Enright AJ (2009), “Reciprocal regulation of microRNA and mRNA profiles in neuronal development and synapse formation.” BMC Genomics 10:419 Details

Ryan TJ, Grant SG (2009), “The origin and evolution of synapses.” Nat Rev Neurosci Details

Tam GW, Redon R, Carter NP, Grant SG (2009), “The role of DNA copy number variation in schizophrenia.” Biol Psychiatry 66(11):1005-12 Details


Carlisle HJ, Fink AE, Grant SG, O'Dell TJ (2008), “Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.” J Physiol 586(Pt 24):5885-900 Details

Coba MP, Valor LM, Kopanitsa MV, Afinowi NO, Grant SG (2008), “Kinase networks integrate profiles of N-methyl-D-aspartate receptor-mediated gene expression in hippocampus.” J Biol Chem 283(49):34101-7 Details

Collins MO, Yu L, Campuzano I, Grant SG, Choudhary JS (2008), “Phosphoproteomic analysis of the mouse brain cytosol reveals a predominance of protein phosphorylation in regions of intrinsic sequence disorder.” Mol Cell Proteomics 7(7):1331-48 Details


Cuthbert PC, Stanford LE, Coba MP, Ainge JA, Fink AE, Opazo P, Delgado JY, Komiyama NH, O'Dell TJ, Grant SG (2007), “Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.” J Neurosci 27(10):2673-82 Details

Delgado JY, Coba M, Anderson CN, Thompson KR, Gray EE, Heusner CL, Martin KC, Grant SG, O'Dell TJ (2007), “NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840.” J Neurosci 27(48):13210-21 Details

Grant SG (2007), “Toward a molecular catalogue of synapses.” Brain Res Rev 55(2):445-9 Details

Laumonnier F, Cuthbert PC, Grant SG (2007), “The role of neuronal complexes in human X-linked brain diseases.” Am J Hum Genet 80(2):205-20 Details

Valor LM, Charlesworth P, Humphreys L, Anderson CN, Grant SG (2007), “Network activity-independent coordinated gene expression program for synapse assembly.” Proc Natl Acad Sci U S A 104(11):4658-63 Details

Valor LM, Grant SG (2007), “Clustered gene expression changes flank targeted gene loci in knockout mice.” PLoS One 2(12):e1303 Details

Zalfa F, Eleuteri B, Dickson KS, Mercaldo V, De Rubeis S, di Penta A, Tabolacci E, Chiurazzi P, Neri G, Grant SG, Bagni C (2007), “A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability.” Nat Neurosci 10(5):578-87 Details


Anderson CN, Grant SG (2006), “High throughput protein expression screening in the nervous system--needs and limitations.” J Physiol 575(Pt 2):367-72 Details

Armstrong JD, Pocklington AJ, Cumiskey MA, Grant SG (2006), “Reconstructing protein complexes: from proteomics to systems biology.” Proteomics 6(17):4724-31 Details

Barnett MW, Watson RF, Vitalis T, Porter K, Komiyama NH, Stoney PN, Gillingwater TH, Grant SG, Kind PC (2006), “Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice.” J Neurosci 26(5):1355-65 Details

Collins MO, Husi H, Yu L, Brandon JM, Anderson CN, Blackstock WP, Choudhary JS, Grant SG (2006), “Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome.” J Neurochem 97 Suppl 1:16-23 Details

Kopanitsa MV, Afinowi NO, Grant SG (2006), “Recording long-term potentiation of synaptic transmission by three-dimensional multi-electrode arrays.” BMC Neurosci 7:61 Details

Pocklington AJ, Cumiskey M, Armstrong JD, Grant SG (2006), “The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour.” Mol Syst Biol 2:2006.0023 Details

Strathdee D, Ibbotson H, Grant SG (2006), “Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent.” PLoS One 1:e4 Details


Bence M, Arbuckle MI, Dickson KS, Grant SG (2005), “Analyses of murine postsynaptic density-95 identify novel isoforms and potential translational control elements.” Brain Res Mol Brain Res 133(1):143-52 Details

Collins MO, Yu L, Coba MP, Husi H, Campuzano I, Blackstock WP, Choudhary JS, Grant SG (2005), “Proteomic analysis of in vivo phosphorylated synaptic proteins.” J Biol Chem 280(7):5972-82 Details

Collins MO, Yu L, Husi H, Blackstock WP, Choudhary JS, Grant SG (2005), “Robust enrichment of phosphorylated species in complex mixtures by sequential protein and peptide metal-affinity chromatography and analysis by tandem mass spectrometry.” Sci STKE 2005(298):pl6 Details

Grant SG (2005), “AMPA receptor trafficking and GluR1.” Science 310(5746):234-5; author reply 234-5 Details

Grant SG, Marshall MC, Page KL, Cumiskey MA, Armstrong JD (2005), “Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases.” Hum Mol Genet 14 Spec No. 2:R225-34 Details

Porter K, Komiyama NH, Vitalis T, Kind PC, Grant SG (2005), “Differential expression of two NMDA receptor interacting proteins, PSD-95 and SynGAP during mouse development.” Eur J Neurosci 21(2):351-62 Details

Toresson H, Grant SG (2005), “Dynamic distribution of endoplasmic reticulum in hippocampal neuron dendritic spines.” Eur J Neurosci 22(7):1793-8 Details


Choudhary J, Grant SG (2004), “Proteomics in postgenomic neuroscience: the end of the beginning.” Nat Neurosci 7(5):440-5 Details

Hermjakob H, Montecchi-Palazzi L, Bader G, Wojcik J, Salwinski L, Ceol A, Moore S, Orchard S, Sarkans U, von Mering C, Roechert B, Poux S, Jung E, Mersch H, Kersey P, Lappe M, Li Y, Zeng R, Rana D, Nikolski M, Husi H, Brun C, Shanker K, Grant SG, Sander C, Bork P, Zhu W, Pandey A, Brazma A, Jacq B, Vidal M, Sherman D, Legrain P, Cesareni G, Xenarios I, Eisenberg D, Steipe B, Hogue C, Apweiler R (2004), “The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data.” Nat Biotechnol 22(2):177-83 Details

McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D, Chambon P, Grant SG, Frame MC (2004), “Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.” Genes Dev 18(24):2998-3003 Details

Yao WD, Gainetdinov RR, Arbuckle MI, Sotnikova TD, Cyr M, Beaulieu JM, Torres GE, Grant SG, Caron MG (2004), “Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity.” Neuron 41(4):625-38 Details