Professor Seth Grant

Seth Grant

University position

Principal Investigator

Institutes

Genes to Cognition and Wellcome Trust Sanger Institute

Email

sg3@sanger.ac.uk

Home page

http://www.genes2cognition.org/

Research Themes

Cellular and Molecular Neuroscience

Cognitive and Behavioural Neuroscience

Interests

The Genes to Cognition programme (G2C) established a framework for studying genes, brain and behaviour in order to link basic molecular research from genomes and experimental genetic organisms with human clinical studies of cognition. The G2C framework was developed around the current understanding of the molecular basis of learning & memory.

The G2C programme collects and integrates data in the areas of psychiatry, human and mouse psychology, cellular neurophysiology and cell biology, proteomics and biochemistry, molecular biology, human and mouse genetics and genomics.

Research Focus

Keywords

learning

proteomics

genetics

plasticity

neural circuit

Clinical conditions

Alzheimer's disease

Autism

Bipolar disorder

Cognitive impairment

Dementia

Learning disabilities

Schizophrenia

Stroke

Equipment

No equipment indicated

Collaborators

Cambridge

Tim Bussey

Stephen Eglen

Gos Micklem

Trevor Robbins

Lisa Saksida

Nigel Unwin

Key publications

Emes RD, Pocklington AJ, Anderson CN, Bayes A, Collins MO, Vickers CA, Croning MD, Malik BR, Choudhary JS, Armstrong JD, Grant SG (2008), “Evolutionary expansion and anatomical specialization of synapse proteome complexity.” Nat Neurosci 11(7):799-806 Details

Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (2000), “Proteomic analysis of NMDA receptor-adhesion protein signaling complexes” Nature Neuroscience 3:661-9

Migaud M, Charlesworth P, Dempster M, Webster LC, Watabe AM, Makhinson M, He Y, Ramsay MF, Morris RG, Morrison JH, O'Dell TJ, Grant SG (1998), “Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.” Nature 396(6710):433-9 Details

Grant SG, O'Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER (1992), “Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice.” Science 258(5090):1903-10 Details

Publications

2009

Bayés A, Grant SG (2009), “Neuroproteomics: understanding the molecular organization and complexity of the brain.” Nat Rev Neurosci 10(9):635-46 Details

Coba MP, Pocklington AJ, Collins MO, Kopanitsa MV, Uren RT, Swamy S, Croning MD, Choudhary JS, Grant SG (2009), “Neurotransmitters drive combinatorial multistate postsynaptic density networks.” Sci Signal 2(68):ra19 Details

Fernández E, Collins MO, Uren RT, Kopanitsa MV, Komiyama NH, Croning MD, Zografos L, Armstrong JD, Choudhary JS, Grant SG (2009), “Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.” Mol Syst Biol 5:269 Details

Ryan TJ, Grant SG (2009), “The origin and evolution of synapses.” Nat Rev Neurosci Details

2008

Carlisle HJ, Fink AE, Grant SG, O'Dell TJ (2008), “Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.” J Physiol 586(Pt 24):5885-900 Details

2007

Cuthbert PC, Stanford LE, Coba MP, Ainge JA, Fink AE, Opazo P, Delgado JY, Komiyama NH, O'Dell TJ, Grant SG (2007), “Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies.” J Neurosci 27(10):2673-82 Details

Zalfa F, Eleuteri B, Dickson KS, Mercaldo V, De Rubeis S, di Penta A, Tabolacci E, Chiurazzi P, Neri G, Grant SG, Bagni C (2007), “A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability.” Nat Neurosci 10(5):578-87 Details

2006

Pocklington AJ, Cumiskey M, Armstrong JD, Grant SG (2006), “The proteomes of neurotransmitter receptor complexes form modular networks with distributed functionality underlying plasticity and behaviour.” Mol Syst Biol 2:2006.0023 Details