Professor Sarah Lummis

Sarah Lummis

University position

Professor

Professor Sarah Lummis is pleased to consider applications from prospective PhD students.

Departments

Department of Biochemistry

Home page

http://www.bioc.cam.ac.uk/uto/lum...

Research Theme

Cellular and Molecular Neuroscience

Interests

My lab works on Cys-loop receptors, which are one of the major classes of ligand-gated ion channels. The family includes in its vertebrate members 5-HT3, nACh, GABAA, GABAC, and glycine receptors. Proteins from this family are critical for fast synaptic transmission, and are also the major target site for many active compounds including anaesthetics, muscle relaxants, insecticides and a range of drugs that treat neurological disorders including Alzheimer's disease, anxiety, epilepsy, learning and attention deficit, and drug addiction. Rational design of more effective drugs requires a detailed molecular knowledge of the sites at which they act, but current information in this area lags well behind that for many other proteins. The aim of our research is to understand the structure and mechanism of action of this family of neurotransmitter-gated ion channels.

5-HT docked into the 5-HT3 receptor binding site
5-HT docked into the 5-HT3 receptor binding site
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Research Focus

Keywords

neurotransmitter

receptor

Cys-loop

Clinical conditions

No direct clinical relevance

Equipment

Cell culture

Computational modelling

Electrophysiology

Protein expression

Radioligand binding

Collaborators

No collaborators listed

Associated News Items


    Key publications

    Thompson AJ, Lummis SCR (2006), “Membrane channels as therapeutic targets: 5-HT3 receptors” Current Pharmaceutical Design 12:24-49

    Thompson AJ, Sullivan N, Lummis SCR (2006), “Characterisation of 5-HT3 receptor mutations identified in schizophrenic patients” J Molecular Neuroscience 30:7-16

    Lummis SCR, Beene DL, Lee LW, Lester HA, Broadhurst RW, Dougherty DA (2005), “Cis-trans isomerisation of a proline opens the pore of a neurotransmitter-gated ion channel” Nature 438(7065):248-52

    Publications

    2014

    Comitani F, Cohen N, Ashby J, Botten D, Lummis SC, Molteni C (2014), “Insights into the binding of GABA to the insect RDL receptor from atomistic simulations: a comparison of models.” J Comput Aided Mol Des Details

    2013

    Del Cadia M, De Rienzo F, Weston DA, Thompson AJ, Menziani MC, Lummis SC (2013), “Exploring a potential palonosetron allosteric binding site in the 5-HT(3) receptor.” Bioorg Med Chem 21(23):7523-8 Details

    Kessler A, Sahin-Nadeem H, Lummis SC, Weigel I, Pischetsrieder M, Buettner A, Villmann C (2013), “GABAA receptor modulation by terpenoids from Sideritis extracts.” Mol Nutr Food Res Details

    Kesters D, Thompson AJ, Brams M, van Elk R, Spurny R, Geitmann M, Villalgordo JM, Guskov A, Danielson UH, Lummis SC, Smit AB, Ulens C (2013), “Structural basis of ligand recognition in 5-HT3 receptors.” EMBO Rep 14(1):49-56 Details

    Lummis SC, Thompson AJ (2013), “Agonists and antagonists induce different palonosetron dissociation rates in 5-HT₃A and 5-HT₃AB receptors.” Neuropharmacology 73:241-6 Details

    O'Brien JA, Lummis SC (2013), “Biolistic transfection of neurons in organotypic brain slices.” Methods Mol Biol 940:157-66 Details

    Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C (2013), “Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).” J Biol Chem 288(12):8355-64 Details

    Thompson AJ, Lummis SC (2013), “A single channel mutation alters agonist efficacy at 5-HT3A and 5-HT3AB receptors.” Br J Pharmacol 170(2):391-402 Details

    Thompson AJ, Lummis SC (2013), “Discriminating between 5-HT(3)A and 5-HT(3)AB receptors.” Br J Pharmacol 169(4):736-47 Details

    Thompson AJ, Verheij MH, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ (2013), “Structure-activity relationships of quinoxaline-based 5-HT3A and 5-HT3AB receptor-selective ligands.” ChemMedChem 8(6):946-55 Details

    2012

    Akdemir A, Edink E, Thompson AJ, Lummis SC, Kooistra AJ, de Graaf C, de Esch IJ (2012), “Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain.” Bioorg Med Chem 20(19):5992-6002 Details

    Ashby JA, McGonigle IV, Price KL, Cohen N, Comitani F, Dougherty DA, Molteni C, Lummis SC (2012), “GABA binding to an insect GABA receptor: a molecular dynamics and mutagenesis study.” Biophys J 103(10):2071-81 Details

    Huang SH, Lewis TM, Lummis SC, Thompson AJ, Chebib M, Johnston GA, Duke RK (2012), “Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors.” Neuropharmacology 63(6):1127-39 Details

    Lummis SC (2012), “5-HT(3) receptors.” J Biol Chem 287(48):40239-45 Details

    Lummis SC, Harrison NJ, Wang J, Ashby JA, Millen KS, Beene DL, Dougherty DA (2012), “Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket.” ACS Chem Neurosci 3(3):186-192 Details

    Simonin J, Vernekar SK, Thompson AJ, Hothersall JD, Connolly CN, Lummis SC, Lochner M (2012), “High-affinity fluorescent ligands for the 5-HT(3) receptor.” Bioorg Med Chem Lett 22(2):1151-5 Details

    Spurny R, Ramerstorfer J, Price K, Brams M, Ernst M, Nury H, Verheij M, Legrand P, Bertrand D, Bertrand S, Dougherty DA, de Esch IJ, Corringer PJ, Sieghart W, Lummis SC, Ulens C (2012), “Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines.” Proc Natl Acad Sci U S A 109(44):E3028-34 Details

    Thompson AJ, Alqazzaz M, Ulens C, Lummis SC (2012), “The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor.” Neuropharmacology 63(4):761-7 Details

    Thompson AJ, McGonigle I, Duke R, Johnston GA, Lummis SC (2012), “A single amino acid determines the toxicity of Ginkgo biloba extracts.” FASEB J 26(5):1884-91 Details

    Thompson AJ, Verheij MH, de Esch IJ, Lummis SC (2012), “VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors.” J Pharmacol Exp Ther 341(2):350-9 Details

    Utkin YN, Weise C, Kasheverov IE, Andreeva TV, Kryukova EV, Zhmak MN, Starkov VG, Hoang NA, Bertrand D, Ramerstorfer J, Sieghart W, Thompson AJ, Lummis SC, Tsetlin VI (2012), “Azemiopsin from Azemiops feae viper venom, a novel polypeptide ligand of nicotinic acetylcholine receptor.” J Biol Chem 287(32):27079-86 Details

    Verheij MH, Thompson AJ, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ (2012), “Design, synthesis, and structure-activity relationships of highly potent 5-HT₃ receptor ligands.” J Med Chem 55(20):8603-14 Details

    2011

    Alqazzaz M, Thompson AJ, Price KL, Breitinger HG, Lummis SC (2011), “Cys-loop receptor channel blockers also block GLIC.” Biophys J 101(12):2912-8 Details

    Lummis SC, McGonigle I, Ashby JA, Dougherty DA (2011), “Two amino acid residues contribute to a cation-π binding interaction in the binding site of an insect GABA receptor.” J Neurosci 31(34):12371-6 Details

    Lummis SC, Thompson AJ, Bencherif M, Lester HA (2011), “Varenicline is a potent agonist of the human 5-hydroxytryptamine3 receptor.” J Pharmacol Exp Ther 339(1):125-31 Details

    O'Brien JA, Lummis SC (2011), “Nano-biolistics: a method of biolistic transfection of cells and tissues using a gene gun with novel nanometer-sized projectiles.” BMC Biotechnol 11:66 Details

    Pless SA, Hanek AP, Price KL, Lynch JW, Lester HA, Dougherty DA, Lummis SC (2011), “A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.” Mol Pharmacol 79(4):742-8 Details

    Thompson AJ, Duke RK, Lummis SC (2011), “Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor.” Mol Pharmacol 80(1):183-90 Details

    Thompson AJ, Jarvis GE, Duke RK, Johnston GA, Lummis SC (2011), “Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site.” Neuropharmacology 60(2-3):488-95 Details

    Thompson AJ, Price KL, Lummis SC (2011), “Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors.” J Physiol 589(Pt 17):4243-57 Details

    Verheij MH, de Graaf C, de Kloe GE, Nijmeijer S, Vischer HF, Smits RA, Zuiderveld OP, Hulscher S, Silvestri L, Thompson AJ, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ (2011), “Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.” Bioorg Med Chem Lett 21(18):5460-4 Details

    Wheeler DW, Thompson AJ, Corletto F, Reckless J, Loke JC, Lapaque N, Grant AJ, Mastroeni P, Grainger DJ, Padgett CL, O'Brien JA, Miller NG, Trowsdale J, Lummis SC, Menon DK, Beech JS (2011), “Anaesthetic impairment of immune function is mediated via GABA(A) receptors.” PLoS One 6(2):e17152 Details

    2010

    Lochner M, Lummis SC (2010), “Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor.” Biophys J 98(8):1494-502 Details

    McGonigle I, Lummis SC (2010), “Molecular characterization of agonists that bind to an insect GABA receptor.” Biochemistry 49(13):2897-902 Details

    Quek GX, Lin D, Halliday JI, Absalom N, Ambrus JI, Thompson AJ, Lochner M, Lummis SC, McLeod MD, Chebib M (2010), “Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors.” ACS Chem Neurosci 1(12):796-809 Details

    Thompson AJ, Lester HA, Lummis SC (2010), “The structural basis of function in Cys-loop receptors.” Q Rev Biophys :1-51 Details

    Thompson AJ, Verheij MH, Leurs R, De Esch IJ, Lummis SC (2010), “An efficient and information-rich biochemical method design for fragment library screening on ion channels.” Biotechniques 49(5):822-9 Details

    Vernekar SK, Hallaq HY, Clarkson G, Thompson AJ, Silvestri L, Lummis SC, Lochner M (2010), “Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives.” J Med Chem 53(5):2324-8 Details

    2009

    Barnes NM, Hales TG, Lummis SC, Peters JA (2009), “The 5-HT3 receptor--the relationship between structure and function.” Neuropharmacology 56(1):273-84 Details

    Bartos M, Price KL, Lummis SC, Bouzat C (2009), “Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors.” J Biol Chem 284(32):21478-87 Details

    Lummis SC (2009), “Locating GABA in GABA receptor binding sites.” Biochem Soc Trans 37(Pt 6):1343-6 Details

    McGonigle I, Lummis SC (2009), “RDL receptors.” Biochem Soc Trans 37(Pt 6):1404-6 Details

    Melis C, Bussi G, Lummis SC, Molteni C (2009), “Trans-cis switching mechanisms in proline analogues and their relevance for the gating of the 5-HT3 receptor.” J Phys Chem B 113(35):12148-53 Details

    Thompson AJ, Lummis SC (2009), “Calcium modulation of 5-HT3 receptor binding and function.” Neuropharmacology 56(1):285-91 Details

    2008

    Bower KS, Price KL, Sturdee LE, Dayrell M, Dougherty DA, Lummis SC (2008), “5-Fluorotryptamine is a partial agonist at 5-HT3 receptors, and reveals that size and electronegativity at the 5 position of tryptamine are critical for efficient receptor function.” Eur J Pharmacol 580(3):291-7 Details

    Melis C, Lummis SC, Molteni C (2008), “Molecular dynamics simulations of GABA binding to the GABAC receptor: the role of Arg104.” Biophys J 95(9):4115-23 Details

    Padgett CL, Lummis SC (2008), “The F-loop of the GABA A receptor gamma2 subunit contributes to benzodiazepine modulation.” J Biol Chem 283(5):2702-8 Details

    Pless SA, Millen KS, Hanek AP, Lynch JW, Lester HA, Lummis SC, Dougherty DA (2008), “A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue.” J Neurosci 28(43):10937-42 Details

    Price KL, Bower KS, Thompson AJ, Lester HA, Dougherty DA, Lummis SC (2008), “A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor.” Biochemistry 47(24):6370-7 Details

    Thompson AJ, Lochner M, Lummis SC (2008), “Loop B is a major structural component of the 5-HT3 receptor.” Biophys J 95(12):5728-36 Details

    Thompson AJ, Lummis SC (2008), “Antimalarial drugs inhibit human 5-HT(3) and GABA(A) but not GABA(C) receptors.” Br J Pharmacol 153(8):1686-96 Details

    2007

    O'Brien JA, Lummis SC (2007), “Diolistics: incorporating fluorescent dyes into biological samples using a gene gun.” Trends Biotechnol 25(11):530-4 Details

    Padgett CL, Hanek AP, Lester HA, Dougherty DA, Lummis SC (2007), “Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97.” J Neurosci 27(4):886-92 Details

    Price KL, Millen KS, Lummis SC (2007), “Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors.” J Biol Chem 282(35):25623-30 Details

    Thompson AJ, Lochner M, Lummis SC (2007), “The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors.” Br J Pharmacol 151(5):666-77 Details

    Thompson AJ, Lummis SC (2007), “The 5-HT3 receptor as a therapeutic target.” Expert Opin Ther Targets 11(4):527-40 Details

    2006

    Harrison NJ, Lummis SC (2006), “Locating the carboxylate group of GABA in the homomeric rho GABA(A) receptor ligand-binding pocket.” J Biol Chem 281(34):24455-61 Details

    Harrison NJ, Lummis SC (2006), “Molecular modeling of the GABA(C) receptor ligand-binding domain.” J Mol Model 12(3):317-24 Details

    Melis C, Chau PL, Price KL, Lummis SC, Molteni C (2006), “Exploring the binding of serotonin to the 5-HT3 receptor by density functional theory.” J Phys Chem B 110(51):26313-9 Details

    O'Brien JA, Lummis SC (2006), “Diolistic labeling of neuronal cultures and intact tissue using a hand-held gene gun.” Nat Protoc 1(3):1517-21 Details

    O'Brien JA, Lummis SC (2006), “Biolistic transfection of neuronal cultures using a hand-held gene gun.” Nat Protoc 1(2):977-81 Details

    Reeves DC, Lummis SC (2006), “Detection of human and rodent 5-HT3B receptor subunits by anti-peptide polyclonal antibodies.” BMC Neurosci 7:27 Details

    Sullivan NL, Thompson AJ, Price KL, Lummis SC (2006), “Defining the roles of Asn-128, Glu-129 and Phe-130 in loop A of the 5-HT3 receptor.” Mol Membr Biol 23(5):442-51 Details

    Thompson AJ, Chau PL, Chan SL, Lummis SC (2006), “Unbinding pathways of an agonist and an antagonist from the 5-HT3 receptor.” Biophys J 90(6):1979-91 Details

    Thompson AJ, Lummis SC (2006), “5-HT3 receptors.” Curr Pharm Des 12(28):3615-30 Details

    Thompson AJ, Padgett CL, Lummis SC (2006), “Mutagenesis and molecular modeling reveal the importance of the 5-HT3 receptor F-loop.” J Biol Chem 281(24):16576-82 Details

    Thompson AJ, Sullivan NL, Lummis SC (2006), “Characterization of 5-HT3 receptor mutations identified in schizophrenic patients.” J Mol Neurosci 30(3):273-81 Details

    2005

    Laude AJ, Tovey SC, Dedos SG, Potter BV, Lummis SC, Taylor CW (2005), “Rapid functional assays of recombinant IP3 receptors.” Cell Calcium 38(1):45-51 Details

    Lummis SC, Beene DL, Lee LW, Lester HA, Broadhurst RW, Dougherty DA (2005), “Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.” Nature 438(7065):248-52 Details

    Lummis SC, L Beene D, Harrison NJ, Lester HA, Dougherty DA (2005), “A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor.” Chem Biol 12(9):993-7 Details

    Price KL, Lummis SC (2005), “FlexStation examination of 5-HT3 receptor function using Ca2+ - and membrane potential-sensitive dyes: advantages and potential problems.” J Neurosci Methods 149(2):172-7 Details

    Thompson AJ, Price KL, Reeves DC, Chan SL, Chau PL, Lummis SC (2005), “Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding.” J Biol Chem 280(21):20476-82 Details

    2004

    Beene DL, Price KL, Lester HA, Dougherty DA, Lummis SC (2004), “Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis.” J Neurosci 24(41):9097-104 Details

    Lummis SC (2004), “The transmembrane domain of the 5-HT3 receptor: its role in selectivity and gating.” Biochem Soc Trans 32(Pt3):535-9 Details

    O'Brien J, Lummis SC (2004), “Biolistic and diolistic transfection: using the gene gun to deliver DNA and lipophilic dyes into mammalian cells.” Methods 33(2):121-5 Details

    Price KL, Lummis SC (2004), “The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor.” J Biol Chem 279(22):23294-301 Details

    2003

    Reeves DC, Sayed MF, Chau PL, Price KL, Lummis SC (2003), “Prediction of 5-HT3 receptor agonist-binding residues using homology modeling.” Biophys J 84(4):2338-44 Details

    Thompson AJ, Lummis SC (2003), “A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptor.” Br J Pharmacol 140(2):359-65 Details

    2002

    Greenfield LJ Jr, Zaman SH, Sutherland ML, Lummis SC, Niemeyer MI, Barnard EA, Macdonald RL (2002), “Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement.” Neuropharmacology 42(4):502-21 Details

    Lummis SC, Fletcher EJ, Green T (2002), “Identification of a new site in the S1 ligand binding region of the NMDA receptor NR2A subunit involved in receptor activation by glutamate.” Neuropharmacology 42(4):437-43 Details

    O'Brien J, Lummis SC (2002), “An improved method of preparing microcarriers for biolistic transfection.” Brain Res Brain Res Protoc 10(1):12-5 Details

    Reeves DC, Lummis SC (2002), “The molecular basis of the structure and function of the 5-HT3 receptor: a model ligand-gated ion channel (review).” Mol Membr Biol 19(1):11-26 Details

    Spier AD, Lummis SC (2002), “Immunological characterization of 5-HT3 receptor transmembrane topology.” J Mol Neurosci 18(3):169-78 Details

    2001

    Deane CM, Lummis SC (2001), “The role and predicted propensity of conserved proline residues in the 5-HT3 receptor.” J Biol Chem 276(41):37962-6 Details

    Gunthorpe MJ, Lummis SC (2001), “Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.” J Biol Chem 276(24):10977-83 Details

    Gunthorpe MJ, Lummis SC (2001), “Conversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.” J Biol Chem 276(14):10977-83 Details

    Niemeyer MI, Lummis SC (2001), “The role of the agonist binding site in Ca(2+) inhibition of the recombinant 5-HT(3A) receptor.” Eur J Pharmacol 428(2):153-61 Details

    O'Brien JA, Holt M, Whiteside G, Lummis SC, Hastings MH (2001), “Modifications to the hand-held Gene Gun: improvements for in vitro biolistic transfection of organotypic neuronal tissue.” J Neurosci Methods 112(1):57-64 Details

    Reeves DC, Goren EN, Akabas MH, Lummis SC (2001), “Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis.” J Biol Chem 276(45):42035-42 Details

    2000

    Gunthorpe MJ, Peters JA, Gill CH, Lambert JJ, Lummis SC (2000), “The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors.” J Physiol 522 Pt 2:187-98 Details

    Hubbard PC, Lummis SC (2000), “Zn(2+) enhancement of the recombinant 5-HT(3) receptor is modulated by divalent cations.” Eur J Pharmacol 394(2-3):189-97 Details

    Hubbard PC, Thompson AJ, Lummis SC (2000), “Functional differences between splice variants of the murine 5-HT(3A) receptor: possible role for phosphorylation.” Brain Res Mol Brain Res 81(1-2):101-8 Details

    Nayak SV, Rondé P, Spier AD, Lummis SC, Nichols RA (2000), “Nicotinic receptors co-localize with 5-HT(3) serotonin receptors on striatal nerve terminals.” Neuropharmacology 39(13):2681-90 Details

    Spier AD, Lummis SC (2000), “The role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain.” J Biol Chem 275(8):5620-5 Details

    Vandenberg JI, Lummis SC (2000), “Ion channels--a plethora of pharmaceutical targets.” Trends Pharmacol Sci 21(11):409-10 Details

    1999

    Gunthorpe MJ, Lummis SC (1999), “Diltiazem causes open channel block of recombinant 5-HT3 receptors.” J Physiol 519 Pt 3:713-22 Details

    Nayak SV, Rondé P, Spier AD, Lummis SC, Nichols RA (1999), “Calcium changes induced by presynaptic 5-hydroxytryptamine-3 serotonin receptors on isolated terminals from various regions of the rat brain.” Neuroscience 91(1):107-17 Details

    Spier AD, Wotherspoon G, Nayak SV, Nichols RA, Priestley JV, Lummis SC (1999), “Antibodies against the extracellular domain of the 5-HT3 receptor label both native and recombinant receptors.” Brain Res Mol Brain Res 67(2):221-30 Details

    1998

    Niemeyer MI, Lummis SC (1998), “Different efficacy of specific agonists at 5-HT3 receptor splice variants: the role of the extra six amino acid segment.” Br J Pharmacol 123(4):661-6 Details

    van Hooft JA, Spier AD, Yakel JL, Lummis SC, Vijverberg HP (1998), “Promiscuous coassembly of serotonin 5-HT3 and nicotinic alpha4 receptor subunits into Ca(2+)-permeable ion channels.” Proc Natl Acad Sci U S A 95(19):11456-61 Details

    1997

    Lummis SC, Baker J (1997), “Radioligand binding and photoaffinity labelling studies show a direct interaction of phenothiazines at 5-HT3 receptors.” Neuropharmacology 36(4-5):665-70 Details

    1996

    Hargreaves AC, Gunthorpe MJ, Taylor CW, Lummis SC (1996), “Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels.” Mol Pharmacol 50(5):1284-94 Details

    1995

    Buckingham SD, Balk ML, Lummis SC, Jewess P, Sattelle DB (1995), “Actions of nitromethylenes on an alpha-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptor.” Neuropharmacology 34(6):591-7 Details

    Green T, Stauffer KA, Lummis SC (1995), “Expression of recombinant homo-oligomeric 5-hydroxytryptamine3 receptors provides new insights into their maturation and structure.” J Biol Chem 270(11):6056-61 Details

    1994

    Hargreaves AC, Lummis SC, Taylor CW (1994), “Ca2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors.” Mol Pharmacol 46(6):1120-8 Details

    Sepúlveda MI, Baker J, Lummis SC (1994), “Chlorpromazine and QX222 block 5-HT3 receptors in N1E-115 neuroblastoma cells.” Neuropharmacology 33(3-4):493-9 Details

    1993

    Buckingham SD, Lummis SC, Balk ML, Schroeder M, Sattelle DB (1993), “Actions of vesamicol on an alpha-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptor.” J Exp Biol 182:255-64 Details

    Lummis SC, Sepúlveda MI, Kilpatrick GJ, Baker J (1993), “Characterization of [3H]meta-chlorophenylbiguanide binding to 5-HT3 receptors in N1E-115 neuroblastoma cells.” Eur J Pharmacol 243(1):7-11 Details

    1992

    Boess FG, Lummis SC, Martin IL (1992), “Molecular properties of 5-hydroxytryptamine3 receptor-type binding sites purified from NG108-15 cells.” J Neurochem 59(5):1692-701 Details

    Boess FG, Sepúlveda MI, Lummis SC, Martin IL (1992), “5-HT3 receptors in NG108-15 neuroblastoma x glioma cells: effect of the novel agonist 1-(m-chlorophenyl)-biguanide.” Neuropharmacology 31(6):561-4 Details

    Lummis SC, Buckingham SD, Balk ML, Holyoke CW Jr, Sattelle DB (1992), “Actions of a series of bisquaternary compounds on nicotinic acetylcholine receptors in insects: ligand binding and electrophysiological studies.” Neuropharmacology 31(4):379-82 Details

    Lummis SC, Martin IL (1992), “Solubilization, purification, and functional reconstitution of 5-hydroxytryptamine3 receptors from N1E-115 neuroblastoma cells.” Mol Pharmacol 41(1):18-23 Details

    1991

    Lummis SC, Nicoletti G, Johnston GA, Holan G (1991), “Gamma-aminobutyric acid-modulated benzodiazepine binding sites in bacteria.” Life Sci 49(15):1079-86 Details

    Sattelle DB, Lummis SC, Wong JF, Rauh JJ (1991), “Pharmacology of insect GABA receptors.” Neurochem Res 16(3):363-74 Details

    Sepúlveda MI, Lummis SC, Martin IL (1991), “The agonist properties of m-chlorophenylbiguanide and 2-methyl-5-hydroxytryptamine on 5-HT3 receptors in N1E-115 neuroblastoma cells.” Br J Pharmacol 104(2):536-40 Details

    Whicker SD, Lummis SC, Black JL (1991), “Beta-adrenoceptors in human airway tissue: relationship between functional responsiveness and receptor number.” Life Sci 49(14):1021-9 Details

    1990

    Lummis SC (1990), “GABA receptors in insects.” Comp Biochem Physiol C 95(1):1-8 Details

    Lummis SC, Buckingham SD, Rauh JJ, Sattelle DB (1990), “Blocking actions of heptachlor at an insect central nervous system GABA receptor.” Proc R Soc Lond B Biol Sci 240(1297):97-106 Details

    Lummis SC, Gundlach AL, Johnston GA, Harper PA, Dodd PR (1990), “Increased gamma-aminobutyric acid receptor function in the cerebral cortex of myoclonic calves with an hereditary deficit in glycine/strychnine receptors.” J Neurochem 55(2):421-6 Details

    Lummis SC, Kilpatrick GJ, Martin IL (1990), “Characterization of 5-HT3 receptors in intact N1E-115 neuroblastoma cells.” Eur J Pharmacol 189(2-3):223-7 Details

    Lummis SC, Martin IL (1990), “Characterization of soluble 5-hydroxytryptamine3 receptors from N1E115 neuroblastoma cells.” Biochem Soc Trans 18(5):1027-8 Details

    Lummis SC, Nielsen M, Kilpatrick GJ, Martin IL (1990), “Target size of 5-HT3 receptors in N1E-115 neuroblastoma cells and rat brain.” Eur J Pharmacol 189(2-3):229-32 Details

    Rauh JJ, Lummis SC, Sattelle DB (1990), “Pharmacological and biochemical properties of insect GABA receptors.” Trends Pharmacol Sci 11(8):325-9 Details

    1989

    Lummis SC, Sattelle DB (1989), “Insect nervous system [(3)H]saxitoxin binding sites: characterization and target size.” Neurochem Int 15(4):391-5 Details

    Wafford KA, Lummis SC, Sattelle DB (1989), “Block of an insect central nervous system GABA receptor by cyclodiene and cyclohexane insecticides.” Proc R Soc Lond B Biol Sci 237(1286):53-61 Details

    1988

    Lummis SC, Ellory JC, Sattelle DB (1988), “The cross-linking reagent dimethyl suberimate modifies the target size of an insect nervous system nicotinic acetylcholine receptor.” Neurosci Lett 87(1-2):145-50 Details

    Pinnock RD, Lummis SC, Chiappinelli VA, Sattelle DB (1988), “Kappa-bungarotoxin blocks an alpha-bungarotoxin-sensitive nicotinic receptor in the insect central nervous system.” Brain Res 458(1):45-52 Details

    1987

    Lummis SC, Chow SC, Holan G, Johnston GA (1987), “gamma-Aminobutyric acid receptor ionophore complexes: differential effects of deltamethrin, dichlorodiphenyltrichloroethane, and some novel insecticides in a rat brain membrane preparation.” J Neurochem 48(3):689-94 Details

    1986

    Lummis SC, Sattelle DB (1986), “Binding sites for [(3)H]GABA, [(3)H]flunitrazepam and [(35)S]TBPS in insect CNS.” Neurochem Int 9(2):287-93 Details

    1985

    Lummis SC, Sattelle DB (1985), “Insect central nervous system gamma-aminobutyric acid.” Neurosci Lett 60(1):13-8 Details

    Lummis SC, Sattelle DB (1985), “Binding of N-[propionyl-3H]propionylated alpha-bungarotoxin and L-[benzilic-4,4'-3H] quinuclidinyl benzilate to CNS extracts of the cockroach Periplaneta americana.” Comp Biochem Physiol C 80(1):75-83 Details

    1984

    Elias MS, Lummis SC, Evans PD (1984), “[3H]mepyramine binding sites in the optic lobe of the locust: autoradiographic and pharmacological studies.” Brain Res 294(2):359-62 Details

    Lummis SC, Sattelle DB, Ellory JC (1984), “Molecular weight estimates of insect cholinergic receptors by radiation inactivation.” Neurosci Lett 44(1):7-12 Details

    1981

    Krogsgaard-Larsen P, Snowman A, Lummis SC, Olsen RW (1981), “Characterization of the binding of the GABA agonist [3H]piperidine-4-sulphonic acid to bovine brain synaptic membranes.” J Neurochem 37(2):401-9 Details

    Olsen RW, Bergman MO, Van Ness PC, Lummis SC, Watkins AE, Napias C, Greenlee DV (1981), “gamma-Aminobutyric acid receptor binding in mammalian brain. Heterogeneity of binding sites.” Mol Pharmacol 19(2):217-27 Details