Professor Sabine Bahn

Sabine Bahn

University position

Professor

Professor Sabine Bahn is pleased to consider applications from prospective PhD students.

Departments

and Erasmus Medical Centre, Rotterdam, NL and Department of Chemical Engineering and Biotechnology

Institutes

Institute of Biotechnology

Email

sb209@cam.ac.uk

Home page

http://www.biot.cam.ac.uk/sb/?n1=...

Research Themes

Cellular and Molecular Neuroscience

Systems and Computational Neuroscience

Interests

The goals of the Bahn Laboratory are to develop molecular diagnostics for schizophrenia and other major neuropsychiatric disorders, to develop and test new hypotheses of the pathological basis of schizophrenia and bipolar affective disorder and to determine the cellular mechanisms which regulate the expression of biomarker molecules altered in these states, with a view to developing novel therapeutic strategies.

Research Focus

Keywords

severe mental illness

multi-omics

biomarker

systems biology

bioinformatics

Clinical conditions

Autistic Spectrum Disorders

Bipolar Disorder

Major depression

Schizophrenia

Equipment

Computational modelling

Metabolomics

Proteomics

Systems Biology

Transcriptomics

Collaborators

No collaborators listed

Publications

2014

Broek JA, Brombacher E, Stelzhammer V, Guest PC, Rahmoune H, Bahn S (2014), “The need for a comprehensive molecular characterization of autism spectrum disorders.” Int J Neuropsychopharmacol 17(4):651-73 Details

de Witte L, Tomasik J, Schwarz E, Guest PC, Rahmoune H, Kahn RS, Bahn S (2014), “Cytokine alterations in first-episode schizophrenia patients before and after antipsychotic treatment.” Schizophr Res 154(1-3):23-9 Details

Guest PC, Chan MK, Gottschalk MG, Bahn S (2014), “The use of proteomic biomarkers for improved diagnosis and stratification of schizophrenia patients.” Biomark Med 8(1):15-27 Details

Haenisch F, Alsaif M, Guest PC, Rahmoune H, Dickerson F, Yolken R, Bahn S (2014), “Multiplex immunoassay analysis of plasma shows prominent upregulation of growth factor activity pathways linked to GSK3β signaling in bipolar patients.” J Affect Disord 156:139-43 Details

Herberth M, Rahmoune H, Schwarz E, Koethe D, Harris LW, Kranaster L, Witt SH, Spain M, Barnes A, Schmolz M, Leweke MF, Guest PC, Bahn S (2014), “Identification of a molecular profile associated with immune status in first-onset schizophrenia patients.” Clin Schizophr Relat Psychoses 7(4):207-15 Details

Steeb H, Ramsey JM, Guest PC, Stocki P, Cooper JD, Rahmoune H, Ingudomnukul E, Auyeung B, Ruta L, Baron-Cohen S, Bahn S (2014), “Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome.” Mol Autism 5(1):4 Details

Stelzhammer V, Haenisch F, Chan MK, Cooper JD, Steiner J, Steeb H, Martins-de-Souza D, Rahmoune H, Guest PC, Bahn S (2014), “Proteomic changes in serum of first onset, antidepressant drug-naïve major depression patients.” Int J Neuropsychopharmacol :1-10 Details

Wesseling H, Guest PC, Lago SG, Bahn S (2014), “Technological advances for deciphering the complexity of psychiatric disorders: merging proteomics with cell biology.” Int J Neuropsychopharmacol :1-15 Details

2013

Albrecht A, Rahmoune H, Leedjärv K, Knorpp T, Joos T, Stocki P, Guest PC, Bahn S (2013), “Development of a novel assay for proprotein converting enzyme activity on a multiplex bead-based array system.” Proteomics 13(20):2976-9 Details

Alsaif M, Haenisch F, Guest PC, Rahmoune H, Bahn S (2013), “Challenges in drug target discovery in bipolar disorder.” Expert Opin Ther Targets 17(5):565-77 Details

Amess B, Kluge W, Schwarz E, Haenisch F, Alsaif M, Yolken RH, Leweke FM, Guest PC, Bahn S (2013), “Application of meta-analysis methods for identifying proteomic expression level differences.” Proteomics 13(14):2072-6 Details

Deng J, Lamb JR, McKeown AP, Miller S, Muglia P, Guest PC, Bahn S, Domenici EH, Rahmoune H (2013), “Identification of altered dipeptidyl-peptidase activities as potential biomarkers for unipolar depression.” J Affect Disord 151(2):667-72 Details

Ernst A, Sharma AN, Elased KM, Guest PC, Rahmoune H, Bahn S (2013), “Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders.” Transl Psychiatry 3:e263 Details

Gottschalk MG, Schwarz E, Bahn S (2013), “[Biomarker research in neuropsychiatry: challenges and potential].” Fortschr Neurol Psychiatr 81(5):243-9 Details

Guest PC, Gottschalk MG, Bahn S (2013), “Proteomics: improving biomarker translation to modern medicine?” Genome Med 5(2):17 Details

Guest PC, Martins-de-Souza D, Schwarz E, Rahmoune H, Alsaif M, Tomasik J, Turck CW, Bahn S (2013), “Proteomic profiling in schizophrenia: enabling stratification for more effective treatment.” Genome Med 5(3):25 Details

Harris LW, Guest PC, Wayland MT, Umrania Y, Krishnamurthy D, Rahmoune H, Bahn S (2013), “Schizophrenia: metabolic aspects of aetiology, diagnosis and future treatment strategies.” Psychoneuroendocrinology 38(6):752-66 Details

Jaros JA, Guest PC, Bahn S, Martins-de-Souza D (2013), “Affinity depletion of plasma and serum for mass spectrometry-based proteome analysis.” Methods Mol Biol 1002:1-11 Details

Koutroukides TA, Jaros JA, Amess B, Martins-de-Souza D, Guest PC, Rahmoune H, Levin Y, Deery M, Charles PD, Hester S, Groen A, Christoforou A, Howard J, Bond N, Bahn S, Lilley KS (2013), “Identification of protein biomarkers in human serum using iTRAQ and shotgun mass spectrometry.” Methods Mol Biol 1061:291-307 Details

Krishnamurthy D, Harris LW, Levin Y, Koutroukides TA, Rahmoune H, Pietsch S, Vanattou-Saifoudine N, Leweke FM, Guest PC, Bahn S (2013), “Metabolic, hormonal and stress-related molecular changes in post-mortem pituitary glands from schizophrenia subjects.” World J Biol Psychiatry 14(7):478-89 Details

Nam CS, Lee J, Bahn S (2013), “Brain-computer interface supported collaborative work: Implications for rehabilitation.” Conf Proc IEEE Eng Med Biol Soc 2013:269-72 Details

Ramsey JM, Guest PC, Broek JA, Glennon JC, Rommelse N, Franke B, Rahmoune H, Buitelaar JK, Bahn S (2013), “Identification of an age-dependent biomarker signature in children and adolescents with autism spectrum disorders.” Mol Autism 4(1):27 Details

Ramsey JM, Schwarz E, Guest PC, van Beveren NJ, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Bahn S (2013), “Distinct molecular phenotypes in male and female schizophrenia patients.” PLoS One 8(11):e78729 Details

Schwarz E, Steiner J, Guest PC, Bogerts B, Bahn S (2013), “Investigation of molecular serum profiles associated with predisposition to antipsychotic-induced weight gain.” World J Biol Psychiatry Details

Schwarz E, van Beveren NJ, Ramsey J, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Guest PC, Bahn S (2013), “Identification of Subgroups of Schizophrenia Patients With Changes in Either Immune or Growth Factor and Hormonal Pathways.” Schizophr Bull Details

Stelzhammer V, Guest PC, Rothermundt M, Sondermann C, Michael N, Schwarz E, Rahmoune H, Bahn S (2013), “Electroconvulsive therapy exerts mainly acute molecular changes in serum of major depressive disorder patients.” Eur Neuropsychopharmacol 23(10):1199-207 Details

Wesseling H, Chan MK, Tsang TM, Ernst A, Peters F, Guest PC, Holmes E, Bahn S (2013), “A combined metabonomic and proteomic approach identifies frontal cortex changes in a chronic phencyclidine rat model in relation to human schizophrenia brain pathology.” Neuropsychopharmacology 38(12):2532-44 Details

2012

Alsaif M, Guest PC, Schwarz E, Reif A, Kittel-Schneider S, Spain M, Rahmoune H, Bahn S (2012), “Analysis of serum and plasma identifies differences in molecular coverage, measurement variability, and candidate biomarker selection.” Proteomics Clin Appl 6(5-6):297-303 Details

Bahn S, Giles M (2012), “Evaluation of the Neurodegenerative Conditions Coordinated Care Program (NCCCP) in Western Australia: barriers to better service provision.” Eval Program Plann 35(1):40-6 Details

Ernst A, Ma D, Garcia-Perez I, Tsang TM, Kluge W, Schwarz E, Guest PC, Holmes E, Sarnyai Z, Bahn S (2012), “Molecular validation of the acute phencyclidine rat model for schizophrenia: identification of translational changes in energy metabolism and neurotransmission.” J Proteome Res 11(7):3704-14 Details

Filiou MD, Martins-de-Souza D, Guest PC, Bahn S, Turck CW (2012), “To label or not to label: applications of quantitative proteomics in neuroscience research.” Proteomics 12(4-5):736-47 Details

Guest PC, Urday S, Ma D, Stelzhammer V, Harris LW, Amess B, Pietsch S, Oheim C, Ozanne SE, Bahn S (2012), “Proteomic analysis of the maternal protein restriction rat model for schizophrenia: identification of translational changes in hormonal signaling pathways and glutamate neurotransmission.” Proteomics 12(23-24):3580-9 Details

Harris LW, Pietsch S, Cheng TM, Schwarz E, Guest PC, Bahn S (2012), “Comparison of peripheral and central schizophrenia biomarker profiles.” PLoS One 7(10):e46368 Details

Hradetzky E, Sanderson TM, Tsang TM, Sherwood JL, Fitzjohn SM, Lakics V, Malik N, Schoeffmann S, O'Neill MJ, Cheng TM, Harris LW, Rahmoune H, Guest PC, Sher E, Collingridge GL, Holmes E, Tricklebank MD, Bahn S (2012), “The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus.” Neuropsychopharmacology 37(2):364-77 Details

Jaros JA, Guest PC, Ramoune H, Rothermundt M, Leweke FM, Martins-de-Souza D, Bahn S (2012), “Clinical use of phosphorylated proteins in blood serum analysed by immobilised metal ion affinity chromatography and mass spectrometry.” J Proteomics 76 Spec No.:36-42 Details

Jaros JA, Martins-de-Souza D, Rahmoune H, Rothermundt M, Leweke FM, Guest PC, Bahn S (2012), “Protein phosphorylation patterns in serum from schizophrenia patients and healthy controls.” J Proteomics 76 Spec No.:43-55 Details

Jaros JA, Martins-de-Souza D, Rahmoune H, Schwarz E, Leweke FM, Guest PC, Bahn S (2012), “Differential phosphorylation of serum proteins reflecting inflammatory changes in schizophrenia patients.” Eur Arch Psychiatry Clin Neurosci 262(5):453-5 Details

Martins-de-Souza D, Alsaif M, Ernst A, Harris LW, Aerts N, Lenaerts I, Peeters PJ, Amess B, Rahmoune H, Bahn S, Guest PC (2012), “The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia.” BMC Res Notes 5:146 Details

Martins-de-Souza D, Guest PC, Guest FL, Bauder C, Rahmoune H, Pietsch S, Roeber S, Kretzschmar H, Mann D, Baborie A, Bahn S (2012), “Characterization of the human primary visual cortex and cerebellum proteomes using shotgun mass spectrometry-data-independent analyses.” Proteomics 12(3):500-4 Details

Martins-de-Souza D, Guest PC, Harris LW, Vanattou-Saifoudine N, Webster MJ, Rahmoune H, Bahn S (2012), “Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients.” Transl Psychiatry 2:e87 Details

Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S (2012), “Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.” J Proteome Res 11(4):2533-43 Details

Martins-de-Souza D, Guest PC, Rahmoune H, Bahn S (2012), “Proteomic approaches to unravel the complexity of schizophrenia.” Expert Rev Proteomics 9(1):97-108 Details

Martins-de-Souza D, Guest PC, Vanattou-Saifoudine N, Rahmoune H, Bahn S (2012), “Phosphoproteomic differences in major depressive disorder postmortem brains indicate effects on synaptic function.” Eur Arch Psychiatry Clin Neurosci 262(8):657-66 Details

Ramsey JM, Schwarz E, Guest PC, van Beveren NJ, Leweke FM, Rothermundt M, Bogerts B, Steiner J, Ruta L, Baron-Cohen S, Bahn S (2012), “Molecular sex differences in human serum.” PLoS One 7(12):e51504 Details

Schwarz E, Guest PC, Rahmoune H, Harris LW, Wang L, Leweke FM, Rothermundt M, Bogerts B, Koethe D, Kranaster L, Ohrmann P, Suslow T, McAllister G, Spain M, Barnes A, van Beveren NJ, Baron-Cohen S, Steiner J, Torrey FE, Yolken RH, Bahn S (2012), “Identification of a biological signature for schizophrenia in serum.” Mol Psychiatry 17(5):494-502 Details

Schwarz E, Guest PC, Rahmoune H, Martins-de-Souza D, Niebuhr DW, Weber NS, Cowan DN, Yolken RH, Spain M, Barnes A, Bahn S (2012), “Identification of a blood-based biological signature in subjects with psychiatric disorders prior to clinical manifestation.” World J Biol Psychiatry 13(8):627-32 Details

Schwarz E, Guest PC, Steiner J, Bogerts B, Bahn S (2012), “Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients.” Transl Psychiatry 2:e82 Details

Schwarz E, Torrey EF, Guest PC, Bahn S (2012), “Biomarker discovery in human cerebrospinal fluid: the need for integrative metabolome and proteome databases.” Genome Med 4(4):39 Details

Stelzhammer V, Amess B, Martins-de-Souza D, Levin Y, Ozanne SE, Martin-Gronert MS, Urday S, Bahn S, Guest PC (2012), “Analysis of the rat hypothalamus proteome by data-independent label-free LC-MS/MS.” Proteomics 12(22):3386-92 Details

Telford JE, Bones J, McManus C, Saldova R, Manning G, Doherty M, Leweke FM, Rothermundt M, Guest PC, Rahmoune H, Bahn S, Rudd PM (2012), “Antipsychotic treatment of acute paranoid schizophrenia patients with olanzapine results in altered glycosylation of serum glycoproteins.” J Proteome Res 11(7):3743-52 Details

Tomasik J, Schwarz E, Guest PC, Bahn S (2012), “Blood test for schizophrenia.” Eur Arch Psychiatry Clin Neurosci 262 Suppl 2:S79-83 Details

Weatherill P, Bahn S, Cooper T (2012), “Bespoke program design for school-aged therapy disability service delivery.” J Soc Work Disabil Rehabil 11(3):166-83 Details

2011

Bahn S, Noll R, Barnes A, Schwarz E, Guest PC (2011), “Challenges of introducing new biomarker products for neuropsychiatric disorders into the market.” Int Rev Neurobiol 101:299-327 Details

Bahn S, Schwarz E (2011), “[Serum-based biomarkers for psychiatric disorders].” Nervenarzt 82(11):1395-6, 1398, 1400 passim Details

Chan MK, Guest PC, Levin Y, Umrania Y, Schwarz E, Bahn S, Rahmoune H (2011), “Converging evidence of blood-based biomarkers for schizophrenia: an update.” Int Rev Neurobiol 101:95-144 Details

Chan MK, Tsang TM, Harris LW, Guest PC, Holmes E, Bahn S (2011), “Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients.” Mol Psychiatry 16(12):1189-202 Details

Guest PC, Martins-de-Souza D, Vanattou-Saifoudine N, Harris LW, Bahn S (2011), “Abnormalities in metabolism and hypothalamic-pituitary-adrenal axis function in schizophrenia.” Int Rev Neurobiol 101:145-68 Details

Guest PC, Schwarz E, Krishnamurthy D, Harris LW, Leweke FM, Rothermundt M, van Beveren NJ, Spain M, Barnes A, Steiner J, Rahmoune H, Bahn S (2011), “Altered levels of circulating insulin and other neuroendocrine hormones associated with the onset of schizophrenia.” Psychoneuroendocrinology 36(7):1092-6 Details

Herberth M, Koethe D, Cheng TM, Krzyszton ND, Schoeffmann S, Guest PC, Rahmoune H, Harris LW, Kranaster L, Leweke FM, Bahn S (2011), “Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients.” Mol Psychiatry 16(8):848-59 Details

Herberth M, Koethe D, Levin Y, Schwarz E, Krzyszton ND, Schoeffmann S, Ruh H, Rahmoune H, Kranaster L, Schoenborn T, Leweke MF, Guest PC, Bahn S (2011), “Peripheral profiling analysis for bipolar disorder reveals markers associated with reduced cell survival.” Proteomics 11(1):94-105 Details

Izmailov R, Guest PC, Bahn S, Schwarz E (2011), “Algorithm development for diagnostic biomarker assays.” Int Rev Neurobiol 101:279-98 Details

Kluge W, Alsaif M, Guest PC, Schwarz E, Bahn S (2011), “Translating potential biomarker candidates for schizophrenia and depression to animal models of psychiatric disorders.” Expert Rev Mol Diagn 11(7):721-33 Details

Koutroukides TA, Guest PC, Leweke FM, Bailey DM, Rahmoune H, Bahn S, Martins-de-Souza D (2011), “Characterization of the human serum depletome by label-free shotgun proteomics.” J Sep Sci 34(13):1621-6 Details

Krishnamurthy D, Levin Y, Harris LW, Umrania Y, Bahn S, Guest PC (2011), “Analysis of the human pituitary proteome by data independent label-free liquid chromatography tandem mass spectrometry.” Proteomics 11(3):495-500 Details

Levin Y, Hradetzky E, Bahn S (2011), “Quantification of proteins using data-independent analysis (MSE) in simple andcomplex samples: a systematic evaluation.” Proteomics 11(16):3273-87 Details

Martins-de-Souza D, Guest PC, Steeb H, Pietsch S, Rahmoune H, Harris LW, Bahn S (2011), “Characterizing the proteome of the human dorsolateral prefrontal cortex by shotgun mass spectrometry.” Proteomics 11(11):2347-53 Details

Martins-de-Souza D, Guest PC, Vanattou-Saifoudine N, Harris LW, Bahn S (2011), “Proteomic technologies for biomarker studies in psychiatry: advances and needs.” Int Rev Neurobiol 101:65-94 Details

Martins-de-Souza D, Guest PC, Vanattou-Saifoudine N, Wesseling H, Rahmoune H, Bahn S (2011), “The need for phosphoproteomic approaches in psychiatric research.” J Psychiatr Res 45(10):1404-6 Details

Martins-de-Souza D, Harris LW, Guest PC, Bahn S (2011), “The role of energy metabolism dysfunction and oxidative stress in schizophrenia revealed by proteomics.” Antioxid Redox Signal 15(7):2067-79 Details

Sarnyai Z, Alsaif M, Bahn S, Ernst A, Guest PC, Hradetzky E, Kluge W, Stelzhammer V, Wesseling H (2011), “Behavioral and molecular biomarkers in translational animal models for neuropsychiatric disorders.” Int Rev Neurobiol 101:203-38 Details

Schwarz E, Guest PC, Rahmoune H, Wang L, Levin Y, Ingudomnukul E, Ruta L, Kent L, Spain M, Baron-Cohen S, Bahn S (2011), “Sex-specific serum biomarker patterns in adults with Asperger's syndrome.” Mol Psychiatry 16(12):1213-20 Details

Schwarz E, VanBeveren NJ, Guest PC, Izmailov R, Bahn S (2011), “The application of multiplexed assay systems for molecular diagnostics.” Int Rev Neurobiol 101:259-78 Details

Schwarz E, Whitfield P, Nahnsen S, Wang L, Major H, Leweke FM, Koethe D, Lio P, Bahn S (2011), “Alterations of primary fatty acid amides in serum of patients with severe mental illness.” Front Biosci (Elite Ed) 3:308-14 Details

Steiner J, Marquardt N, Pauls I, Schiltz K, Rahmoune H, Bahn S, Bogerts B, Schmidt RE, Jacobs R (2011), “Human CD8(+) T cells and NK cells express and secrete S100B upon stimulation.” Brain Behav Immun 25(6):1233-41 Details

Stelzhammer V, Rothermundt M, Guest PC, Michael N, Sondermann C, Kluge W, Martins-de-Souza D, Rahmoune H, Bahn S (2011), “Proteomic changes induced by anaesthesia and muscle relaxant treatment prior to electroconvulsive therapy.” Proteomics Clin Appl 5(11-12):644-9 Details

Yang X, Levin Y, Rahmoune H, Ma D, Schöffmann S, Umrania Y, Guest PC, Bahn S (2011), “Comprehensive two-dimensional liquid chromatography mass spectrometric profiling of the rat hippocampal proteome.” Proteomics 11(3):501-5 Details

2010

Cheng TM, Lu YE, Guest PC, Rahmoune H, Harris LW, Wang L, Ma D, Stelzhammer V, Umrania Y, Wayland MT, Lió P, Bahn S (2010), “Identification of targeted analyte clusters for studies of schizophrenia.” Mol Cell Proteomics 9(3):510-22 Details

Duncan CE, Webster MJ, Rothmond DA, Bahn S, Elashoff M, Shannon Weickert C (2010), “Prefrontal GABA(A) receptor alpha-subunit expression in normal postnatal human development and schizophrenia.” J Psychiatr Res 44(10):673-81 Details

Giger T, Khaitovich P, Somel M, Lorenc A, Lizano E, Harris LW, Ryan MM, Lan M, Wayland MT, Bahn S, Pääbo S (2010), “Evolution of neuronal and endothelial transcriptomes in primates.” Genome Biol Evol 2:284-92 Details

Guest PC, Wang L, Harris LW, Burling K, Levin Y, Ernst A, Wayland MT, Umrania Y, Herberth M, Koethe D, van Beveren JM, Rothermundt M, McAllister G, Leweke FM, Steiner J, Bahn S (2010), “Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naïve schizophrenia patients.” Mol Psychiatry 15(2):118-9 Details

Herberth M, Krzyszton DN, Koethe D, Craddock MR, Bulger E, Schwarz E, Guest P, Leweke FM, Bahn S (2010), “Differential effects on T-cell function following exposure to serum from schizophrenia smokers.” Mol Psychiatry 15(4):364-71 Details

Levin Y, Bahn S (2010), “Quantification of proteins by label-free LC-MS/MS.” Methods Mol Biol 658:217-31 Details

Levin Y, Jaros JA, Schwarz E, Bahn S (2010), “Multidimensional protein fractionation of blood proteins coupled to data-independent nanoLC-MS/MS analysis.” J Proteomics 73(3):689-95 Details

Levin Y, Wang L, Schwarz E, Koethe D, Leweke FM, Bahn S (2010), “Global proteomic profiling reveals altered proteomic signature in schizophrenia serum.” Mol Psychiatry 15(11):1088-100 Details

Martins-de-Souza D, Harris LW, Guest PC, Turck CW, Bahn S (2010), “The role of proteomics in depression research.” Eur Arch Psychiatry Clin Neurosci 260(6):499-506 Details

Schwarz E, Izmailov R, Spain M, Barnes A, Mapes JP, Guest PC, Rahmoune H, Pietsch S, Leweke FM, Rothermundt M, Steiner J, Koethe D, Kranaster L, Ohrmann P, Suslow T, Levin Y, Bogerts B, van Beveren NJ, McAllister G, Weber N, Niebuhr D, Cowan D, Yolken RH, Bahn S (2010), “Validation of a blood-based laboratory test to aid in the confirmation of a diagnosis of schizophrenia.” Biomark Insights 5:39-47 Details

Stanta JL, Saldova R, Struwe WB, Byrne JC, Leweke FM, Rothermund M, Rahmoune H, Levin Y, Guest PC, Bahn S, Rudd PM (2010), “Identification of N-glycosylation changes in the CSF and serum in patients with schizophrenia.” J Proteome Res 9(9):4476-89 Details

Steiner J, Jacobs R, Panteli B, Brauner M, Schiltz K, Bahn S, Herberth M, Westphal S, Gos T, Walter M, Bernstein HG, Myint AM, Bogerts B (2010), “Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity.” Eur Arch Psychiatry Clin Neurosci 260(7):509-18 Details

Steiner J, Walter M, Guest P, Myint AM, Schiltz K, Panteli B, Brauner M, Bernstein HG, Gos T, Herberth M, Schroeter ML, Schwarz MJ, Westphal S, Bahn S, Bogerts B (2010), “Elevated S100B levels in schizophrenia are associated with insulin resistance.” Mol Psychiatry 15(1):3-4 Details

Wang L, Lockstone HE, Guest PC, Levin Y, Palotás A, Pietsch S, Schwarz E, Rahmoune H, Harris LW, Ma D, Bahn S (2010), “Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophrenia.” J Proteome Res 9(1):521-7 Details

2009

Harris LW, Lockstone HE, Khaitovich P, Weickert CS, Webster MJ, Bahn S (2009), “Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia.” BMC Med Genomics 2:28 Details

Kim WS, Wong J, Weickert CS, Webster MJ, Bahn S, Garner B (2009), “Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex.” J Neurochem 109(4):1053-66 Details

Lan MJ, McLoughlin GA, Griffin JL, Tsang TM, Huang JT, Yuan P, Manji H, Holmes E, Bahn S (2009), “Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder.” Mol Psychiatry 14(3):269-79 Details

Levin Y, Wang L, Ingudomnukul E, Schwarz E, Baron-Cohen S, Palotás A, Bahn S (2009), “Real-time evaluation of experimental variation in large-scale LC-MS/MS-based quantitative proteomics of complex samples.” J Chromatogr B Analyt Technol Biomed Life Sci 877(13):1299-305 Details

Ma D, Chan MK, Lockstone HE, Pietsch SR, Jones DN, Cilia J, Hill MD, Robbins MJ, Benzel IM, Umrania Y, Guest PC, Levin Y, Maycox PR, Bahn S (2009), “Antipsychotic treatment alters protein expression associated with presynaptic function and nervous system development in rat frontal cortex.” J Proteome Res 8(7):3284-97 Details

Ma D, Guest PC, Bahn S (2009), “Metabonomic studies of schizophrenia and psychotropic medications: focus on alterations in CNS energy homeostasis.” Bioanalysis 1(9):1615-26 Details

McLoughlin GA, Ma D, Tsang TM, Jones DN, Cilia J, Hill MD, Robbins MJ, Benzel IM, Maycox PR, Holmes E, Bahn S (2009), “Analyzing the effects of psychotropic drugs on metabolite profiles in rat brain using 1H NMR spectroscopy.” J Proteome Res 8(4):1943-52 Details

Schwarz E, Leweke FM, Bahn S, Liò P (2009), “Clinical bioinformatics for complex disorders: a schizophrenia case study.” BMC Bioinformatics 10 Suppl 12:S6 Details

Somel M, Franz H, Yan Z, Lorenc A, Guo S, Giger T, Kelso J, Nickel B, Dannemann M, Bahn S, Webster MJ, Weickert CS, Lachmann M, Pääbo S, Khaitovich P (2009), “Transcriptional neoteny in the human brain.” Proc Natl Acad Sci U S A 106(14):5743-8 Details

Weickert CS, Elashoff M, Richards AB, Sinclair D, Bahn S, Paabo S, Khaitovich P, Webster MJ (2009), “Transcriptome analysis of male-female differences in prefrontal cortical development.” Mol Psychiatry 14(6):558-61 Details

2008

Craddock RM, Huang JT, Jackson E, Harris N, Torrey EF, Herberth M, Bahn S (2008), “Increased alpha-defensins as a blood marker for schizophrenia susceptibility.” Mol Cell Proteomics 7(7):1204-13 Details

Harris LW, Wayland M, Lan M, Ryan M, Giger T, Lockstone H, Wuethrich I, Mimmack M, Wang L, Kotter M, Craddock R, Bahn S (2008), “The cerebral microvasculature in schizophrenia: a laser capture microdissection study.” PLoS One 3(12):e3964 Details

Herberth M, Schwarz E, Bahn S (2008), “Problems and promise of immunological factors as biomarkers for schizophrenia.” Biomark Med 2(4):385-95 Details

Huang JT, Wang L, Prabakaran S, Wengenroth M, Lockstone HE, Koethe D, Gerth CW, Gross S, Schreiber D, Lilley K, Wayland M, Oxley D, Leweke FM, Bahn S (2008), “Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues.” Mol Psychiatry 13(12):1118-28 Details

Khaitovich P, Lockstone HE, Wayland MT, Tsang TM, Jayatilaka SD, Guo AJ, Zhou J, Somel M, Harris LW, Holmes E, Pääbo S, Bahn S (2008), “Metabolic changes in schizophrenia and human brain evolution.” Genome Biol 9(8):R124 Details

Schwarz E, Bahn S (2008), “Biomarker discovery in psychiatric disorders.” Electrophoresis 29(13):2884-90 Details

Schwarz E, Bahn S (2008), “Cerebrospinal fluid: identification of diagnostic markers for schizophrenia.” Expert Rev Mol Diagn 8(2):209-16 Details

Schwarz E, Bahn S (2008), “The utility of biomarker discovery approaches for the detection of disease mechanisms in psychiatric disorders.” Br J Pharmacol 153 Suppl 1:S133-6 Details

Schwarz E, Prabakaran S, Whitfield P, Major H, Leweke FM, Koethe D, McKenna P, Bahn S (2008), “High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides.” J Proteome Res 7(10):4266-77 Details

2007

Craddock RM, Lockstone HE, Rider DA, Wayland MT, Harris LJ, McKenna PJ, Bahn S (2007), “Altered T-cell function in schizophrenia: a cellular model to investigate molecular disease mechanisms.” PLoS One 2(8):e692 Details

Huang JT, Leweke FM, Tsang TM, Koethe D, Kranaster L, Gerth CW, Gross S, Schreiber D, Ruhrmann S, Schultze-Lutter F, Klosterkötter J, Holmes E, Bahn S (2007), “CSF metabolic and proteomic profiles in patients prodromal for psychosis.” PLoS One 2(8):e756 Details

Huang JT, McKenna T, Hughes C, Leweke FM, Schwarz E, Bahn S (2007), “CSF biomarker discovery using label-free nano-LC-MS based proteomic profiling: technical aspects.” J Sep Sci 30(2):214-25 Details

Levin Y, Schwarz E, Wang L, Leweke FM, Bahn S (2007), “Label-free LC-MS/MS quantitative proteomics for large-scale biomarker discovery in complex samples.” J Sep Sci 30(14):2198-203 Details

Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ, Bahn S (2007), “Gene expression profiling in the adult Down syndrome brain.” Genomics 90(6):647-60 Details

Prabakaran S, Wengenroth M, Lockstone HE, Lilley K, Leweke FM, Bahn S (2007), “2-D DIGE analysis of liver and red blood cells provides further evidence for oxidative stress in schizophrenia.” J Proteome Res 6(1):141-9 Details

Schwarz E, Levin Y, Wang L, Leweke FM, Bahn S (2007), “Peptide correlation: a means to identify high quality quantitative information in large-scale proteomic studies.” J Sep Sci 30(14):2190-7 Details

Tkachev D, Mimmack ML, Huffaker SJ, Ryan M, Bahn S (2007), “Further evidence for altered myelin biosynthesis and glutamatergic dysfunction in schizophrenia.” Int J Neuropsychopharmacol 10(4):557-63 Details

2006

Holmes E, Tsang TM, Huang JT, Leweke FM, Koethe D, Gerth CW, Nolden BM, Gross S, Schreiber D, Nicholson JK, Bahn S (2006), “Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia.” PLoS Med 3(8):e327 Details

Huang JT, Leweke FM, Oxley D, Wang L, Harris N, Koethe D, Gerth CW, Nolden BM, Gross S, Schreiber D, Reed B, Bahn S (2006), “Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis.” PLoS Med 3(11):e428 Details

Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ, Bahn S (2006), “Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes.” Mol Psychiatry 11(10):965-78 Details

Somel M, Khaitovich P, Bahn S, Pääbo S, Lachmann M (2006), “Gene expression becomes heterogeneous with age.” Curr Biol 16(10):R359-60 Details

Tsang TM, Huang JT, Holmes E, Bahn S (2006), “Metabolic profiling of plasma from discordant schizophrenia twins: correlation between lipid signals and global functioning in female schizophrenia patients.” J Proteome Res 5(4):756-60 Details

Wayland MT, Bahn S (2006), “Reproducibility of microarray studies: concordance of current analysis methods.” Prog Brain Res 158:109-25 Details

2005

Agius M, Zaman R, Singh S, Gallagher O, Jones PB, McGuire P, Power P, Craig T, Bahn S, Grech A, Casha C, Pace C, Cassar D, Blinc-Pesek M, Avgustin B, Gruber E, Biocina SM, Andelic J, Dinolova R, van Os J, Lambert M (2005), “Psychiatry in Europe.” Br J Psychiatry 187:92 Details

Franz H, Ullmann C, Becker A, Ryan M, Bahn S, Arendt T, Simon M, Pääbo S, Khaitovich P (2005), “Systematic analysis of gene expression in human brains before and after death.” Genome Biol 6(13):R112 Details

Jackson ES, Wayland MT, Fitzgerald W, Bahn S (2005), “A microarray data analysis framework for postmortem tissues.” Methods 37(3):247-60 Details

2004

Mimmack ML, Brooking J, Bahn S (2004), “Quantitative polymerase chain reaction: validation of microarray results from postmortem brain studies.” Biol Psychiatry 55(4):337-45 Details

Prabakaran S, Swatton JE, Ryan MM, Huffaker SJ, Huang JT, Griffin JL, Wayland M, Freeman T, Dudbridge F, Lilley KS, Karp NA, Hester S, Tkachev D, Mimmack ML, Yolken RH, Webster MJ, Torrey EF, Bahn S (2004), “Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress.” Mol Psychiatry 9(7):684-97, 643 Details

Ryan MM, Huffaker SJ, Webster MJ, Wayland M, Freeman T, Bahn S (2004), “Application and optimization of microarray technologies for human postmortem brain studies.” Biol Psychiatry 55(4):329-36 Details

Swatton JE, Prabakaran S, Karp NA, Lilley KS, Bahn S (2004), “Protein profiling of human postmortem brain using 2-dimensional fluorescence difference gel electrophoresis (2-D DIGE).” Mol Psychiatry 9(2):128-43 Details

Swatton JE, Sellers LA, Faull RL, Holland A, Iritani S, Bahn S (2004), “Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain.” Eur J Neurosci 19(10):2711-9 Details

Wilson KE, Ryan MM, Prime JE, Pashby DP, Orange PR, O'Beirne G, Whateley JG, Bahn S, Morris CM (2004), “Functional genomics and proteomics: application in neurosciences.” J Neurol Neurosurg Psychiatry 75(4):529-38 Details

2003

Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, Jones PB, Starkey M, Webster MJ, Yolken RH, Bahn S (2003), “Oligodendrocyte dysfunction in schizophrenia and bipolar disorder.” Lancet 362(9386):798-805 Details

2002

Bahn S (2002), “Gene expression in bipolar disorder and schizophrenia: new approaches to old problems.” Bipolar Disord 4 Suppl 1:70-2 Details

Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN, Emson P (2002), “Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study.” Lancet 359(9303):310-5 Details

Mimmack ML, Ryan M, Baba H, Navarro-Ruiz J, Iritani S, Faull RL, McKenna PJ, Jones PB, Arai H, Starkey M, Emson PC, Bahn S (2002), “Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22.” Proc Natl Acad Sci U S A 99(7):4680-5 Details

2001

Bahn S, Augood SJ, Ryan M, Standaert DG, Starkey M, Emson PC (2001), “Gene expression profiling in the post-mortem human brain--no cause for dismay.” J Chem Neuroanat 22(1-2):79-94 Details

Ryan M, Starkey M, Faull R, Emson P, Bahn S (2001), “Indexing-based differential display--studies on post-mortem Alzheimer's brains.” Brain Res Mol Brain Res 88(1-2):199-202 Details

2000

Göttgens B, Barton LM, Gilbert JG, Bench AJ, Sanchez MJ, Bahn S, Mistry S, Grafham D, McMurray A, Vaudin M, Amaya E, Bentley DR, Green AR, Sinclair AM (2000), “Analysis of vertebrate SCL loci identifies conserved enhancers.” Nat Biotechnol 18(2):181-6 Details

1999

Bahn S, Wisden W, Dunnett SB, Svendsen C (1999), “The intrinsic specification of gamma-aminobutyric acid type A receptor alpha6 subunit gene expression in cerebellar granule cells.” Eur J Neurosci 11(6):2194-8 Details

Sinclair AM, Göttgens B, Barton LM, Stanley ML, Pardanaud L, Klaine M, Gering M, Bahn S, Sanchez M, Bench AJ, Fordham JL, Bockamp E, Green AR (1999), “Distinct 5' SCL enhancers direct transcription to developing brain, spinal cord, and endothelium: neural expression is mediated by GATA factor binding sites.” Dev Biol 209(1):128-42 Details

1998

Greene WK, Bahn S, Masson N, Rabbitts TH (1998), “The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development.” Mol Cell Biol 18(12):7030-7 Details

1997

Bahn S, Jones A, Wisden W (1997), “Directing gene expression to cerebellar granule cells using gamma-aminobutyric acid type A receptor alpha6 subunit transgenes.” Proc Natl Acad Sci U S A 94(17):9417-21 Details

Jones A, Korpi ER, McKernan RM, Pelz R, Nusser Z, Mäkelä R, Mellor JR, Pollard S, Bahn S, Stephenson FA, Randall AD, Sieghart W, Somogyi P, Smith AJ, Wisden W (1997), “Ligand-gated ion channel subunit partnerships: GABAA receptor alpha6 subunit gene inactivation inhibits delta subunit expression.” J Neurosci 17(4):1350-62 Details

1996

Bahn S, Harvey RJ, Darlison MG, Wisden W (1996), “Conservation of gamma-aminobutyric acid type A receptor alpha 6 subunit gene expression in cerebellar granule cells.” J Neurochem 66(5):1810-8 Details

Jones A, Bahn S, Grant AL, Köhler M, Wisden W (1996), “Characterization of a cerebellar granule cell-specific gene encoding the gamma-aminobutyric acid type A receptor alpha 6 subunit.” J Neurochem 67(3):907-16 Details

Wisden W, Korpi ER, Bahn S (1996), “The cerebellum: a model system for studying GABAA receptor diversity.” Neuropharmacology 35(9-10):1139-60 Details

1994

Bahn S, Volk B, Wisden W (1994), “Kainate receptor gene expression in the developing rat brain.” J Neurosci 14(9):5525-47 Details

1993

Bahn S, Ganter U, Bauer J, Otten U, Volk B (1993), “Influence of phenytoin on cytoskeletal organization and cell viability of immortalized mouse hippocampal neurons.” Brain Res 615(1):160-9 Details