Dr Steve Edgley

Steve Edgley

University position

Reader

Dr Steve Edgley is pleased to consider applications from prospective PhD students.

Departments

Department of Physiology, Development and Neuroscience

Email

sae1000@cam.ac.uk

Home page

http://www.pdn.cam.ac.uk/groups/... (personal home page)

Research Themes

Systems and Computational Neuroscience

Cellular and Molecular Neuroscience

Interests

I’m interested in how movements are controlled. Our everyday movements are performed with little conscious thought and are remarkably precise. Despite what the textbooks tell you, the way in which this is accomplished is poorly understood. I work at several levels, the main ones being at the level of spinal circuits, and at the level of the cerebellar information processing.

My spinal cord work has involved interneurone circuits, recently commissural neurones that connect the two sides of the cord. My cerebellar work has used electrophysiological approaches to examine what inputs influence cerebellar neurones and how information is processed in the circuit. This work has examined how the climbing fibre system behaves, and more recently, how Golgi cells are activated in relation to the local granule and Purkinje cells.

juxtacellularly labelled Golgi cell
Juxtacellularly labelled Golgi cell
Click image to view full-size

Research Focus

Keywords

cerebellum

spinal cord

electrophysiology

spike discharge

neural circuit

Clinical conditions

Cerebellar ataxias

Movement disorders

Olivocerebellar atrophy

Spinocerebellar ataxia

Stroke

Traumatic brain injury

Equipment

Behavioural analysis

Electrophysiological recording techniques

Extracellular recording

Intracellular recording

Ionophoresis

Neuroanatomical tracing

Collaborators

United Kingdom

Richard Apps Web: http://www.bris.ac.uk/neurosc...

Stuart Baker Web: http://www.staff.ncl.ac.uk/stuart....

Paul Dean Web: http://www.shef.ac.uk/psychol...

David Maxwell Web: http://www.gla.ac.uk/ibls/NB...

Chris Yeo Web: http://www.anat.ucl.ac.uk/researc...

International

Elzbieta Jankowska Web: http://www.physiology.gu.se/jankowska/

Associated News Items


    Key publications

    Soteropoulos DS, Edgley SA, Baker SN (2013), “Spinal commissural connections to motoneurons controlling the primate hand and wrist.” J Neurosci 33(23):9614-25 Details

    Xu W, Jones S, Edgley SA (2013), “Event time representation in cerebellar mossy fibres arising from the lateral reticular nucleus.” J Physiol 591(Pt 4):1045-62 Details

    Zaaimi B, Edgley SA, Soteropoulos DS, Baker SN (2012), “Changes in descending motor pathway connectivity after corticospinal tract lesion in macaque monkey.” Brain 135(Pt 7):2277-89 Details

    Jankowska E, Edgley SA (2010), “Functional subdivision of feline spinal interneurons in reflex pathways from group Ib and II muscle afferents; an update.” Eur J Neurosci 32(6):881-93 Details

    Publications

    2013

    Edgley SA, Gandevia SC (2013), “Batteries and the brain.” J Physiol 591(Pt 13):3105 Details

    Van Dijck G, Van Hulle MM, Heiney SA, Blazquez PM, Meng H, Angelaki DE, Arenz A, Margrie TW, Mostofi A, Edgley S, Bengtsson F, Ekerot CF, Jörntell H, Dalley JW, Holtzman T (2013), “Probabilistic identification of cerebellar cortical neurones across species.” PLoS One 8(3):e57669 Details

    2011

    Holtzman T, Sivam V, Zhao T, Frey O, van der Wal PD, de Rooij NF, Dalley JW, Edgley SA (2011), “Multiple extra-synaptic spillover mechanisms regulate prolonged activity in cerebellar Golgi cell-granule cell loops.” J Physiol 589(Pt 15):3837-54 Details

    Soteropoulos DS, Edgley SA, Baker SN (2011), “Lack of evidence for direct corticospinal contributions to control of the ipsilateral forelimb in monkey.” J Neurosci 31(31):11208-19 Details

    2010

    Lemon RN, Edgley SA (2010), “Life without a cerebellum.” Brain 133(Pt 3):652-4 Details

    Mostofi A, Holtzman T, Grout AS, Yeo CH, Edgley SA (2010), “Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex.” J Neurosci 30(26):8920-34 Details

    Xu W, Edgley SA (2010), “Cerebellar Golgi cells in the rat receive convergent peripheral inputs via a lateral reticular nucleus relay.” Eur J Neurosci 32(4):591-7 Details

    2009

    Holtzman T, Cerminara NL, Edgley SA, Apps R (2009), “Characterization in vivo of bilaterally branching pontocerebellar mossy fibre to Golgi cell inputs in the rat cerebellum.” Eur J Neurosci 29(2):328-39 Details

    Riddle CN, Edgley SA, Baker SN (2009), “Direct and indirect connections with upper limb motoneurons from the primate reticulospinal tract.” J Neurosci 29(15):4993-9 Details

    2008

    Aggelopoulos NC, Chakrabarty S, Edgley SA (2008), “Presynaptic control of transmission through group II muscle afferents in the midlumbar and sacral segments of the spinal cord is independent of corticospinal control.” Exp Brain Res 187(1):61-70 Details

    Xu W, Edgley SA (2008), “Climbing fibre-dependent changes in Golgi cell responses to peripheral stimulation.” J Physiol 586(Pt 20):4951-9 Details

    2006

    Baker MR, Edgley SA (2006), “Non-uniform olivocerebellar conduction time in the vermis of the rat cerebellum.” J Physiol 570(Pt 3):501-6 Details

    Bannatyne BA, Edgley SA, Hammar I, Jankowska E, Maxwell DJ (2006), “Differential projections of excitatory and inhibitory dorsal horn interneurons relaying information from group II muscle afferents in the cat spinal cord.” J Neurosci 26(11):2871-80 Details

    Edgley SA, Aggelopoulos NC (2006), “Short latency crossed inhibitory reflex actions evoked from cutaneous afferents.” Exp Brain Res 171(4):541-50 Details

    Holtzman T, Mostofi A, Phuah CL, Edgley SA (2006), “Cerebellar Golgi cells in the rat receive multimodal convergent peripheral inputs via the lateral funiculus of the spinal cord.” J Physiol 577(Pt 1):69-80 Details

    Holtzman T, Rajapaksa T, Mostofi A, Edgley SA (2006), “Different responses of rat cerebellar Purkinje cells and Golgi cells evoked by widespread convergent sensory inputs.” J Physiol 574(Pt 2):491-507 Details

    Jankowska E, Edgley SA (2006), “How can corticospinal tract neurons contribute to ipsilateral movements? A question with implications for recovery of motor functions.” Neuroscientist 12(1):67-79 Details

    Jankowska E, Stecina K, Cabaj A, Pettersson LG, Edgley SA (2006), “Neuronal relays in double crossed pathways between feline motor cortex and ipsilateral hindlimb motoneurones.” J Physiol 575(Pt 2):527-41 Details

    2005

    Jankowska E, Edgley SA, Krutki P, Hammar I (2005), “Functional differentiation and organization of feline midlumbar commissural interneurones.” J Physiol 565(Pt 2):645-58 Details

    2004

    Edgley SA, Jankowska E, Hammar I (2004), “Ipsilateral actions of feline corticospinal tract neurons on limb motoneurons.” J Neurosci 24(36):7804-13 Details

    Edgley SA, Winter AP (2004), “Different effects of fatiguing exercise on corticospinal and transcallosal excitability in human hand area motor cortex.” Exp Brain Res 159(4):530-6 Details

    Hammar I, Bannatyne BA, Maxwell DJ, Edgley SA, Jankowska E (2004), “The actions of monoamines and distribution of noradrenergic and serotoninergic contacts on different subpopulations of commissural interneurons in the cat spinal cord.” Eur J Neurosci 19(5):1305-16 Details

    Pardoe J, Edgley SA, Drew T, Apps R (2004), “Changes in excitability of ascending and descending inputs to cerebellar climbing fibers during locomotion.” J Neurosci 24(11):2656-66 Details

    2003

    Bannatyne BA, Edgley SA, Hammar I, Jankowska E, Maxwell DJ (2003), “Networks of inhibitory and excitatory commissural interneurons mediating crossed reticulospinal actions.” Eur J Neurosci 18(8):2273-84 Details

    Edgley SA, Jankowska E, Krutki P, Hammar I (2003), “Both dorsal horn and lamina VIII interneurones contribute to crossed reflexes from feline group II muscle afferents.” J Physiol 552(Pt 3):961-74 Details

    Jankowska E, Hammar I, Slawinska U, Maleszak K, Edgley SA (2003), “Neuronal basis of crossed actions from the reticular formation on feline hindlimb motoneurons.” J Neurosci 23(5):1867-78 Details

    Krutki P, Jankowska E, Edgley SA (2003), “Are crossed actions of reticulospinal and vestibulospinal neurons on feline motoneurons mediated by the same or separate commissural neurons?” J Neurosci 23(22):8041-50 Details

    2001

    Baker MR, Javid M, Edgley SA (2001), “Activation of cerebellar climbing fibres to rat cerebellar posterior lobe from motor cortical output pathways.” J Physiol 536(Pt 3):825-39 Details

    Edgley SA (2001), “Organisation of inputs to spinal interneurone populations.” J Physiol 533(Pt 1):51-6 Details

    1999

    Edgley SA, Lemon RN (1999), “Experiments using transcranial magnetic brain stimulation in man could reveal important new mechanisms in motor control.” J Physiol 521 Pt 3:565 Details

    1997

    Aggelopoulos NC, Chakrabarty S, Edgley SA (1997), “Evoked excitability changes at the terminals of midlumbar premotor interneurons in the cat spinal cord.” J Neurosci 17(4):1512-8 Details

    Armand J, Olivier E, Edgley SA, Lemon RN (1997), “Postnatal development of corticospinal projections from motor cortex to the cervical enlargement in the macaque monkey.” J Neurosci 17(1):251-66 Details

    Edgley SA, Eyre JA, Lemon RN, Miller S (1997), “Comparison of activation of corticospinal neurons and spinal motor neurons by magnetic and electrical transcranial stimulation in the lumbosacral cord of the anaesthetized monkey.” Brain 120 ( Pt 5):839-53 Details

    Olivier E, Edgley SA, Armand J, Lemon RN (1997), “An electrophysiological study of the postnatal development of the corticospinal system in the macaque monkey.” J Neurosci 17(1):267-76 Details

    1996

    Aggelopoulos NC, Bawa P, Edgley SA (1996), “Activation of midlumbar neurones by afferents from anterior hindlimb muscles in the cat.” J Physiol 497 ( Pt 3):795-802 Details

    Aggelopoulos NC, Burton MJ, Clarke RW, Edgley SA (1996), “Characterization of a descending system that enables crossed group II inhibitory reflex pathways in the cat spinal cord.” J Neurosci 16(2):723-9 Details

    1995

    Aggelopoulos NC, Duke C, Edgley SA (1995), “Non-uniform conduction time in the olivocerebellar pathway in the anaesthetized cat.” J Physiol 486 ( Pt 3):763-8 Details

    Aggelopoulos NC, Edgley SA (1995), “Segmental localisation of the relays mediating crossed inhibition of hindlimb motoneurones from group II afferents in the anaesthetized cat spinal cord.” Neurosci Lett 185(1):60-4 Details

    1994

    Armand J, Edgley SA, Lemon RN, Olivier E (1994), “Protracted postnatal development of corticospinal projections from the primary motor cortex to hand motoneurones in the macaque monkey.” Exp Brain Res 101(1):178-82 Details

    Davies HE, Edgley SA (1994), “Inputs to group II-activated midlumbar interneurones from descending motor pathways in the cat.” J Physiol 479 ( Pt 3):463-73 Details

    1992

    Asif M, Edgley SA (1992), “Projections of group II-activated midlumbar spinocerebellar tract neurones to the region of nucleus Z in the cat.” J Physiol 448:565-78 Details

    Bajwa S, Edgley SA, Harrison PJ (1992), “Crossed actions on group II-activated interneurones in the midlumbar segments of the cat spinal cord.” J Physiol 455:205-17 Details

    1991

    Arya T, Bajwa S, Edgley SA (1991), “Crossed reflex actions from group II muscle afferents in the lumbar spinal cord of the anaesthetized cat.” J Physiol 444:117-31 Details

    Edgley SA, Grant GM (1991), “Inputs to spinocerebellar tract neurones located in stilling's nucleus in the sacral segments of the rat spinal cord.” J Comp Neurol 305(1):130-8 Details

    1990

    Edgley SA, Eyre JA, Lemon RN, Miller S (1990), “Excitation of the corticospinal tract by electromagnetic and electrical stimulation of the scalp in the macaque monkey.” J Physiol 425:301-20 Details

    1989

    Edgley SA, Wallace NA (1989), “A short-latency crossed pathway from cutaneous afferents to rat hindlimb motoneurones.” J Physiol 411:469-80 Details

    1988

    Armstrong DM, Edgley SA (1988), “Discharges of interpositus and Purkinje cells of the cat cerebellum during locomotion under different conditions.” J Physiol 400:425-45 Details

    Armstrong DM, Edgley SA, Lidierth M (1988), “Complex spikes in Purkinje cells of the paravermal part of the anterior lobe of the cat cerebellum during locomotion.” J Physiol 400:405-14 Details

    Edgley SA, Gallimore CM (1988), “The morphology and projections of dorsal horn spinocerebellar tract neurones in the cat.” J Physiol 397:99-111 Details

    Edgley SA, Jankowska E (1988), “Information processed by dorsal horn spinocerebellar tract neurones in the cat.” J Physiol 397:81-97 Details

    Edgley SA, Jankowska E, Shefchyk S (1988), “Evidence that mid-lumbar neurones in reflex pathways from group II afferents are involved in locomotion in the cat.” J Physiol 403:57-71 Details

    Edgley SA, Lidierth M (1988), “Step-related discharges of Purkinje cells in the paravermal cortex of the cerebellar anterior lobe in the cat.” J Physiol 401:399-415 Details

    1987

    Cavallari P, Edgley SA, Jankowska E (1987), “Post-synaptic actions of midlumbar interneurones on motoneurones of hind-limb muscles in the cat.” J Physiol 389:675-89 Details

    Edgley SA, Jankowska E (1987), “An interneuronal relay for group I and II muscle afferents in the midlumbar segments of the cat spinal cord.” J Physiol 389:647-74 Details

    Edgley SA, Jankowska E (1987), “Field potentials generated by group II muscle afferents in the middle lumbar segments of the cat spinal cord.” J Physiol 385:393-413 Details

    Edgley SA, Lidierth M (1987), “The discharges of cerebellar Golgi cells during locomotion in the cat.” J Physiol 392:315-32 Details

    1984

    Armstrong DM, Edgley SA (1984), “Discharges of Purkinje cells in the paravermal part of the cerebellar anterior lobe during locomotion in the cat.” J Physiol 352:403-24 Details

    Armstrong DM, Edgley SA (1984), “Discharges of nucleus interpositus neurones during locomotion in the cat.” J Physiol 351:411-32 Details