Dr Steve Edgley
University position
Reader
Dr Steve Edgley is pleased to consider applications from prospective PhD students.
Departments
Department of Physiology, Development and Neuroscience
Home page
http://www.pdn.cam.ac.uk/groups/... (personal home page)
Research Themes
Interests
I’m interested in how movements are controlled. Our everyday movements are performed with little conscious thought and are remarkably precise. Despite what the textbooks tell you, the way in which this is accomplished is poorly understood. I work at several levels, the main ones being at the level of spinal circuits, and at the level of the cerebellar information processing.
My spinal cord work has involved interneurone circuits, recently commissural neurones that connect the two sides of the cord. My cerebellar work has used electrophysiological approaches to examine what inputs influence cerebellar neurones and how information is processed in the circuit. This work has examined how the climbing fibre system behaves, and more recently, how Golgi cells are activated in relation to the local granule and Purkinje cells.
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Research Focus
Keywordscerebellum spinal cord electrophysiology spike discharge neural circuit |
Clinical conditionsCerebellar ataxias Movement disorders Olivocerebellar atrophy Spinocerebellar ataxia Stroke Traumatic brain injury |
Equipment
Behavioural analysis
Electrophysiological recording techniques
Extracellular recording
Intracellular recording
Ionophoresis
Neuroanatomical tracing
Collaborators
United KingdomRichard Apps Web: http://www.bris.ac.uk/neurosc... Stuart Baker Web: http://www.staff.ncl.ac.uk/stuart.... Paul Dean Web: http://www.shef.ac.uk/psychol... David Maxwell Web: http://www.gla.ac.uk/ibls/NB... Chris Yeo Web: http://www.anat.ucl.ac.uk/researc... InternationalElzbieta Jankowska Web: http://www.physiology.gu.se/jankowska/ |
Key publications
Mostofi A, Holtzman T, Grout AS, Yeo CH, Edgley SA (2010), “Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex.” J Neurosci 30(26):8920-34 Details
Xu W, Edgley SA (2008), “Climbing fibre-dependent changes in Golgi cell responses to peripheral stimulation.” J Physiol 586(Pt 20):4951-9 Details
Holtzman T, Mostofi A, Phuah CL, Edgley SA (2006), “Cerebellar Golgi cells in the rat receive multimodal convergent peripheral inputs via the lateral funiculus of the spinal cord.” J Physiol 577(Pt 1):69-80 Details
Holtzman T, Rajapaksa T, Mostofi A, Edgley SA (2006), “Different responses of rat Cerebellar Golgi cell and Purkinje cells evoked by somatosensory afferent inputs” Journal of Physiology 574(Pt 2):491-507 Details
Edgley SA, Jankowska E, Hammar I (2004), “Ipsilateral Actions of Feline Corticospinal Tract Neurons on Limb Motoneurons” Journal of Neuroscience 24:7804-13 Details
Jankowska E, Hammar I, Slawinska U, Maleszak K, Edgley SA (2003), “Neuronal basis of crossed actions from the reticular formation on feline hindlimb motoneurons.” J Neurosci 23(5):1867-78 Details
Publications
2010
Jankowska E, Edgley SA (2010), “Functional subdivision of feline spinal interneurons in reflex pathways from group Ib and II muscle afferents; an update.” Eur J Neurosci 32(6):881-93 Details
Xu W, Edgley SA (2010), “Cerebellar Golgi cells in the rat receive convergent peripheral inputs via a lateral reticular nucleus relay.” Eur J Neurosci 32(4):591-7 Details
2009
Holtzman T, Cerminara NL, Edgley SA, Apps R (2009), “Characterization in vivo of bilaterally branching pontocerebellar mossy fibre to Golgi cell inputs in the rat cerebellum.” Eur J Neurosci 29(2):328-39 Details
Riddle CN, Edgley SA, Baker SN (2009), “Direct and indirect connections with upper limb motoneurons from the primate reticulospinal tract.” J Neurosci 29(15):4993-9 Details
2008
Aggelopoulos NC, Chakrabarty S, Edgley SA (2008), “Presynaptic control of transmission through group II muscle afferents in the midlumbar and sacral segments of the spinal cord is independent of corticospinal control.” Exp Brain Res 187(1):61-70 Details
2006
Baker MR, Edgley SA (2006), “Non-uniform olivocerebellar conduction time in the vermis of the rat cerebellum.” J Physiol 570(Pt 3):501-6 Details
Bannatyne BA, Edgley SA, Hammar I, Jankowska E, Maxwell DJ (2006), “Differential projections of excitatory and inhibitory dorsal horn interneurons relaying information from group II muscle afferents in the cat spinal cord.” J Neurosci 26(11):2871-80 Details
Jankowska E, Stecina K, Cabaj A, Pettersson LG, Edgley SA (2006), “Neuronal relays in double crossed pathways between feline motor cortex and ipsilateral hindlimb motoneurones.” J Physiol 575(Pt 2):527-41 Details
2004
Hammar I, Bannatyne BA, Maxwell DJ, Edgley SA, Jankowska E (2004), “The actions of monoamines and distribution of noradrenergic and serotoninergic contacts on different subpopulations of commissural interneurons in the cat spinal cord.” Eur J Neurosci 19(5):1305-16 Details
Pardoe J, Edgley SA, Drew T, Apps R (2004), “Changes in excitability of ascending and descending inputs to cerebellar climbing fibers during locomotion.” J Neurosci 24(11):2656-66 Details
2003
Krutki P, Jankowska E, Edgley SA (2003), “Are crossed actions of reticulospinal and vestibulospinal neurons on feline motoneurons mediated by the same or separate commissural neurons?” J Neurosci 23(22):8041-50 Details
1997
Aggelopoulos NC, Chakrabarty S, Edgley SA (1997), “Evoked excitability changes at the terminals of midlumbar premotor interneurons in the cat spinal cord.” J Neurosci 17(4):1512-8 Details
Edgley SA, Eyre JA, Lemon RN, Miller S (1997), “Comparison of activation of corticospinal neurons and spinal motor neurons by magnetic and electrical transcranial stimulation in the lumbosacral cord of the anaesthetized monkey.” Brain 120 ( Pt 5):839-53 Details
Research and Collaboration
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